Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, L1 and G1 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by positive allosteric modulation of the ?-aminobutyric acid B (GABA-B) receptor. Methods for making the compounds are described. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

Abstract: The present application relates to isolated proteins, particularly monoclonal antibodies, in particular CDR-grafted, humanized antibodies which bind to RAGE protein. Specifically, these antibodies have the ability to inhibit the binding of RAGE to its various ligands. The antibodies or portions thereof of described in the present application are useful for treating a disease or disorder characterized by or induced by pathophysiological ligands of RAGE, for example missfolded proteins like amyloid ? and advanced glycation-end-products.

Abstract: A microvalve device is provided that includes a through via located in an island structure supported on a thermally-insulating membrane supported by a frame. The through via is surrounded by a meltable sealing material. A heater element is positioned on the island structure for sealing the material over the through via by heating the sealing material.

Abstract: In one embodiment the disclosure relates to an apparatus for depositing an organic material on a substrate, including a source heater for heating organic particles to form suspended organic particles; a transport stream for delivering the suspended organic particles to a discharge nozzle, the discharge nozzle having a plurality of micro-pores, the micro-pores providing a conduit for passage of the suspended organic particles; and a nozzle heater for pulsatingly heating the micro-pores nozzle to discharge the suspended organic particles from the discharge nozzle.

Abstract: A transducer connects with a support arm. The support arm supports only some of the weight, even in a locked state. By only supporting a portion or less than all of the weight, the support arm allows downward movement or pressure, but less than the pressure applied without any resistance for the gravity acting on the support arm. The pressure maintains contact between the patient and the transducer for scanning.

Abstract: The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.

Abstract: Disclosed is an electrical contact element for contacting an electrical strand conductor, wherein the electrical contact element has a connecting side and a plugging side. A splicing element is provided in a connecting sleeve that forms the connecting side so as to electrically contact an electrical strand conductor in a more effective manner. The splicing element is provided for the purpose of separating out the individual strands of the conductor, contacting as large as possible a surface of the individual strands and penetrating the surface of the strands during a squeezing or crimping action. The arrangement provides a reliable, electrical contact of strand conductors in which a surface of the individual strands that is not suitable for being contacted and is poorly conductive is penetrated.

Abstract: A lubricating grease is provided that comprises 90 to 99.45 percent by mass of perfluoropolyethers (PFPE) and 0.5 to 5 percent by mass of fumed silica.

Abstract: A composition for prevention or reduction of fatigue damage, especially trench formation or micropitting, of the surfaces of drive elements, is provided that comprises 0.1 to 40% by weight of surface-modified nanoparticles, and 99.9 to 60% by weight of a carrier material suitable for application to the drive element surfaces.

Abstract: The present invention relates to the identification, functionality and use of domains from the N terminus of the receptor for Advanced Glycation End Products (AGER). These domains, called receptor multimerization epitope (RME), are highly conserved in all AGER protein sequences. They represent the mediators for AGER self-association and heteromerization with other proteins. The invention likewise relates to the identification, functionality and use of peptides derived from the C domain of AGER (AGER-CDP). The AGER RMEs and AGER-CDPs of the invention are suitable as target for identifying AGER ligands which modulate the natural ligand interaction; as immunogen for active or passive immunization of individuals, as diagnostic means for identifying immunogenic reactions, and as peptide ligands for modulating protein-protein interactions involving AGER.

Abstract: Provided are diagnostic assays and method s of using the diagnostic assays for detecting and quantifying RGMa fragments in a sample. The methods may be used detection of the RGMa fragments to monitoring drug treatment and effectiveness of drug treatment in neurodegenerative diseases.

Abstract: The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.

Abstract: In a water drain plug (10) for a cavity (16) of a vehicle, in particular a side sill (14), comprising a base body (18) which can be fixed in an aperture (12) of the cavity (14) and has an opening (20) in which a sealing element (22) is arranged that is adapted to be moved between a closing position in which the opening (20) is tightly closed, and an opening position in which the opening (20) is open, the sealing element (22) is mounted in the base body (18) for pivoting movement about a retaining axis (36).

