Abstract: An object of the present invention is to provide a novel marker that can be used to predict the effect of anti-PD-1 antibody/anti-PD-L1 antibody therapy with high sensitivity, and use thereof. Provided is a biomarker for predicting the effect of anti-PD-1 antibody/anti-PD-L1 antibody therapy, including an immunoglobulin superfamily containing leucine-rich repeat (ISLR).

Abstract: A hollow golf club head 1 comprises a face portion 2 which includes a club face 2a for striking a ball, and a main body 3 extending rearward of the head from the face portion 2. The face Portion 2 is made of a low-specific-gravity material having a specific gravity of 4.0 or less. The main body 3 is provided in its face portion 2 side with a low stiffness zone 10 where the stiffness is locally reduced.

Abstract: A microscope system includes a microscope body, an XY stage mounted on the microscope body and including a stage configured to place a slide as an observation target and move in an X-axis direction and a Y-axis direction perpendicular to each other, and an XY two-dimensional scale plate fixed to the stage. The XY two-dimensional scale plate is provided with a first mark that provides axis information in the X-axis direction throughout a movable range of the stage in the Y-axis direction and a second mark that provides axis information in the Y-axis direction throughout a movable range of the stage in the X-axis direction, which are used to recognize X- and Y-coordinates of the stage.

Abstract: A microscope system comprises a microscope body, a stage configured to place a slide as an observation target and move in an X direction and a Y direction. The microscope system changes an arrangement of the placed slide with respect to the stage so as to cause a direction indicated by a mark provided on the slide placed on the stage to align with one of the X direction and the Y direction of the stage.

Abstract: A microscope system comprises a microscope body, an image sensor mounted on the microscope body, and a stage that moves in an X-axis direction and a Y-axis direction, and places a slide as an observation object. The stage includes a mark used to indicate a stage reference position. The microscope system obtains positions of the stage in the X-axis direction and the Y-axis direction, and detects the stage reference position indicated by a mark provided on the stage and a slide reference position indicated by a mark provided on a slide placed on the stage. The microscope system manages the position of the stage by coordinates based on the slide reference position if the slide reference position is detected, and manages the position of the stage by coordinates based on the stage reference position if the slide reference position is not detected.

Abstract: Provided is a method of evaluating stability of a golf swing. The method comprises calculating a force indicator that represents a force that acts on a body of a golfer during the golf swing and evaluating stability of the golf swing according to a magnitude of the force indicator. In the calculating, the force indicator may be calculated during the golf swing made with a specific golf club, and in the evaluating, the stability of the golf swing may be evaluated as a characteristic of the specific golf club, in accordance with the magnitude of the force indicator.

Abstract: A hollow golf club head comprises a face part having a face for striking a ball, and a main body extending rearward from the face part. The main body is provided with a low-rigidity zone which comprises through holes and connecting portions arranged alternately along a peripheral edge of the face. The through holes penetrate the main body from the outside to the inside of the main body. The connecting portions extend in the front-back direction of the head, and include an oblique connecting portion comprising an oblique part inclined with respect to the front-back direction.

Abstract: A microscope system comprises a microscope body, a stage configured to place a slide as an observation target and move in an X direction and a Y direction. The microscope system changes an arrangement of the placed slide with respect to the stage so as to cause a direction indicated by a mark provided on the slide placed on the stage to align with one of the X direction and the Y direction of the stage.

Abstract: A hollow golf club head 1 comprises a face portion 2 which includes a club face 2a for striking a ball, and a main body 3 extending rearward of the head from the face portion 2. The face Portion 2 is made of a low-specific-gravity material having a specific gravity of 4.0 or less. The main body 3 is provided in its face portion 2 side with a low stiffness zone 10 where the stiffness is locally reduced.

Abstract: A golf club includes a head 200, a shaft 300, and a tip engagement part RT having a reverse-tapered shape and being disposed at a tip end portion of the shaft 300. The tip engagement part RT includes a sleeve 400 having a reverse-tapered shape and being fixed to the tip end portion of the shaft 300, and a spacer 500 having a reverse-tapered shape and being externally fitted to the sleeve 400. The spacer 500 has a divided structure. The hosel part 202 includes a hosel hole 204. The hosel hole 204 includes a reverse-tapered hole 206 corresponding to the shape of the outer surface of the tip engagement part RT. The hosel hole 204 allows the sleeve 400 to pass through the hosel hole 204. The tip engagement part RT is fitted to the reverse-tapered hole 206, and the sleeve 400 is fitted inside the spacer 500.

Abstract: A golf club 100 includes a tip engagement part RT having a reverse-tapered shape and being disposed at a tip end portion of a shaft 300, and a screw member 600. The tip engagement part RT includes a sleeve 400 fixed to the tip end portion of the shaft 300. The sleeve 400 has a sleeve-side connection part 410. The screw member 600 has a screw-side connection part 602 that can be detachably connected to the sleeve-side connection part 410, and a male screw part 604. The head 200 has a female screw part 220. When the screw member 600 is rotated in a first direction, the screw member 600 presses the tip engagement part RT in an engaging direction. When the screw member 600 is rotated in a second direction, the screw member 600 pulls the tip engagement part RT in an engagement releasing direction.

