Abstract: The object of the present invention is to provide a sliding member, a prosthesis and a method of producing the sliding member, which can suppress production of abrasive wear debris by suppressing friction of the sliding section, and also can maintain satisfactory mechanical characteristics in vivo. A sliding member comprising: a substrate 1 capable of forming hydroxyl groups; and a biocompatible material layer 4 laminated on appropriate sections of the substrate 1, wherein hydroxyl groups are formed on at least a required section of a surface of the substrate 1 by surface treating to form a surface-treated layer 2, while the biocompatible material layer 4 is formed from a polymer containing phosphorylcholine groups, and wherein the substrate 1 and the biocompatible material layer 4 are joined via a binder layer 3 formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.

Abstract: The present invention provides a bearing material that is excellent in durability and is capable of maintaining wear resistance over a long period of time. The bearing material of the present invention is a high wear-resistance bearing material 10 for being used under a humid environment comprising: a base body 12 made of a polymer material having a methylene group; and a polymer layer 30 covering a bearing surface 16 of the substrate 12, the polymer layer 30 comprising polymer chains which have a phosphorylcholine group and are grafted from the bearing surface 16, wherein a phosphoric index of the sliding surface 16 which is calculated by dividing a peak intensity of phosphate group in an infrared spectrum measured on the sliding surface by a peak intensity of the methylene group therein is not less than 0.28.

Abstract: An object of the present invention is to provide a method of producing a bearing material having excellent wear-resistance and oxidation resistance. The method of producing a bearing material 10 according to the present invention comprises molding a substrate 12 containing a radical scavenger and a polymer material; washing at least a part 16 of the substrate 12 with a washing liquid; and grafting a polymer chain having a phosphorylcholine group from at least the part 16 of the surface after washing so as to form a polymer film 30 on at least the part of the surface.

Abstract: The object of the present invention is to provide a joint prosthesis, bearing material and a production method thereof, which suppresses wear in a sliding section and suppresses the production of abrasive powder even during repeated daily operation. To achieve the object, there is provided a biomaterial comprising: a substrate made of metal, alloy or ceramic; and a biocompatible material layer laminated on the substrate, wherein hydroxyl groups are formed on the substrate by surface-treating, while the biocompatible material layer comprises a polymer containing phosphorylcholine groups, the substrate and the biocompatible material layer are bound via a binder layer which is combined with the hydroxyl groups of the substrate and with the biocompatible material layer.

Abstract: The present invention is directed to a method for replacing a nucleus pulposus in an intervertebral disk, which method includes: providing a spinal intervertebral disk replacement molded-dry-product for nucleus pulposus including a polyvinylalcohol gel having a percentage of saturated water content of 18 to 50 wt % before irradiation and being irradiated with ? ray at an intensity of 20 to 100 kGy; and inserting the spinal intervertebral disk replacement molded-dry-product for nucleus pulposus into a prosthetic space inside an anulus fibrosus through an incision opening of the anulus fibrosus, wherein the molded-dry-product changes its shape into an almost cylindrical or almost elliptically cylindrical shape so that a hollow region comes into existence at a shape deformation rate of 150 vol % or more and at a volume swelling ratio of 135 vol % or less by water absorption.

Abstract: Disclosed is a graft polymerization method which has solved problems involved in use of a solvent, a radical initiator and high-energy radiation when a monomer is graft-polymerized on the surface of a polymer base. The graft polymerization method is characterized in that a polymerization product is obtained by immersing a polymer base (i) having a ketone group on the surface into a reaction system containing a monomer (ii) and then irradiating the polymer base (i) with light so that polymerization of the monomer starts from the surface of the polymer base (i).

Abstract: Disclosed is a sliding member with excellent durability and capable of maintaining wear resistance over a long period of time. Further disclosed is an artificial joint member for which the film thickness of the polymer base material is reduced. Further disclosed is an artificial joint which is capable of demonstrating high lubricity, biocompatibility, and resistance to dislocation after introduction into the body. Further disclosed are a medical appliance material and a medical appliance which demonstrate excellent biocompatibility.

Abstract: The object of the present invention is to provide a joint prosthesis, bearing material and a production method thereof, which suppresses wear in a sliding section and suppresses the production of abrasive powder even during repeated daily operation. To achieve the object, there is provided a biomaterial comprising: a substrate made of metal, alloy or ceramic; and a biocompatible material layer laminated on the substrate, wherein hydroxyl groups are formed on the substrate by surface-treating, while the biocompatible material layer comprises a polymer containing phosphorylcholine groups, the substrate and the biocompatible material layer are bound via a binder layer which is combined with the hydroxyl groups of the substrate and with the biocompatible material layer.

Abstract: The object of the present invention is to provide a joint prosthesis, bearing material and a production method thereof, which suppresses wear in a sliding section and suppresses the production of abrasive powder even during repeated daily operation. To achieve the object, there is provided a biomaterial comprising: a substrate made of metal, alloy or ceramic; and a biocompatible material layer laminated on the substrate, wherein hydroxyl groups are formed on the substrate by surface-treating, while the biocompatible material layer comprises a polymer containing phosphorylcholine groups, the substrate and the biocompatible material layer are bound via a binder layer which is combined with the hydroxyl groups of the substrate and with the biocompatible material layer.

