Abstract: An active-pulse blood analysis system has an optical sensor that illuminates a tissue site with multiple wavelengths of optical radiation and outputs sensor signals responsive to the optical radiation after attenuation by pulsatile blood flow within the tissue site. A monitor communicates with the sensor signals and is responsive to arterial pulses within a first bandwidth and active pulses within a second bandwidth so as to generate arterial pulse ratios and active pulse ratios according to the wavelengths. An arterial calibration curve relates the arterial pulse ratios to a first arterial oxygen saturation value and an active pulse calibration curve relates the active pulse ratios to a second arterial oxygen saturation value. Decision logic outputs one of the first and second arterial oxygen saturation values based upon perfusion and signal quality.

Abstract: The present invention relates to the development of and use of genetically modified human differentiated cells coupled with xenotransplantation into animal models to identify injury and disease-specific RNA and/or protein biomarkers. Specifically, the present invention encompasses two complementary methods for biomarker discovery that enable the direct and selective labelling, isolation, and analysis of human-specific RNA and/or proteins from xenotransplantation (or chimeric) animal models. Both methods involve the treatment of animal models with an RNA analog and/or amino acid analog that enables the specific isolation and quantification of human RNAs and/or proteins for the identification of novel human biomarkers for a large array of human injuries and diseases.

Abstract: An active-pulse blood analysis system has an optical sensor that illuminates a tissue site with multiple wavelengths of optical radiation and outputs sensor signals responsive to the optical radiation after attenuation by pulsatile blood flow within the tissue site. A monitor communicates with the sensor signals and is responsive to arterial pulses within a first bandwidth and active pulses within a second bandwidth so as to generate arterial pulse ratios and active pulse ratios according to the wavelengths. An arterial calibration curve relates the arterial pulse ratios to a first arterial oxygen saturation value and an active pulse calibration curve relates the active pulse ratios to a second arterial oxygen saturation value. Decision logic outputs one of the first and second arterial oxygen saturation values based upon perfusion and signal quality.

Abstract: The present disclosure describes example systems, methods, apparatuses, and medical devices for obtaining physiological parameter data from a wearable patient monitoring device. An example patient monitoring device can include an emitter and a detector. The emitter can emit light through tissue of a patient. The detector can sense the light after it passes through and is attenuated by the tissue and can generate a signal indicative of the sensed light. When the patient monitoring device is attached to or worn by the patient, the emitter and detector are aligned such that the light from the emitter travels through an opening between a first bone and a second bone of the patient prior to being sensed by the detector.

Abstract: A fuel system including a fuel metering unit, a heat exchanger, a plurality of fuel nozzles, and a coke filtration system. The fuel metering unit is configured to meter a flow of a hydrocarbon fuel. The heat exchanger is fluidly connected to the fuel metering unit. The heat exchanger is configured to heat the hydrocarbon fuel to improve engine performance or efficiency. The plurality of fuel nozzles is fluidly connected to the heat exchanger downstream of the heat exchanger to receive the hydrocarbon fuel heated by the heat exchanger. The coke filtration system includes at least one filter to remove coke particles in the heated fuel. The coke filtration system is located upstream of the plurality of fuel nozzles and directly downstream of the heat exchanger.

Abstract: A computer-implemented method for determining a hydration status of a user, the computer-implemented method. The computer-implemented method comprises acquiring, from sensor on a wearable device worn by a user, data including bodily parameter data related to the user. The computer-implemented method further comprises applying a model to the bodily parameter data to obtain hydration information related to the user. The model derives, from the hydration information, a hydration rank indicative of a hydration status of the user. The hydration rank is a given grade on a hydration rank scale.

Abstract: An optical physiological sensor configured to perform high speed spectral sweep analysis of sample tissue being measured to non-invasively predict an analyte level of a patient. An emitter of the optical physiological sensor can be regulated to operate at different temperatures to emit radiation at different wavelengths. Variation in emitter drive current, duty cycle, and forward voltage can also be used to cause the emitter to emit a range of wavelengths. Informative spectral data can be obtained during the sweeping of specific wavelength regions of sample tissue.

