Patents by Inventor Massimo Ferrari

Massimo Ferrari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6846950
    Abstract: A process for synthesis of 1-(aminomethyl)cyclohexane acetic acid hydrochloride (Gabapentin hydrochloride) comprising: a) Reaction of a mixture of acetic anhydride/ammonium acetate with 1,1-cyclohexane-diacetic acid to yield 3,3-pentamethylene glutarimide; b) Treatment of 3,3-pentamethylene glutarimide with sodium hydroxide in an aqueous solution up to dissolution, dripping the solution thus obtained into a sodium hydroxide/sodium hypochlorite mixture, which is also aqueous, followed by acidification with hydrochloric acid to yield gabapentine hydrochloride.
    Type: Grant
    Filed: April 22, 2003
    Date of Patent: January 25, 2005
    Assignee: Erregierre S.p.A.
    Inventors: Massimo Ferrari, Marcello Ghezzi, Paolo Belotti
  • Publication number: 20040063997
    Abstract: A process for synthesis of 1-(aminomethyl)cyclohexane acetic acid hydrochloride (Gabapentin hydrochloride) comprising:
    Type: Application
    Filed: April 22, 2003
    Publication date: April 1, 2004
    Applicant: ERREGIERRE S.P.A.
    Inventors: Massimo Ferrari, Marcello Ghezzi, Paolo Belotti
  • Patent number: 5973169
    Abstract: Process for the preparation of ipriflavone consisting in the following steps:a) reaction of 2,4-dihydroxy-phenyl-benzyl-ketone of formula (II) with ethyl orthoformate in dimethylformamide as solvent and in the presence of a catalyst consisting of morpholine, to yield 7-hydroxyisoflavone of formula (III),b) separation of product (III) from the reaction residue,c) alkylation of product (III) from step b) with isopropyl halide to obtain ipriflavone, wherein:I. step a) is carried out at a temperature ranging from 115 to 120.degree. C. using a 2,4-dihydroxy-phenyl-benzyl-ketone (II) weight/solvent volume (w/v) ratio lower than 1:4;II. step b) consists in the precipitation of the corresponding salt with dicyclohexylamine of formula (IV).The process yields 7-hydroxyisoflavone (III) in high yields within short reaction times (2 h max.) and ipriflavone with impurity .ltoreq.0.1%.
    Type: Grant
    Filed: February 22, 1999
    Date of Patent: October 26, 1999
    Assignee: Erregierre S.p.A.
    Inventor: Massimo Ferrari
  • Patent number: 5650522
    Abstract: Process for the preparation of derivatives having general formula (I) ##STR1## wherein the meaning of R will be defined in the text, characterized by the reaction between a compound having formula ##STR2## wherein X is an halogen, and an alkaline salt of a methyl dialkylmalonate.
    Type: Grant
    Filed: June 14, 1996
    Date of Patent: July 22, 1997
    Assignee: Erregierre S.P.A.
    Inventors: Antonio Bonaldi, Massimo Ferrari, Egidio Molinari, Fabrizio Zinetti