Patents by Inventor Masayuki Kyomoto

Masayuki Kyomoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11111367
    Abstract: A resin molded body includes: a polyolefin element formed of polyolefin, including a crystalline region and an amorphous region; and a hydrophilic copolymer contained in at least part of a surface of the polyolefin element, the hydrophilic copolymer including a copolymer of 2-methacryloyloxyethyl phosphorylcholine (MPC) of 45% or greater on a mole fraction basis and at least one other monomer. In the resin molded body, the MPC polymer is immersed through the surface by applying heat treatment.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: September 7, 2021
    Assignees: KYOCERA CORPORATION, THE UNIVERSITY OF TOKYO
    Inventors: Masayuki Kyomoto, Kazuhiko Ishihara
  • Publication number: 20210205495
    Abstract: In a molding step as step A1, a polymer material is molded and a substrate having a predetermined shape is obtained. In a polymer film forming step as step A2, the obtained substrate is immersed in a treatment aqueous solution including a compound having a phosphorylcholine group and a water-soluble inorganic salt, and the substrate in that state is irradiated with an ultraviolet light to form on a surface of the substrate a polymer film including polymer chains caused by polymerization of the compound having a phosphorylcholine group. A method for manufacturing a sliding member for an artificial joint as mentioned above makes it possible to efficiently manufacture a sliding member for an artificial joint having excellent wear resistance.
    Type: Application
    Filed: February 16, 2017
    Publication date: July 8, 2021
    Applicants: KYOCERA Corporation, The University of Tokyo
    Inventors: Shihori YAMANE, Masayuki KYOMOTO, Kazuhiko ISHIHARA
  • Publication number: 20210196862
    Abstract: A composite material in one of embodiments includes a crystal phase of titanium fluoride and a metal crystal phase of titanium. The crystal phase of the titanium fluoride is present in a first region located away from a surface in a depth direction.
    Type: Application
    Filed: May 30, 2019
    Publication date: July 1, 2021
    Inventors: Kenichi SAIGA, Kenichi WATANABE, Masayuki KYOMOTO
  • Patent number: 10800708
    Abstract: The object of the present invention is to provide an antibacterial material capable of sustaining antibacterial properties for a long time. The object can be solved by a silver-containing calcium phosphate sintered body having silver particles therein, wherein an average particle diameter of the silver particles is 0.01 to 0.5 ?m.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: October 13, 2020
    Assignees: TOKYO INSTITUTE OF TECHNOLOGY, KYOCERA CORPORATION
    Inventors: Toshiyuki Ikoma, Tomoaki Sugiyama, Hiroaki Igashira, Yugo Fukuyama, Michimasa Kamo, Masayuki Kyomoto, Takashi Sasaki
  • Publication number: 20200190298
    Abstract: A resin molded body includes: a polyolefin element formed of polyolefin, including a crystalline region and an amorphous region; and a hydrophilic copolymer contained in at least part of a surface of the polyolefin element, the hydrophilic copolymer including a copolymer of 2-methacryloyloxyethyl phosphorylcholine (MPC) of 45% or greater on a mole fraction basis and at least one other monomer. In the resin molded body, the MPC polymer is immersed through the surface by applying heat treatment.
    Type: Application
    Filed: March 20, 2018
    Publication date: June 18, 2020
    Applicants: KYOCERA Corporation, The University of Tokyo
    Inventors: Masayuki KYOMOTO, Kazuhiko ISHIHARA
  • Publication number: 20190345316
    Abstract: A resin molded body, includes: a polyolefin element including a crystalline region and an amorphous region; and a hydrophilic polymer contained in a region from a surface of the polyolefin element to part of the amorphous region located below the surface. Or, a method for producing a resin molded body, includes: preparing a polyolefin element including a crystalline region and an amorphous region; forming a coating of a hydrophilic polymer on a surface of the polyolefin element; and applying heat treatment to the polyolefin element on which the coating of the hydrophilic polymer is formed, wherein by applying the heat treatment, the coating of the hydrophilic polymer is immersed in a region from the surface to part of the amorphous region located below the surface.
