Abstract: An agitator is capable of more efficiently applying a shear force to a treatment target fluid through the action of an intermittent jet flow.

Abstract: The present application provides a microsphere comprising a lactic acid-glycolic acid copolymer (PLGA) or polylactide (PLA) as a main component, in which a biologically active substance is uniformly dispersed, wherein an average volume-based particle diameter of the microsphere is 1 ?m or more and 150 ?m or less, and a variation coefficient of area ratios in six regions is 0.35 or less, wherein the area ratios in six regions are calculated by (s/A)×100 (%) wherein the six regions are prepared by preparing a cross section observation sample obtained by cutting the microsphere; observing the cross section observation sample with an electron microscope at a magnification capable of confirming the biologically active substance in the microsphere or a higher magnification; and dividing the electron microscope observation image into six regions; and A is an area of a respective divided region, and s is a sum of cross section areas of the biologically active substance included in the respective divided region.

Abstract: A vacuum deaerator degasses material to be processed by placing a rotating rotor with a screen in a vacuum vessel, introducing a liquid material to be processed into the rotor from the interior thereof and causing the liquid to pass through the screen to refine the same. The vacuum deaerator is characterized in that: the screen is a cylinder with a circular cross-section and is in the form of a porous plate in which a plurality of through holes are opened in the radial direction of the cylindrical screen; and the screen is provided such that the area of inflow openings is greater than the area of outflow openings, where the inflow openings are openings of a plurality of penetration portions provided on the inner wall face of the screen and the outflow openings are openings of the plurality of penetration portions provided on the outer wall dace of the screen. Thus, the processing capacity of the vacuum deaerator is improved without increasing the size of the device.

Abstract: The present application provides approximately spherical lactic acid-glycolic acid copolymer (PLGA) microparticles comprising a biologically active substance, wherein an average volume-based particle diameter of the PLGA microparticles is 1 ?m or more and 150 ?m or less, and a Reactive Span Factor (R.S.F.) of the PLGA microparticles is satisfied with formula (1): 0.1<(R.S.F.)?1.7 formula (1), wherein an R.S.F. means (D90?D10)/D50; D90 is a particle diameter (?m) corresponding to the cumulative 90% by volume of the cumulative particle diameter distribution from the small particle side; D50 is a particle diameter (?m) corresponding to the cumulative 50% by volume of the cumulative particle diameter distribution from the small particle side; and D10 is a particle diameter (?m) corresponding to the cumulative 10% by volume of the cumulative particle diameter distribution from the small particle side; and an efficient production method thereof.

Abstract: The present invention relates to silicon coated metal microparticles in which at least a part of a surface of a metal microparticle composed of at least one of metal elements or metalloid elements is coated with silicon, wherein the silicon coated metal microparticles are a product obtained by a reduction treatment of silicon compound coated precursor microparticles in which at least a part of a surface of a precursor microparticle containing a precursor of the metal microparticles is coated with a silicon compound, or silicon doped precursor microparticles containing a precursor of the metal microparticles. Because it is possible particularly to strictly control a particle diameter of the silicon compound coated metal microparticle by controlling conditions of the reduction treatment, design of a more appropriate composition can become facilitated, compared with a conventional composition, in terms of diversified usages and desired properties of silicon compound coated metal microparticles.

Abstract: The present application provides a microsphere comprising a lactic acid-glycolic acid copolymer (PLGA) or polylactide (PLA) as a main component, in which a biologically active substance is uniformly dispersed, wherein an average volume-based particle diameter of the microsphere is 1 ?m or more and 150 ?m or less, and a variation coefficient of area ratios in six regions is 0.35 or less, wherein the area ratios in six regions are calculated by (s/A)×100 (%) wherein the six regions are prepared by preparing a cross section observation sample obtained by cutting the microsphere; observing the cross section observation sample with an electron microscope at a magnification capable of confirming the biologically active substance in the microsphere or a higher magnification; and dividing the electron microscope observation image into six regions; and A is an area of a respective divided region, and s is a sum of cross section areas of the biologically active substance included in the respective divided region.

