Abstract: Provided is an estimation device capable of estimating a current position with a high degree of accuracy. A driving support system includes: a vehicle mounted device 1 that is mounted on a vehicle and performs a control concerning vehicle driving support; a LIDAR 2; a gyroscope sensor 3; and a vehicle speed sensor 4. The vehicle mounted device 1 acquires, from the LIDAR 2, a measurement value ztk indicating a positional relationship between a reference landmark Lk of an index k and the own vehicle. The vehicle mounted device 1 calculates a post estimated value x{circumflex over (?)}t by correcting a prior estimated value x?t estimated, on the basis of the measurement value ztk and a position vector mk of the reference landmark Lk included in a map DB 10, from a moving speed measured by the vehicle speed sensor 4 and an angular rate measured by the gyroscope sensor 3.

Abstract: Provided is a battery wiring module according to which a load that acts on module-side terminals accompanying expansion or contraction of battery cells can be reduced. A housing includes a wire accommodating portion for accommodating wires, multiple terminal accommodating portions for accommodating module-side terminals, and first elastic joining portions that join the wire accommodating portion and the terminal accommodating portions in an elastically-deformable manner in the direction in which the battery cells are aligned.

Abstract: Provided are methods for culturing a cancer stem cell-derived tissue, which comprise the step of three-dimensionally culturing a cancer stem cell-derived tissue after treating it with a therapeutic agent for diseases. The culture methods of the present disclosure enable the construction of cell clusters analogous to therapeutic agent-resistant tissues which are characteristically seen in tissues of patients who have actually been administered with a therapeutic agent for diseases. The cell clusters of the present disclosure are useful for elucidating the mechanism for acquiring anticancer agent resistance, identifying a therapeutic target therefor, or screening for a therapeutic agent. The preferred disease in the present disclosure is cancer.

Abstract: The purpose of the present invention is to provide: a cancer stem cell mass from which cells incapable of forming cancer are substantially removed and which has a characteristic property of reproducing a layered structure of a cancer tissue; a process for producing the cancer stem cell mass; and use of the cancer stem cell mass. For achieving the purpose, the present inventors grew a human cancer tissue repeatedly in a NOG mouse, separated cancer cells from the grown cancer tissue, and made a comparison of various cancer cell culture processes with each other. As a result, a cancer stem cell composition which is homogeneous and is substantially free of the coexistence of cells capable of forming cancer and cells incapable of forming cancer in a mixed state can be produced successively by employing an attached culture process using a serum-free stem cell culture medium rather than a generally employed floating culture process, and consequently the present invention has been accomplished.

Abstract: To provide a film excellent in breakage resistance and uniform stretchability, and a method for its production. The film is a single-layer film characterized in that it is made of a blend resin of two kinds of resins both belonging to any one of ETFE, PFA, FEP, ECTFE and PMP, wherein the melt flow rate of the film is at least 6 g/10 min. and less than 20 g/10 min., and ? of the film as measured by a prescribed measurement method is at least 0.99.

Abstract: A laser processing machine for killing specific cells from a group of cells on a surface of a layer containing an ingredient capable of absorbing laser light, the laser processing machine being configured to: control a laser light source to output laser light at 5 W or less and at a wavelength of 380 nm or greater such that the laser light source is applied to a second area on a second surface of the layer opposed to the first surface; and control an actuator to provide a relative movement between the second area where the laser light is applied and the layer at a rate of 2000 mm/sec or less such that the irradiated second area absorbs energy to generate heat that kills unwanted cells on a first area of the first surface and the laser light does not instantly kill the specific cells on the first area upon irradiation.

Abstract: A cell culture vessel for use with a laser processing machine, including: a layer containing an ingredient that generates heat upon laser irradiation; the layer kills specific cells from among a group of cells cultured on a first surface of the layer when a second surface of the layer is irradiated with laser light having an output of 5W or less at a wavelength of 380 nm or greater and a relative movement between a second area on the second surface where the laser light is applied and the layer is at a rate of 2000 mm/sec or less such that the second area absorbs energy of the laser light to generate heat that kills the specific cells that are present on a first area of the first surface and the laser light does not instantly kill the specific cells on the first area upon irradiation with the laser light.

