Abstract: A power network for a motor vehicle includes a first partial power network connected to a supply potential, a second partial power network, and a coupling element which couples the second partial power network to the supply potential via the first partial power network. The coupling element has a reversible disconnect function, such that the coupling element reversibly decouples the first partial power network from the second partial power network based on a physical value of the first partial power network.

Abstract: A positioning arrangement for positioning a sheet metal element on a flange joint includes a flange with a medium passage opening, and a mating flange with a medium passage opening. The mating flange is connected to the flange with a plurality of fastening screws and the respective medium passage openings of the flange and the mating flange communicate with each other. The positioning arrangement also includes a sheet metal element with an abutment section. The abutment section is arranged in an abutment plane between the flange and the mating flange around the medium passage openings. The sheet metal element also includes at least three first tabs, which are arranged at a first through-hole of the sheet metal element and project transversely to the abutment plane into a first receiving hole in the mating flange. The at least three first tabs are received with radial clearance in the first receiving hole.

Abstract: A ripple voltage detector circuit comprises a pulse generator, a direct current-to-direct current (DC-DC) converter coupled to the pulse generator, and a first control loop coupled to the pulse generator and the DC-DC converter. The first control loop is configured to measure an output voltage of the DC-DC converter, determine an output ripple voltage of the output voltage, determine a ripple coefficient based on the output ripple voltage, determine a reference peak inductor current based on the ripple coefficient, and determine a peak value of an inductor current during a switching cycle, and transition a switching state of the DC-DC converter based on the reference peak inductor current and the peak value of the inductor current.

Abstract: The description relates to a joining head for fastening a fastening element by a die to the surface of a component with a gripper that can be linearly displaced in a first displacement direction RG and a magazine that can be linearly displaced in a second displacement direction RM. The magazine contains a plurality of fastening elements, with the first displacement direction RG running transversely to the second displacement direction RM.

Abstract: A waveguide assembly comprising a first waveguide, and a second waveguide designed as a dielectric multimodal waveguide, and a waveguide transition for transmitting an electromagnetic wave between the first waveguide and the second waveguide, the waveguide transition having a dielectric waveguide piece which is between the first waveguide and the second waveguide. The dielectric waveguide piece is capable of guiding a smaller mode number than the second waveguide, at least in a front section, facing the first waveguide.

Abstract: A ripple voltage detector circuit comprises a pulse generator, a direct current-to-direct current (DC-DC) converter coupled to the pulse generator, and a first control loop coupled to the pulse generator and the DC-DC converter. The first control loop is configured to measure an output voltage of the DC-DC converter, determine an output ripple voltage of the output voltage, determine a ripple coefficient based on the output ripple voltage, determine a reference peak inductor current based on the ripple coefficient, and determine a peak value of an inductor current during a switching cycle, and transition a switching state of the DC-DC converter based on the reference peak inductor current and the peak value of the inductor current.

Abstract: A method of producing an elastically deformable functional part for a medical device, devices for such methods, and a medical device having such a functional part. The functional part has an openable slit arrangement that widens or opens upon elastic deformation of the functional part and closes again in the absence of the deformation.

Abstract: A doorframe fastening for a folding door comprises a doorframe profiled section (1), which has a securing limb (2) and a door leaf suspension (3). The doorframe fastening reliably withstands high weight loads and reduces noise emission but still allows a long-term use while avoiding cold bridges and damage from corrosion. An inner support limb (7) protrudes from the securing limb (2), said inner support limb being connected to an outer support limb (9) via a thermally insulating separating web (8), and the door leaf suspension (3) is supported both on the inner (7) as well as on the outer support limb (9).

Abstract: The invention provides methods for specifically altering the DNA sequence in a genome, in particular for genome editing by deleting or replacing a sequence of interest. Advantageously, the invention uses two non-identical sequences naturally occurring in a genome as target sites two which DNA-recombining enzymes are generated. The invention is in particular useful for medicine, in particular to repair a mutation in a genome or to delete predefined genetic material from cells or tissue and to cure diseases. An advantage of the invention is that it allows precise site directed altering of DNA without engaging host DNA repair pathways and thereby works without inducing random insertions and deletions (indels).

Abstract: The invention relates to Transmission Charged Particle Beam (TCPB) apparatus comprising a sample holder, for holding a sample, a source for producing a beam of charged particles and an illuminator for directing said beam so as to irradiate the sample; The TCPB apparatus comprises an imaging system, for receiving a flux of charged particles transmitted through the sample and directing it onto a sensing device. Further, a controller is provided for controlling at least some operational aspects of the TCPB apparatus. As defined herein, the controller is arranged for receiving calibration data of said TCPB apparatus and using said calibration data for optically aligning said TCPB apparatus. Said calibration data may be obtained in a calibration session, wherein different settings for eucentric focus can be used as a measure of eucentric height, so that the TCPB apparatus can be optically aligned in absence of a sample on the sample holder.

