Abstract: The present disclosure provides certain 3H,4H-thieno[2,3-d]pyrimidin-4-one derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.

Abstract: A nonwoven fabric. The nonwoven fabric can include a first surface and a second surface and a visually discernible pattern of three-dimensional features on one of the first or second surface. Each of the three-dimensional features can define a microzone comprising a first region and a second region. The first and second regions can have a difference in values for an intensive property, and wherein in at least one of the microzones, the first region is hydrophobic and the second region is hydrophilic.

Abstract: Methods of providing an air- and/or moisture-barrier coating on at least a portion of a two-dimensional material are described. In particular, the methods provide an improved approach for providing a doped two-dimensional material, preferably graphene, on a substrate wherein at least a portion of the two-dimensional material is coated with an air- and/or moisture-barrier coating that comprises an inorganic oxide, fluoride or sulfide. Two-dimensional materials provided with an air- and/or moisture impermeable inorganic oxide, fluoride or sulfide coating and an electronic device comprising the same are also described.

Abstract: A method of capturing and disposing of fats, oil and/or grease is disclosed. The method comprises: providing a porous container formed of a porous fabric; positioning in the porous container an absorbent material capable of absorbing a quantity of fats, oil and grease through the porous fabric of the porous container; placing the container and the absorbent material contained therein in a grease trap comprising a source of fats, oil and/or grease for absorbing the fats, oil and/or grease; removing the porous container of absorbent material and absorbed fat, oil and/or grease from the source of fats, oil and/or grease; removing the absorbent material, fats, oil and/or grease from the removed porous container; and extracting the absorbed fats, oil, and/or grease from the absorbent material.

Abstract: A vehicle panel includes channels, wherein a first channel includes a first wire capable and a second channel includes a second wire and each wire is capable of carrying at least one of power or a vehicle data signal. The panel also includes a connection point connectable to at least one of a battery or a vehicle computing system, wherein selection of connection between the vehicle computing system or battery to a given connection point provided to a given one of the first or second channels dictates whether the channel carries the vehicle data signal or power. Also, the panel includes holes connecting to the first wire and at least two of the holes connecting to the second wire allowing a connection probe to be inserted into a respective hole to connect to a wire included in a channel to which the hole connects.

Abstract: Methods, apparatus, systems, and articles of manufacture are disclosed that increase data reuse for multiply and accumulate (MAC) operations. An example apparatus includes a MAC circuit to process a first context of a set of a first type of contexts stored in a first buffer and a first context of a set of a second type of contexts stored in a second buffer. The example apparatus also includes control logic circuitry to, in response to determining that there is an additional context of the second type to be processed in the set of the second type of contexts, maintain the first context of the first type in the first buffer. The control logic circuitry is also to, in response to determining that there is an additional context of the first type to be processed in the set of the first type of contexts maintain the first context of the second type in the second buffer and iterate a pointer of the second buffer from a first position to a next position in the second buffer.

Abstract: A method of capturing and disposing of fats, oil and/or grease (“FOG”) is disclosed. The method includes providing a vacuum truck to a user, wherein the vacuum truck has a tank with (1) a vacuum hose; (2) an inlet to the tank connected directly to the hose; (3) an outlet from the tank; (4) and one or more mixing components. The method also calls for positioning an absorbent material within the tank that is capable of absorbing a quantity of FOG. Next, FOG is vacuumed from a grease trap via the hose and mixed with the absorbent material to create a biofuel. Finally, the biofuel is discharged from the outlet of the tank into a containment device at a burn facility and subsequently burned. Alternatively, the absorbent material may be contained within a containment device at the burn facility and mixed with the FOG at the facility before being burned.

Abstract: The present invention relates to a cell which co-expresses: (i) a first chimeric antigen receptor (CAR) at the cell surface, comprising an antigen-binding domain which binds to CD19; (ii) a second CAR at the cell surface, comprising an antigen-binding domain which binds to CD22; (iii) dominant negative SHP2 (dSHP2); and (iv) dominant negative TGF? receptor II (dnTGF?RII).

Abstract: A nonwoven fabric. The nonwoven fabric can include a first surface and a second surface and a visually discernible pattern of three-dimensional features on one of the first or second surface. Each of the three-dimensional features can define a microzone comprising a first region and a second region. The first and second regions can have a difference in values for an intensive property, and wherein in at least one of the microzones, the first region is hydrophobic and the second region is hydrophilic.

Abstract: A device and method for protecting and installing a fire protection sprinkler. The protective and installation device has two discrete protective members coupled to one another about the sprinkler by a releasable locking arrangement defined by a connection between the two discrete protective members. At least one of the members includes a torque assist portion for applying torque to the fire protection sprinkler and each of the members includes a deflector protection portion.

