Abstract: Thiazole intermediates for cepham compounds are described.

Abstract: This invention relates to novel cephem compounds, of high antimicrobial activity, and to novel compounds which are useful as intermediates therefor, of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group; andR.sup.2 is cyclo (lower) alkenyl, or salt thereof.

Abstract: This invention relates to novel cephem compounds of high antimicrobial activity of the formula ##STR1## wherein R.sup.1 is amino;R.sup.2 is carboxy or a protected carboxy group;A is hydroxy (lower) alkylene, amino (lower) alkylene, protected amino (lower) alkylene, lower alkenylene, hydroxyimino (lower) alkylene, lower alkoxyimino (lower) alkylene, or lower alkenyloxyimino (lower) alkylene; andR.sup.3 is carboxy or a protected carboxy group,and pharmaceutically acceptable salts thereof.

Abstract: This invention relates to novel cephem compounds of high antimicrobial activity, of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group;R.sup.2 is lower alkenyl, lower alkynyl, unsubstituted cycloalkyl, phenyl (lower) alkyl, phenyl (lower) alkyl substituted with halogen, or lower alkylthio (lower) alkyl; andR.sup.3 is hydrogen, carbamoyl or hydroxy (lower) alkyl, and pharmaceutically acceptable salts thereof.

Abstract: This invention relates to novel 7-acylaminocephalosporanic acid derivatives and pharmaceutically acceptable salts thereof, of high antimicrobial activity, said novel derivatives having the formula ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.2 is carboxy(lower)alkyl, protected carboxy(lower)alkyl, carboxy(lower)alkenyl, protected carboxy(lower)alkenyl, or lower unsaturated aliphatic hydrocarbon,R.sup.3 is hydrogen, halogen, methyl, lower alkoxy, lower alkylthiomethyl, lower alkanoyloxymethyl or a heterocyclicthiomethyl which may have suitable substituents(s),R.sup.4 is carboxy or protected carboxy,R.sup.5 is hydrogen or lower alkyl, andX is halogen,provided that when R.sup.3 is lower alkanoyloxymethyl, then R.sup.2 is lower unsaturated aliphatic hydrocarbon, and pharmaceutically acceptable salts thereof.

Abstract: This invention relates to novel cephem compounds of high antimicrobial activity of the formula: ##STR1## wherein R.sub.1 is amino, lower alkanoylamino or halo(lower)alkanoylamino,R.sub.2 is lower alkyl, lower alkylthio(lower)alkyl, lower alkenyl, lower alkynyl, carboxy(lower)alkyl or esterified carboxy(lower)alkyl, andX is halogen;and pharmaceutically acceptable salts thereof.

Abstract: This invention relates to novel cephem compounds of high antimicrobial activity, said compounds being of the formula: ##STR1## wherein R.sup.1 is a group of the formula: ##STR2## in which R.sup.5 is amino or a protected amino group; and R.sup.6 is lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, cyclo(lower)alkenyl, aryl, ar(lower)alkyl, or halogen-substituted ar(lower)alkyl;R.sup.2 is carboxy or a protected carboxy group;A is hydroxy(lower)alkylene, amino(lower)alkylene, protected amino(lower)alkylene, lower alkenylene, hydroxyimino(lower)alkylene, lower alkoxyimino(lower)alkylene, or lower alkenyloxyimino(lower)alkylene; andR.sup.3 is carboxy or a protected carboxy group, and pharmaceutically acceptable salts thereof.

Abstract: The invention relates to new cephem compounds of high antimicrobial activity, the compounds having the formula ##STR1## wherein R.sup.1 is amino or a protected amino groupR.sup.2 is a saturated 4 to 8-membered heteromonocyclic group containing one sulfur atom;R.sup.3 is carboxy or a protected carboxy group andR.sup.4 is hydrogen, lower alkyl, or a group of the formula:--CH.sub.2 R.sup.4awhereR.sup.4a is acyloxy a heterocyclicthio group which may have suitable substituents or pyridinio which may have suitable substituents with the proviso that R.sup.3 is COO.sup.- when R.sup.4a is pyridinio which may have suitable substituents.

Abstract: A 3,7-disubstituted-3-cephem-4-carboxylic acid of the general formula: ##STR1## having antibacterial activity, processes for preparing same, and pharmaceutical compositions thereof for treating infectious diseases in humans and animals.

Abstract: This invention relates to a new cephem compound of the formula: ##STR1## wherein R.sup.1 is amino or a substituted amino group;R.sup.2 is carboxy or a protected carboxy group;R.sup.3 is a tetrazolyl group having a lower alkynyl group; andX is --S-- or ##STR2## and pharmaceutically acceptable salts thereof, of high antimicrobial activity.

Abstract: The invention relates to new cephem compounds of high antimicrobial activity, the new cephem compounds comprising aminothiazole cycloalkenyloxyimino acetamido cephem derivatives.

Abstract: This invention relates to new compounds of high antibiotic activity of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group; andR.sup.2 is C.sub.2 to C.sub.6 alkyl.

Abstract: Preparation of pharmaceutical composition comprising, treatment of human and animal diseases with, and compound of 3,7-disubstituted-3-cepham-4-carboxylic acid.