Abstract: The present invention provide a compound having an orexin receptor antagonistic activity, which is expected to be useful as medicaments such as agents for the prophylaxis or treatment of sleep disorder, depression, anxiety disorder, panic disorder, schizophrenia, drug dependence, Alzheimer's disease and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Abstract: Provided are a drive force transmission member and control unit. The drive force transmission member has multiple first engaging portions. Drive force is transmitted from the drive force transmission member to a drive force receiving member with each first engaging portion engaged with a second engaging portion of the drive force receiving member. The second engaging portions are movable in a radial direction centered on a rotation axis line of the drive force transmission member. The control unit performs rotation control of forward rotation of the drive force transmission member by ?° and thereafter backward rotation by ?° after a cartridge is mounted to an apparatus main body but before image formation. Each of the multiple first engaging portions is upstream in the forward rotation direction of the drive force transmission member from the second engaging portion out of the multiple second engaging portions with which engaging will be realized.

Abstract: The present invention provides a new cyclic compound having a CCR antagonist activity, especially a CCR5 antagonist activity, and the use thereof. The compound of the present invention is represented by the formula: wherein, R1 is a 5- to 6-membered ring group which may be substituted; X1 is a bond or the like; ring A is a 5- to 6-membered ring group which may be substituted; ring B is a 8- to 10-membered ring group which may be substituted; X2 is a bivalent group of 1 to 4 atom; Z1 is a bivalent cyclic ring group or the like; Z2 is a bond or the like; and R2 is an amino group, a nitrogen-containing heterocyclic group which may be substituted or the like, or a salt thereof.

Abstract: The present invention provide a compound having an orexin receptor antagonistic activity, which is expected to be useful as medicaments such as agents for the prophylaxis or treatment of sleep disorder, depression, anxiety disorder, panic disorder, schizophrenia, drug dependence, Alzheimer's disease and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Abstract: A cartridge has a surface to be biased which is connected to a first surface extending in an intersecting direction that intersects with an insertion direction from an upstream side to a downstream side in the insertion direction, and an engaging portion engaging with a support member that supports the cartridge inside a main body and has a biasing member that biases an engaged portion to be engaged with the engaging portion in the intersecting direction. The engaged portion has a biasing surface extending in the intersecting direction from the upstream side to the downstream side in the insertion direction. Movement of the support member in the intersecting direction by the closing operation of an opening and closing member, the surface to be biased is biased by the biasing surface, the cartridge contacts with a positioning portion, and positioning of the cartridge is performed.

Abstract: Provided is a compound or a salt thereof, which has an excellent JAK inhibitory action, and is useful as a prophylactic or therapeutic agent for autoimmune diseases (rheumatoid arthritis, psoriasis, inflammatory bowel disease, Sjogren's syndrome, Behcet's syndrome, multiple sclerosis, systemic lupus erythematosus, etc.), cancer (leukemia, uterine leiomyosarcoma, prostate cancer, multiple myeloma, cachexia, myelofibrosis, etc.) and the like. The present invention relates to a compound represented by the formula (I) wherein each symbol is as defined in the present specification, or a salt thereof.

Abstract: Provided is a compound or a salt thereof, which has an excellent JAK inhibitory action, and is useful as a prophylactic or therapeutic agent for autoimmune diseases (rheumatoid arthritis, psoriasis, inflammatory bowel disease, Sjogren's syndrome, Behcet's syndrome, multiple sclerosis, systemic lupus erythematosus, etc.), cancer (leukemia, uterine leiomyosarcoma, prostate cancer, multiple myeloma, cachexia, myelofibrosis, etc.) and the like. The present invention relates to a compound represented by the formula (I) wherein each symbol is as defined in the present specification, or a salt thereof.

Abstract: An image forming apparatus including a cartridge having an image carrying member, and an apparatus main body from which the cartridge is capable of being detached in a longitudinal direction of the cartridge. While being positioned such that a first end side of the cartridge is in contact with a positioning portion of a frame, the cartridge that has been inserted when a door is in an open position is disposed under an intermediate transfer body such that a distance to a surface of the intermediate transfer body opposing the cartridge is greater on a second end side than on the first end side, and by moving the door to a closed position, the cartridge is pivoted with urging force of an urging member and the image carrying member is made to come into contact with the intermediate transfer body.

Abstract: An image forming apparatus in which a process cartridge including a recess is configured in a detachable manner inside an apparatus main body, the image forming apparatus including, a guiding member guiding the process cartridge into the apparatus main body in a longitudinal direction, the guiding member moving up and down together with the process cartridge moving the process cartridge to an image forming position, and a lock member moving in a lifting and lowering direction intersecting a mounting direction of the process cartridge by interlocking with an up and down movement of the guiding member, in which the lock member moves in the lifting and lowering direction by interlocking with the upward movement of the guiding member, and the movement of the process cartridge in the longitudinal direction is restricted by the lock member engaging with the recess of the process cartridge.

