Patents by Inventor Marvin H. Caruthers

Marvin H. Caruthers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibition of reverse transcriptase by phosphorodithioates
    Patent number: 5695979
    Abstract: The present invention describes a method for the inhibition of reverse transcriptase by contacting said reverse transcriptase with oligonucleotides having have at least one phosphorodithioate internucleotide linkage of the formula ##STR1## within the phosphorus backbone of the oligonucleotide.
    Type: Grant
    Filed: March 28, 1995
    Date of Patent: December 9, 1997
    Assignee: Competitive Technologies, Inc.
    Inventors: Marvin H. Caruthers, William S. Marshall, Wolfgang Brill, John Nielsen
  • Nucleoside thiophosphoramidites
    Patent number: 5684148
    Abstract: The present invention relates to new and useful nucleoside thiophosphoroamidites and polynucleotide phosphorodithioate compounds as well as the processes whereby these compounds may be used for synthesizing new mononucleotides and polynucleotides having phosphorothioate and phosphorodithioate internucleotide linkages.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: November 4, 1997
    Assignee: Competitive Technologies, Inc.
    Inventors: Marvin H. Caruthers, Wolfgang K. D. Brill, Eric Yau, Michael Ma, John Nielsen
  • Polynucleotide phosphorodithioate compounds
    Patent number: 5602244
    Abstract: Dinucleoside phosphorodithioate phosphoramidite precursors useful in the synthesis of oligonucleotide phosphorodithioate which can be used as antisense inhibitors of translation.
    Type: Grant
    Filed: May 8, 1995
    Date of Patent: February 11, 1997
    Assignee: Competitive Technologies, Inc.
    Inventors: Marvin H. Caruthers, Wolfgang K.-D. Brill, Eric Yau, Michael Ma, John Nielsen
  • Polynucleotide phosphorodithioate
    Patent number: 5453496
    Abstract: Oligonucleotides having at least one phosphorodithioate internucleotide linkage. Phosphorodithioate oligonucleotides exhibit stronger antiviral activity than the corresponding phoshorothioate derivatives.
    Type: Grant
    Filed: October 15, 1993
    Date of Patent: September 26, 1995
    Assignee: University Patents, Inc.
    Inventors: Marvin H. Caruthers, William S. Marshall, Wolfgang Brill, John Nielsen
  • Polynucleotide phosphorodithioates
    Patent number: 5278302
    Abstract: The present invention relates to novel oligonucleotides having phosphorodithioate internucleotide linkages which may be used for the treatment of diseases caused by viruses.
    Type: Grant
    Filed: November 18, 1991
    Date of Patent: January 11, 1994
    Assignee: University Patents, Inc.
    Inventors: Marvin H. Caruthers, William S. Marshall
  • Nucleoside thiophosphoramidites
    Patent number: 5218103
    Abstract: The present invention relates to new and useful nucleside thiophosphoramidite, polynucleotide dithioate phosphoramidite and polynucleotide phosphorothioamidate phosphoramidite compounds as well as the process whereby these compounds can be used for synthesizing new monoucleotides and polynucleotides having phosphorodithioate, phosphorothioamidate, phosphorothiotriesters and phosphorothioate internucleotide linkages.
    Type: Grant
    Filed: January 22, 1991
    Date of Patent: June 8, 1993
    Assignee: University Patents, Inc.
    Inventors: Marvin H. Caruthers, Yun-Xi Ma, Eric K. Yau, John Nielsen, Wolfgang Brill
  • Process for preparing polynucleotides
    Patent number: 5153319
    Abstract: New and useful intermediate nucleotides bound to an inorganic polymer support, including the preparation thereof, and processes for the conversion to oligonucleotides which are especially useful for the synthesis of polynucleotides, particularly ribonucleic (RNA) and deoxyribonucleic (DNA) acids, are described.
    Type: Grant
    Filed: March 31, 1986
    Date of Patent: October 6, 1992
    Assignee: University Patents, Inc.
    Inventors: Marvin H. Caruthers, Mark D. Matteucci
  • Process for preparing polynucleotides
    Patent number: 5132418
    Abstract: This invention is a process for the production of oligonucleotides which comprises:(a) converting an inorganic polymer into a coupling agent-polymer;(b) combining the coupling agent-polymer with a blocked nucleoside to obtain a blocked nucleoside-modified support; and(c) removing the blocking group from the blocked nucleoside-modified support to provide for the coupling of nucleotides to the nucleoside-modified support.
