Abstract: Computer-implemented methods and apparatuses for assigning or attributing at least one environmental attribute associated with input material(s) to target material(s), wherein the target material(s) are produced by a chemical production network using at least one of the input materials).

Abstract: The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.

Abstract: The invention provides a compound of formula (1). or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: A method for homogenizing glass includes the method: providing a cylindrical blank composed of the glass having a cylindrical outer surface that extends along a longitudinal axis of the blank between a first end face and a second end face, forming a shear zone in the blank by softening a longitudinal section of the blank and subjecting it to a thermal-mechanical intermixing treatment, and displacing the shear zone along the longitudinal axis of the blank. The displacement of the shear zone along the longitudinal axis of the blank is superimposed by a simultaneous oscillating motion of the shear zone along the longitudinal axis of the blank. The first end of the blank is rotated at a first rotational speed and the second end of the blank is rotated at a second rotational speed. An oscillating motion of the shear zone is generated by periodically varying the first and/or second rotational speed.

Abstract: The invention relates to an indane compound according to Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, L, n and p are as defined herein. The compounds are useful for treating antibacterial infection either as stand-alone antibiotics, or in combination with further antibiotics.

Abstract: Disclosed are systems for producing a nitrogen containing chemical associated with a digital asset, methods for producing a nitrogen containing chemical associated with a digital asset, apparatuses for generating a digital asset, computer-implemented methods for generating a chemical passport, computer program elements for generating a digital asset, uses of a nitrogen containing chemical associated with a digital asset, uses of a digital asset, products produced from the nitrogen containing chemical and associated with a digital asset, a digital asset including one or more decentral identifier(s) and data related to the environmental impact data, apparatuses for producing a product associated with the digital asset and methods for producing a product associated with the digital asset.

Abstract: Disclosed are systems for producing an unsaturated compound associated with a digital asset, methods for producing an unsaturated compound associated with a digital asset, apparatuses for generating a digital asset, computer-implemented methods for generating a chemical passport, computer program elements for generating a digital asset, uses of an unsaturated compound associated with a digital asset, uses of a digital asset, products produced from the unsaturated compound and associated with a digital asset, a digital asset including one or more decentral identifier(s) and data related to the environmental impact data, apparatuses for producing a product associated with the digital asset and methods for producing a product associated with the digital asset.

Abstract: The present invention encompasses compounds of the formula I which are suitable for the treatment of diseases related to Vanin, and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.

Abstract: The present invention provides a chimeric antigen receptor (CAR) which specifically binds CD79 as well as a nucleic acid sequence and a vector encoding the CAR. It further provides a cell which expresses the CAR at the cell surface.

Abstract: Disclosed are systems for producing a CO compound associated with a digital asset, methods for producing a CO compound associated with a digital asset, apparatuses for generating a digital asset, computer-implemented methods for generating a chemical passport, computer program elements for generating a digital asset, uses of a CO compound associated with a digital asset, uses of a digital asset, products produced from the CO compound and associated with a digital asset, a digital asset including one or more decentral identifier(s) and data related to the environmental impact data, apparatuses for producing a product associated with the digital asset and methods for producing a product associated with the digital asset.

Abstract: Disclosed are systems for producing an amino resin composition associated with a digital asset, methods for producing an amino resin composition associated with a digital asset, apparatuses for generating a digital asset, computer-implemented methods for generating a chemical pass-port, computer program elements for generating a digital asset, uses of an amino resin composition associated with a digital asset, uses of a digital asset, products produced from the amino resin composition and associated with a digital asset, a digital asset including one or more de-central identifier(s) and data related to the environmental impact data, apparatuses for producing a product associated with the digital asset and methods for producing a product associated with the digital asset.

Abstract: Methods of producing bioconjugates of O-antigen polysaccharides covalently linked to a carrier protein using recombinant host cells are provided. The recombinant host cells used in the methods described herein encode a particular oligosaccharyl transferase enzyme depending on the O-antigen polysaccharide bioconjugate to be produced. The oligosaccharyl transferase enzymes can be PglB oligosaccharyl transferase or variants thereof. Also provided are compositions containing the bioconjugates, and methods of using the bioconjugates and compositions described herein to vaccinate a subject against extra-intestinal pathogenic E. coli. (ExPEC).

