Patents by Inventor Martin S. Linsell

Martin S. Linsell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBSTITUTED BENZENECARBOXAMIDES AS IL-17A MODULATORS
    Publication number: 20230141212
    Abstract: The disclosure herein provides compounds and pharmaceutical compositions of the structure of Formula I: for the modulation of IL-17A, useful for the treatment of inflammatory conditions, such as psoriasis.
    Type: Application
    Filed: December 28, 2022
    Publication date: May 11, 2023
    Inventors: Paul R. FATHEREE, Martin S. LINSELL, John R. JACOBSEN, Wouter A. VAN DER LINDEN, Timothy J. CHURCH, Claudio AQUINO, Margot G. PAULICK
  • SUBSTITUTED BENZENECARBOXAMIDES AS IL-17A MODULATORS
    Publication number: 20230145481
    Abstract: The disclosure herein provides compounds and pharmaceutical compositions of the structure of Formula I: for the modulation of IL-17A, useful for the treatment of inflammatory conditions, such as psoriasis.
    Type: Application
    Filed: December 28, 2022
    Publication date: May 11, 2023
    Inventors: Paul R. FATHEREE, Martin S. LINSELL, John R. JACOBSEN, Wouter A. VAN DER LINDEN, Timothy J. CHURCH, Claudio AQUINO, Margot G. PAULICK
  • IL-17 LIGANDS AND USES THEREOF
    Publication number: 20230053746
    Abstract: Provided herein are novel ligands and pharmaceutical compositions thereof which modulate IL-17A. Also provided are methods for preparing the IL-17A modulators. Such compounds may be useful in the treatment and/or prevention of, for example, inflammation, cancer or autoimmune disease.
    Type: Application
    Filed: July 15, 2022
    Publication date: February 23, 2023
    Inventors: Paul R. FATHEREE, Martin S. LINSELL, John R. JACOBSEN, Wouter VAN DER LINDEN, Timothy J. CHURCH, Claudio AQUINO, Margot PAULICK
  • IL-17 ligands and uses thereof
    Patent number: 11447468
    Abstract: Provided herein are novel ligands and pharmaceutical compositions thereof which modulate IL-17A. Also provided are methods for preparing the IL-17A modulators. Such compounds may be useful in the treatment and/or prevention of, for example, inflammation, cancer or autoimmune disease.
    Type: Grant
    Filed: February 6, 2020
    Date of Patent: September 20, 2022
    Assignee: DICE ALPHA, INC.
    Inventors: Paul R. Fatheree, Martin S. Linsell, John R. Jacobsen, Wouter Van der Linden, Timothy J. Church, Claudio Aquino, Margot Paulick
  • SUBSTITUTED BENZENECARBOXAMIDES AS IL-17A MODULATORS
    Publication number: 20220235038
    Abstract: The disclosure herein provides compounds and pharmaceutical compositions of the structure of Formula I: for the modulation of IL-17A, useful for the treatment of inflammatory conditions, such as psoriasis.
    Type: Application
    Filed: January 27, 2022
    Publication date: July 28, 2022
    Inventors: Paul R. FATHEREE, Martin S. LINSELL, John R. JACOBSEN, Wouter A. VAN DER LINDEN, Timothy J. CHURCH, Claudio AQUINO, Margot G. PAULICK
  • Substituted benzenecarboxamides as IL-17A modulators
    Patent number: 11274094
    Abstract: The disclosure herein provides compounds and pharmaceutical compositions for the modulation of IL-17A useful for the treatment of inflammatory conditions, such as psoriasis.
    Type: Grant
    Filed: December 11, 2020
    Date of Patent: March 15, 2022
    Assignee: DICE ALPHA, INC.
    Inventors: Paul R. Fatheree, Martin S. Linsell, John R. Jacobsen, Wouter A. Van Der Linden, Timothy J. Church, Claudio Aquino, Margot G. Paulick
  • IL-17A MODULATORS AND USES THEREOF
    Publication number: 20210101886
    Abstract: The disclosure herein provides compounds and pharmaceutical compositions for the modulation of IL-17A useful for the treatment of inflammatory conditions, such as psoriasis.
    Type: Application
    Filed: December 11, 2020
    Publication date: April 8, 2021
    Inventors: Paul R. FATHEREE, Martin S. LINSELL, John R. JACOBSEN, Wouter A. VAN DER LINDEN, Timothy J. CHURCH, Claudio AQUINO, Margot G. PAULICK
  • IL-17 Ligands And Uses Thereof
    Publication number: 20200247785
    Abstract: Provided herein are novel ligands and pharmaceutical compositions thereof which modulate IL-17A. Also provided are methods for preparing the IL-17A modulators. Such compounds may be useful in the treatment and/or prevention of, for example, inflammation, cancer or autoimmune disease.
