Abstract: The present invention relates to novel arylsulphonamide compounds, defined by formula I and the description, as well as their method of preparation and their therapeutic use

Abstract: The present invention concerns novel benzenesulphonamide compounds, defined by formula I and the description, their method of preparation and their use in therapy.

Abstract: The present invention relates to novel arylsulphonamide compounds, defined by formula I and the description, as well as their method of preparation and their therapeutic use.

Abstract: The present invention relates to derivatives of 5-cyano-1H-indole of formula (I): in which R1, R2, X and n are as defined in claim 1, as well as to their pharmaceutically acceptable salts, solvates and hydrates. Pharmaceutical compositions containing them, as well as their use for the preparation of medicaments intended for the preventative or curative treatment of illnesses which are dependent upon the activation of the interleukin CXCR2 receptor and of the chemokines of the same family, are also subjects of the invention.

Abstract: The present invention relates to the 5-phenyl-1H-indole derivatives of formula (I): 1

Abstract: The present invention relates to novel N-(phenylsulphonyl)glycyl-glycine compounds, which are defined by formula I and the description, as well as their method of preparation and their use in therapeutics 1

Abstract: The present invention relates to novel compounds which inhibit the action of CXC chemokines, such as IL-8, Gro, NAP-2, ENA-78 etc., on their receptors, to the process for their preparation and to their use for obtaining drugs. According to the invention, said compounds are novel indole derivatives selected from the group consisting of: i) the products of the formula  in which: X is a double bond —C═C— or a sulfur atom; R1 is a halogen, a nitro group, a trifluoromethyl group or a C1-C3 alkyl group; R2, R3 and R4 are each independently a hydrogen atom, a halogen, a C1-C3 alkyl group, a nitro group, a trifluoromethyl group or a cyano group, or R2 and R3 form a fused aromatic ring together with the aromatic ring to which they are attached; and n is equal to 2 or 3; and ii) esters of the compounds of formula I and addition salts of said compounds with a mineral or organic base.

Abstract: The invention concerns compounds selected among the group consisting of (i) compounds of formula (I) wherein: Het1 represents a nitrogenous heterocycle with 5 apices, in particular imidazole, pyrazole, or triazole; Het2 represents a nitrogenous heterocycle with 4, 5 or 6 apices, selected among the heterocycles: (II) wherein R1 and R2 are defined as mentioned in the description; and (ii) their additive salts. The invention also concerns the method for preparing said compounds and their use in therapy, in particular for treating pathologies involving bradykinine.

Abstract: The present invention relates to compounds selected from the group consisting of: (i) the compounds of the formula  in which X is a halogen atom, A is a group —NH—(CH2)n—NH—CO—, —NH—CH2— or Q is a group R1 is hydrogen, halogen, C1-C3 alkyl or C1-C5 1-oxoalkyl, R2 is H or OH and n is 2, 3 or 4; and (ii) their addition salts. It further relates to the process for their preparation and to their use in therapeutics, especially for combating pathological conditions involving bradykinin.

Abstract: This invention relates to compounds of the formula where X is halogen, R1 is H or a C1-C3 alkyl, R2 is H or OH and R3 is one of in which A is a single bond or a —CO(CH2)p—NH— group, R4 is H or —C(═NR5)NHR′5, R5 and R′5 are each H or a C1-C6 alkyl group, R6 is H or a C1-C3 alkyl group, m is 0, 1 or 2; n is 2, 3 or 4; p is 1, 2 or 3; plus their acid addition salts. The invention likewise relates to the method for their preparation and their therapeutic applications.

Abstract: The present invention relates to compounds selected from the group consisting of the compounds of formula (I): ##STR1## X is a halogen atom, A is --CH.sub.2 --, --CH(OH)--, --CH(NH--COCH.sub.3)-- or S, R is H, CO.sub.2 H, CO.sub.2 --B--R.sub.1 or CO--N(R.sub.2)--B--R.sub.1, B is linear, branched or cyclic C.sub.1 -C.sub.10 -alkylene, R.sub.1 is H, CH.sub.2 OH, CH.sub.2 --O--CH.sub.3, CH.sub.2 --NR.sub.3 R.sub.4 or phenyl, R.sub.2 is H or C.sub.1 -C.sub.4 -alkyl, R.sub.3 is H or linear, branched or cyclic C.sub.1 -C.sub.10 -alkyl, R.sub.4 is H or linear or branched C.sub.1 -C.sub.10 -alkyl, it being possible for NR.sub.3 R.sub.4 to be a saturated heterocyclic radical having from 5 to 8 ring members and containing at least one nitrogen atom, and the carbon carrying the substituent R, when Q is saturated, can be of indeterminate (R,S) configuration or of determinate (R) or (S) configuration; and their addition salts.

Abstract: Compounds selected from the group which consists of the compounds of formula (I), ##STR1## wherein each of X.sub.1 and X.sub.2 which are the same or different, is halogen or a C.sub.1-3 alkoxy group, R.sub.1 is H, CF.sub.3 or a C.sub.1-3 alkyl group, R.sub.2 is a hydrogen atom or an OH group, A is group (a), (b) or (c), B is a single bond, --CO--, --CO--CH.sub.2 --, --CO--CH.sub.2 --O--, --CO--CH.dbd.CH or --SO.sub.2 --, m is 2 or 3, N is 0, 1, 2 or 3, R.sub.3 is a hydrogen atom or a methyl group and W is CH or N, the amidine group C(.dbd.NR.sub.2)NH.sub.2 being in the 2, 3 or 4 position on the aromatic ring, and addition salts thereof, are disclosed. A method for preparing said compounds, and the therapeutical use thereof, particularly for treating diseases in which bradykinin is involved, are also disclosed.

Abstract: The present invention relates to compounds selected from the group consisting of(i) the compounds of formula I: ##STR1## in which: X is a halogen atom or a methyl group,A is a group --N(R.sub.3)CO-- or --CO--N(R.sub.3)--,B is a single bond, --CH.sub.2 -- or --CH.sub.2 --O--,R.sub.1 is H, a C.sub.1 -C.sub.3 alkyl group or a CF.sub.3 group,R.sub.2 and R.sub.3 are each independently H or a C.sub.1 -C.sub.3 alkyl group,W is CH or N, andn is 2, 3, 4 or 5; and(ii) their addition salts.It further relates to the process for their preparation and to their use in therapeutics, especially for combating pathological conditions involving bradykinin.

Abstract: The present invention relates to novel compounds of the formula in which:X is a halogen atom,R.sub.1 and R.sub.2, which are identical or different, are each --H or --A--B--R.sub.3,A is a linear or branched C.sub.1 -C.sub.12 -alkylene chain,B is a single bond, a divalent phenylene group or a divalent indolyl group of the structure ##STR1## R.sub.3 is --H, --OH, --NR.sub.4 R.sub.5 or --COR.sub.6, R.sub.6 is --OH, --OCH.sub.3, --OC.sub.2 H.sub.5 or --NR.sub.4 R.sub.5,R.sub.4 and R.sub.5, which are identical or different, are each H, a C.sub.1 -C.sub.4 -alkyl group, --(CH.sub.2).sub.n --OH, --(CH.sub.2).sub.n --N(CH.sub.3).sub.2 or --CO--CH.sub.3, andn is an integer with a value of 2, 3 or 4; and their addition salts. It further relates to their preparation and to their use in therapeutics, especially for the treatment of pathological conditions involving bradykinin.