Abstract: The problem of the present invention is to provide a compound having a PDE2A inhibitory action, and useful as a prophylactic or therapeutic drug for schizophrenia, Alzheimer's disease and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

Abstract: A compound represented by the formula (I): wherein each symbol is as described in the SPECIFICATION, or a salt thereof has a PDE2A inhibitory action, and is useful as a prophylactic or therapeutic drug for schizophrenia, Alzheimer's disease and the like.

Abstract: Provided is a compound or a salt thereof, which has an excellent JAK inhibitory action, and is useful as a prophylactic or therapeutic agent for autoimmune diseases (rheumatoid arthritis, psoriasis, inflammatory bowel disease, Sjogren's syndrome, Behcet's syndrome, multiple sclerosis, systemic lupus erythematosus, etc.), cancer (leukemia, uterine leiomyosarcoma, prostate cancer, multiple myeloma, cachexia, myelofibrosis, etc.) and the like. The present invention relates to a compound represented by the formula (I) wherein each symbol is as defined in the present specification, or a salt thereof.

Abstract: A cleaning device includes a cleaning unit configured to perform cleaning while in contact with a light transmission member, the cleaning unit being movable with respect to the transmission member in a first direction and a second direction differing in orientation. The cleaning unit includes a first cleaning portion and a second cleaning portion capable of coming into contact with the transmission member, moves in the first direction while keeping the first cleaning portion in contact with the transmission member and keeping the second cleaning portion away from the transmission member, and moves in the second direction while keeping the first cleaning portion away from the transmission member and keeping the second cleaning portion in contact with the transmission member.

Abstract: The present invention provides a new cyclic compound having a CCR antagonist activity, especially a CCR5 antagonist activity, and the use thereof. The compound of the present invention is represented by the formula: wherein, R1 is a 5- to 6-membered ring group which may be substituted; X1 is a bond or the like; ring A is a 5- to 6-membered ring group which may be substituted; ring B is a 8- to 10-membered ring group which may be substituted; X2 is a bivalent group of 1 to 4 atom; Z1 is a bivalent cyclic ring group or the like; Z2 is a bond or the like; and R2 is an amino group, a nitrogen-containing heterocyclic group which may be substituted or the like, or a salt thereof.

Abstract: Provided is an image forming apparatus including an apparatus electric-contact that is connectable to a cartridge electric-contact of a cartridge, which is equipped with a memory that stores information related to the cartridge, such that the information is transmitted from the cartridge to a main apparatus body of the image forming apparatus; a connector having the apparatus electric-contact and a first engaging unit that is engageable with the cartridge so as to position the cartridge electric-contact and the apparatus electric-contact in a predetermined direction; and a connector holder that holds the connector in a movable manner. The connector holder has a second engaging unit that is engageable with the cartridge. The connector is movable in the predetermined direction.

Abstract: The present invention provides an agent for the prophylaxis or treatment of autoimmune diseases (e.g., psoriasis, rheumatoid arthritis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus etc.) and the like, which has a superior Tyk2 inhibitory action. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

Abstract: The present invention provides an image forming apparatus including a moving member configured to support a first process cartridge and move the first process cartridge to a position for forming an image, and a detection unit configured to detect a state of a second process cartridge, in which the moving member holds the detection unit.

Abstract: A sheet conveying apparatus including: a skew feeding correcting portion configured to correct skew feeding of a sheet, the skew feeding correcting portion including: a rotary member pair configured to convey the sheet; a shutter member configured to abut against a leading edge of a sheet being conveyed, and having a home position; and a moving member arranged with a gap formed between the moving member and the shutter member positioned in the home position, such that the shutter member is moveable independently from the home position up to a point of engagement with the moving member, when the gap is closed, and such that the moving member is movable integrally with the shutter member while the gap is closed, wherein the rotary member pair is arranged to nip a sheet during a period in which the shutter member is configured to move integrally with the moving member.

Abstract: The present invention provides an agent for the prophylaxis or treatment of autoimmune diseases (e.g., psoriasis, rheumatoid arthritis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus etc.) and the like, which has a superior Tyk2 inhibitory action. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

Abstract: An image reading apparatus includes a reader unit configured to read an image of a conveyed document at a reading position, a transparent member arranged at the reading position and including a conductive layer, which is earthed, on a surface of the transparent member, a conveyance unit configured to convey the document to the reading position, and a guide member that is earthed, provided along the surface of the transparent member, and positioned so as to intersect with a conveyance direction of the document conveyed by the conveyance unit.