Abstract: The present disclosure aims to provide a battery wiring module according to which it is possible to easily inspect erroneous assembly resulting from rising of wires. A housing of the battery storage module includes a wire storage groove that contains wires and a cover member that covers the wire storage groove. The wire storages groove includes a bottom wall, side walls that stand upright from the bottom wall and oppose each other, and a protruding portion that protrude from a side wall toward an opposing side wall. The cover member includes a through hole that opposes the protruding portion from a side opposite to the bottom wall.

Abstract: Provided is a battery wiring module that can suppress a case in which a cover comes off. The battery wiring module includes a housing having a wire storage groove that stores multiple wires. The housing includes a first storage groove and second storage grooves that both extend in an X direction and are arranged side by side in a Y direction orthogonal to the X direction, and third storage grooves that are in communication with the first storage groove and the second storage grooves. The housing includes a first cover, second covers, and third covers that respectively cover the first storage groove, the second storage grooves, and the third storage grooves. The first cover has abutting portions that abut on outer surfaces on sides of the third covers opposite to the underside surfaces opposing the third storage grooves.

Abstract: Provided is a battery wiring module that allows module-side terminals to be easily mounted to a housing. The battery wiring module includes module-side terminals that are electrically connected to bus bars connecting battery terminals of a plurality of battery cells; wires with ends on one side connected to the module-side terminals; and a housing for accommodating the wires and the module-side terminals. The housing includes a plurality of terminal accommodating portions for accommodating the module-side terminals. The terminal accommodating portions include insertion ports into which the module-side terminals are partially inserted, and recesses that are located upstream of the insertion ports in a direction in which the module-side terminals are inserted and that are lower than terminal seat surfaces on which the module-side terminals can be placed.

Abstract: An objective of the present invention is to obtain two types of substantively homogeneous cancer stem cell populations which can be characterized using the cell surface marker Lgr5, and to provide cancer therapeutics using an antibody against a cell membrane molecule specifically expressed in these cancer stem cells by identifying said cell membrane molecule. A further objective is to provide, using an antibody against a cell membrane molecule specifically expressed in cancer stem cells, a reagent for detecting cancer stem cells, and a method for diagnosing and sorting cancer patients. The present inventors discovered that highly pure large intestine cancer stem cells (CSC) can be obtained in a large quantity, and identified the two types of conditions of large intestine CSCs distinguishable through Lgr5 expression. Moreover, the present inventors discovered that an antibody against a cell membrane molecule specifically expressed in said cancer stem cells can damage said cells.

Abstract: A method of killing specific cells from among a group of cells cultured in a culture vessel by quick and brief laser treatment, the cell culture vessel comprising a main body and a to-be-irradiated layer attached to the main body, the to-be-irradiated layer containing an ingredient capable of absorbing laser light upon laser irradiation, the group of cells being cultured on the surface of the to-be-irradiated layer, the method comprising: applying laser light to a partial area of the to-be-irradiated layer directly below the specific cells.

Abstract: The purpose of the present invention is to provide: a cancer stem cell mass from which cells incapable of forming cancer are substantially removed and which has a characteristic property of reproducing a layered structure of a cancer tissue; a process for producing the cancer stem cell mass; and use of the cancer stem cell mass. For achieving the purpose, the present inventors grew a human cancer tissue repeatedly in a NOG mouse, separated cancer cells from the grown cancer tissue, and made a comparison of various cancer cell culture processes with each other. As a result, a cancer stem cell composition which is homogeneous and is substantially free of the coexistence of cells capable of forming cancer and cells incapable of forming cancer in a mixed state can be produced successively by employing an attached culture process using a serum-free stem cell culture medium rather than a generally employed floating culture process, and consequently the present invention has been accomplished.

Abstract: An objective of the present invention is to obtain two types of substantively homogeneous cancer stem cell populations which can be characterized using the cell surface marker Lgr5, and to provide cancer therapeutics using an antibody against a cell membrane molecule specifically expressed in these cancer stem cells by identifying said cell membrane molecule. A further objective is to provide, using an antibody against a cell membrane molecule specifically expressed in cancer stem cells, a reagent for detecting cancer stem cells, and a method for diagnosing and sorting cancer patients. The present inventors discovered that highly pure large intestine cancer stem cells (CSC) can be obtained in a large quantity, and identified the two types of conditions of large intestine CSCs distinguishable through Lgr5 expression. Moreover, the present inventors discovered that an antibody against a cell membrane molecule specifically expressed in said cancer stem cells can damage said cells.