Abstract: A fluid treatment device with a new configuration is provided. The fluid treatment device is provided with an upstream treatment unit defined by treatment surfaces that rotate relative to each other, and a downstream treatment unit arranged downstream of the upstream treatment unit. The upstream treatment unit is configured such that, by passing the fluid to be treated into an upstream treatment space defined by the treatment surfaces, the fluid to be treated is subjected to upstream treatment. The downstream treatment unit is provided with a downstream treatment space which performs the function of retaining and mixing the fluid to be treated by means of a labyrinth seal. An upstream outlet of the fluid to be treated from the upstream treatment unit opens into the downstream treatment space, and the downstream treatment space is configured to use the labyrinth seal to perform the function of controlling retention time.

Abstract: Provided is a method for producing an organic compound, the method making it possible to ensure an adequate reaction time and obtain a targeted substance at a high yield even in an organic reaction that requires a relatively long time to complete the reaction.

Abstract: With an aim to provide a method for producing an oxide particle with controlled color characteristics and also provide an oxide particle with controlled color characteristics, the present invention provides a method for producing an oxide particle, wherein the color characteristics of the oxide particle are controlled by controlling a ratio of an M-OH bond between an element (M) and a hydroxide group (OH) or an M-OH bond/M-O bond ratio, where the element (M) is one element or plural different elements other than oxygen or hydrogen included in the oxide particle selected from metal oxide particles and semi-metal oxide particles. According to the present invention, by controlling the M-OH bond or the M-OH bond/M-O bond ratio of the metal oxide particle or the semi-metal oxide particle, the oxide particle with controlled color characteristics of any of reflectance, transmittance, molar absorption coefficient, hue, and saturation can be provided.

Abstract: A stirrer is provided such that a fluid being processed can be more efficiently shown by way of the action of an intermittent jet flow and processing capacity can be improved. The stirrer concentrically includes a rotor that includes a plurality of flat vanes and that rotates, and a screen that is place around the rotor. The screen includes a plurality of slits in the circumferential direction thereof, and screen members that are positioned between adjacent slits. The fluid being processed is discharged by rotation of the rotor from the inside of the screen to the outside as an intermittent jet flow through the slits. The width of the distal working face on the distal end of the vane in the rotational direction is smaller than the width of the basal end of the vane in the rotational direction.

Abstract: The purpose of the present invention is to provide novel solid gold-nickel alloy nanoparticles and a production method thereof. Provided are solid gold-nickel alloy nanoparticles having a particle diameter of 500 nm or less. In particular, gold-nickel alloy nanoparticle are provided in which the concentration of nickel in the gold-nickel alloy is 2.0-92.7 wt %, and the main component is a gold-nickel alloy in which gold and nickel are in a nano-level fine mixed state. The gold-nickel alloy particles have as the main component a substitutional solid solution of gold and nickel. These gold-nickel alloy particles are optimally formed by mixing and discharging gold ions, and a substance having reducing characteristics in the thin film fluid occurring between processing surfaces which are arranged facing each other, which can move towards and away from each other, and at least one of which rotates relative to the other.

Abstract: A method of producing efficiently and stably core-shell type oxide particles, wherein the entire surface of the core oxide particles is uniformly coated with the shell oxide, includes at least two steps of: Step 1 of precipitating the core oxide particles in a mixed fluid prepared by mixing an oxide raw material liquid for core and an oxide precipitation solvent and Step 2 of coating the entire surface of the core oxide particles uniformly with the shell oxide by mixing the mixed fluid and an oxide raw material liquid for shell.

Abstract: A pigment composition for a green filter includes a green pigment consisting of a halogenated zinc phthalocyanine, wherein as spectral transmission characteristics of a dispersion containing only the green pigment as a pigment, the transmittance at 400 nm is 1% or less; the transmittance at 450 nm is 25% or less; the transmittance at 600 nm is 30% or less; the transmittance at 650 nm is 0.3% or less; the transmittance at the peak wavelength is 80% or more; the half value width of the peak wavelength is 120 nm or less; the transmittance at 750 nm is 1% or less; and the transmittance at 800 nm is 20% or less. The pigment composition for a green filter has low transmittance in the blue range, low transmittance in the near infrared range, and high transmittance in the green range by only a green pigment.

