Patents by Inventor Masaaki Ishizuka
Masaaki Ishizuka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20090177560Abstract: A parts management method is performed by a parts management device for managing parts used to produce an assembly product. Firstly, parts identification information and number of parts corresponding to an assembly product of which production is started are read from a storage device, respectively, as used-parts identification information and a used number. Secondly, parts container information of a parts container that accommodates parts used for an assembly product of which production is started is read from a storage device that stores parts container information, for each parts container. Then, parts container information that includes an updated number of parts is written into a storage device. The updated number of parts is obtained by subtracting the number of used parts from number of parts identified by the used-parts identification information read in the firstly reading.Type: ApplicationFiled: March 21, 2009Publication date: July 9, 2009Applicant: FUJITSU LIMITEDInventor: Masaaki Ishizuka
-
Patent number: 7060821Abstract: A compound represented by formula (I); a process for producing a compound (substance F-1490) of formula (I), wherein X represents —O— and R represents a hydroxyl group, by using a microorganism belonging to the genus Cunninghamella; and a Cunninghamella sp. F-1490 strain (FERM BP-8287) capable of producing the substance F-1490; and an osteoclast differentiation inhibitory agent containing as an active ingredient the compound represented by formula (I): wherein X represents —O— or —CH2—, and R represents a hydroxyl group when X represents —O—, or a hydrogen atom when X represents —CH2—.Type: GrantFiled: March 6, 2003Date of Patent: June 13, 2006Assignees: Mercian Corporation, Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hiroyuki Kumagai, Tomohiro Sameshima, Motoko Matsufuji, Naoto Kawamura, Kunio Isshiki, Hiroyuki Inoue, Tetsuya Someno, Masaaki Ishizuka, Tomio Takeuchi
-
Publication number: 20040024015Abstract: A method for enhancing the efficacy of chemotherapy and/or radiation in the treatment of cancer in animals, particularly humans, is provided wherein certain isocoumarin derivatives which exhibit unique radiosensitization activity and/or chemopotentiation properties are employed in a combination treatment with ionizing radiation and/or chemotherapy.Type: ApplicationFiled: June 30, 2003Publication date: February 5, 2004Inventors: Corinne L. Reimer, Naoki Agata, Tomio Takeuchi, Hiroyuki Kumagai, Takeo Yoshioka, Masaaki Ishizuka, Donald W. Kufe, Ralph R. Weichselbaum
-
Patent number: 6589981Abstract: A method for enhancing the efficacy of chemotherapy and/or radiation in the treatment of cancer in animals, particularly humans, is provided wherein certain isocoumarin derivatives which exhibit unique radiosensitization activity and/or chemopotentiation properties are employed in a combination treatment with ionizing radiation and/or chemotherapy.Type: GrantFiled: February 27, 2001Date of Patent: July 8, 2003Assignees: ILEX Oncology, Inc., Mercian CorporationInventors: Corinne L. Reimer, Naoki Agata, Tomio Takeuchi, Hiroyuki Kumagai, Takeo Yoshioka, Masaaki Ishizuka, Donald W. Kufe, Ralph R. Weichselbaum
-
Publication number: 20020019366Abstract: A method for enhancing the efficacy of chemotherapy and/or radiation in the treatment of cancer in animals, particularly humans, is provided wherein certain isocoumarin derivatives which exhibit unique radiosensitization activity and/or chemopotentiation properties are employed in a combination treatment with ionizing radiation and/or chemotherapy.Type: ApplicationFiled: February 27, 2001Publication date: February 14, 2002Inventors: Corinne L. Reimer, Naoki Agata, Tomio Takeuchi, Hiroyuki Kumagai, Takeo Yoshioka, Masaaki Ishizuka, Donald W. Kufe, Ralph R. Weichselbaum
-
Patent number: 6245810Abstract: A novel amino acid derivative represented by the general formula (I) shown below or a salt thereof have now been provided by chemical synthesis, and it has been found that these new compounds stimulate proliferation and physiological activities of the T cells of mammals, have an immunomodulating activity and also have an antitumor activity or a carcinostatic activity. It has also been found that these new compounds have an effect of stimulating the proliferation of hematopoietic stem cells. wherein y is 0 or 1; R1 represents an unsubstituted C1-C8 alkyl group or others; R2 represents a hydrogen atom, a C1-C5 alkyl group or others; R3 represents a hydrogen atom, a C1-C8 alkyl group or others; R4 represents a hydrogen atom, a C1-C3 alkyl group or others; R5 represents a group —OR42, a group or others.Type: GrantFiled: June 30, 1998Date of Patent: June 12, 2001Assignees: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Masaaki Ishizuka, Masaji Kawazu, Toshiaki Katsumi, Yoshihide Fuse, Kenji Maeda, Tomio Takeuchi