    Type: Application
    Filed: March 20, 2018
    Publication date: November 14, 2019
    Applicants: KYOCERA Corporation, The University of Tokyo
    Inventors: Masayuki KYOMOTO, Kazuhiko ISHIHARA
  • Publication number: 20190177229
    Abstract: The object of the present invention is to provide an antibacterial material capable of sustaining antibacterial properties for a long time. The object can be solved by a silver-containing calcium phosphate sintered body having silver particles therein, wherein an average particle diameter of the silver particles is 0.01 to 0.5 ?m.
    Type: Application
    Filed: February 28, 2017
    Publication date: June 13, 2019
    Applicants: Tokyo Institute of Technology, KYOCERA Corporation
    Inventors: Toshiyuki IKOMA, Tomoaki SUGIYAMA, Hiroaki IGASHIRA, Yugo FUKUYAMA, Michimasa KAMO, Masayuki KYOMOTO, Takashi SASAKI
  • Patent number: 9907656
    Abstract: To provide a prosthetic member that is less likely to degrade its mechanical properties even when using it in the presence of squalene, and a method of producing the same. The prosthetic member in the present invention includes a substrate exhibiting excellent antioxidant properties and including an antioxidant and a polymer material, and a polymer film(s) covering a surface of the substrate and comprising a (meth)acrylate compound. The method for producing the prosthetic member in the present invention includes the steps of: forming a substrate comprising an antioxidant and a polymer material, cleaning a surface of the substrate with a cleaning liquid, and covering the cleaned surface of the substrate with a polymer film(s) comprising a (meth)acrylate compound.
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: March 6, 2018
    Assignee: KYOCERA CORPORATION
    Inventor: Masayuki Kyomoto
  • Patent number: 9700651
    Abstract: An object of the present invention is to provide a method of producing a bearing material having excellent wear-resistance and oxidation resistance. The method of producing a bearing material 10 according to the present invention comprises molding a substrate 12 containing a radical scavenger and a polymer material; washing at least a part 16 of the substrate 12 with a washing liquid; and grafting a polymer chain having a phosphorylcholine group from at least the part 16 of the surface after washing so as to form a polymer film 30 on at least the part of the surface.
    Type: Grant
    Filed: May 30, 2013
    Date of Patent: July 11, 2017
    Assignee: KYOCERA MEDICAL CORPORATION
    Inventors: Masayuki Kyomoto, Shihori Yamane, Kenichi Saiga
  • Publication number: 20160213476
    Abstract: To provide a prosthetic member that is less likely to degrade its mechanical properties even when using it in the presence of squalene, and a method of producing the same. The prosthetic member in the present invention includes a substrate exhibiting excellent antioxidant properties and including an antioxidant and a polymer material, and a polymer film(s) covering a surface of the substrate and comprising a (meth)acrylate compound. The method for producing the prosthetic member in the present invention includes the steps of: forming a substrate comprising an antioxidant and a polymer material, cleaning a surface of the substrate with a cleaning liquid, and covering the cleaned surface of the substrate with a polymer film(s) comprising a (meth)acrylate compound.
    Type: Application
    Filed: October 3, 2014
    Publication date: July 28, 2016
    Applicant: KYOCERA Medical Corporation
    Inventor: Masayuki KYOMOTO
  • Patent number: 9216241
    Abstract: An object is to provide a medical device having excellent antithrombotic and sliding characteristics, which can exert a cell adhesion inhibitory effect. A medical device comprising: a substrate capable of forming hydroxyl groups; and a biocompatible material layer laminated on the substrate at an appropriate position, wherein the hydroxyl groups are formed on a surface of the substrate at least at a required position by a surface treatment, while the biocompatible material layer is formed from a polymer containing phosphorylcholine groups, and wherein the substrate and the biocompatible material layer are joined via a binder layer formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: December 22, 2015
    Assignees: KYOCERA MEDICAL CORPORATION, THE UNIVERSITY OF TOKYO
    Inventors: Masayuki Kyomoto, Kazuhiko Ishihara, Kozo Nakamura, Yoshio Takatori, Hiroshi Kawaguchi, Toru Moro
  • Patent number: 9192694
    Abstract: The object of the present invention is to provide a sliding member, a prosthesis and a method of producing the sliding member, which can suppress production of abrasive wear debris by suppressing friction of the sliding section, and also can maintain satisfactory mechanical characteristics in vivo. A sliding member comprising: a substrate 1 capable of forming hydroxyl groups; and a biocompatible material layer 4 laminated on appropriate sections of the substrate 1, wherein hydroxyl groups are formed on at least a required section of a surface of the substrate 1 by surface treating to form a surface-treated layer 2, while the biocompatible material layer 4 is formed from a polymer containing phosphorylcholine groups, and wherein the substrate 1 and the biocompatible material layer 4 are joined via a binder layer 3 formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.
