Patents by Inventor Masuyoshi Yamada
Masuyoshi Yamada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9184037Abstract: A mass spectrometer including a sample attaching member of attaching a sample, an ionizing chamber including an introductory port of the sample attaching member and an ionization source of generating a sample ion, a vacuumed chamber having a mass analyzer of analyzing the sample ion, and an opening/closing mechanism provided between the ionizing chamber and the vacuumed chamber, in which the opening/closing mechanism is controlled from a closed state to an open state after introducing the sample attaching member into the ionizing chamber to thereby enable to perform ionization with inconsiderable fragmentation at a high sensitivity with a high throughput.Type: GrantFiled: June 20, 2012Date of Patent: November 10, 2015Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATIONInventors: Shun Kumano, Masuyuki Sugiyama, Yuichiro Hashimoto, Hideki Hasegawa, Masuyoshi Yamada, Hidetoshi Morokuma, Shuhei Hashiba
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Patent number: 9171704Abstract: A mass spectrometer of reduced size and weight is provided which is capable to conduct highly accurate mass spectroscopy. The mass spectrometer includes an ion source adapted to ionize gas flowing in from outside in order to ionize a measurement sample and a mass spectroscopy section for separating the ionized measurement sample. The ion source has its interior reduced in pressure by differential pumping from the mass spectroscopy section and ionizes the gas when the interior pressure rises as it inhales the gas, and the mass spectroscopy section separates the ionized measurement sample when its interior pressure falls after inhale of the gas. The mass spectrometer may further include a restriction device for suppressing a flow rate of the gas the ion source inhales and an open/close device for opening and closing a flow of the gas the ion source inhales.Type: GrantFiled: September 19, 2014Date of Patent: October 27, 2015Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATIONInventors: Hidetoshi Morokuma, Yuichiro Hashimoto, Masuyuki Sugiyama, Masuyoshi Yamada, Hideki Hasegawa
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Patent number: 9105453Abstract: A portable mass spectrometer that is carried to a sampling site to conduct analysis incorporates measures against erroneous operation. To prevent erroneous operation, when a measurement sample cannot be accurately analyzed because of contamination in the measurement sample, a criterion for aborting the sample measurement is provided and mass spectrometer control maintenance is performed. When urine is measured, the mass spectrometer detects the substances contained in the urine and automatically determines whether the sample is urine. The mass spectrometer then automatically selects an analysis condition specific to urine samples to make a measurement. Also with respect to sweat and saliva, the mass spectrometer similarly selects a specific analysis condition.Type: GrantFiled: April 22, 2013Date of Patent: August 11, 2015Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATIONInventors: Tsukasa Shishika, Hidetoshi Morokuma, Masuyoshi Yamada, Hiroyuki Inoue
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Publication number: 20150108341Abstract: A portable mass spectrometer that is carried to a sampling site to conduct analysis incorporates measures against erroneous operation. To prevent erroneous operation, when a measurement sample cannot be accurately analyzed because of contamination in the measurement sample, a criterion for aborting the sample measurement is provided and mass spectrometer control maintenance is performed. When urine is measured, the mass spectrometer detects the substances contained in the urine and automatically determines whether the sample is urine. The mass spectrometer then automatically selects an analysis condition specific to urine samples to make a measurement. Also with respect to sweat and saliva, the mass spectrometer similarly selects a specific analysis condition.Type: ApplicationFiled: April 22, 2013Publication date: April 23, 2015Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATIONInventors: Tsukasa Shishika, Hidetoshi Morokuma, Masuyoshi Yamada, Hiroyuki Inoue