-
Patent number: 6160017Abstract: The invention relates to an agent for preventing and treating ulcerous colitis and/or Crohn's disease, comprising conagenin or a pharmaceutically acceptable salt thereof as an active ingredient. According to the present invention, there is provided an agent for preventing and treating ulcerous colitis and/or Crohn's disease, which has high therapeutic effect and safety.Type: GrantFiled: February 14, 2000Date of Patent: December 12, 2000Assignees: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Taiho Pharmaceutical Co., Ltd.Inventors: Masaaki Ishizuka, Kenji Maeda, Tomio Takeuchi, Tadayoshi Shiraishi, Masakazu Fukushima
-
Patent number: 5952380Abstract: A pharmaceutical composition for treating diarrhea comprising an anti-diarrhea effective amount of conagenin or a salt thereof, and a pharmaceutically acceptable carrier. The pharmaceutical composition is particularly useful against diarrhea caused by the administration of cancer chemotherapeutic agents.Type: GrantFiled: March 27, 1997Date of Patent: September 14, 1999Assignees: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Taino Pharmaceutical Co., Ltd., Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Masaaki Ishizuka, Kenji Maeda, Tomio Takeuchi, Toshiyuki Toko, Tadayoshi Shiraishi
-
Patent number: 5798387Abstract: A novel amino acid derivative represented by the general formula (I) shown below or a salt thereof have now been provided by chemical synthesis, and it has been found that these new compounds stimulate proliferation and physiological activities of the T cells of mammals, have an immunomodulating activity and also have an antitumor activity or a carcinostatic activity. It has also been found that these new compounds have an effect of stimulating the proliferation of hematopoietic stem cells. ##STR1## wherein y is 0 or 1; R.sup.1 represents an unsubstituted C.sub.1 -C.sub.8 alkyl group or others;R.sup.2 represents a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group or others;R.sup.3 represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group or others;R.sup.4 represents a hydrogen atom, a C.sub.1 -C.sub.3 alkyl group or others;R.sup.5 represents a group --OR.sup.42, a group ##STR2## or others.Type: GrantFiled: November 25, 1996Date of Patent: August 25, 1998Assignees: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Masaaki Ishizuka, Masaji Kawazu, Toshiaki Katsumi, Yoshihide Fuse, Kenji Maeda, Tomio Takeuchi
-
Patent number: 5527820Abstract: As new antibiotics are obtained delaminomycins A, B and C having a formula (I) or (I') shown below, or salts thereof. Delaminomycins preferentially inhibit T cells and are useful as immunosuppressants, antineoplastic agents and antibacterial agents. ##STR1## wherein X is a hydroxyl group for delaminomycin A, a methoxy group for delaminomycin B and a hydrogen atom for delaminomycin C.Type: GrantFiled: January 20, 1995Date of Patent: June 18, 1996Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Masaaki Ishizuka, Mitsuhiro Ueno, Hironobu Iinuma, Hiroshi Naganawa, Masa Hamada, Kenji Maeda, Tomio Takeuchi
-
Patent number: 5098935Abstract: A new antibiotic, named Conagenin, is provided which can exhibit useful carcinostatic or antitumor activities on carcinomas and tumors, particularly malignant tumors, of mammalian animals including man. Conagenin can be produced by fermentation of microorganisms of genus Streptomyces, typically Streptomyces roseosporus MI696-AF3 strain identified under the deposit number FERM BP-2738. Conagenin has formula (I) and is useful for medicinal purposes, particularly as carcinostatic agent or antitumor agent for inhibiting carcinomas and malignant tumors of mammalian animals, including man.Type: GrantFiled: May 17, 1990Date of Patent: March 24, 1992Assignees: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Masaaki Ishizuka, Takashi Yamashita, Hiroshi Naganawa, Hironobu Iinuma, Kunio Isshiki, Masa Hamada, Kenji Maeda, Tomio Takeuchi
-
Patent number: 5096924Abstract: As a new antibiotic is provided a compound, now nominated as MI43-37F11 substance, which has formula ##STR1## This MI43-37F11 substance has an antitumor activity, an activity to enhance the production of interleukin-1 in vivo in a mammalian, and an activity to activate a macrophage in vivo in a mammalian. MI43-37F11 substance may be produced by cultivation of Streptoverticillium eurocidicum MI43-37F11 strain identified as FERM BP-2783.Type: GrantFiled: May 31, 1990Date of Patent: March 17, 1992Assignee: 501 Azidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Masaaki Ishizuka, Hiroyuki Kumagai, Tsutomu Sawa, Hiroshi Naganawa, Hironobu Iinuma, Kunio Isshiki, Masa Hamada, Kenji Maeda, Tomio Takeuchi