Abstract: An optical physiological sensor configured to perform high speed spectral sweep analysis of sample tissue being measured to non-invasively predict an analyte level of a patient. An emitter of the optical physiological sensor can be regulated to operate at different temperatures to emit radiation at different wavelengths. Variation in emitter drive current, duty cycle, and forward voltage can also be used to cause the emitter to emit a range of wavelengths. Informative spectral data can be obtained during the sweeping of specific wavelength regions of sample tissue.

Abstract: A premixer for a gas turbine combustor includes a centerbody, a swirler assembly, and a mixing duct. The swirler assembly includes an inner swirler with vanes that rotate air in a first direction and an outer swirler with vanes that rotate air in an opposite direction. The inner swirler vanes and the outer swirler vanes are separated by an annular splitter. The outer swirler vanes define an outlet plane, and the inner swirler vanes each have a trailing edge that is disposed at an acute angle relative to the outlet plane. In one aspect, the inner swirler is axially offset from the outer swirler. The mixing duct may also define fuel passages that deliver fuel to fuel outlets on the downstream end of the mixing duct. The premixer is designed for operation on gaseous fuel or liquid fuel.

Abstract: An active-pulse blood analysis system has an optical sensor that illuminates a tissue site with multiple wavelengths of optical radiation and outputs sensor signals responsive to the optical radiation after attenuation by pulsatile blood flow within the tissue site. A monitor communicates with the sensor signals and is responsive to arterial pulses within a first bandwidth and active pulses within a second bandwidth so as to generate arterial pulse ratios and active pulse ratios according to the wavelengths. An arterial calibration curve relates the arterial pulse ratios to a first arterial oxygen saturation value and an active pulse calibration curve relates the active pulse ratios to a second arterial oxygen saturation value. Decision logic outputs one of the first and second arterial oxygen saturation values based upon perfusion and signal quality.

Abstract: An active-pulse blood analysis system has an optical sensor that illuminates a tissue site with multiple wavelengths of optical radiation and outputs sensor signals responsive to the optical radiation after attenuation by pulsatile blood flow within the tissue site. A monitor communicates with the sensor signals and is responsive to arterial pulses within a first bandwidth and active pulses within a second bandwidth so as to generate arterial pulse ratios and active pulse ratios according to the wavelengths. An arterial calibration curve relates the arterial pulse ratios to a first arterial oxygen saturation value and an active pulse calibration curve relates the active pulse ratios to a second arterial oxygen saturation value. Decision logic outputs one of the first and second arterial oxygen saturation values based upon perfusion and signal quality.

Abstract: A device is disclosed, which includes a processor and a memory in communication with the processor. The memory includes executable instructions that, when executed by the processor, cause the processor to control the device to perform functions of providing a graphical user interface for a user on a display; displaying a user interface component on the graphical user interface; providing a pointer on the graphical user interface controlled by the user to interact with the user interface component on the graphical user interface; in response to the pointer being positioned over the displayed user interface component, and displaying after a dynamic hover trigger delay a hover graphic proximate to the component wherein the dynamic hover trigger delay dynamically changes depending on movement of the pointer by the user.

Abstract: An electrically isolated coupler may include a driven body, a drive body and an insulating member. The drive body is made of first metallic material and has a driven end configured to interface with a fastening component. The driven body includes a first interface portion and the drive body includes a second interface portion. The drive body is made of a second metallic material and has a drive end configured to interface with a driving tool. The insulating member is disposed between the drive body and the driven body to electrically isolate the drive body and the driven body from each. The first interface portion includes at least one axially extending portion that extends toward the drive body, and the second interface portion includes at least one axially extending portion that extends toward the driven body. The insulating member is disposed between the respective at least one axially extending portions of the first and second interface portions.