Abstract: The invention relates to a ball-and-socket implant (I), in particular an acetabular implant, preferably in the shape of a spherical cup shell, said implant having at least one region with a surface structure (2, 7). The at least one region extends between the equator and the pole of the spherical cup shell. The surface structure comprises a plurality of structural elements (6), each of which is formed by a plurality of intersecting ridges (3, 8) with opposite inclinations. The number of structural elements (6) on the equator (5) or on a circle of latitude near the equator is the same as on a circle of latitude near the pole. The ridges (3, 8) have a curvature such that the inclination of the ridges with respect to the circles of latitude, and thus an angle between a tangent of the ridge curvature and a circle of latitude, continuously increases from the equator (5) to the pole (4).

Abstract: The disclosure relates to providing printed structures of polymer that have substantially flat printed surfaces. In one embodiment, the disclosure relates to a post-printing treatment apparatus for receiving a substrate supporting a polymer printing thereon. The polymer can be PMMA or other suitable polymer. In a related embodiment, the polymer defines a thermoplastic polymer having a glass transition temperature. The apparatus can comprise of a chamber, and input manifold, an exhaust manifold, a solvent reservoir and a gas reservoir. The solvent reservoir provides one or more solvent systems adapted to chemically bind, and potentially react, with the polymer. The gas reservoir provides one or more gases for drying the substrate and printed polymer after the solvent treatment step. In one application, a substrate having printed surface thereon is placed in the chamber and exposed to the solvent system for sufficient period of time to provide substantially flat print surfaces.

Abstract: A process and an apparatus for producing liquid pig iron or liquid primary steel products from charge materials formed by iron ores and additions. The charge materials are subjected to a further reduction in a reducing zone (1) and are then fed to a smelting zone or a smelting unit (2), in particular a fusion gasifier, for smelting with the addition of carbon carriers and oxygen-containing gas to form a fixed bed. A CO- and H2-containing reduction gas is formed, which gas is introduced into the reducing zone converted there and drawn off as top gas. The hot top gas, laden with solid matter, after separation of the solids, is subjected at least to a dry coarse separation and at least parts of the hot solids segregated by the separation are returned into the smelting zone or the smelting unit (2) or the reducing unit (1). In addition, the top gas is treated in a further fine separation stage (13A).

Abstract: When arrangements with a repeating working cycle such as, for example, in the case of engine test benches, are being controlled, resonances which have to be damped by the control system are often excited by the test specimen (for example an internal combustion engine) in the working range of the arrangement. The invention proposes for this purpose a control concept in which a modified actual value rist—mod is determined from a current actual value rist—akt of the control system and from a predicted imminent system-delay-free actual value on the basis of the actual value of a previous working cycle, and said modified actual value rist—mod is fed to the control system.

Abstract: A piston for a pretensioner device (10) for a motor vehicle seat belt system of a type having a gas generator (17) with the piston (21) guided in a tube (16) that closes a pressure space (20) in the tube (16). The pressure space (20) can be pressurized by the gas generator (17), driving the piston (21) to undergo pretensioning operation transmitted to the seat belt system by a force transmission means. The piston has a dome shaped front side adapted to engage a force transmission element and a skirt forming a sealing lip oriented toward the pressure space. At least one slot is formed in the outer surface of the piston extending axially from the sealing lip. The slot can be enlarged by the material erosion caused by the pressure and/or pressure conditions in the pressure space produced by gas from the gas generator.

Abstract: The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or portions thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but nor limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.

Abstract: An operating microscope including an optical unit for forming an image of an object plane in oculars of the microscope, an optoelectronic image receiver coupled to the microscope and optics to form images, of objects placed in a region between a front objective of the microscope and an object plane of the microscope, on the optoelectronic image receiver. The microscope has a magnification factor of the optics to form images, and a system to detect optical markings forming a markings pattern placed on a surgical instrument or an object placed in the region between the front objective of the microscope and the object plane of the microscope. The system calculates a geometrical position and orientation of the markings pattern in relation to the optoelectronic image receiver, relative to the microscope.