Abstract: The object of the present invention is to provide a sliding member, a prosthesis and a method of producing the sliding member, which can suppress production of abrasive wear debris by suppressing friction of the sliding section, and also can maintain satisfactory mechanical characteristics in vivo. A sliding member comprising: a substrate 1 capable of forming hydroxyl groups; and a biocompatible material layer 4 laminated on appropriate sections of the substrate 1, wherein hydroxyl groups are formed on at least a required section of a surface of the substrate 1 by surface treating to form a surface-treated layer 2, while the biocompatible material layer 4 is formed from a polymer containing phosphorylcholine groups, and wherein the substrate 1 and the biocompatible material layer 4 are joined via a binder layer 3 formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.

Abstract: Disclosed are: a sliding member which is capable of maintaining wear resistance over a long period of time; an artificial joint member in which the polymer base is reduced in thickness; and an artificial joint which exhibits high lubricating properties in the body, biocompatibility and resistance to dislocation. Specifically disclosed is a polymer sliding material which has a coating layer (B) that is composed of a graft polymer containing a phosphorylcholine group and having a density of at least 1.4 g/cm3 on at least a part of the surface of a polymer base (A) that has a ketone group on the surface. The sliding material can be obtained by immersing the polymer base (A) into a liquid of a monomer (C) that has a phosphorylcholine group, and causing surface graft polymerization by irradiation of light. Also specifically disclosed are an artificial joint member using the polymer sliding material, and an artificial joint.

Abstract: Disclosed is a sliding member with excellent durability and capable of maintaining wear resistance over a long period of time. Further disclosed is an artificial joint member for which the film thickness of the polymer base material is reduced. Further disclosed is an artificial joint which is capable of demonstrating high lubricity, biocompatibility, and resistance to dislocation after introduction into the body. Further disclosed are a medical appliance material and a medical appliance which demonstrate excellent biocompatibility.

Abstract: Disclosed is a graft polymerization method which has solved problems involved in use of a solvent, a radical initiator and high-energy radiation when a monomer is graft-polymerized on the surface of a polymer base. The graft polymerization method is characterized in that a polymerization product is obtained by immersing a polymer base (i) having a ketone group on the surface into a reaction system containing a monomer (ii) and then irradiating the polymer base (i) with light so that polymerization of the monomer starts from the surface of the polymer base (i).

Abstract: An object is to provide a medical device having excellent antithrombotic and sliding characteristics, which can exert a cell adhesion inhibitory effect. A medical device comprising: a substrate capable of forming hydroxyl groups; and a biocompatible material layer laminated on the substrate at an appropriate position, wherein the hydroxyl groups are formed on a surface of the substrate at least at a required position by a surface treatment, while the biocompatible material layer is formed from a polymer containing phosphorylcholine groups, and wherein the substrate and the biocompatible material layer are joined via a binder layer formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.

Abstract: The object of the present invention is to provide a joint prosthesis, bearing material and a production method thereof, which suppresses wear in a sliding section and suppresses the production of abrasive powder even during repeated daily operation. To achieve the object, there is provided a biomaterial comprising: a substrate made of metal, alloy or ceramic; and a biocompatible material layer laminated on the substrate, wherein hydroxyl groups are formed on the substrate by surface-treating, while the biocompatible material layer comprises a polymer containing phosphorylcholine groups, the substrate and the biocompatible material layer are bound via a binder layer which is combined with the hydroxyl groups of the substrate and with the biocompatible material layer.

Abstract: To provide a spinal intervertebral disk replacement material for nucleus pulposus which is relatively superior in load resistance that causes smaller damage of the anulus fibrosus by insertion during operation, remains in the anulus fibrosus stably after operation, and also allows prevention of the damage of the vertebral body cartilage endplate and the anulus fibrosus surrounding the prosthetic portion by sliding, and a production method thereof. The present invention relates to a spinal intervertebral disk replacement material for nucleus pulposus, comprising a dry polyvinylalcohol gel having a percentage of saturated water content of 18 to 50 wt % that changes its shape at a shape deformation rate of 150 vol % or more by water absorption.

Abstract: The present invention provides a bearing material that is excellent in durability and is capable of maintaining wear resistance over a long period of time. The bearing material of the present invention is a high wear-resistance bearing material 10 for being used under a humid environment comprising: a base body 12 made of a polymer material having a methylene group; and a polymer layer 30 covering a bearing surface 16 of the substrate 12, the polymer layer 30 comprising polymer chains which have a phosphorylcholine group and are grafted from the bearing surface 16, wherein a phosphoric index of the sliding surface 16 which is calculated by dividing a peak intensity of phosphate group in an infrared spectrum measured on the sliding surface by a peak intensity of the methylene group therein is not less than 0.28.

Abstract: To provide a spinal intervertebral disk replacement material for nucleus pulposus which is relatively superior in load resistance that causes smaller damage of the anulus fibrosus by insertion during operation, remains in the anulus fibrosus stably after operation, and also allows prevention of the damage of the vertebral body cartilage endplate and the anulus fibrosus surrounding the prosthetic portion by sliding, and a production method thereof. The present invention relates to a spinal intervertebral disk replacement material for nucleus pulposus, comprising a dry polyvinylalcohol gel having a percentage of saturated water content of 18 to 50 wt % that changes its shape at a shape deformation rate of 150 vol % or more by water absorption.