Abstract: The present application provides a microsphere in which a main agent is uniformly dispersed in a polymer matrix, wherein an average volume-based particle diameter of the microsphere is 1 ?m or more and 150 ?m or less, and a variation coefficient of area ratios in four regions is 0.35 or less, wherein the area ratios in four regions are calculated by (s/A)×100(%) wherein the four regions are prepared by preparing a cross section observation sample obtained by cutting the microsphere; observing the cross section observation sample with an electron microscope at a magnification capable of confirming the main agent in the microsphere or a higher magnification; and dividing the electron microscope observation image into four regions; and A is an area of a respective divided region, and s is a sum of cross section areas of the main agent included in the respective divided region.

Abstract: The present application provides a microsphere comprising a lactic acid-glycolic acid copolymer (PLGA) or polylactide (PLA) as a main component, in which a biologically active substance is uniformly dispersed, wherein an average volume-based particle diameter of the microsphere is 1 ?m or more and 150 ?m or less, and a variation coefficient of area ratios in six regions is 0.35 or less, wherein the area ratios in six regions are calculated by (s/A)×100 (%) wherein the six regions are prepared by preparing a cross section observation sample obtained by cutting the microsphere; observing the cross section observation sample with an electron microscope at a magnification capable of confirming the biologically active substance in the microsphere or a higher magnification; and dividing the electron microscope observation image into six regions; and A is an area of a respective divided region, and s is a sum of cross section areas of the biologically active substance included in the respective divided region.

Abstract: The present application provides a microsphere comprising a lactic acid-glycolic acid copolymer (PLGA) as a main component, in which a biologically active substance is uniformly dispersed, wherein an average volume-based particle diameter of the microsphere is 1 ?m or more and 150 ?m or less, and a mass of the biologically active substance or an empty hole of 1.5 ?m or more is not present in the microsphere. The microsphere of the present invention can appropriately control the initial release amount of the biologically active substance and its release rate during a subsequent release period, and can continuously release the biologically active substance in vivo for a predetermined period of time.

Abstract: The purpose of this invention is to provide a filtration membrane module with which is possible to improve the centrifugal separation effect of the primary-side flowpath during filtration, and the centrifugal separation effect of the area following the outer peripheral surface of the flowpath membrane element of the outer ring-shaped flowpath during backwash, and improve filtration efficiency and cleaning efficiency while curbing the accumulation of deposits on the membrane surface during filtration and during backwash. This filtration membrane module comprises: a membrane element equipped with a primary-side flowpath on the outside of a hollow cylindrical filtration surface; and a cylindrical housing positioned on the outside thereof. A flow adjuster is positioned inside the primary-side flowpath. A flow adjuster for backwash is positioned inside the secondary-side flowpath, which is an outer ring-shaped flowpath between the membrane element and the housing.

Abstract: A stirrer is provided that can more efficiently achieve shearing applied, by an action of an intermittent jet flow, to a fluid to be processed.

Abstract: A method for modifying a fine particle dispersion liquid with which dispersibility and dispersion stability can be improved includes performing filtration to remove impurities in a dispersion liquid using a dispersion liquid modifying device provided with a removal unit that uses a filtration membrane. The quantity of impurities is reduced from a first region until said quantity reaches a second pH-dependent region. In the second pH-dependent region, the dispersibility of the fine particles in the dispersion liquid is in a range in which the dispersibility depends more on a change in dispersion liquid pH than on a change in the quantity of impurities in the dispersion liquid. With the quantity of impurities reduced to the second pH-dependent region, the dispersibility of the fine particles is controlled by adjusting the pH of the fine particle dispersion liquid.

Abstract: A stirrer is provided such that a fluid being processed can be more efficiently shown by way of the action of an intermittent jet flow and processing capacity can be improved. The stirrer concentrically includes a rotor that includes a plurality of flat vanes and that rotates, and a screen that is place around the rotor. The screen includes a plurality of slits in the circumferential direction thereof, and screen members that are positioned between adjacent slits. The fluid being processed is discharged by rotation of the rotor from the inside of the screen to the outside as an intermittent jet flow through the slits. The width of the distal working face on the distal end of the vane in the rotational direction is smaller than the width of the basal end of the vane in the rotational direction.