Abstract: Systems, methods, and apparatuses for enabling a plurality of non-invasive, physiological sensors to obtain physiological measurements from essentially the same, overlapping, or proximate regions of tissue of a patient are disclosed. Each of a plurality of sensors can be integrated with or attached to a multi-sensor apparatus and can be oriented such that each sensor is directed towards, or can obtain a measurement from, the same or a similar location.

Abstract: A premixer for a gas turbine combustor includes a centerbody, a swirler assembly, and a mixing duct. The swirler assembly includes an inner swirler with vanes that rotate air in a first direction and an outer swirler with vanes that rotate air in an opposite direction. The inner swirler vanes and the outer swirler vanes are separated by an annular splitter. The outer swirler vanes define an outlet plane, and the inner swirler vanes each have a trailing edge that is disposed at an acute angle relative to the outlet plane. In one aspect, the inner swirler is axially offset from the outer swirler. The mixing duct may also define fuel passages that deliver fuel to fuel outlets on the downstream end of the mixing duct. The premixer is designed for operation on gaseous fuel or liquid fuel.

Abstract: An active-pulse blood analysis system has an optical sensor that illuminates a tissue site with multiple wavelengths of optical radiation and outputs sensor signals responsive to the optical radiation after attenuation by pulsatile blood flow within the tissue site. A monitor communicates with the sensor signals and is responsive to arterial pulses within a first bandwidth and active pulses within a second bandwidth so as to generate arterial pulse ratios and active pulse ratios according to the wavelengths. An arterial calibration curve relates the arterial pulse ratios to a first arterial oxygen saturation value and an active pulse calibration curve relates the active pulse ratios to a second arterial oxygen saturation value. Decision logic outputs one of the first and second arterial oxygen saturation values based upon perfusion and signal quality.

Abstract: An active-pulse blood analysis system has an optical sensor that illuminates a tissue site with multiple wavelengths of optical radiation and outputs sensor signals responsive to the optical radiation after attenuation by pulsatile blood flow within the tissue site. A monitor communicates with the sensor signals and is responsive to arterial pulses within a first bandwidth and active pulses within a second bandwidth so as to generate arterial pulse ratios and active pulse ratios according to the wavelengths. An arterial calibration curve relates the arterial pulse ratios to a first arterial oxygen saturation value and an active pulse calibration curve relates the active pulse ratios to a second arterial oxygen saturation value. Decision logic outputs one of the first and second arterial oxygen saturation values based upon perfusion and signal quality.

Abstract: The present disclosure describes example systems, methods, apparatuses, and medical devices for obtaining physiological parameter data from a wearable patient monitoring device. An example patient monitoring device can include an emitter and a detector. The emitter can emit light through tissue of a patient. The detector can sense the light after it passes through and is attenuated by the tissue and can generate a signal indicative of the sensed light. When the patient monitoring device is attached to or worn by the patient, the emitter and detector are aligned such that the light from the emitter travels through an opening between a first bone and a second bone of the patient prior to being sensed by the detector.

Abstract: The present disclosure relates to a fuel-air premixer for a turbine system. The fuel-air premixer includes a swirler and a centerbody. The swirler is configured to direct a flow of air through the premixer, and the centerbody is configured to inject fuel into the flow of air. Additionally, the centerbody includes an airfoil shape that reduces and/or substantially eliminates recirculation pockets to prevent autoignition and/or flame holding in a combustion chamber. Accordingly, the turbine system may produce fewer NOx emissions.

Abstract: Methods for identifying a subject with a cancer eligible for treatment with an inhibitor of a Table 1 molecule, optionally a SRC kinase inhibitor or a MET kinase inhibitor, are provided. The methods comprise testing a biological sample from the subject for a deficiency in EPHB6 receptor levels, wherein the subject is eligible for treatment with an inhibitor of a Table 1 molecule, optionally a SRC kinase inhibitor or a MET kinase inhibitor, if EPHB6 receptor levels in the biological sample are deficient.