Abstract: The present invention provides a chimeric cytokine receptor (CCR) comprising: (i) an exodomain which binds to a ligand selected from a tumour secreted factor, a chemokine and a cell-surface antigen; and (ii) a cytokine receptor endodomain.

Abstract: Disclosed are systems for producing an output material associated with a digital asset, methods for producing an output material associated with a digital asset, apparatuses for generating a digital asset, computer-implemented methods for generating a chemical passport, computer program elements for generating a digital asset, uses of an output material associated with a digital asset, uses of a digital asset, products produced from the output material and associated with a digital asset, a digital asset including one or more decentral identifier(s) and data related to the environmental impact data, apparatuses for producing a product associated with the digital asset and methods for producing a product associated with the digital asset.

Abstract: The present invention relates to assisting scapula positioning in chest X-ray imaging. Provided is a system and related method for assisting subject positioning in chest X-ray imaging, wherein the system comprises an optical detection device (110), a user interface (130), and a processor (120), connected to the optical detection device (110) and the user interface (130). Thereby, the processor (120) is configured to receive an optical image signal of a rear view of the subject(S), determine a current positioning of a scapula of the subject(S) based on the optical image signal, wherein the current positioning of the scapula is assessed as to whether and/or to which extent it would overlap or would not overlap a lung field of the subject to be imaged and determine a feedback for positioning the subject(S) and/or its scapula based on the determined current positioning of the scapula. The user interface (130) is configured to provide the feedback for positioning the subject.

Abstract: A system produces a machine fluid associated with a machine fluid passport or digital asset and/or a polyisobutene associated with a polyisobutene passport or digital asset. The system includes a chemical production network configured to produce the machine fluid and/or the polyisobutene from one or more input materials through one or more chemical processes associated with one or more environmental attributes. A production operating apparatus is configured to generate the machine fluid and/or polyisobutene passport or digital asset. The chemical production network, or a chemical production system, is configured to provide the machine fluid and/or the polyisobutene in association with the machine fluid and/or the polyisobutene passport or digital asset. Further methods produce the machine fluid and/or the polyisobutene and the passport or digital asset. The machine fluid and the digital asset are provided.

Abstract: A structure including a substrate and a coating over the substrate is acoustically excited to measure acoustic response in the structure. The measured acoustic response in the structure is filtered to remove acoustic response of the substrate and determine acoustic response of the coating. The acoustic response of the coating is used to inspect the coating for failure.

Abstract: Disclosed are systems for producing a polyamide composition associated with a digital asset, methods for producing a polyamide composition associated with a digital asset, apparatuses for generating a digital asset, computer-implemented methods for generating a chemical passport, computer program elements for generating a digital asset, uses of a polyamide composition associated with a digital asset, uses of a digital asset, products produced from the polyamide composition and associated with a digital asset, a digital asset including one or more decentral identifier(s) and data related to the environmental impact data, apparatuses for producing a product associated with the digital asset and methods for producing a product associated with the digital asset.

Abstract: A method of preventing queries from accessing database files based on metadata. The method includes determining a first metadata associated with a particular file and a second metadata associated with a changed version of the particular file. The method includes directing, based on the first metadata associated with the particular file, a first query for the particular file to a first file that is associated with the particular file. The method includes preventing a second query for the particular file from accessing the particular file by directing, based on the second metadata associated with the changed version of the particular file, the second query to the changed version of the particular file instead of the particular file.

Abstract: A device and method for protecting and installing a fire protection sprinkler. The protective and installation device has two discrete protective members coupled to one another about the sprinkler by a releasable locking arrangement defined by a connection between the two discrete protective members. At least one of the members includes a torque assist portion for applying torque to the fire protection sprinkler and each of the members includes a deflector protection portion.