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Publication number: 20150041641Abstract: A mass spectrometer of reduced size and weight is provided which is capable to conduct highly accurate mass spectroscopy. The mass spectrometer includes an ion source adapted to ionize gas flowing in from outside in order to ionize a measurement sample and a mass spectroscopy section for separating the ionized measurement sample. The ion source has its interior reduced in pressure by differential pumping from the mass spectroscopy section and ionizes the gas when the interior pressure rises as it inhales the gas, and the mass spectroscopy section separates the ionized measurement sample when its interior pressure falls after inhale of the gas. The mass spectrometer may further include a restriction device for suppressing a flow rate of the gas the ion source inhales and an open/close device for opening and closing a flow of the gas the ion source inhales.Type: ApplicationFiled: September 19, 2014Publication date: February 12, 2015Inventors: Hidetoshi MOROKUMA, Yuichiro HASHIMOTO, Masuyuki SUGIYAMA, Masuyoshi YAMADA, Hideki HASEGAWA
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Patent number: 8866070Abstract: A mass spectrometer of reduced size and weight is provided which is capable to conduct highly accurate mass spectroscopy. The mass spectrometer includes an ion source adapted to ionize gas flowing in from outside in order to ionize a measurement sample and a mass spectroscopy section for separating the ionized measurement sample. The ion source has its interior reduced in pressure by differential pumping from the mass spectroscopy section and ionizes the gas when the interior pressure rises as it inhales the gas, and the mass spectroscopy section separates the ionized measurement sample when its interior pressure falls after inhale of the gas. The mass spectrometer may further include a restriction device for suppressing a flow rate of the gas the ion source inhales and an open/close device for opening and closing a flow of the gas the ion source inhales.Type: GrantFiled: November 4, 2011Date of Patent: October 21, 2014Assignee: Hitachi High-Technologies CorporationInventors: Hidetoshi Morokuma, Yuichiro Hashimoto, Masuyuki Sugiyama, Masuyoshi Yamada, Hideki Hasegawa
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Patent number: 8835834Abstract: An object is to measure both cations and anions with high duty cycle. In a mass spectrometer comprising an ion source (1), an ion guide part (31), and an ion trap (32), while ions are being mass-selectively ejected from the ion trap, ions having a polarity reverse to that of the ions trapped in the ion trap are introduced into the ion guide part.Type: GrantFiled: July 9, 2010Date of Patent: September 16, 2014Assignee: Hitachi High-Technologies CorporationInventors: Masuyuki Sugiyama, Yuichiro Hashimoto, Hisashi Nagano, Hideki Hasegawa, Yasuaki Takada, Masuyoshi Yamada
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Patent number: 8803084Abstract: A mass spectrometer featured in including an ion source including a first electrode, a second electrode, and a dielectric unit having a sample introducing unit and a sample discharging unit and provided between the first electrode and the second electrode, a power source of ionizing a sample by a discharge generated between the first electrode and the second electrode by applying an alternating current voltage to either one of the first electrode and the second electrode, a mass spectrometry unit of analyzing an ion discharged from the sample discharging unit, and a light irradiating unit of irradiating an area of generating the discharge with light.Type: GrantFiled: December 24, 2012Date of Patent: August 12, 2014Assignee: Hitachi High-Technologies CorporationInventors: Kazushige Nishimura, Yuichiro Hashimoto, Masuyuki Sugiyama, Masuyoshi Yamada, Hidetoshi Morokuma
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Publication number: 20130048851Abstract: A mass spectrometer for efficiently ionizing a sample with less carry-over. The ratio of the amount of sample gas to that of a whole headspace gas is increased by decreasing the pressure inside of a sample vessel in which the sample is sealed thereby efficiently ionizing the sample.Type: ApplicationFiled: July 31, 2012Publication date: February 28, 2013Inventors: Shun KUMANO, Masuyuki SUGIYAMA, Yuichiro HASHIMOTO, Hideki HASEGAWA, Masuyoshi YAMADA, Kazushige NISHIMURA, Hidetoshi MOROKUMA
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Publication number: 20130032711Abstract: A unit which calculates a diameter of a throttle part of a valve and a diameter of an orifice from changes of vacuum degrees measured by vacuum gauges disposed in an ion source and a vacuum chamber having a mass analysis part in order to maintain a flow rate of reagent gas flowing in the ion source to be always fixed and changes vacuum degree in a reagent introduction part, the ion source or the vacuum chamber in order to correct difference from standard value is provided. A unit which measures discharge voltage, discharge current and plasma luminous intensity to grasp current situation in order to maintain plasma generation state in the ion source to be fixed and changes discharge condition such as discharge voltage in order to correct change part from standard value is provided.Type: ApplicationFiled: August 2, 2012Publication date: February 7, 2013Applicant: Hitachi High-Technologies CorporationInventors: Koji ISHIGURO, Masuyoshi Yamada, Hidetoshi Morokuma, Masuyuki Sugiyama, Yuichiro Hashimoto
