Patents by Inventor Masaaki Ishizuka

Masaaki Ishizuka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunopotentiator
    Patent number: 4559362
    Abstract: This invention relates to an immunopotentiator or an immunopotentiating method using spermidine or its pharmacologically acceptable salt as an active ingredient.
    Type: Grant
    Filed: November 9, 1983
    Date of Patent: December 17, 1985
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Hamao Umezawa, Tomio Takeuchi, Masaaki Ishizuka
  • 2'-Deoxyoxanosine
    Patent number: 4530998
    Abstract: This invention relates to 2'-deoxy-oxanosine represented by the following formula: ##STR1## and process for the preparation thereof. This new compound exhibits a growth inhibiting action to gram-negative bacteria and has a carcinostatic action.
    Type: Grant
    Filed: March 5, 1984
    Date of Patent: July 23, 1985
    Assignee: Zaidan Hojin Biseibutsu Kagaku KenkyuKai
    Inventors: Hamao Umezawa, Tomio Takeuchi, Masaaki Ishizuka, Tomohisa Takita, Nobuyoshi Shimada, Kuniki Kato
  • Ebelactones and production thereof
    Patent number: 4358602
    Abstract: New physiologically active substances, ebelactone A and ebelactone B which are generally termed ebelactone are produced from a new microorganism, Streptomyces MG7-G1 strain identified FERM-P 5363 or ATCC No. 31860 and ATCC No. 31880. Ebelactone is useful as a host defense stimulator having an activity to enhance cell-mediated immunity, and also as an anti-inflammatory agent.
    Type: Grant
    Filed: March 4, 1981
    Date of Patent: November 9, 1982
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kao
    Inventors: Hamao Umezawa, Takaaki Aoyagi, Tomio Takeuchi, Masa Hamada, Shinichi Kondo, Masaaki Ishizuka
  • Compound with immunopotentiating activity and production and uses thereof
    Patent number: 4335250
    Abstract: A new compound is produced which has the general formula: ##STR1## wherein R represents hydrogen atom or a lower alkyl group and which exhibits an immunopotentiating activity. This new compound as well as its pharmaceutically acceptable salts and hydrates are useful for immunotherapy and treatment of immune diseases and disorders in living animals including human beings. The new compound can be produced by reduction of a hydroxyterephthalic acid alkyl ester or by esterification of the corresponding 3-hydroxy-4-(hydroxymethyl)-benzoic acid.
    Type: Grant
    Filed: July 12, 1979
    Date of Patent: June 15, 1982
    Assignee: Banyu Pharmaceutical Co., Ltd.
    Inventors: Hamao Umezawa, Tomio Takeuchi, Takaaki Aoyagi, Masaaki Ishizuka, Hajime Morishima, Takuzo Yamamoto, Junji Yoshizawa, Masaaki Hosoi, Ikuo Matsumoto
  • Antibiotic auromomycin, and process for production thereof
    Patent number: 4259319
    Abstract: A new antibiotic designated as auromomycin is prepared from the culture broth of Streptomyces macromomyceticus, a macromomycin-producing strain, as yellow crystals. Auromomycin is recovered in pure form from the culture broth by using hydrophobic chromatography with Octyl Sephalose CL-4B or Phenyl Sepharose CL-4B.
    Type: Grant
    Filed: August 25, 1978
    Date of Patent: March 31, 1981
    Assignees: Kanegafuchi Chemical Industry Company, Limited, Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Hamao Umezawa, Tomio Takeuchi, Masaaki Ishizuka, Kiyoshi Watanabe, Toshiaki Yamashita, Noriyuki Naoi, Takayoshi Hidaka
  • Cultivating streptomyces to produce an esterase inhibitor
    Patent number: 4242453
    Abstract: A new physiologically active substance named esterastin is now provided, which inhibits the activity of esterase and is useful as an immunosuppressive drug. Esterastin is produced by cultivating a micro-organism Streptomyces MD4-C1 identified as FERM-P 3723 or ATCC. 31336 in a culture medium under aerobic conditions and recovering it from the resulting culture.