Abstract: An image pickup apparatus includes an optical device, a transparent conductive film, an electrode pad, and a penetrating electrode. In the optical device, an optical element area for receiving light is formed on a first surface side of a substrate, and an external connection terminal is formed on a side of a second surface opposite to the first surface of the substrate. The transparent conductive film is formed to face the first surface of the substrate. The electrode pad is formed on the first surface of the substrate and configured to perform connection with a fixed potential. The penetrating electrode is connected to the electrode pad and formed to penetrate the substrate between the first surface and second surface. The transparent conductive film is connected to the electrode pad, and the penetrating electrode is connected to the external connection terminal on the side of the second surface of the substrate.

Abstract: A housing is provided with a terminal accommodation portion accommodating a module-side terminal and having an opening through which the module-side terminal is introduced. The terminal accommodation portion includes a bottom portion and a third wall portion serving as an accommodation-side regulating portion that regulates displacement of the module-side terminal. A cover that seals the opening of the terminal accommodation portion includes first and second regulating wall portions serving as a cover-side regulating portion that regulates displacement of the module-side terminal at a different position from that of the bottom portion and the third wall portion.

Abstract: Provided is a battery wiring module that can suppress the occurrence of short circuits. The battery wiring module includes a module-side terminal that is configured to be electrically connected to a bus bar that connects battery terminals of a plurality of battery cells to each other, a wire having one end that is configured to be connected to the module-side terminal, and a housing that is configured to house the wire and the module-side terminal. The housing includes a terminal housing portion that is configured to house the module-side terminal, and a hole portion that is provided on a bottom portion of the terminal housing portion and interconnects an interior region and an exterior region of the terminal housing portion. The battery wiring module further includes a cover portion that has an insulating property and is configured to cover the hole portion.

Abstract: To provide a mold release film which has excellent mold releasing property and is capable of reducing contamination of a mold in a sealing step; a process for producing the mold release film; and a process for producing a semiconductor package by using the mold release film. The mold release film 1 is a mold release film to be disposed on a surface of a mold which is to be in contact with a curable resin, in the production of a semiconductor package by disposing a semiconductor element in the mold, and sealing it with the curable resin to form a resin sealed portion. This mold release film 1 comprises a resin-side mold release layer 2 to be in contact with the curable resin at the time of forming the resin sealed portion, and a gas barrier layer 3. The gas barrier layer 3 contains at least one polymer (I) selected from the group consisting of a polymer having vinyl alcohol units and a polymer having vinylidene chloride units, and the thickness of the gas barrier layer 3 is from 0.1 to 5 ?m.

Abstract: An image pickup apparatus includes an optical device, a transparent conductive film, an electrode pad, and a penetrating electrode. In the optical device, an optical element area for receiving light is formed on a first surface side of a substrate, and an external connection terminal is formed on a side of a second surface opposite to the first surface of the substrate. The transparent conductive film is formed to face the first surface of the substrate. The electrode pad is formed on the first surface of the substrate and configured to perform connection with a fixed potential. The penetrating electrode is connected to the electrode pad and formed to penetrate the substrate between the first surface and second surface. The transparent conductive film is connected to the electrode pad, and the penetrating electrode is connected to the external connection terminal on the side of the second surface of the substrate.

Abstract: Provided is a battery wiring module that can suppress the occurrence of short circuits. The battery wiring module includes a module-side terminal that is configured to be electrically connected to a bus bar that connects battery terminals of a plurality of battery cells to each other, a wire having one end that is configured to be connected to the module-side terminal, and a housing that is configured to house the wire and the module-side terminal. The housing includes a terminal housing portion that is configured to house the module-side terminal, and a hole portion that is provided on a bottom portion of the terminal housing portion and interconnects an interior region and an exterior region of the terminal housing portion. The battery wiring module further includes a cover portion that has an insulating property and is configured to cover the hole portion.