    Type: Grant
    Filed: June 18, 1984
    Date of Patent: July 21, 1992
    Assignee: University Patents, Inc.
    Inventors: Marvin H. Caruthers, Mark D. Matteucci
  • Process for oligonucleo tide synthesis using phosphormidite intermediates
    Patent number: 4973679
    Abstract: A new class of nucleoside phosphoramidites which are relatively stable to permit isolation thereof and storage at room temperature. The phosphoramidites are derivatives of saturated secondary amines.
    Type: Grant
    Filed: September 18, 1986
    Date of Patent: November 27, 1990
    Assignee: University Patents, Inc.
    Inventors: Marvin H. Caruthers, Serge L. Beaucage
  • DNA sequences encoding hybrid lymphoblastoid-leukocyte human interferons
    Patent number: 4734491
    Abstract: DNA sequences encoding for novel human lymphoblastoid-leukocyte hybrid interferons. Methods of making nucleotide sequences comprising ribosome binding sites, promoter regions, and segments of human lymphoblastoid and leukocyte interferons are described. DNA sequences for hybrid interferons are cloned and expressed in plasmid vectors. Transformed microorganisms and novel lymphoblastoid-leukocyte polypeptide interferons having biological or immunological acitivity are disclosed.
    Type: Grant
    Filed: August 31, 1984
    Date of Patent: March 29, 1988
    Assignee: University Patents, Inc.
    Inventor: Marvin H. Caruthers
  • Hybrid lymphoblastoid-leukocyte human interferons
    Patent number: 4716217
    Abstract: DNA sequences encoding for novel human lymphoblastoid-leukocyte hybrid interferons. Methods of making nucleotide sequences comprising ribosome binding sites, promoter regions, and segments of human lymphoblastoid and leukocyte interferons are described. DNA sequences for hybrid interferons are cloned and expressed in plasmid vectors. Transformed microorganisms and novel lymphoblastoid-leukocyte polypeptide interferons having biological or immunological activity are disclosed.
    Type: Grant
    Filed: August 31, 1984
    Date of Patent: December 29, 1987
    Assignee: University Patents, Inc.
    Inventors: Marvin H. Caruthers, Michael Leineweber, Moshe Leitner, Yitzhak Stabinsky
  • Phosphoramidite nucleoside compounds
    Patent number: 4668777
    Abstract: A new class of nucleoside phosphoramidites which are relatively stable to permit isolation thereof and storage at room temperature. The phosphoramidites are derivatives of saturated secondary amines.
    Type: Grant
    Filed: August 6, 1984
    Date of Patent: May 26, 1987
    Assignee: University Patents, Inc.
    Inventors: Marvin H. Caruthers, Serge L. Beaucage
  • Nucleosides useful in the preparation of polynucleotides
    Patent number: 4500707
    Abstract: New and useful intermediate nucleotides bound to an inorganic polymer support, including the preparation thereof, and processes for the conversion to oligonucleotides which are especially useful for the synthesis of polynucleotides, particularly ribonucleic (RNA) and deoxyribonucleic acids (DNA).
    Type: Grant
    Filed: March 16, 1982
    Date of Patent: February 19, 1985
    Assignee: University Patents, Inc.
    Inventors: Marvin H. Caruthers, Mark D. Matteucci
  • Process for preparing polynucleotides
    Patent number: 4458066
    Abstract: New and useful intermediate nucleotides bound to an inorganic polymer support, including the preparation thereof, and processes for the conversion to oligonucleotides which are especially useful for the synthesis of polynucleotides, particularly ribonucleic (RNA) and deoxyribonucleic acids (DNA).
    Type: Grant
    Filed: March 24, 1981
    Date of Patent: July 3, 1984
    Assignee: University Patents, Inc.
    Inventors: Marvin H. Caruthers, Mark D. Matteucci
  • Phosphoramidite compounds and processes
    Patent number: 4415732
    Abstract: A new class of nucleoside phosphoramidites which are relatively stable to permit isolation thereof and storage at room temperature. The phosphoramidites are derivatives of saturated secondary amines.
    Type: Grant
    Filed: March 27, 1981
    Date of Patent: November 15, 1983
    Assignee: University Patents, Inc.
    Inventors: Marvin H. Caruthers, Serge L. Beaucage