Patents by Inventor Mary Collins
Mary Collins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210298393Abstract: A multi-layer antibacterial glove for providing effective and fashionable protection against germs includes a glove body comprising an inner layer, a second layer, a third layer, and an outer layer. The inner layer is breathable and is configured to form fit a user's hand. The second layer is continuously disposed around the inner layer. The second layer is moisture-resistant. The third layer continuously disposed around the second layer and is antibacterial. The outer layer is continuously disposed around the third layer. The outer layer is a fashionable or functional glove material.Type: ApplicationFiled: March 24, 2020Publication date: September 30, 2021Inventor: Mary Collins
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Patent number: 10344005Abstract: Disclosed herein is a novel method for preparing cyclophanes, comprising forming a disulfide cyclophane by contacting a linker moiety which includes two or more thiol groups, with a metal salt and an oxidant. The disulfide cyclophane is then desulfurized to form a thiacyclophane comprising thioether bridges. This thiacyclophane optionally may be further desulfurized to form an unsaturated hydrocarbon cyclophane, which can then be reduced to form a saturated hydrocarbon cyclophane. The various cyclophanes can be synthesized in a ring form, such as a dimer, trimer or tetramer etc., or they can be synthesized in a tetrahedral or larger structure. Also disclosed are novel cyclophanes formed by the disclosed method.Type: GrantFiled: September 7, 2017Date of Patent: July 9, 2019Assignee: University of OregonInventors: Darren W. Johnson, Mary Collins
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Publication number: 20170369456Abstract: Disclosed herein is a novel method for preparing cyclophanes, comprising forming a disulfide cyclophane by contacting a linker moiety which includes two or more thiol groups, with a metal salt and an oxidant. The disulfide cyclophane is then desulfurized to form a thiacyclophane comprising thioether bridges. This thiacyclophane optionally may be further desulfurized to form an unsaturated hydrocarbon cyclophane, which can then be reduced to form a saturated hydrocarbon cyclophane. The various cyclophanes can be synthesized in a ring form, such as a dimer, trimer or tetramer etc., or they can be synthesized in a tetrahedral or larger structure. Also disclosed are novel cyclophanes formed by the disclosed method.Type: ApplicationFiled: September 7, 2017Publication date: December 28, 2017Applicant: University of OregonInventors: Darren W. Johnson, Mary Collins
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Patent number: 9840720Abstract: Lentiviral packaging cells and methods for producing the same are provided herein. Specifically, lentiviral packaging cells capable of producing lentiviral vector suitable for use in clinical trials are provided. Methods for producing lentiviral packaging cells capable of producing lentiviral vector suitable for use in clinical trials are described.Type: GrantFiled: February 13, 2013Date of Patent: December 12, 2017Assignee: UCL Business PLCInventors: Mary Collins, Yasuhiro Takeuchi, Sean Knight
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Patent number: 9790192Abstract: Disclosed herein is a novel method for preparing cyclophanes, comprising forming a disulfide cyclophane by contacting a linker moiety which includes two or more thiol groups, with a metal salt and an oxidant. The disulfide cyclophane is then desulfurized to form a thiacyclophane comprising thioether bridges. This thiacyclophane optionally may be further desulfurized to form an unsaturated hydrocarbon cyclophane, which can then be reduced to form a saturated hydrocarbon cyclophane. The various cyclophanes can be synthesized in a ring form, such as a dimer, trimer or tetramer etc., or they can be synthesized in a tetrahedral or larger structure. Also disclosed are novel cyclophanes formed by the disclosed method.Type: GrantFiled: November 18, 2015Date of Patent: October 17, 2017Assignee: University of OregonInventors: Darren W. Johnson, Mary Collins
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Publication number: 20160137598Abstract: Disclosed herein is a novel method for preparing cyclophanes, comprising forming a disulfide cyclophane by contacting a linker moiety which includes two or more thiol groups, with a metal salt and an oxidant. The disulfide cyclophane is then desulfurized to form a thiacyclophane comprising thioether bridges. This thiacyclophane optionally may be further desulfurized to form an unsaturated hydrocarbon cyclophane, which can then be reduced to form a saturated hydrocarbon cyclophane. The various cyclophanes can be synthesized in a ring form, such as a dimer, trimer or tetramer etc., or they can be synthesized in a tetrahedral or larger structure. Also disclosed are novel cyclophanes formed by the disclosed method.Type: ApplicationFiled: November 18, 2015Publication date: May 19, 2016Applicant: UNIVERSITY OF OREGONInventors: Darren W. Johnson, Mary Collins
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Publication number: 20150023933Abstract: Lentiviral packaging cells and methods for producing the same are provided herein. Specifically, lentiviral packaging cells capable of producing lentiviral vector suitable for use in clinical trials are provided. Methods for producing lentiviral packaging cells capable of producing lentiviral vector suitable for use in clinical trials are described.Type: ApplicationFiled: February 13, 2013Publication date: January 22, 2015Applicant: UCL Business PLCInventors: Mary Collins, Yasuhiro Takeuchi, Sean Knight
