Abstract: An object of the present invention is to provide an agent that potentiates the antitumor effect of an anticancer agent by allowing efficient accumulation of the anticancer agent in tumor tissue. The administration of carbonate apatite with the anticancer agent allows efficient accumulation of the anticancer agent in the tumor tissue to dramatically potentiate the antitumor effect of the anticancer agent.

Abstract: A single cross member extending in a vehicle width direction is provided between a portion of a side sill which is positioned near a center pillar and a tunnel portion. A pair of seat-rail mounting seats are provided at a lower portion of the tunnel portion to be spaced apart from the cross member in a vehicle longitudinal direction. A seat rail is rigidly connected to the pair of seat-rail mounting seats at its bottom face. Thereby, the lightweight, high rigidity, and quietness of the vehicle can be attained.

Abstract: An electric vehicle that is able to effectively cool the inverter while incorporating the inverter in the swing arm, and enhance the strength of the swing arm. The electric vehicle includes a driving wheel, a hollow swing arm main body for supporting the driving wheel, and an inverter accommodated in the swing arm main body. The swing arm main body includes a plurality of arc-shaped heat radiation fins provided in a wall surface facing a side face of the driving wheel, the heat radiation fins being concentric with the driving wheel. The inverter is in contact with the back face of the wall surface.

Abstract: An in-vehicle device is capable of coupling to a portable terminal, receives content data played by the portable terminal that has been coupled, and outputs the content data that has been received. While music is being played back by the portable terminal, the in-vehicle device estimates a remaining battery level of the portable terminal after playback of the music to be next played back finishes, and provides, when the estimated value is a threshold value or less, notification of the remaining battery level before the playback of music starts and/or after the playback finishes.

Abstract: A method for forming a sealing film, in which a buffer layer and a barrier layer whose density is higher than that of the buffer layer are alternately formed on a substrate, includes forming a first buffer layer on a surface of the substrate, forming a first barrier layer on a surface of the first buffer layer, and forming a second buffer layer on a surface of the first barrier layer. A ratio of a thickness of a portion of the first buffer layer in a thickness direction of the substrate relative to a thickness of a portion of the first buffer layer in an inclined direction that is inclined with respect to the thickness direction is closer to 1 than a ratio of a thickness of a portion of the second buffer layer in the thickness direction relative to a thickness of a portion of the second buffer layer in the inclined direction.

Abstract: A sealed contact device capable of maintaining a function for drawing a generated arc to disappear rapidly and reliably for a long period. An electromagnetic relay includes a housing, a stationary contact and a moving contact which are disposed opposite to each other in the housing, and a pair of permanent magnets and disposed opposite to the stationary contact and the moving contact. An arc generated between the stationary contact and the moving contact is drawn due to a current conducting between the stationary contact and the moving contact and magnetic forces of the permanent magnets. An arc shield member is disposed in a position in which an arc in the housing is induced.

Abstract: An object of the present invention is to provide an agent that potentiates the antitumor effect of an anticancer agent by allowing efficient accumulation of the anticancer agent in tumor tissue. The administration of carbonate apatite with the anticancer agent allows efficient accumulation of the anticancer agent in the tumor tissue to dramatically potentiate the antitumor effect of the anticancer agent.

Abstract: An electric vehicle that is able to effectively cool the inverter while incorporating the inverter in the swing arm, and enhance the strength of the swing arm. The electric vehicle includes a driving wheel, a hollow swing arm main body for supporting the driving wheel, and an inverter accommodated in the swing arm main body. The swing arm main body includes a plurality of arc-shaped heat radiation fins provided in a wall surface facing a side face of the driving wheel, the heat radiation fins being concentric with the driving wheel. The inverter is in contact with the back face of the wall surface.

Abstract: The purpose of the present invention is to provide a colorectal cancer drug that uses microRNA exhibiting outstanding effectiveness in colorectal cancer patients, particularly colorectal cancer patients having a mutated KRAS gene. miR4689 and/or miR4685-3p can suppress the growth of colorectal cancer cells, particularly colorectal cancer cells having a mutated KRAS gene, and thus exhibit an effective antitumor effect.

Abstract: Provided is a novel useful microRNA having improved anti-tumour activity, obtained by introducing a variation in a microRNA which is present in-vivo and which exhibits an anti-tumour effect. This microRNA containing a base sequence (SEQ ID NO: 1) obtained by varying a predetermined region of the base sequence of miR-29b is able to exhibit a particularly outstanding anti-tumour effect.

Abstract: A sealed contact device having a small number of components and high productivity. In the sealed contact device a ring-shaped flange portion extending laterally from a lower opening edge part of a metallic case is welded and integrated with an upper surface of a plate-shaped yoke to form an internal space and a stationary contact and a moving contact are opposed to each other in the internal space so as to enable approach/separation. A ring-shaped projection provided along a lower surface of the ring-shaped flange portion is integrated with the upper surface of the plate-shaped yoke by resistance welding.