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Patent number: 8368013Abstract: An analyzer performs dielectric barrier discharge and ionization of a sample by a reaction between the sample and excited molecules or ions generated by the dielectric barrier discharge at a pressure lower than an atmospheric pressure.Type: GrantFiled: April 12, 2011Date of Patent: February 5, 2013Assignee: Hitachi High-Technologies CorporationInventors: Masako Ishimaru, Yuichiro Hashimoto, Hideki Hasegawa, Masuyoshi Yamada, Masuyuki Sugiyama, Hidetoshi Morokuma
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Publication number: 20120326022Abstract: A mass spectrometer including a sample attaching member of attaching a sample, an ionizing chamber including an introductory port of the sample attaching member and an ionization source of generating a sample ion, a vacuumed chamber having a mass analyzer of analyzing the sample ion, and an opening/closing mechanism provided between the ionizing chamber and the vacuumed chamber, in which the opening/closing mechanism is controlled from a closed state to an open state after introducing the sample attaching member into the ionizing chamber to thereby enable to perform ionization with inconsiderable fragmentation at a high sensitivity with a high throughputType: ApplicationFiled: June 20, 2012Publication date: December 27, 2012Inventors: Shun KUMANO, Masuyuki Sugiyama, Yuichiro Hashimoto, Hideki Hasegawa, Masuyoshi Yamada, Hidetoshi Morokuma, Shuhei Hashiba
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Patent number: 8319194Abstract: The mass spectrometer includes an ion source; a mass spectrometry part; a sample container; a heater for the sample container; a first gas tube connected to the sample container to introduce a gas into the sample container; and a second gas tube connected to the sample container to transfer a headspace gas of the sample container to the ion source, in which the ion source generates ions of the headspace gas and the mass spectrometry part performs mass spectrometry of the ions. Thereby, the mass spectrometer as a drug detection equipment can analyze various drugs in urine rapidly and with high sensitivity.Type: GrantFiled: August 22, 2011Date of Patent: November 27, 2012Assignee: Hitachi High-Technologies CorporationInventors: Makoto Hashimoto, Takefumi Yokokura, Masuyoshi Yamada, Hiroyuki Inoue, Hidetoshi Morokuma
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Patent number: 8253097Abstract: In a mass spectrometer having ion sources capable of switching between atmospheric pressure chemical ionization and electron impact ionization, a first gas chromatography device capable of separating a sample to meet a condition suitable for atmospheric pressure chemical ionization measurement is connected to upstream of an atmospheric pressure chemical ionization ion source. Part of the sample separated by the first gas chromatography device is introduced to a second gas chromatography device by distributing a flow channel. In the second gas chromatography device, a target substance and background ingredients contained in the sample are further separated and are introduced to an electron impact ionization ion source. By separating the target substance from the background ingredients, an electron impact ionization spectrum of the target substance is obtained without an effect of the background ingredients.Type: GrantFiled: February 29, 2008Date of Patent: August 28, 2012Assignee: Hitachi, Ltd.Inventors: Masako Ishimaru, Masuyoshi Yamada
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Publication number: 20120112061Abstract: A mass spectrometer of reduced size and weight is provided which is capable to conduct highly accurate mass spectroscopy. The mass spectrometer includes an ion source adapted to ionize gas flowing in from outside in order to ionize a measurement sample and a mass spectroscopy section for separating the ionized measurement sample. The ion source has its interior reduced in pressure by differential pumping from the mass spectroscopy section and ionizes the gas when the interior pressure rises as it inhales the gas, and the mass spectroscopy section separates the ionized measurement sample when its interior pressure falls after inhale of the gas. The mass spectrometer may further include a restriction device for suppressing a flow rate of the gas the ion source inhales and an open/close device for opening and closing a flow of the gas the ion source inhales.Type: ApplicationFiled: November 4, 2011Publication date: May 10, 2012Inventors: Hidetoshi MOROKUMA, Yuichiro HASHIMOTO, Masuyuki SUGIYAMA, Masuyoshi YAMADA, Hideki HASEGAWA
