Patents by Inventor Masahiko Shioi
Masahiko Shioi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11768155Abstract: The present disclosure provides a detection device capable of detecting a low concentration of an analyte with high sensitivity. The detection apparatus according to the present disclosure comprises a metal microstructure on which a first VHH antibody having a property of binding specifically to the analyte is immobilized and which generate surface plasmon by being irradiated with excitation light, an inlet through which a second VHH antibody and a sample that may contain an analyte are introduced, wherein the second VHH antibody has a property of binding specifically to the analyte and is labeled with a fluorescent substance, a light source for irradiating the metal microstructure to which the second VHH antibody and the sample have been introduced with the excitation light, and a detection unit for detecting the analyte on the basis of fluorescence generated from the fluorescent substance by the irradiation of the excitation light.Type: GrantFiled: January 20, 2020Date of Patent: September 26, 2023Assignee: PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD.Inventors: Hiroto Yanagawa, Masahiko Shioi, Kazuaki Nishio, Emina Ikeuchi
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Publication number: 20200232992Abstract: A pathogen detection system includes pathogen detectors disposed in different locations, and a controller. The pathogen detectors include a first pathogen detector and a second pathogen detector. The first pathogen detector transmits a first detection result obtained as a result of pathogen detection to the controller, and the second pathogen detector transmits a second detection result obtained as a result of pathogen detection to the controller. In a case where the first detection result satisfies a predetermined condition, the controller causes the second pathogen detector to change a mode related to the pathogen detection from a first mode to a second mode.Type: ApplicationFiled: April 6, 2020Publication date: July 23, 2020Inventors: MASAHIKO SHIOI, OSAMU AKASAKA, NORIAKI FUKUMOTO
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Publication number: 20200166455Abstract: The present disclosure provides a detection device capable of detecting a low concentration of an analyte with high sensitivity. The detection apparatus according to the present disclosure comprises a metal microstructure on which a first VHH antibody having a property of binding specifically to the analyte is immobilized and which generate surface plasmon by being irradiated with excitation light, an inlet through which a second VHH antibody and a sample that may contain an analyte are introduced, wherein the second VHH antibody has a property of binding specifically to the analyte and is labeled with a fluorescent substance, a light source for irradiating the metal microstructure to which the second VHH antibody and the sample have been introduced with the excitation light, and a detection unit for detecting the analyte on the basis of fluorescence generated from the fluorescent substance by the irradiation of the excitation light.Type: ApplicationFiled: January 20, 2020Publication date: May 28, 2020Inventors: HIROTO YANAGAWA, MASAHIKO SHIOI, KAZUAKI NISHIO, EMINA IKEUCHI
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Patent number: 10194939Abstract: A sensor embedding device according to the present disclosure is a sensor embedding device which embeds a sensor in a subject, the sensor having a sensing region in which to detect a state of the subject, including: a needle to be inserted in the subject, the needle having a hole; a sensor retainer to retain the sensor so that the sensor is ready to be embedded inside the subject in such a manner that the sensing region is oriented in a predetermined direction; and a movable section to move the sensor into the subject with a slide of the sensor retainer inside the hole.Type: GrantFiled: November 13, 2015Date of Patent: February 5, 2019Assignee: Panasonic Intellectual Property Management Co., Ltd.Inventors: Masaru Minamiguchi, Yasuaki Okumura, Tatsurou Kawamura, Takahiro Aoki, Masahiko Shioi
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Patent number: 9964491Abstract: An exemplary sensor chip includes a substrate, a metal pattern formed on a side of the substrate that is irradiated with excitation light, and a first substance and a second substance provided near the metal pattern. A first intensity Xa of the first surface-enhanced Raman-scattered light from the first substance and a second intensity Xb of the second surface-enhanced Raman-scattered light from the second substance are detected. An intensity ratio Xc, as obtained by dividing the second intensity Xb with the first intensity Xa, is calculated.Type: GrantFiled: May 6, 2015Date of Patent: May 8, 2018Assignee: PANASONIC CORPORATIONInventors: Yasuaki Okumura, Tatsurou Kawamura, Masahiko Shioi, Masaru Minamiguchi