    Type: Grant
    Filed: May 14, 1979
    Date of Patent: December 30, 1980
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Hamao Umezawa, Takaaki Aoyagi, Tomio Takeuchi, Masa Hamada, Masaaki Ishizuka
  • Pharmacological compound with immunopotentiating activity and production and uses thereof
    Patent number: 4238507
    Abstract: A new compound having the formula ##STR1## and now designated forphenicinol is produced, which exhibits an immunopotentiating activity. This new compound as well as its pharmaceutically acceptable salts and hydrates are useful for immunotherapy and treatment of immune diseases and disorders in living animals, including human beings. The new compound can be produced by hydrolysis of the corresponding aminonitrile compound of the formula ##STR2## or by reduction of forphenicine.
    Type: Grant
    Filed: March 16, 1979
    Date of Patent: December 9, 1980
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Hamao Umezawa, Tomio Takeuchi, Takaaki Aoyagi, Masaaki Ishizuka, Hajime Morishima, Ikuo Matsumoto, Takuzo Yamamoto
  • Process for producing antibiotics MA 144-M.sub.1 and MA 144-M.sub.2
    Patent number: 4219622
    Abstract: New antitumor agents designated MA 144-M.sub.1 and MA 144-M.sub.2, which are anthracycline glycosides and inhibit the growth of gram-positive bacteria, e.g. Staphyococcus aureus, Bacillus subtilis and Sarcina lutea, and inhibit the growth of animal tumors such as leukemia L 1210, P 388 and sarcoma 180 are produced by fermentation of MA 144-producing strains of streptomyces and by the chemical or enzymatic conversion of aclacinomycin A or cinerubin A.
    Type: Grant
    Filed: March 5, 1979
    Date of Patent: August 26, 1980
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Hamao Umezawa, Tomio Takeuchi, Hiroshi Naganawa, Masaaki Ishizuka, Norio Shibamoto, Toshikazu Oki, Taiji Inui
  • Process for preparing antibiotics MA 144-M.sub.1 and MA 144-M.sub.2
    Patent number: 4204038
    Abstract: New antitumor agents designated MA 144-M.sub.1 and MA 144-M.sub.2, which are anthracycyline glycosides and inhibit the growth of gram-positive bacteria, e.g. Staphyococcus aureus, Bacillus subtilis and Sarcina lutea, and inhibit the growth of animal tumors such as leukemia L 1210, P 388 and sarcoma 180 are produced by fermentation of MA 144-producing strains of streptomyces and by the chemical or enzymatic conversion of aclacinomycin A or cinerubin A.
    Type: Grant
    Filed: February 21, 1978
    Date of Patent: May 20, 1980
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Hamao Umezawa, Tomio Takeuchi, Hiroshi Naganawa, Masaaki Ishizuka, Norio Shibamoto, Toshikazu Oki, Taiji Inui
  • Process for producing antibiotic baumycin complex and components
    Patent number: 4198480
    Abstract: A novel anthracycline antibiotic complex designated herein as baumycin complex is produced by fermentation of a baumycin-producing strain of Streptomyces, e.g. Streptomyces coeruleorubidus ME 130-A4 (FERM-P3540, ATCC 31276). The complex and four bioactive components thereof designated baumycin A.sub.1, A.sub.2, B.sub.1 and B.sub.2 are useful as antibacterial and antitumor agents.
    Type: Grant
    Filed: March 15, 1978
    Date of Patent: April 15, 1980
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Hamao Umezawa, Tomio Takeuchi, Masa Hamada, Masaaki Ishizuka, Hiroshi Naganawa, Toshikazu Oki, Taiji Inui
  • Anthracycline glycosides from streptomyces
    Patent number: 4192915
    Abstract: New antitumor agents designated rhodirubin A and B, which are anthracycline glycosides and inhibit the growth of gram-positive bacteria and mammalian tumors, are produced by fermentation of rhodirubin-producing strains of Streptomyces, e.g. Streptomyces sp. ME 505-HEI (ATCC 31273).