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Publication number: 20120112059Abstract: An object is to measure both cations and anions with high duty cycle. In a mass spectrometer comprising an ion source (1), an ion guide part (31), and an ion trap (32), while ions are being mass-selectively ejected from the ion trap, ions having a polarity reverse to that of the ions trapped in the ion trap are introduced into the ion guide part.Type: ApplicationFiled: July 9, 2010Publication date: May 10, 2012Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATIONInventors: Masuyuki Sugiyama, Yuichiro Hashimoto, Hisashi Nagano, Hideki Hasegawa, Yasuaki Takada, Masuyoshi Yamada
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Publication number: 20120049055Abstract: The mass spectrometer includes an ion source; a mass spectrometry part; a sample container; a heater for the sample container; a first gas tube connected to the sample container to introduce a gas into the sample container; and a second gas tube connected to the sample container to transfer a headspace gas of the sample container to the ion source, in which the ion source generates ions of the headspace gas and the mass spectrometry part performs mass spectrometry of the ions. Thereby, the mass spectrometer as a drug detection equipment can analyze various drugs in urine rapidly and with high sensitivity.Type: ApplicationFiled: August 22, 2011Publication date: March 1, 2012Inventors: Makoto Hashimoto, Takefumi Yokokura, Masuyoshi Yamada, Hiroyuki Inoue, Hidetoshi Morokuma
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Publication number: 20110253889Abstract: An analyzer performs dielectric barrier discharge and ionization of a sample by a reaction between the sample and excited molecules or ions generated by the dielectric barrier discharge at a pressure lower than an atmospheric pressure.Type: ApplicationFiled: April 12, 2011Publication date: October 20, 2011Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATIONInventors: Masako ISHIMARU, Yuichiro HASHIMOTO, Hideki HASEGAWA, Masuyoshi YAMADA, Masuyuki SUGIYAMA, Hidetoshi MOROKUMA
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Publication number: 20110248157Abstract: Objects of the present invention is to provide a quadrupole mass filter that can be fabricated at low cost and has a high transmission efficiency even under a high pressure (0.5 mTorr or more), and to provide a mass spectrometer or mass spectrometry method that reduces crosstalk in a wide mass range. Now, in a mass spectrometer, an ion separating unit is configured to include quadrupole rod electrodes that form a quadrupole radio-frequency electric field, electrodes that form a quadrupole electrostatic field, and a power supply that allows the voltage of the electrodes to form a quadrupole electrostatic field to change. In a collision cell configured to perform collision induced dissociation, harmonic potentials in a plurality of stages are produced to resonance excite ions in the axial direction, so that the ions obtain kinetic energy to move in the direction of the detector. This energy allows a time period to shorten for which ions stay in the collision cell.Type: ApplicationFiled: October 13, 2009Publication date: October 13, 2011Inventors: Masuyuki Sugiyama, Yuichiro Hashimoto, Hideki Hasegawa, Masuyoshi Yamada, Hiroyuki Yasuda, Shinji Nagai, Shintaro Kubo, Takefumi Yokokura
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Publication number: 20110204221Abstract: When a high-speed analyzer such as a quadrupole mass filter is united with an analyzer which requires a reaction time of 10 msec, such as an ion dissociation chamber of the ion trap type, a problem arises that an ion loss occurs due to a difference in analysis speed between the analyzers. A high-throughput analysis is intended to be achieved by eliminating this loss. A pre ion trap (4) is provided between a quadrupole filter (3) and an ion dissociation chamber (5), and ions are accumulated in the pre ion trap (4) while operations such as dissociation, isolation and ejection are being performed in the ion dissociation chamber (5). This configuration solves a problem with the ion dissociation chamber (5), which is a decrease in transmittance of the dissociation chamber (5), i.e., a decrease in throughput, and accordingly enables a high-throughput structural analysis on a measurement sample.Type: ApplicationFiled: October 8, 2009Publication date: August 25, 2011Inventors: Hiroyuki Satake, Masuyoshi Yamada