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Patent number: 9921163Abstract: A method (200) for determining a concentration of an analyte in a fluid or fluid sample, comprises: providing (201) a SERS substrate comprising receptor molecules (107) capable of binding competitor molecules (106); contacting (202) the SERS substrate (102) with a fluid (sample) comprising analyte (108) and such competitor molecules (106); radiating (203) the SERS substrate (102) with a light source while measuring a SERS signal; and determining (205) a concentration of the analyte (108) based on the measured signal level. A corresponding device and system are also provided.Type: GrantFiled: February 13, 2014Date of Patent: March 20, 2018Assignees: IMEC vzw, Panasonic CorporationInventors: Hilde Jans, Masahiko Shioi, Karolien Jans, Liesbet Lagae
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Patent number: 9861303Abstract: An exemplary apparatus for measuring the concentration of a test substance in an organism disclosed herein includes: a measurement system which measures first and second concentrations that are concentrations of the test substance at positions A and B, respectively, where the positions A and B are located inside of the organism but outside of the blood vessel of the organism, and the position B is located more distant from the blood vessel than the position A is; and a decision circuit which determines, based on the first and second concentrations, whether or not an equilibrium has been established yet between a concentration of the test substance inside of the blood vessel and a concentration of the test substance measured at a position inside of the organism but outside of the blood vessel of the organism.Type: GrantFiled: February 25, 2015Date of Patent: January 9, 2018Assignee: Panasonic Intellectual Property Management Co., Ltd.Inventors: Tatsurou Kawamura, Yasuaki Okumura, Masaru Minamiguchi, Masahiko Shioi
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Patent number: 9610033Abstract: An exemplary sensor chip includes a substrate, a metal pattern, a proximate substance, and a light shielding layer. The metal pattern is on the substrate. The proximate substance is on or near the metal pattern. The light shielding layer is provided on the substrate so as to cover the metal pattern and the proximate substance. The light shielding layer is a layer that blocks the excitation light from going into the proximate substance, and is made of a substance which becomes degraded inside a subject.Type: GrantFiled: November 24, 2015Date of Patent: April 4, 2017Assignee: PANASONIC CORPORATIONInventors: Yasuaki Okumura, Tatsurou Kawamura, Masaru Minamiguchi, Masahiko Shioi
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Publication number: 20160073938Abstract: An exemplary sensor chip includes a substrate, a metal pattern, a proximate substance, and a light shielding layer. The metal pattern is on the substrate. The proximate substance is on or near the metal pattern. The light shielding layer is provided on the substrate so as to cover the metal pattern and the proximate substance. The light shielding layer is a layer that blocks the excitation light from going into the proximate substance, and is made of a substance which becomes degraded inside a subject.Type: ApplicationFiled: November 24, 2015Publication date: March 17, 2016Inventors: Yasuaki OKUMURA, Tatsurou KAWAMURA, Masaru MINAMIGUCHI, Masahiko SHIOI
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Publication number: 20160066953Abstract: A sensor embedding device according to the present disclosure is a sensor embedding device which embeds a sensor in a subject, the sensor having a sensing region in which to detect a state of the subject, including: a needle to be inserted in the subject, the needle having a hole; a sensor retainer to retain the sensor so that the sensor is ready to be embedded inside the subject in such a manner that the sensing region is oriented in a predetermined direction; and a movable section to move the sensor into the subject with a slide of the sensor retainer inside the hole.Type: ApplicationFiled: November 13, 2015Publication date: March 10, 2016Inventors: Masaru MINAMIGUCHI, Yasuaki OKUMURA, Tatsurou KAWAMURA, Takahiro AOKI, Masahiko SHIOI
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Publication number: 20150233836Abstract: An exemplary sensor chip includes a substrate, a metal pattern formed on a side of the substrate that is irradiated with excitation light, and a first substance and a second substance provided near the metal pattern. A first intensity Xa of the first surface-enhanced Raman-scattered light from the first substance and a second intensity Xb of the second surface-enhanced Raman-scattered light from the second substance are detected. An intensity ratio Xc, as obtained by dividing the second intensity Xb with the first intensity Xa, is calculated.Type: ApplicationFiled: May 6, 2015Publication date: August 20, 2015Inventors: Yasuaki OKUMURA, Tatsurou KAWAMURA, Masahiko SHIOI, Masaru MINAMIGUCHI