-
Patent number: 4870172Abstract: A novel compound having anti-tumor activity is disclosed which is 1,12-dihydroxy-1,6,12,17-tetraazacyclodocosan-2,5,13,16-tetrone produced microbiologically by culturing a microorganism belonging to the genus of Alteromonas or, in particular, Alteromonas haloplanktis SB-1123. The characterization data of the compound and the microbiological properties of the microorganism are described. The results of in vitro assays are given for the anti-tumor activity of the compound against L-1210 and IMC carcinoma cells.Type: GrantFiled: July 16, 1987Date of Patent: September 26, 1989Assignee: Microbial Chemistry Research FoundationInventors: Yoshiro Okami, Shogo Kurasawa, Toshiyuki Kamayama, Atsushi Takahashi, Masaaki Ishizuka, Hamao Umezawa, deceased
-
Patent number: 4859593Abstract: New physiologically active substances, arphamenine A and arphamenine B which are generically termed arphamenine are produced from a new microorganism, BMG361-CF4 strain identified as FERM P-6521 or FERM BP-286 or ATCC No. 39373. Arphamenine is useful as a host defence stimulator having an activity to enhance cell-mediated immunity, and also as an anti-tumor agent.Type: GrantFiled: December 16, 1985Date of Patent: August 22, 1989Assignee: Zaidin Hojin Biseibutsu Kagaku Kenky KaiInventors: Hamao Umezawa, Takaaki Aoyagi, Tomio Takeuchi, Masa Hamada, Masaaki Ishizuka
-
Patent number: 4851446Abstract: The present invention relates to an immunosuppressing method which comprises administering a spergualin-related compound represented by the following formula ##STR1## (wherein R.sub.1 is --(CH.sub.2).sub.4 --, --(CH.sub.2).sub.6 --, ##STR2## R.sub.2 is --(CH.sub.2).sub.2 -- or --CH.dbd.CH--; and R.sub.3 is ##STR3## or pharmacologically acceptable salts thereof in an effective amount to a warm-blood animal.Type: GrantFiled: March 6, 1987Date of Patent: July 25, 1989Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, deceased, Tomio Takeuchi, Masaaki Ishizuka, Fuminori Abe, Akio Fujii, Teruya Nakamura
-
Patent number: 4786754Abstract: A stable, non-hygroscopic, crystalline .gamma.-form of bestatin is prepared from the .alpha.- or .beta.-form of bestatin by heating at a temperature of from about 148.degree. C. to the melting point of bestatin, or by suspending or kneading in certan specified solvents.Type: GrantFiled: July 13, 1987Date of Patent: November 22, 1988Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu HaiInventors: Takashi Terada, Tetsushi Saino, Terukatsu Sakurai, Hamao Umezawa, Masaaki Ishizuka
-
Patent number: 4778824Abstract: This invention relates to method for suppressing a transplantation immunity and treating an allergic disease and an autoimmune disease in a mammal which comprises administering spergualin or a pharmaceutically acceptable salt thereof in effective amount to the said mammal.Type: GrantFiled: June 30, 1987Date of Patent: October 18, 1988Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Tomio Takeuchi, Masaaki Ishizuka, Fuminori Abe, Akio Fujii, Teruya Nakamura
-
Patent number: 4769490Abstract: A stable, non-hygroscopic, crystalline .gamma.-form of bestatin is prepared from the .alpha.- or .beta.-form of bestatin by heating at a temperature of from about 148.degree. C. to the melting point of bestatin, or by suspending or kneading in certain specified solvents.Type: GrantFiled: April 2, 1987Date of Patent: September 6, 1988Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Takashi Terada, Tetsushi Saino, Terukatsu Sakurai, Hamao Umezawa, Masaaki Ishizuka
-
Patent number: 4663342Abstract: A compound of the formula (I) ##STR1## which is identified as an actinonin has now been found to potentiate the immune response in animals bearing Ascites Sarcoma 180 tumor cells.Type: GrantFiled: June 27, 1985Date of Patent: May 5, 1987Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Takaaki Aoyagi, Tomio Takeuchi, Masa Hamada, Masaaki Ishizuka
-
Patent number: 4595698Abstract: New physiologically active substances, arphamenine A and arphamenine B which are generically termed arphamenine are produced from a new microorganism, BMG361-CF4 strain identified as FERM P-6521 or FERM BP-286 or ATCC No. 39373. Arphamenine is useful as a host defence stimulator having an activity to enhance cell-mediated immunity, and also as an anti-tumor agent.Type: GrantFiled: June 2, 1983Date of Patent: June 17, 1986Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Takaaki Aoyagi, Tomio Takeuchi, Masa Hamada, Masaaki Ishizuka