    Type: Grant
    Filed: October 2, 2008
    Date of Patent: November 24, 2015
    Assignees: KYOCERA MEDICAL CORPORATION, THE UNIVERSITY OF TOKYO
    Inventors: Masayuki Kyomoto, Kazuhiko Ishihara, Kozo Nakamura, Yoshio Takatori, Hiroshi Kawaguchi, Toru Moro
  • Patent number: 9044323
    Abstract: The present invention provides a bearing material that is excellent in durability and is capable of maintaining wear resistance over a long period of time. The bearing material of the present invention is a high wear-resistance bearing material 10 for being used under a humid environment comprising: a base body 12 made of a polymer material having a methylene group; and a polymer layer 30 covering a bearing surface 16 of the substrate 12, the polymer layer 30 comprising polymer chains which have a phosphorylcholine group and are grafted from the bearing surface 16, wherein a phosphoric index of the sliding surface 16 which is calculated by dividing a peak intensity of phosphate group in an infrared spectrum measured on the sliding surface by a peak intensity of the methylene group therein is not less than 0.28.
    Type: Grant
    Filed: February 5, 2007
    Date of Patent: June 2, 2015
    Assignee: KYOCERA MEDICAL CORPORATION
    Inventors: Masayuki Kyomoto, Toru Moro, Kazuhiko Ishihara, Tomohiro Konno, Kozo Nakamura, Yoshio Takatori, Hiroshi Kawaguchi, Hiroaki Takadama, Makoto Kondo, Noboru Yamawaki, Takeshi Nizuka, Masami Hashimoto
  • Publication number: 20150141545
    Abstract: An object of the present invention is to provide a method of producing a bearing material having excellent wear-resistance and oxidation resistance. The method of producing a bearing material 10 according to the present invention comprises molding a substrate 12 containing a radical scavenger and a polymer material; washing at least a part 16 of the substrate 12 with a washing liquid; and grafting a polymer chain having a phosphorylcholine group from at least the part 16 of the surface after washing so as to form a polymer film 30 on at least the part of the surface.
    Type: Application
    Filed: May 30, 2013
    Publication date: May 21, 2015
    Applicant: KYOCERA Medical Corporation
    Inventors: Masayuki Kyomoto, Shihori Yamane, Kenichi Saiga
  • Patent number: 9034414
    Abstract: The object of the present invention is to provide a joint prosthesis, bearing material and a production method thereof, which suppresses wear in a sliding section and suppresses the production of abrasive powder even during repeated daily operation. To achieve the object, there is provided a biomaterial comprising: a substrate made of metal, alloy or ceramic; and a biocompatible material layer laminated on the substrate, wherein hydroxyl groups are formed on the substrate by surface-treating, while the biocompatible material layer comprises a polymer containing phosphorylcholine groups, the substrate and the biocompatible material layer are bound via a binder layer which is combined with the hydroxyl groups of the substrate and with the biocompatible material layer.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: May 19, 2015
    Assignees: KYOCERA MEDICAL CORPORATION, THE UNIVERSITY OF TOKYO, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
    Inventors: Masayuki Kyomoto, Kazuhiko Ishihara, Yasuhiko Iwasaki, Toru Moro, Kozo Nakamura, Yoshio Takatori, Hiroshi Kawaguchi, Tomohiro Konno, Noboru Yamawaki
  • Patent number: 9011545
    Abstract: The present invention is directed to a method for replacing a nucleus pulposus in an intervertebral disk, which method includes: providing a spinal intervertebral disk replacement molded-dry-product for nucleus pulposus including a polyvinylalcohol gel having a percentage of saturated water content of 18 to 50 wt % before irradiation and being irradiated with ? ray at an intensity of 20 to 100 kGy; and inserting the spinal intervertebral disk replacement molded-dry-product for nucleus pulposus into a prosthetic space inside an anulus fibrosus through an incision opening of the anulus fibrosus, wherein the molded-dry-product changes its shape into an almost cylindrical or almost elliptically cylindrical shape so that a hollow region comes into existence at a shape deformation rate of 150 vol % or more and at a volume swelling ratio of 135 vol % or less by water absorption.
