Patents by Inventor Mathew Paul
Mathew Paul has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190203253Abstract: Methods for identifying a subject with a cancer eligible for treatment with an inhibitor of a Table 1 molecule, optionally a SRC kinase inhibitor or a MET kinase inhibitor, are provided. The methods comprise testing a biological sample from the subject for a deficiency in EPHB6 receptor levels, wherein the subject is eligible for treatment with an inhibitor of a Table 1 molecule, optionally a SRC kinase inhibitor or a MET kinase inhibitor, if EPHB6 receptor levels in the biological sample are deficient.Type: ApplicationFiled: July 5, 2017Publication date: July 4, 2019Inventors: Franco Joseph Vizeacoumar, Andrew Freywald, James Mathew Paul, Frederick Sagayaraj Vizeacoumar
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Patent number: 9989560Abstract: A system is disclosed for detecting and calculating the level of ambient and/or environmental noise, such as electromagnetic interference generated by electric power lines, ambient lights, light dimmers, television or computer displays, power supplies or transformers, and medical equipment. In some embodiments, the system performs frequency analysis on the interference signal detected by light photodetectors and determines the power of the interference signal concentrated in the analyzed frequency bands. The worst-case interference level can be determined by selecting the maximum from the computed power values. In some embodiments, the determined interference signal power can be compared with the noise tolerance of a patient monitoring system configured to reliably and noninvasively detect physiological parameters of a user. The results of the comparison can be presented to the user audio-visually. In some embodiments, the system can be used to perform spot check measurements of electromagnetic interference.Type: GrantFiled: June 5, 2014Date of Patent: June 5, 2018Assignee: MASIMO CORPORATIONInventors: Jeroen Poeze, Jesse Chen, Mathew Paul, Marcelo Lamego, Massi Joe E. Kiani
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Publication number: 20180146902Abstract: An active-pulse blood analysis system has an optical sensor that illuminates a tissue site with multiple wavelengths of optical radiation and outputs sensor signals responsive to the optical radiation after attenuation by pulsatile blood flow within the tissue site. A monitor communicates with the sensor signals and is responsive to arterial pulses within a first bandwidth and active pulses within a second bandwidth so as to generate arterial pulse ratios and active pulse ratios according to the wavelengths. An arterial calibration curve relates the arterial pulse ratios to a first arterial oxygen saturation value and an active pulse calibration curve relates the active pulse ratios to a second arterial oxygen saturation value. Decision logic outputs one of the first and second arterial oxygen saturation values based upon perfusion and signal quality.Type: ApplicationFiled: August 7, 2017Publication date: May 31, 2018Inventors: Massi Joe E. Kiani, Mathew Paul, Jesse Chen, Marcelo M. Lamego
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Patent number: 9724025Abstract: An active-pulse blood analysis system has an optical sensor that illuminates a tissue site with multiple wavelengths of optical radiation and outputs sensor signals responsive to the optical radiation after attenuation by pulsatile blood flow within the tissue site. A monitor communicates with the sensor signals and is responsive to arterial pulses within a first bandwidth and active pulses within a second bandwidth so as to generate arterial pulse ratios and active pulse ratios according to the wavelengths. An arterial calibration curve relates the arterial pulse ratios to a first arterial oxygen saturation value and an active pulse calibration curve relates the active pulse ratios to a second arterial oxygen saturation value. Decision logic outputs one of the first and second arterial oxygen saturation values based upon perfusion and signal quality.Type: GrantFiled: July 10, 2014Date of Patent: August 8, 2017Assignee: Masimo CorporationInventors: Massi Joe E. Kiani, Mathew Paul, Jesse Chen, Marcelo M. Lamego
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Publication number: 20170102147Abstract: The present disclosure relates to a fuel-air premixer for a turbine system. The fuel-air premixer includes a swirler and a centerbody. The swirler is configured to direct a flow of air through the premixer, and the centerbody is configured to inject fuel into the flow of air. Additionally, the centerbody includes an airfoil shape that reduces and/or substantially eliminates recirculation pockets to prevent autoignition and/or flame holding in a combustion chamber. Accordingly, the turbine system may produce fewer NOx emissions.Type: ApplicationFiled: October 9, 2015Publication date: April 13, 2017Inventors: Liangyu Wang, Anthony John Dean, Keith Robert McManus, Kapil Kumar Singh, Suhui Li, Sravan Kumar Dheeraj Kapilavai, Mathew Paul Thariyan, Owen Graham
