Abstract: Apertures having references edges are situated to define a sample irradiation zone and a shielded zone. The sample irradiation zone includes a portion proximate the shielded zone that is conjugate to a detector. A sample is scanned into the sample irradiation zone from the shielded zone so that the sample can remain unexposed until situated properly with respect to the detector for imaging. Irradiation exposure of the sample is reduced, permitting superior imaging.

Abstract: The present invention relates to compounds for the treatment of diseases related to DUX4 expression, such as muscular dystrophies, wherein the disease is facioscapulohumeral muscular dystrophy (FSHD). It also relates to use of such compounds, or to methods of use of such compounds.

Abstract: Apertures having references edges are situated to define a sample irradiation zone and a shielded zone. The sample irradiation zone includes a portion proximate the shielded zone that is conjugate to a detector. A sample is scanned into the sample irradiation zone from the shielded zone so that the sample can remain unexposed until situated properly with respect to the detector for imaging. Irradiation exposure of the sample is reduced, permitting superior imaging.

Abstract: A power network for a motor vehicle includes a first partial power network connected to a supply potential, a second partial power network, and a coupling element which couples the second partial power network to the supply potential via the first partial power network. The coupling element has a reversible disconnect function, such that the coupling element reversibly decouples the first partial power network from the second partial power network based on a physical value of the first partial power network.

Abstract: A fastener arrangement (100) for establishing a screw-connection comprising a main body (1) with a central axis (10) having a head (11) and a shaft (12) protruding from the lower side of the head in direction of the central axis (10), and having at its end facing away from the head (10) a thread (13), a driving element (2) penetrated by the shaft (12) and abutting with an upper end against the lower side of the head (11), wherein the driving element (2) positively engages with the main body (1) in a rotational direction around the central axis (10) in screw-in direction of the thread (13). The positive engagement between the main body (1) and the driving element (2) is designed such that if a first shaft section (121) of the main body (1) that penetrates the driving element (2) lengthens to a certain extent in the indented use of the fastener arrangement (100), the positive engagement is released.

Abstract: A waveguide assembly, comprising an electrical circuit assembly, a dielectric waveguide with a longitudinal axis (A), and a waveguide transition lying therebetween for transmitting an electromagnetic wave between the electrical circuit assembly and the dielectric waveguide. The waveguide transition has a first electrically conductive plate and a second electrically conductive plate which are arranged between the electrical circuit assembly and the dielectric waveguide in an offset manner to each other in the direction of the longitudinal axis (A) of the dielectric waveguide.

Abstract: A waveguide assembly comprising a first waveguide, and a second waveguide designed as a dielectric multimodal waveguide, and a waveguide transition for transmitting an electromagnetic wave between the first waveguide and the second waveguide, the waveguide transition having a dielectric waveguide piece which is between the first waveguide and the second waveguide. The dielectric waveguide piece is capable of guiding a smaller mode number than the second waveguide, at least in a front section, facing the first waveguide.

Abstract: The present invention relates to compounds for the treatment of diseases related to DUX4 expression, such as muscular dystrophies. It also relates to use of such compounds, or to methods of use of such compounds.

Abstract: The invention provides methods and means for specifically altering the DNA sequence in a genome, in particular for genome editing by deleting or replacing a sequence of interest. Advantageously, the invention uses two non-identical sequences naturally occurring in a genome as target sites two which DNA-recombining enzymes are generated. The invention is in particular useful for medicine, in particular to repair a mutation in a genome or to delete predefined genetic material from cells or tissue and to cure diseases. An advantage of the invention is that it allows precise site directed altering of DNA without engaging host DNA repair pathways and thereby works without inducing random insertions and deletions (indels).

Abstract: Essentially ethylene thiourea free cross linkable composition comprising a chloroprene rubber having defined contents of cations from the second or third main group and resinate anions are provided, which possess improved curing characteristics for increased productivity and lower vulcanization temperatures for energy-saving manufacturing methods and vulcanizates obtained by using said chloroprene rubber.

Abstract: The present invention relates to compounds for the treatment of diseases related to DUX4 expression, such as muscular dystrophies, wherein the disease is facioscapulohumeral muscular dystrophy (FSHD). It also relates to use of such compounds, or to methods of use of such compounds.