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Publication number: 20140024024Abstract: Novel methods of probing multiple targets in a biological sample are provide whereby the targets are DNA, RNA and protein. The method comprises subjecting the sample to an in situ hybridization reaction using a labeled nucleic acid probe that binds an RNA target, observing a signal, and optionally removing the signal. The method further comprises an antigen retrieval protocol, observing a signal, removing the signal, and optionally applying a protease treatment to access the sample's DNA targets by subjecting the sample to an in situ hybridization reaction using a labeled nucleic acid probe, observing a signal from the labeled DNA targets, and optionally removing the signal.Type: ApplicationFiled: July 17, 2012Publication date: January 23, 2014Applicant: General Electric CompanyInventors: Anup Sood, Michael John Gerdes, Antti Eljas Seppo, Wei Gao, Fiona Mary Ginty, Elizabeth Mary Collins
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Patent number: 8143385Abstract: The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-21 receptor (IL-21R). The antibodies can act as antagonists of IL-21R activity, thereby modulating immune responses in general, and those mediated by IL-21R in particular. The disclosed compositions and methods may be used for example, in diagnosing, treating or preventing inflammatory disorders, autoimmune diseases, allergies, transplant rejection, cancer, and other immune system disorders.Type: GrantFiled: January 14, 2009Date of Patent: March 27, 2012Assignees: Wyeth LLC, MedImmune Ltd.Inventors: Viia Valge-Archer, Andrew James Williams, Deborah A. Young, Matthew J. Whitters, Mary Collins, Joann Witek
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Patent number: 8088905Abstract: This disclosure provides antibodies and antigen-binding fragments that can act as agonists and/or antagonists of PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those mediated by TcR and CD28, in particular. The disclosed compositions and methods may be used for example, in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, and other immune system disorders.Type: GrantFiled: March 16, 2009Date of Patent: January 3, 2012Assignees: Wyeth, MedImmune LimitedInventors: Mary Collins, Clive R. Wood, Beatriz M. Carreno, Deborah Luxenberg, Jason Jussif, Laura L. Carter, Frances K. Bennett, Viia Valge-Archer, John Andrews, Caroline Russell
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Publication number: 20110142833Abstract: The present invention provides methods of screening for compositions useful for treating, ameliorating, or preventing fibrosis and/or fibrosis-associated conditions by measuring changes in the level(s) of IL-21 and/or IL-21 receptor (IL-21R) (e.g., the level of expression of IL-21 and/or IL-21R protein and/or mRNA, the level of activity of IL-21 and/or IL-21R, the level of interaction of IL-21 with IL-21R). The invention further provides antagonists of IL-21 or IL-21R for the treatment of fibrosis and/or fibrosis-associated conditions. Further provided herein are methods of diagnosing, prognosing, and monitoring the progress (e.g., the course of treatment) of fibrosis and/or fibrosis-associated conditions by measuring the level of IL-21 and/or IL-21R (i.e., the level of activity of IL-21 and/or IL-21R, the level of expression of IL-21 and/or IL-21R (e.g., the level of IL-21 and/or IL-21R gene products), and/or the level of interaction of IL-21 with IL-21R).Type: ApplicationFiled: February 18, 2011Publication date: June 16, 2011Inventors: Deborah A. YOUNG, Thomas A. Wynn, Mary Collins, Michael J. Grusby
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Patent number: 7910105Abstract: The present invention provides methods of screening for compositions useful for treating, ameliorating, or preventing fibrosis and/or fibrosis-associated conditions by measuring changes in the level(s) of IL-21 and/or IL-21 receptor (IL-21R) (e.g., the level of expression of IL-21 and/or IL-21R protein and/or mRNA, the level of activity of IL-21 and/or IL-21R, the level of interaction of IL-21 with IL-21R). The invention further provides antagonists of IL-21 or IL-21R for the treatment of fibrosis and/or fibrosis-associated conditions. Further provided herein are methods of diagnosing, prognosing, and monitoring the progress (e.g., the course of treatment) of fibrosis and/or fibrosis-associated conditions by measuring the level of IL-21 and/or IL-21R (i.e., the level of activity of IL-21 and/or IL-21R, the level of expression of IL-21 and/or IL-21R (e.g., the level of IL-21 and/or IL-21R gene products), and/or the level of interaction of IL-21 with IL-21R).Type: GrantFiled: April 13, 2006Date of Patent: March 22, 2011Assignees: Wyeth LLC, The United States of America as represented by the Department of Health and Human Services, President and Fellows of Harvard CollegeInventors: Deborah A. Young, Thomas A. Wynn, Mary Collins, Michael J. Grusby