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Publication number: 20160367173Abstract: An optical physiological sensor configured to perform high speed spectral sweep analysis of sample tissue being measured to non-invasively predict an analyte level of a patient. An emitter of the optical physiological sensor can be regulated to operate at different temperatures to emit radiation at different wavelengths. Variation in emitter drive current, duty cycle, and forward voltage can also be used to cause the emitter to emit a range of wavelengths. Informative spectral data can be obtained during the sweeping of specific wavelength regions of sample tissue.Type: ApplicationFiled: May 20, 2016Publication date: December 22, 2016Inventors: Cristiano Dalvi, Ferdyan Lesmana, Hung Vo, Jeroen Poeze, Jesse Chen, Kevin Pauley, Mathew Paul, Sean Merritt, Thomas B. Blank, Massi Joe E. Kiani
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Patent number: 9445759Abstract: A blood glucose calibration system has a noninvasive sensor that attaches to a person's tissue site so as to generate multi-stream physiological data responsive to that person's blood constituents. Composite parameters, each in the form of a mathematical combination of invasive blood panel parameters, are derived from a general population and are responsive to the multi-stream physiological data. A population-based, blood glucose estimate for that person is derived from a weighted and scaled combination of these composite parameters. An individualized blood glucose estimate is then derived from the population-based blood glucose estimate and intermittent invasive test strip measurements of that particular individual.Type: GrantFiled: December 24, 2012Date of Patent: September 20, 2016Assignee: CERCACOR LABORATORIES, INC.Inventors: Marcelo M. Lamego, Massi Joe E. Kiani, Jesse Chen, Mathew Paul, Hoi Wong
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Patent number: 9163559Abstract: An internal combustion engine and a method of operation are described involving: supplying intake gas from an intake manifold (18) to an air intake port of a combustion chamber in a cylinder (11); selectively operating an air intake valve using a first operating profile (30) and, on demand, switching selective operation of the air intake valve to a second operating profile (31) in which the closing of the air intake valve is delayed compared to the closing of the air intake valve using the first operating profile; wherein at the point (43) of or prior to switching from the first operating profile to the second operating profile the pressure of the intake gas in the intake manifold is increased.Type: GrantFiled: December 6, 2011Date of Patent: October 20, 2015Assignee: Perkins Engines Company LimitedInventors: Mathew Paul Nicholson, Christopher Thorne
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Publication number: 20150012231Abstract: A system is disclosed for detecting and calculating the level of ambient and/or environmental noise, such as electromagnetic interference generated by electric power lines, ambient lights, light dimmers, television or computer displays, power supplies or transformers, and medical equipment. In some embodiments, the system performs frequency analysis on the interference signal detected by light photodetectors and determines the power of the interference signal concentrated in the analyzed frequency bands. The worst-case interference level can be determined by selecting the maximum from the computed power values. In some embodiments, the determined interference signal power can be compared with the noise tolerance of a patient monitoring system configured to reliably and noninvasively detect physiological parameters of a user. The results of the comparison can be presented to the user audio-visually. In some embodiments, the system can be used to perform spot check measurements of electromagnetic interference.Type: ApplicationFiled: June 5, 2014Publication date: January 8, 2015Inventors: Jeroen Poeze, Jesse Chen, Mathew Paul, Marcelo Lamego, Massi Joe E. Kiani
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Publication number: 20140275872Abstract: A quality control system for patient monitors is disclosed. The quality control system can include a quality check insert having optical properties. In an embodiment, the insert is placed within a sensor, irradiated with light, and then the light is detected after attenuation by the insert. The detected light is processed using the same or different processing methodologies typically used to determine measurement values for physiological parameters of a monitored patient. When a patient monitor is functioning properly, the results of the processing provide values within a predetermined range of values. When the patient monitor is not functioning properly, the results of the processing provide values outside the predetermined range of values. The quality control system can include quality control parameters indicative of a properly functioning active pulse motor of the sensor, emitters of the sensor, detectors of the sensor, accelerometers of the sensors, and/or temperature sensors of the system.Type: ApplicationFiled: March 11, 2014Publication date: September 18, 2014Applicant: Cercacor Laboratories, Inc.Inventors: Sean Merritt, Kevin Pauley, Jesse Chen, Justin Mathew Paul, Marcelo M. Lamego