Abstract: Contact adhesive compositions comprising polychloroprene and, based on the polychloroprene content, 10 to 99 wt % of ethylene-vinyl acetate copolymer exhibit outstanding adhesion to substrates such as ethylene-vinyl acetate copolymers, thermoplastic elastomers or flexible PVC. The contact adhesive compositions of the invention are especially suitable for use in the bonding of articles, preferably articles in which at least part of the articles to be bonded consists of polyurethane, flexible PVC, ethylene-vinyl acetate copolymers and/or thermoplastic elastomers. This allows the adhesive composition to be employed widely in the footwear industry, for the bonding of roofing membranes containing flexible PVC, ethylene-propylene-diene rubber (EPDM) and/or ethylene-vinyl acetate copolymers, or for the bonding of synthetic leather based on flexible PVC.

Abstract: Essentially ETU-free cross linkable compositions comprising chloroprene rubber, a cross-linker and a vulcanization accelerator, which have a defined content of ions from the second or third main group and resinate anions and thus possesses improved curing characteristics, a process for vulcanization of such compositions and vulcanizates obtained thereby.

Abstract: A soundbar includes a housing, at least two transducers of a first group and at least one transducer of a second group. The at least two transducers of the first group are arranged at the front side of the housing and configured to emit sound in a first direction in accordance with two first audio signals so as to reproduce a two dimensional sound field. The at least one transducer of a second group is arranged at second side of the housing and configured to emit sound in a second direction in accordance with a second audio signal such that the sound emitted by the at least one transducer of the second group reaches a predefined listener's position in a reflected manner to extend the two dimensional sound field in a height direction. The reflection reflecting the sound emitted by the at least one transducer of the second group has an order of at least two.

Abstract: A drawer pull-out guide includes at least one guide rail. The guide rail includes a longitudinally extending first limb and at least one longitudinally extending second limb angled from the first limb, the first limb and the second limb being connected to one another along their longitudinal direction by an angled region. The angled region includes at least one material diminution extending along the angled region and being formed by a recess.

Abstract: A loudspeaker includes one or more drivers and at least two waveguides. The one or more drivers are arranged to emit soundwaves. The waveguides are coupled to the one or more drivers to receive the soundwaves emitted by the one or more drivers. The first of the at least two waveguides has an output position at a first position of the loudspeaker and is configured to forward the received soundwaves to the output at the first position, wherein a second of the at least two waveguides has an output position at a second position of the loudspeaker and is configured to forward the received soundwaves to the output at the second position.

Abstract: A connecting device for a medical infusion system includes a connection piece which has a connecting profile for the connection of a functional part of the infusion system. The connecting device also has a resiliently flexible, cup-like valve body which is arranged in the connection piece and has a valve casing and cap-shaped top region which is provided with a slit arrangement. Further, the connecting device has a dimensionally stable base portion on which a base ring of the valve casing is supported and which is firmly connected to the connection piece. In the unloaded initial state, the valve casing has a convex internal contour which, starting from the cap-shaped top region, first expands in the direction of the base ring and subsequently narrows again, forming an O-like internal longitudinal section. The connecting device can be in the form of a three-way stopcock for an infusion system.

Abstract: A method of manufacturing a welding stud. The welding stud comprises a weldable portion of light metal and a functional portion of steel. The method comprises the steps of: providing a welding part of a light metal and partially defining a recess, providing a function part of a steel and which includes a protrusion, providing a press with a die and a punch, arranging the welding part on the die and the function part on the press such that the protrusion opposes the recess, and manufacturing the welding stud by impacting the welding part and the function part into the die by the punch such that the protrusion enters the recess and the welding portion forms a sleeve around an end of the function portion to form the welding stud with the welding part forming the weldable portion and the function part forming the functional portion.

Abstract: Provided is a method and a device for the lossless compression of a data stream which includes a sequence of structured data objects which have a list of properties which each contain a key value pair, the method having the following steps: dividing the structured data objects of the data stream into a constant data object portion which has key value pairs with constant values and into variable data object portions which have key value pairs with variable values; transmitting the constant data object portion of the structured data objects once to a receiver; and transmitting the variable data object portions of the divided data objects of the data stream to the receiver.

Abstract: An apparatus for providing a current loudspeaker-enclosure-microphone system description of a loudspeaker-enclosure-microphone system is provided. The apparatus has a first transformation unit for generating a plurality of wave-domain loudspeaker audio signals. Moreover, the apparatus has a second transformation unit for generating a plurality of wave-domain microphone audio signals. Furthermore, the apparatus has a system description generator for generating the current loudspeaker-enclosure-microphone system description based on the plurality of wave-domain loudspeaker audio signals, based on the plurality of wave-domain microphone audio signals, and based on a plurality of coupling values, wherein the system description generator is configured to determine each coupling value assigned to a wave-domain pair of a plurality of wave-domain pairs by determining a relation indicator indicating a relation between a loudspeaker-signal-transformation value and a microphone-signal-transformation value.