Patents by Inventor Martin S. Linsell

Martin S. Linsell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing glycopeptide phosphonate derivatives
    Patent number: 7728104
    Abstract: Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without isolation of intermediate reaction products, thereby generating less waste and improving the overall efficiency and yield of the process.
    Type: Grant
    Filed: October 24, 2007
    Date of Patent: June 1, 2010
    Assignee: Theravance, Inc.
    Inventors: Michael R. Leadbetter, Martin S. Linsell, Junning Lee, Jyanwei Liu
  • Glycopeptide derivatives and pharmaceutical compositions containing the same
    Patent number: 7723470
    Abstract: Disclosed are compounds of the formula: or a trifluoroacetic acid salt thereof, wherein A, B and Fmoc are as defined herein. Such compounds are useful as synthetic intermediates for preparing glycopeptides antibiotics.
    Type: Grant
    Filed: October 24, 2007
    Date of Patent: May 25, 2010
    Assignee: Theravance, Inc.
    Inventors: J. Kevin Judice, Paul Ross Fatheree, Bernice M. T. Lam, Michael R. Leadbetter, Martin S. Linsell, YongQi Mu, Sean Gary Trapp, Guang Yang, Yan Zhu
  • Cross-linked glycopeptide-cephalosporin antibiotics
    Patent number: 7713931
    Abstract: This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: August 24, 2007
    Date of Patent: May 11, 2010
    Assignee: Theravance, Inc.
    Inventors: Paul R. Fatheree, Martin S. Linsell, Daniel Marquess, S. Derek Turner
  • Cross-linked glycopeptide-cephalosporin antibiotics
    Patent number: 7655621
    Abstract: This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: August 24, 2007
    Date of Patent: February 2, 2010
    Assignee: Theravance, Inc.
    Inventors: Paul R. Fatheree, Martin S. Linsell, Daniel Marquess, S. Derek Turner
  • Cross-linked glycopeptide-cephalosporin antibiotics
    Patent number: 7649080
    Abstract: This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: August 24, 2007
    Date of Patent: January 19, 2010
    Assignee: Theravance, Inc.
    Inventors: Paul R. Fatheree, Martin S. Linsell, Daniel Marquess, S. Derek Turner
  • Cross-linked glycopeptide-cephalosporin antibiotics
    Patent number: 7612037
    Abstract: This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: October 25, 2007
    Date of Patent: November 3, 2009
    Assignee: Theravance, Inc.
    Inventors: Paul R. Fatheree, Martin S. Linsell, Daniel D. Long, Daniel Marquess, Edmund J. Moran, Matthew B. Nodwell, S. Derek Turner, James Aggen
  • Cross-linked glycopeptide-cephalosporin antibiotics
    Patent number: 7601690
    Abstract: This invention provides cross-linked glycopeptides—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: August 24, 2007
    Date of Patent: October 13, 2009
    Assignee: Theravance, Inc.
    Inventors: Paul R. Fatheree, Martin S. Linsell, Daniel Marquess, S. Derek Turner
  • GLYCOPEPTIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
    Publication number: 20090215982
    Abstract: Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: —Ra—Y—Rb-(Z)x where Ra, Rb, Y, Z and x are as defined, and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
    Type: Application
    Filed: May 8, 2009
    Publication date: August 27, 2009
    Inventors: J. Kevin Judice, Paul Ross Fatheree, Bernice M.T. Lam, Michael R. Leadbetter, Martin S. Linsell, YongQi Mu, Sean Gary Trapp, Guang Yang, Yan Zhu
  • Amidine substituted aryl aniline compounds
    Patent number: 7566785
    Abstract: The invention provides novel ?2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with ?2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: September 8, 2005
    Date of Patent: July 28, 2009
    Assignee: Theravance, Inc.
    Inventors: Martin S. Linsell, John R. Jacobsen, Ningning Xu
  • Cross-linked glycopeptide-cephalosporin antibiotics
    Patent number: 7553962
    Abstract: This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: August 24, 2007
    Date of Patent: June 30, 2009
    Assignee: Theravance, Inc.
    Inventors: Paul R. Fatheree, Martin S. Linsell, Daniel Marquess, S. Derek Turner
  • Cross-linked glycopeptide-cephalosporin antibiotics
    Publication number: 20090137460
    Abstract: This invention provides cross-linked glycopeptide—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: June 19, 2008
    Publication date: May 28, 2009
    Inventors: Daniel Marquess, Martin S. Linsell, S. Derek Turner, Sean G. Trapp, Daniel D. Long, Paul R. Fatheree
  • Amino-Substituted Ethylamino Beta2 Adrenergic Receptor Agonists
    Publication number: 20090111850
    Abstract: The invention provides novel ?2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with ?2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: April 30, 2008
    Publication date: April 30, 2009
    Inventors: Martin S. Linsell, John R. Jacobsen, Daisuke Roland Saito
  • Glycopeptide phosphonate derivatives
    Publication number: 20080312407
    Abstract: Disclosed are glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
    Type: Application
    Filed: October 24, 2007
    Publication date: December 18, 2008
    Inventors: Michael R. Leadbetter, Martin S. Linsell
  • Process for preparing glycopeptide phosphonate derivatives
    Publication number: 20080227963
    Abstract: Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without isolation of intermediate reaction products, thereby generating less waste and improving the overall efficiency and yield of the process.
    Type: Application
    Filed: October 24, 2007
    Publication date: September 18, 2008
    Inventors: Michael R. Leadbetter, Martin S. Linsell, Junning Lee, Jyanwei Liu
  • Cross-linked glycopeptide-cephalosporin antibiotics
    Publication number: 20080194465
    Abstract: This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: August 24, 2007
    Publication date: August 14, 2008
    Inventors: Paul R. Fatheree, Martin S. Linsell, Daniel D. Long, Daniel Marquess, Edmund J. Moran, Matthew B. Nodwell, S. Derek Turner, James Aggen
  • Cross-linked glycopeptide-cephalosporin antibiotics
    Publication number: 20080194464
    Abstract: This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: August 24, 2007
    Publication date: August 14, 2008
    Inventors: Paul R. Fatheree, Martin S. Linsell, Daniel D. Long, Daniel Marquess, Edmund J. Moran, Matthew B. Nodwell, S. Derek Turner, James Aggen
  • Cross-linked glycopeptide-cephalosporin antibiotics
    Patent number: 7405199
    Abstract: This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: September 22, 2005
    Date of Patent: July 29, 2008
    Assignee: Theravance, Inc.
    Inventors: Daniel Marquess, Martin S. Linsell, Paul Fatheree, Michael R. Leadbetter
  • Diamine ?adrenergic receptor agonists
    Patent number: 7402673
    Abstract: The invention provides novel ?2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with ?2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: June 2, 2005
    Date of Patent: July 22, 2008
    Assignee: Theravance, Inc.
    Inventor: Martin S. Linsell
  • Amino-substituted ethylamino ?adrenergic receptor agonists
    Patent number: 7399863
    Abstract: The invention provides novel ?2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with ?2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: September 21, 2004
    Date of Patent: July 15, 2008
    Assignee: Theravance, Inc.
    Inventors: Martin S. Linsell, John R. Jacobsen, Daisuke Roland Saito
  • Intermediate for preparing glycopeptide derivatives
    Patent number: 7351791
    Abstract: This invention provides 9-fluorenylmethoxycarbonyl compounds that are useful as intermediates for preparing glycopeptide antibiotics.
    Type: Grant
    Filed: April 17, 2006
    Date of Patent: April 1, 2008
    Assignee: Theravance, Inc.
    Inventor: Martin S. Linsell