    Type: Grant
    Filed: April 20, 1978
    Date of Patent: March 11, 1980
    Assignee: Bristol-Myers Company
    Inventors: Hamao Umezawa, Tomio Takeuchi, Masa Hamada, Masaaki Ishizuka, Hiroshi Naganawa, Toshikazu Oki, Taiji Inui
  • Physiologically active substance esterastin
    Patent number: 4189438
    Abstract: A new physiologically active substance named esterastin is now provided, which inhibits the activity of esterase and is useful as an immunosuppressive drug. Esterastin is produced by cultivating a microorganism Streptomyces MD4-C1 identified as FERM-P 3723 or ATCC. 31336 in a culture medium under aerobic conditions and recovering it from the resulting culture.
    Type: Grant
    Filed: January 30, 1978
    Date of Patent: February 19, 1980
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Hamao Umezawa, Takaaki Aoyagi, Tomio Takeuchi, Masa Hamada, Masaaki Ishizuka
  • Antibiotic baumycin complex and components thereof
    Patent number: 4147778
    Abstract: A novel anthracycline antibiotic complex designated herein as baumycin complex is produced by fermentation of a baumycin-producing strain of Streptomyces, e.g. Streptomyces coeruleorubidus ME 130-A4 (FERM-P3540, ATCC 31276). The complex and four bioactive components thereof designated baumycin A.sub.1, A.sub.2, B.sub.1 and B.sub.2 are useful as antibacterial and antitumor agents.
    Type: Grant
    Filed: May 16, 1977
    Date of Patent: April 3, 1979
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Hamao Umezawa, Tomio Takeuchi, Masa Hamada, Masaaki Ishizuka, Hiroshi Naganawa, Toshikazu Oki, Taiji Inui
  • Anthracycline glycosides
    Patent number: 4127714
    Abstract: New antitumor agents designated rhodirubin A and B, which are anthracycline glycosides and inhibit the growth of gram-positive bacteria and mammalian tumors, are produced by fermentation of rhodirubin-producing strains of Streptomyces, e.g. Streptomyces sp. ME 505-HEI (ATCC 31273).
    Type: Grant
    Filed: August 9, 1977
    Date of Patent: November 28, 1978
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Hamao Umezawa, Tomio Takeuchi, Masa Hamada, Masaaki Ishizuka, Hiroshi Naganawa, Toshikazu Oki, Taiji Inui
  • Neothramycin antibiotics
    Patent number: 4105658
    Abstract: There are disclosed two new antibiotics formerly denominated MC916-A and MC916-B and now called neothramycin A and neothramycin B which are potent inhibitors of the growth of leukemia cells, e.g. Leukemia L-1210 cells in mice. They are produced by controlled fermentation of Streptomyces FERM-P 2452 (A.T.C.C. 31123).
    Type: Grant
    Filed: February 19, 1976
    Date of Patent: August 8, 1978
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Hamao Umezawa, Tomio Takeuchi, Masa Hamada, Shinichi Kondo, Masaaki Ishizuka, Hiroshi Naganawa
  • Production of antibiotics neothramycin A and neothramycin B
    Patent number: 4049497
    Abstract: There are disclosed two new antibiotics formerly denominated MC916-A and MC916-B and now called neothramycin A and neothramycin B which are potent inhibitors of the growth of leukemia cells, e.g. Leukema L-1210 cells in mice. They are produced by controlled fermentation of Streptomyces FERM-P 2452 (A.T.C.C. 31123).
    Type: Grant
    Filed: December 6, 1976
    Date of Patent: September 20, 1977
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Hamao Umezawa, Tomio Takeuchi, Masa Hamada, Shinichi Kondo, Masaaki Ishizuka, Hiroshi Naganawa
  • Antitumor antibiotic macracidmycin
    Patent number: 3992524
    Abstract: A new antitumor agent named macracidmycin, which is a macromolecular peptide and inhibits the growth of various tumor cells and experimental animal tumors such as Ehrlich ascites carcinoma and Sarcoma 180 is produced by the fermentation of a microorganism belonging to the genus Streptomyces which has been designated Streptomyces atrofaciens (M590-G2 and A.T.C.C. 31104); it is recovered from the broth by conventional methods for recovering antibiotics.
    Type: Grant
    Filed: March 3, 1975
    Date of Patent: November 16, 1976
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Hamao Umezawa, Tomio Takeuchi, Masa Hamada, Masaaki Ishizuka, Akira Takamatsu, Toshikazu Oki, Hiroshi Tone