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Patent number: 9068891Abstract: A method for measuring a concentration of a biogenic substance in a living body includes steps of: preparing an apparatus including a light source, a substrate which has periodic metal structures and generates surface enhanced Raman scattering light by being irradiated with light from the light source, and spectroscopic means which disperses and detects the light, wherein the periodic metal structure is arranged with first and second distances in first and second direction respectively, the first distance is set to generate surface plasmon by matching a phase of the light from the light source, and the second distance is smaller than the first distance and is set between 300 nm and 350 nm; irradiating the substrate with the light from the light source to generate the surface enhanced Raman scattering; detecting the scattering with the spectroscopic means; and calculating the concentration of the biogenic substance based on the scattering.Type: GrantFiled: January 4, 2013Date of Patent: June 30, 2015Assignees: PANASONIC CORPORATION, IMEC vzw, Katholieke Universiteit Leuven, K.U.Leuven R&DInventors: Masahiko Shioi, Kristof Lodewijks, Pol Van Dorpe, Hilde Jans
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Publication number: 20150164393Abstract: An exemplary apparatus for measuring the concentration of a test substance in an organism disclosed herein includes: a measurement system which measures first and second concentrations that are concentrations of the test substance at positions A and B, respectively, where the positions A and B are located inside of the organism but outside of the blood vessel of the organism, and the position B is located more distant from the blood vessel than the position A is; and a decision circuit which determines, based on the first and second concentrations, whether or not an equilibrium has been established yet between a concentration of the test substance inside of the blood vessel and a concentration of the test substance measured at a position inside of the organism but outside of the blood vessel of the organism.Type: ApplicationFiled: February 25, 2015Publication date: June 18, 2015Inventors: Tatsurou KAWAMURA, Yasuaki OKUMURA, Masaru MINAMIGUCHI, Masahiko SHIOI
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Patent number: 8867032Abstract: A substrate is described that is suitable for surface enhanced optical detection. The substrate comprises an electrically conductive layer The substrate further comprises at least one nanoparticle comprising an electrically conductive portion. The electrically conductive portion may provide an opening to an underlying material. Such at least one nanoparticles may be a nanoring, a nanodisc, or a non-spherical nanoshell. The substrate further comprises a dielectric spacer for spacing the electrically conductive layer from the at least one nanoparticles. The dielectric spacer is a dielectric material substantially only present under the at least one nanoparticle, leaving the electrically conductive layer uncovered from dielectric material at positions away from the nanoparticles. The at least one nanoparticle and the dielectric spacer are interfaced along a first major surface and the at least one nanoparticle comprises an upstanding surface not in line with an upstanding surface of the dielectric spacer.Type: GrantFiled: March 22, 2011Date of Patent: October 21, 2014Assignees: IMEC, Panasonic Corporation, Katholieke Universiteit Leuven, Ku Leuven R&DInventors: Pol Van Dorpe, Kristof Lodewijks, Masahiko Shioi, Jian Ye
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Publication number: 20140234219Abstract: A method (200) for determining a concentration of an analyte in a fluid or fluid sample, comprises: providing (201) a SERS substrate comprising receptor molecules (107) capable of binding competitor molecules (106); contacting (202) the SERS substrate (102) with a fluid (sample) comprising analyte (108) and such competitor molecules (106); radiating (203) the SERS substrate (102) with a light source while measuring a SERS signal; and determining (205) a concentration of the analyte (108) based on the measured signal level. A corresponding device and system are also provided.Type: ApplicationFiled: February 13, 2014Publication date: August 21, 2014Applicants: PANASONIC CORPORATION, IMEC VZWInventors: Hilde Jans, Masahiko Shioi, Karolien Jans, Liesbet Lagae