Abstract: A method for directing queries to encrypted database files includes acquiring a mapping that links a first encrypted file with a different encrypted file. The first encrypted file is generated based on a first encryption key. The method includes generating, by one or more processors based on the mapping, an updated mapping to link a second encrypted file with the different encrypted file. The second encrypted file is generated based on a second encryption key. The method includes directing, using the mapping, a first query to the first encrypted file when the first query arrives before generating the updated mapping; and. The method includes directing, using the updated mapping, a second query to the second encrypted file when a second query arrives after generating the updated mapping.

Abstract: A computer-implemented method for generating a proof of identify may include (1) generating a unique single user profile (USUP) based on data derived from the computing device; (2) encrypting the USUP, which may include retrieving at least one encryption value set, generating at least one character matrix based on the USUP, and executing at least one transformation operation on the at least one character matrix; (3) storing the encrypted USUP as a binary fingerprint; and (4) transmitting the binary fingerprint to a computing device. A computer-implemented method for self-authenticating may include (1) generating a first USUP based on data derived from the computing device; (2) obtaining a first binary fingerprint; (3) deriving a second USUP from the first binary fingerprint; (4) obtaining a second binary fingerprint; (5) deriving a third USUP from the second binary fingerprint; and (6) stopping decryption when the three USUPs do not match.

Abstract: Methods related to survey scanning in diagnostic medical imaging. At least one aspect relates to a method for generating, using a machine learning model, a simulation of medical image data in accordance with a defined set of acquisition parameters for a medical imaging apparatus, based on processing of an initial 3D image data set (e.g. a survey image dataset).

Abstract: Hydrocarbon flow into multi-lateral wells is analyzed by controlled release of tracers from the surface. Hydrocarbons flow into a lateral formed from a wellbore into a subterranean zone. A wellbore production tubing is installed within the wellbore and extends toward the lateral. The wellbore production tubing defines an annulus between an outer surface of the tubing and an inner wall of the wellbore. Hydrocarbons flowing from the lateral into the annulus flow within an internal volume defined by a body attached to the outer surface of the tubing. The hydrocarbons mix with tracers residing within the internal volume. A mixture of the hydrocarbons with the tracers flow out of the internal volume and towards the surface. At the surface, a concentration of the tracers in the mixture flowed to the surface is analyzed. Based on a result of the analyzing, properties of hydrocarbon flow into the lateral are determined.

Abstract: A tractor has a processor and memory storing machine-readable instructions that, when executed by the processor, cause the processor to: select at least one image captured by a camera of a parking spot being passed by the tractor when a point-of-interest (POI) of the parking spot is most centered within a field of view of the camera, store the image in the memory in association with the parking spot, determine that the parking spot is occupied after a costmap for the parking spot is populated by the LIDAR, retrieve the image corresponding to the parking spot from the memory, determine, from the image, a trailer identifier of a trailer parked in the parking spot; and send a message defining the parking spot and the trailer identifier to an inventory service for use in updating a yard inventory.

Abstract: The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.

Abstract: There is provided a controller, a system, computer software and a method for detecting a ligature on a door mounted within a door frame on mounting means. A load applied by the door to the mounting means is detected by a load sensor. An angle of the door relative to the door frame is detected by an angle sensor. Baseline load data is obtained, the baseline load data being indicative of an expected load applied by the door to the mounting means as a function of the angle of the door. The method comprises determining a threshold load value indicative of a ligature on the door for the measured angle in dependence on the baseline load data and the detected angle of the door; determining whether the detected load exceeds the threshold load value for the detected angle; and outputting an indication of a detected ligature event if the detected load exceeds the threshold load value.

Abstract: The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.

Abstract: System and methods to provide ceiling-only suppression fire protection of up to fifty feet (50 ft.) of rack storage of cartoned unexpanded plastic commodities and less hazardous commodities, such as for example, Class 1, Class 2, Class 3, Class 4 and/or combinations thereof beneath a ceiling having a maximum ceiling height up to fifty-five feet (55 ft.). The systems and methods provide for hydraulic and system parameters that include a hydraulic design area based upon five to no more than twelve hydraulically most remote sprinklers spaced at a preferred sprinkler-to-sprinkler spacing of eight to ten feet (8-10 ft.) coupled to two to four branch lines tied to a common cross main supply pipe of firefighting fluid.

Abstract: A method of capturing and disposing of fats, oil and/or grease is disclosed. The method comprises: providing a porous container formed of a porous fabric; positioning in the porous container an absorbent material capable of absorbing a quantity of fats, oil and grease through the porous fabric of the porous container; placing the container and the absorbent material contained therein in a grease trap comprising a source of fats, oil and/or grease for absorbing the fats, oil and/or grease; removing the porous container of absorbent material and absorbed fat, oil and/or grease from the source of fats, oil and/or grease; removing the absorbent material, fats, oil and/or grease from the removed porous container; and extracting the absorbed fats, oil, and/or grease from the absorbent material.