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Publication number: 20110033451Abstract: The present invention provides isolated and purified polynucleotides and polypeptides related to the IL-17F signaling pathway. The invention also provides antibodies to IL-17F homodimers and IL-17A/IL-17F heterodimers, and methods of isolating and purifying members of the IL-17 family, including IL-17A/IL-17F heterodimers, from a natural source. The present invention also is directed to novel methods for diagnosing, prognosing, monitoring the progress of, and treating and/or preventing disorders related to IL-17F signaling, i.e., IL-17F-associated disorders, including, but not limited to, inflammatory disorders, such as autoimmune diseases (e.g., arthritis (including rheumatoid arthritis), psoriasis, systemic lupus erythematosus, and multiple sclerosis), respiratory diseases (e.g., COPD, cystic fibrosis, asthma, allergy), transplant rejection (including solid organ transplant rejection), and inflammatory bowel diseases or disorders (IBDs, e.g., ulcerative colitis, Crohn's disease).Type: ApplicationFiled: June 30, 2010Publication date: February 10, 2011Applicant: Wyeth LLCInventors: Beatriz M. Carreno, Mary Collins, Jill F. Wright, Neil M. Wolfman, Maya Arai, Kenneth Jacobs, Zhijian Lu, Yongjing Guo, Yongchang Qiu
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Publication number: 20100297151Abstract: The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-21 receptor (IL-21R). The antibodies can act as antagonists of IL-21R activity, thereby modulating immune responses in general, and those mediated by IL-21R in particular. The disclosed compositions and methods may be used for example, in diagnosing, treating or preventing inflammatory disorders, autoimmune diseases, allergies, transplant rejection, cancer, and other immune system disorders.Type: ApplicationFiled: January 14, 2009Publication date: November 25, 2010Applicants: WYETH, CAMBRIDGE ANTIBODY TECHNOLOGY LIMITEDInventors: Viia Valge-Archer, Andrew James Williams, Deborah A. Young, Matthew J. Whitters, Mary Collins, Joann Witek
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Publication number: 20100223685Abstract: A transgenic non-human mammal with a disruption in its IL-21 receptor gene is provided, along with methods of using the transgenic non-human mammal.Type: ApplicationFiled: January 6, 2010Publication date: September 2, 2010Inventors: Marion KASAIAN, Matthew WHITTERS, Andrea WURSTER, Mary COLLINS, Deborah YOUNG, Michael GRUSBY
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Patent number: 7731946Abstract: Methods and compositions for modulating T helper (Th) cell development and function using modulators of IL-21, e.g., human IL-21, activity or level.Type: GrantFiled: November 12, 2007Date of Patent: June 8, 2010Assignees: Wyeth LLC, The President and Fellows of Harvard CollegeInventors: Michael J. Grusby, Andrea Wurster, Deborah Young, Mary Collins, Matthew Whitters
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Publication number: 20100086516Abstract: Polynucleotides encoding the IL-13 receptor and fragments thereof are disclosed. IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor and methods for their identification are also disclosed. Methods of medical treatment using such molecules and antagonists of the IL-13/IL-13R interaction are also provided.Type: ApplicationFiled: March 20, 2009Publication date: April 8, 2010Applicants: GENETICS INSTITUTE, LLC, THE JOHNS HOPKINS UNIVERSITYInventors: Mary Collins, Debra Donaldson, Lori Fitz, Tamlyn Neben, Matthew J. Whitters, Clive Wood, Marsha Wills-Karp
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Publication number: 20100080809Abstract: The present invention provides novel isolated and purified polynucleotides and polypeptides related to a novel ligand for glucocorticoid-induced TNF receptor (GITR). The invention also provides antibodies to the GITR ligand (GITRL). The present invention also is directed to novel methods for diagnosing, prognosing, monitoring the progress of, and treating disorders arising from disregulation of the immune system (e.g., autoimmune disorders, inflammatory diseases, and transplant rejection, and cancers and infectious diseases) using GITRL and/or modulators of GITRL. The present invention is further directed to novel therapeutics and therapeutic targets and to methods of screening and assessing test compounds for the intervention (treatment) and prevention of said disorders arising from disregulation of the immune system, as related to GITRL and GITR.Type: ApplicationFiled: August 28, 2009Publication date: April 1, 2010Applicants: Wyeth, The Government of the United StatesInventors: Mary Collins, Ethan Menahem Shevach, Rebecca Suzanne McHugh, Matthew James Whitters, Deborah Ann Young, Michael Chapman Byrne, Padmalatha S. Reddy, Geoffrey Laurence Stephens, Beatriz M. Carreno
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Patent number: 7674591Abstract: Polynucleotides encoding the IL-13 receptor and fragments thereof are disclosed. IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor and methods for their identification are also disclosed.Type: GrantFiled: February 27, 2006Date of Patent: March 9, 2010Assignee: Genetics Institute, LLCInventors: Mary Collins, Debra Donaldson, Lori Fitz, Tamlyn Neben, Matthew Whitters, Clive Wood
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Patent number: 7666421Abstract: The invention relates to a humanized anti-B7-2 antibody that comprises a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant rejection, inflammatory disorders and infectious diseases by administering humanized anti-B7-2 and/or anti-B7-1 antibodies.Type: GrantFiled: December 5, 2005Date of Patent: February 23, 2010Assignee: Genetics Institute, LLCInventors: Man Sung Co, Maximiliano Vasquez, Beatriz Carreno, Abbie Cheryl Celniker, Mary Collins, Samuel Goldman, Gary S. Gray, Andrea Knight, Denise O'Hara, Bonita Rup, Geertruida M. Veldman