    Type: Application
    Filed: February 6, 2020
    Publication date: August 6, 2020
    Inventors: Paul R. Fatheree, Martin S. Linsell, John R. Jacobsen, Wouter Van der Linden, Timothy J. Church, Claudio Aquino, Margot Paulick
  • Cross-linked glycopeptide-cephalosporin antibiotics
    Patent number: 8314217
    Abstract: This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: December 8, 2010
    Date of Patent: November 20, 2012
    Assignee: Theravance, Inc.
    Inventor: Martin S. Linsell
  • GLYCOPEPTIDE PHOSPHONATE DERIVATIVES
    Publication number: 20120283195
    Abstract: Disclosed are glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
    Type: Application
    Filed: December 16, 2011
    Publication date: November 8, 2012
    Applicant: THERAVANCE, INC.
    Inventors: Michael R. Leadbetter, Martin S. Linsell
  • ANTIBACTERIAL FLUOROQUINOLONE ANALOGS
    Publication number: 20120058989
    Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein A, B, D, E, G, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Application
    Filed: April 7, 2011
    Publication date: March 8, 2012
    Applicant: Achaogen, Inc.
    Inventors: Allan S. Wagman, Heinz E. Moser, Glenn A. McEnroe, James B. Aggen, Martin S. Linsell, Adam A. Goldblum, John H. Griffin, Lloyd J. Simons, Thomas R. Belliotti, Christina R. Harris, Toni-Jo Poel, Michael J. Melnick, Ricky D. Gaston
  • Process for preparing glycopeptide phosphonate derivatives
    Patent number: 8093354
    Abstract: Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without isolation of intermediate reaction products, thereby generating less waste and improving the overall efficiency and yield of the process.
    Type: Grant
    Filed: April 13, 2010
    Date of Patent: January 10, 2012
    Assignee: Theravance, Inc.
    Inventors: Michael R. Leadbetter, Martin S. Linsell, Junning Lee, Jyanwei Liu
  • Cross-linked glycopeptide-cephalosporin antibiotics
    Patent number: 8084417
    Abstract: This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: June 19, 2008
    Date of Patent: December 27, 2011
    Assignee: Theravance, Inc.
    Inventors: Daniel Marquess, Martin S. Linsell, S. Derek Turner, Sean G. Trapp, Daniel D. Long, Paul R. Fatheree
  • CROSS-LINKED GLYCOPEPTIDE-CEPHALOSPORIN ANTIBIOTICS
    Publication number: 20110224130
    Abstract: This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: December 8, 2010
    Publication date: September 15, 2011
    Applicant: THERAVANCE, INC.
    Inventor: Martin S. LINSELL
  • Amino-substituted ethylamino ?adrenergic receptor agonists
    Patent number: 7964730
    Abstract: The invention provides novel ?2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with ?2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: June 21, 2011
    Assignee: Theravance, Inc.
    Inventors: Martin S. Linsell, John R. Jacobsen, Daisuke Roland Saito
  • PROCESS FOR PREPARING GLYCOPEPTIDE PHOSPHONATE DERIVATIVES
    Publication number: 20110060122
    Abstract: Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without isolation of intermediate reaction products, thereby generating less waste and improving the overall efficiency and yield of the process.
    Type: Application
    Filed: April 13, 2010
    Publication date: March 10, 2011
    Applicant: THERAVANCE, INC.
    Inventors: Michael R. Leadbetter, Martin S. Linsell, Junning Lee, Jyanwei Liu
  • Cephalosporin compounds
    Patent number: 7871997
    Abstract: This invention provides cephalosporin compounds and salts thereof. Such compounds are useful for preparing cross-linked glycopeptide-cephalosporin antibiotics.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: January 18, 2011
    Assignee: Theravance, Inc.
    Inventors: Paul R. Fatheree, Martin S. Linsell, Daniel Marquess, Daniel D. Long, Jason P. Chinn, Matthew B. Nodwell, Edmund J. Moran, James B. Aggen
  • CROSS-LINKED GLYCOPEPTIDE-CEPHALOSPORIN ANTIBIOTICS
    Publication number: 20100197569
    Abstract: This invention provides cross-linked glycopeptide—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: April 13, 2010
    Publication date: August 5, 2010
    Applicant: THERAVANCE, INC.
    Inventors: Paul R. Fatheree, Martin S. Linsell, Daniel D. Long, Daniel Marquess, Edmund J. Moran, Matthew B. Nodwell, S. Derek Turner, James Aggen
  • GLYCOPEPTIDE PHOSPHONATE DERIVATIVES
    Publication number: 20100160211
    Abstract: Disclosed are glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
    Type: Application
    Filed: March 2, 2010
    Publication date: June 24, 2010
    Applicant: THERAVANCE, INC.
    Inventors: Michael R. Leadbetter, Martin S. Linsell
  • Cross-linked glycopeptide-cephalosporin antibiotics
    Patent number: 7728127
    Abstract: This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: August 24, 2007
    Date of Patent: June 1, 2010
    Assignee: Theravance, Inc.
    Inventors: Paul R. Fatheree, Martin S. Linsell, Daniel Marquess, S. Derek Turner