    Type: Grant
    Filed: February 6, 2013
    Date of Patent: April 21, 2015
    Assignee: BMG Incorporated
    Inventors: Takashi Nakamura, Suonghyu Hyon, Masayuki Kyomoto, Makoto Kondo
  • Patent number: 8795841
    Abstract: Disclosed is a graft polymerization method which has solved problems involved in use of a solvent, a radical initiator and high-energy radiation when a monomer is graft-polymerized on the surface of a polymer base. The graft polymerization method is characterized in that a polymerization product is obtained by immersing a polymer base (i) having a ketone group on the surface into a reaction system containing a monomer (ii) and then irradiating the polymer base (i) with light so that polymerization of the monomer starts from the surface of the polymer base (i).
    Type: Grant
    Filed: November 20, 2009
    Date of Patent: August 5, 2014
    Assignees: Japan Medical Materials Corporation, The University of Tokyo
    Inventors: Masayuki Kyomoto, Kazuhiko Ishihara
  • Patent number: 8765265
    Abstract: Disclosed is a sliding member with excellent durability and capable of maintaining wear resistance over a long period of time. Further disclosed is an artificial joint member for which the film thickness of the polymer base material is reduced. Further disclosed is an artificial joint which is capable of demonstrating high lubricity, biocompatibility, and resistance to dislocation after introduction into the body. Further disclosed are a medical appliance material and a medical appliance which demonstrate excellent biocompatibility.
    Type: Grant
    Filed: December 25, 2009
    Date of Patent: July 1, 2014
    Assignees: Kyocera Medical Corporation, The University of Tokyo
    Inventors: Masayuki Kyomoto, Kazuhiko Ishihara
  • Publication number: 20140170331
    Abstract: The object of the present invention is to provide a joint prosthesis, bearing material and a production method thereof, which suppresses wear in a sliding section and suppresses the production of abrasive powder even during repeated daily operation. To achieve the object, there is provided a biomaterial comprising: a substrate made of metal, alloy or ceramic; and a biocompatible material layer laminated on the substrate, wherein hydroxyl groups are formed on the substrate by surface-treating, while the biocompatible material layer comprises a polymer containing phosphorylcholine groups, the substrate and the biocompatible material layer are bound via a binder layer which is combined with the hydroxyl groups of the substrate and with the biocompatible material layer.
    Type: Application
    Filed: February 21, 2014
    Publication date: June 19, 2014
    Applicants: KYOCERA Medical Corporation, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY, THE UNIVERSITY OF TOKYO
    Inventors: Masayuki KYOMOTO, Kazuhiko ISHIHARA, Yasuhiko IWASAKI, Toru MORO, Kozo NAKAMURA, Yoshio TAKATORI, Hiroshi KAWAGUCHI, Tomohiro KONNO, Noboru YAMAWAKI
  • Patent number: 8697238
    Abstract: The object of the present invention is to provide a joint prosthesis, bearing material and a production method thereof, which suppresses wear in a sliding section and suppresses the production of abrasive powder even during repeated daily operation. To achieve the object, there is provided a biomaterial comprising: a substrate made of metal, alloy or ceramic; and a biocompatible material layer laminated on the substrate, wherein hydroxyl groups are formed on the substrate by surface-treating, while the biocompatible material layer comprises a polymer containing phosphorylcholine groups, the substrate and the biocompatible material layer are bound via a binder layer which is combined with the hydroxyl groups of the substrate and with the biocompatible material layer.
    Type: Grant
    Filed: March 26, 2007
    Date of Patent: April 15, 2014
    Assignees: Kyocera Medical Corporation, The University of Tokyo, National University Corporation Tokyo Medical and Dental University
    Inventors: Masayuki Kyomoto, Kazuhiko Ishihara, Yasuhiko Iwasaki, Toru Moro, Kozo Nakamura, Yoshio Takatori, Hiroshi Kawaguchi, Tomohiro Konno, Noboru Yamawaki