Abstract: A sealed contact device having a small number of components and high productivity. In the sealed contact device a ring-shaped flange portion extending laterally from a lower opening edge part of a metallic case is welded and integrated with an upper surface of a plate-shaped yoke to form an internal space and a stationary contact and a moving contact are opposed to each other in the internal space so as to enable approach/separation. A ring-shaped projection provided along a lower surface of the ring-shaped flange portion is integrated with the upper surface of the plate-shaped yoke by resistance welding.

Abstract: A sealed contact device capable of maintaining a function for drawing a generated arc to disappear rapidly and reliably for a long period. An electromagnetic relay includes a housing, a stationary contact and a moving contact which are disposed opposite to each other in the housing, and a pair of permanent magnets and disposed opposite to the stationary contact and the moving contact. An arc generated between the stationary contact and the moving contact is drawn due to a current conducting between the stationary contact and the moving contact and magnetic forces of the permanent magnets. An arc shield member is disposed in a position in which an arc in the housing is induced.

Abstract: A fluid application system includes: an application apparatus that discharges a fluid to a workpiece; a movement apparatus that moves the application apparatus and the workpiece; and a control apparatus. At the time of adjusting the output of a power source to thereby vary the discharge amount of the fluid from the nozzle by a target variation amount F1, the control apparatus sets the output of the power source to a value beyond a theoretical output N1 of the power source obtained from the target variation amount F1 of the discharge amount, and then sets the output of the power source to the theoretical output N1 such that the change amount of the internal pressure of the nozzle is coincident with an amount P1 by which the internal pressure of the nozzle needs to change, the amount P1 being obtained from the target variation amount F1 of the discharge amount.

Abstract: A single cross member extending in a vehicle width direction is provided between a portion of a side sill which is positioned near a center pillar and a tunnel portion. A pair of seat-rail mounting seats are provided at a lower portion of the tunnel portion to be spaced apart from the cross member in a vehicle longitudinal direction. A seat rail is rigidly connected to the pair of seat-rail mounting seats at its bottom face. Thereby, the lightweight, high rigidity, and quietness of the vehicle can be attained.

Abstract: A principal object of the present invention is to provide a pharmaceutical composition that can produce a high antitumor effect by efficiently delivering a drug with antitumor activity to tumor tissues with the aid of carbonate apatite nanoparticles. The present invention provides a pharmaceutical composition including carbonate apatite nanoparticles with an average particle size of at most 50 nm containing a drug with antitumor activity and a pharmacologically acceptable solvent in which the carbonate apatite nanoparticles containing the drug are dispersed.

Abstract: The present invention provides a specific combination of colon cancer markers based on statistical knowledge, which is capable of detecting a larger number of colon cancer patients in an earlier stage while maintaining high specificity. A multiplex colon cancer marker panel comprising a combination of five colon cancer markers of Carcinoembryonic antigen-related cell adhesion molecule 5, Carbohydrate antigen 19-9, Galectin-4, APEX nuclease and Actin-related protein 2. A method for analyzing colon cancer markers using multiplex colon cancer marker panel.

Abstract: A three-step screening of selection for resistance against pathogenic bacteria infection, selection for resistance against pathogenic fungi infection, and selection for sensitivity to salicylic acid was carried out on Arabidopsis thaliana lines highly expressing rice full-length cDNA (rice-FOX Arabidopsis lines) which were prepared by using a FOX hunting system. As a result, one Arabidopsis thaliana line (line K15424) selected in all of the three types of screening was successfully selected. Line K15424 carries a rice full-length cDNA. Rice overexpressing AK070024 was produced, and resistance against rice bacterial leaf blight was assayed using the T1 generation. As a result, it was confirmed that AK070024-overexpressing rice is resistant against bacterial leaf blight and blast.

Abstract: A filtering apparatus includes a cylindrical filter F having a cylinder axis in a vertical direction, and a casing C surrounding the filter F, in which untreated water a is filtered through the filter F from an outer circumferential surface to an inner circumferential surface of the filter F, and the resulting filtered water a? is guided to the outside of the casing C. The filter F includes a plurality of divided filters arranged in the direction of the cylinder axis, and the divided filters can be easily repaired and replaced. The divided filters can be connected and integrated together via reinforcing rods 33 by using threaded connections 36, and can be individually detached. When a sealing member 38 is provided between upper and lower facing surfaces of the divided filters, the untreated water does not flow from an upper surface and a lower surface of the divided filters, and the sealing member is rotated together with the filter and does not slide.