Abstract: A golf club head 1 having a hollow (i) therein comprises a face portion 2 having a face 2a for striking a ball, a crown portion 3 forming the head top surface, and a sole portion 4 forming a bottom of the head. One of or each of the crown portion 3 and the sole portion 4 is provided with a plurality of grooves bent in the same direction.

Abstract: A microscope system comprises a microscope body, an image sensor mounted on the microscope body via mounting means and configured to capture an observation image under a microscope, and a stage that moves in an X-axis direction and a Y-axis direction, which are orthogonal to each other, and places a slide as an observation object and includes a mark used to indicate a stage reference position. The microscope system obtains positions of the stage in the X-axis direction and the Y-axis direction, and detects, from an image captured by the image sensor, the stage reference position indicated by a mark provided on the stage and a slide reference position indicated by a mark provided on a slide placed on the stage. The microscope system manages the position of the stage by coordinates based on the slide reference position if the slide reference position is detected, and manages the position of the stage by coordinates based on the stage reference position if the slide reference position is not detected.

Abstract: A microscope system comprises a microscope body, a stage configured to place a slide as an observation target and move in an X direction and a Y direction. The microscope system changes an arrangement of the placed slide with respect to the stage so as to cause a direction indicated by a mark provided on the slide placed on the stage to align with one of the X direction and the Y direction of the stage.

Abstract: A microscope system includes a microscope body, an XY stage mounted on the microscope body and including a stage configured to place a slide as an observation target and move in an X-axis direction and a Y-axis direction perpendicular to each other, and an XY two-dimensional scale plate fixed to the stage. The XY two-dimensional scale plate is provided with a first mark that provides axis information in the X-axis direction throughout a movable range of the stage in the Y-axis direction and a second mark that provides axis information in the Y-axis direction throughout a movable range of the stage in the X-axis direction, which are used to recognize X- and Y-coordinates of the stage.

Abstract: A gear mechanism, including: a first gear; and a second gear. The first gear and the second gear are arranged at an inclination angle to form a first meshing region and a second meshing region. Multiple tooth tip portions of the first gear and multiple tooth tip portions of the second gear are each formed to be held in contact with each other at one point in the first meshing region. Multiple recessed portions of the first gear and multiple recessed portions of the second gear are each formed to conform to a passing region extending along movement of one of the multiple mating tooth tip portions at the time of moving in the second meshing region.

Abstract: A gear mechanism, including: a first gear; and a second gear. The first gear and the second gear are arranged at an inclination angle to form a first meshing region and a second meshing region. Multiple tooth tip portions of the first gear and multiple tooth tip portions of the second gear are each formed to be held in contact with each other at one point in the first meshing region. Multiple recessed portions of the first gear and multiple recessed portions of the second gear are each formed to conform to a passing region extending along movement of one of the multiple mating tooth tip portions at the time of moving in the second meshing region.

Abstract: A gear mechanism includes: a first gear; a second gear; an input shaft; a tilting shaft; an output shaft; a swing gear including: first teeth different in number by one tooth from teeth of the first gear; and second teeth different in number by one tooth from teeth of the second gear, the swing gear being configured to mesh with the first gear and the second gear at a certain tilting angle; and a coupling unit configured to couple the input shaft and the tilting shaft to each other so as to prevent relative rotation between the input shaft and the tilting shaft, and to allow the tilting shaft to freely swing about a center part between the first gear and the second gear in a plane including an input rotational axis.

Abstract: An actuator includes a housing, an output shaft arranged coaxially with the housing, and provided so as to freely rotate with respect to the housing, and a drive mechanism for rotationally driving the output shaft with respect to the housing. The drive mechanism includes a first gear, a second gear, a swing gear, a rotor magnetic circuit, and a stator magnetic circuit. The swing gear is arranged between the first gear and the second gear, and is provided so as to freely rotate about a tilting axis, which is tilted with respect to an axis of the housing. The rotor magnetic circuit is fixed to the swing gear. The stator magnetic circuit is fixed to the housing, and configured to generate an electromagnetic force of attracting or repulsing the rotor magnetic circuit, to thereby swing the swing gear.

Abstract: Provided is a watch capable of performing digital display as well as analog display. The watch can offer digital display without posing disadvantages peculiar to a liquid crystal panel. On the other hand, the watch can reduce the restrictions in design and make the digital display larger and easier to see. The watch includes a light-shielding plate 22 on the rear side of the dial 24. In the light-shielding plate, light-transmitting holes 23 are made piercing from a front of the light-shielding plate to a rear thereof. Thin chip LEDs 17 are inserted in the light-transmitting holes, and mounted on a circuit board 16. The circuit board is placed on the rear side of the light-shielding plate. On the rear side of the circuit board, an analog movement 13 is provided, and an LED drive circuit 33 for driving the LEDs is placed. Thus, the LEDs 17 for digital display are placed on the rear side of the dial.