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Patent number: 8735170Abstract: A biogenic substance concentration measuring apparatus includes an optical measuring apparatus for measuring optical properties of a first substrate and a second substrate by using a cell for biogenic substance concentration measurement that includes: the first substrate on which a plurality of first metallic nanorods, each of which is modified with a substance that bonds specifically to a test substance, are immobilized such that the long axes thereof are aligned in the same direction; and the second substrate on which a plurality of second metallic nanorods, each of which is modified with a blocking substance, are immobilized such that the long axes thereof are aligned perpendicularly to the long axes of the first metallic nanorods on the first substrate, and calculates a biogenic substance concentration with high accuracy from the optical properties.Type: GrantFiled: May 30, 2012Date of Patent: May 27, 2014Assignee: Panasonic CorporationInventors: Masaru Minamiguchi, Tatsurou Kawamura, Masahiko Shioi, Atsushi Matsubara
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Patent number: 8548545Abstract: One of the purposes of the present invention is to provide a biogenic substance concentration measuring method with improved measuring accuracy. An embodiment of the present invention provides a method for measuring a concentration of a biogenic substance contained in a living body, the method comprises steps of preparing a measuring device, wherein the measuring device comprises a light source, an optical filter, and a light receiver; irradiating a substantially-parallel light from the light source onto a particle chip implanted in a skin though a position on the surface of the skin to generate a reflected light; inclining the light source and calculating the concentration of the biogenic substance on the basis of the difference of signals before and after the inclination.Type: GrantFiled: April 27, 2012Date of Patent: October 1, 2013Assignee: Panasonic CorporationInventors: Tatsurou Kawamura, Masaru Minamiguchi, Masahiko Shioi
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Patent number: 8515508Abstract: The object of the present invention is to provide a method for measuring concentration of a biological substance contained in a living body in which deterioration of the accuracy due to the reflected light and the interruption component is suppressed. Linear-polarized light is emitted to a particle chip implanted in the skin with modulating its modulating direction continuously. A surface enhanced Raman scattering light of the biological substance generated on the particle chip. A concentration of the biological substance is calculated based on the received signal. The receiving signal satisfy the following equation: R(t)=Am ·sin(?t)+D, where R(t): received signal, Am: amplitude, t: time, D: a constant number, and ?: angular speed.Type: GrantFiled: October 6, 2011Date of Patent: August 20, 2013Assignee: Panasonic CorporationInventors: Tatsurou Kawamura, Masahiko Shioi, Masaru Minamiguchi
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Patent number: 8509868Abstract: One of the purposes of the present invention is to provide a biogenic substance concentration measuring method with improved measuring accuracy. An embodiment of the present invention provides a method for measuring a concentration of a biogenic substance contained in a living body, the method comprises steps of preparing a measuring device, wherein the measuring device comprises a light source, an optical filter, and a light receiver; irradiating different focused lights from the light source onto a particle chip implanted in a skin though a position on the surface of the skin to generate corresponding reflected lights; calculating the concentration of the biogenic substance on the basis of the difference of signals obtained from the reflected lights.Type: GrantFiled: May 30, 2012Date of Patent: August 13, 2013Assignee: Panasonic CorporationInventors: Tatsurou Kawamura, Masaru Minamiguchi, Masahiko Shioi
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Publication number: 20130003058Abstract: A substrate is described that is suitable for surface enhanced optical detection. The substrate comprises an electrically conductive layer (110), such as for example a gold layer. It furthermore comprises at least one nanoparticle (1404) comprising an electrically conductive portion. The electrically conductive portion in some embodiments provides an opening to an underlying material. Such at least one nanoparticles (1404) thus may for example be a nanoring, a nanodisc, or a non-spherical nanoshell. The substrate furthermore comprises a dielectric spacer (1406) for spacing the electrically conductive layer from the at least one nanoparticles. The dielectric spacer (1406) is a dielectric material substantially only present under the at least one nanoparticle (1404), leaving the electrically conductive layer (110) uncovered from dielectric material at positions away from the nanoparticles (1404).Type: ApplicationFiled: March 22, 2011Publication date: January 3, 2013Applicants: IMEC, KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D, PANASONIC CORPORATIONInventors: Pol Van Dorpe, Kristof Lodewijks, Masahiko Shioi, Jian Ye