Abstract: The invention provides methods and means for specifically altering the DNA sequence in a genome, in particular for genome editing by deleting or replacing a sequence of interest. Advantageously, the invention uses two non-identical sequences naturally occurring in a genome as target sites two which DNA-recombining enzymes are generated. The invention is in particular useful for medicine, in particular to repair a mutation in a genome or to delete predefined genetic material from cells or tissue and to cure diseases. An advantage of the invention is that it allows precise site directed altering of DNA without engaging host DNA repair pathways and thereby works without inducing random insertions and deletions (in-dels).

Abstract: A dispenser cartridge (1) for a drinking-water dispensing system (2), by means of which at least partially carbonated drinking water can be discharged from an outlet element (3) of the drinking-water dispensing system (2), wherein the dispenser cartridge (1) is provided and set up for introducing a dispenser substance (4) into the drinking water, wherein the dispensing cartridge (1) comprises a mount (5) for an exchangeable dispensing capsule (6) comprising the dispenser substance (4), wherein the dispensing capsule (6) can be held in the mount (5) in such a manner that at least a part of the drinking water flows through or around at least a part of the dispensing capsule (6), and wherein the dispensing cartridge (1) is set up in such a manner that it can be detachably installed in the outlet element (3) of the drinking-water dispensing system (2).

Abstract: A method for operating a vehicle electrical system, which includes an energy store. The energy store is assigned a sensor processing unit, and an electronic load distributor. At least one measured variable is detected using the sensor processing unit, and a parameter of the energy store is calculated taking the at least one measured variable into account. A plausibility check of the at least one measured variable is carried out, and a plausibility check of the calculation is carried out, for which purpose the electronic load distributor is used.

Abstract: A ripple voltage detector circuit comprises a pulse generator, a direct current-to-direct current (DC-DC) converter coupled to the pulse generator, and a first control loop coupled to the pulse generator and the DC-DC converter. The first control loop is configured to measure an output voltage of the DC-DC converter, determine an output ripple voltage of the output voltage, determine a ripple coefficient based on the output ripple voltage, determine a reference peak inductor current based on the ripple coefficient, and determine a peak value of an inductor current during a switching cycle, and transition a switching state of the DC-DC converter based on the reference peak inductor current and the peak value of the inductor current.

Abstract: The description relates to a joining head for fastening a fastening element by a die to the surface of a component with a gripper that can be linearly displaced in a first displacement direction RG and a magazine that can be linearly displaced in a second displacement direction RM . The magazine contains a plurality of fastening elements, with the first displacement direction RG running transversely to the second displacement direction RM.

Abstract: Methods include holding a sample with a movement stage configured to rotate the sample about a rotation axis, directing an imaging beam to a first sample location with the sample at a first rotational position about the rotation axis and detecting a first transmitted imaging beam image, rotating the sample using the movement stage about the rotation axis to a second rotational position, and directing the imaging beam to a second sample location by deflecting the imaging beam in relation to an optical axis of the imaging beam and detecting a second transmitted imaging beam image, wherein the second sample location is spaced apart from the first sample location at least at least in relation to the optical axis. Related systems and apparatus are also disclosed.

Abstract: Methods include holding a sample with a movement stage configured to rotate the sample about a rotation axis, directing an imaging beam to a first sample location with the sample at a first rotational position about the rotation axis and detecting a first transmitted imaging beam image, rotating the sample using the movement stage about the rotation axis to a second rotational position, and directing the imaging beam to a second sample location by deflecting the imaging beam in relation to an optical axis of the imaging beam and detecting a second transmitted imaging beam image, wherein the second sample location is spaced apart from the first sample location at least at least in relation to the optical axis. Related systems and apparatus are also disclosed.

Abstract: Apertures having references edges are situated to define a sample irradiation zone and a shielded zone. The sample irradiation zone includes a portion proximate the shielded zone that is conjugate to a detector. A sample is scanned into the sample irradiation zone from the shielded zone so that the sample can remain unexposed until situated properly with respect to the detector for imaging. Irradiation exposure of the sample is reduced, permitting superior imaging.

Abstract: The present invention relates to compounds for the treatment of diseases related to DUX4 expression, such as muscular dystrophies, wherein the disease is facioscapulohumeral muscular dystrophy (FSHD). It also relates to use of such compounds, or to methods of use of such compounds.

Abstract: Apertures having references edges are situated to define a sample irradiation zone and a shielded zone. The sample irradiation zone includes a portion proximate the shielded zone that is conjugate to a detector. A sample is scanned into the sample irradiation zone from the shielded zone so that the sample can remain unexposed until situated properly with respect to the detector for imaging. Irradiation exposure of the sample is reduced, permitting superior imaging.