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Patent number: 8754776Abstract: A system is disclosed for detecting and calculating the level of ambient and/or environmental noise, such as electromagnetic interference generated by electric power lines, ambient lights, light dimmers, television or computer displays, power supplies or transformers, and medical equipment. In some embodiments, the system performs frequency analysis on the interference signal detected by light photodetectors and determines the power of the interference signal concentrated in the analyzed frequency bands. The worst-case interference level can be determined by selecting the maximum from the computed power values. In some embodiments, the determined interference signal power can be compared with the noise tolerance of a patient monitoring system configured to reliably and non-invasively detect physiological parameters of a user. The results of the comparison can be presented to the user audio-visually. In some embodiments, the system can be used to perform spot check measurements of electromagnetic interference.Type: GrantFiled: June 14, 2013Date of Patent: June 17, 2014Assignee: Cercacor Laboratories, Inc.Inventors: Jeroen Poeze, Jesse Chen, Mathew Paul, Marcelo Lamego, Massi Joe E. Kiani
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Publication number: 20130278430Abstract: A system is disclosed for detecting and calculating the level of ambient and/or environmental noise, such as electromagnetic interference generated by electric power lines, ambient lights, light dimmers, television or computer displays, power supplies or transformers, and medical equipment. In some embodiments, the system performs frequency analysis on the interference signal detected by light photodetectors and determines the power of the interference signal concentrated in the analyzed frequency bands. The worst-case interference level can be determined by selecting the maximum from the computed power values. In some embodiments, the determined interference signal power can be compared with the noise tolerance of a patient monitoring system configured to reliably and non-invasively detect physiological parameters of a user. The results of the comparison can be presented to the user audio-visually. In some embodiments, the system can be used to perform spot check measurements of electromagnetic interference.Type: ApplicationFiled: June 14, 2013Publication date: October 24, 2013Inventors: Jeroen POEZE, Jesse CHEN, Mathew Paul, Marcelo Lamego, Massi Joe E. Kiani
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Patent number: 8471713Abstract: A system is disclosed for detecting and calculating the level of ambient and/or environmental noise, such as electromagnetic interference generated by electric power lines, ambient lights, light dimmers, television or computer displays, power supplies or transformers, and medical equipment. In some embodiments, the system performs frequency analysis on the interference signal detected by light photodetectors and determines the power of the interference signal concentrated in the analyzed frequency bands. The worst-case interference level can be determined by selecting the maximum from the computed power values. In some embodiments, the determined interference signal power can be compared with the noise tolerance of a patient monitoring system configured to reliably and non-invasively detect physiological parameters of a user. The results of the comparison can be presented to the user audio-visually. In some embodiments, the system can be used to perform spot check measurements of electromagnetic interference.Type: GrantFiled: July 22, 2010Date of Patent: June 25, 2013Assignee: Cercacor Laboratories, Inc.Inventors: Jeroen Poeze, Jesse Chen, Mathew Paul, Marcelo Lamego, Massi Joe E. Kiani
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Publication number: 20130052312Abstract: Method steps to manufacture non-alcoholic and alcoholic toddy drinks by use of only irradiation (gamma irradiation) or only filtering. The present invention will enable the shelf life of the toddy drink to be extended for several months and possibly years without change in the nature and taste of the toddy drink. One embodiment of the present invention can be used to preserve the toddy drink before fermentation starts to produce a sweet organic soft (non-alcoholic) drink. Another embodiment can be used to control fermentation of the toddy drink to produce a sweet organic hard (alcoholic) drink. Irradiation or filtration keeps the food material almost intact and at the same time destroys the microbes and parasites. Irradiation can be done after packing or bottling in small measures or in bulk quantities. Filtration is performed in bulk quantities.Type: ApplicationFiled: July 27, 2012Publication date: February 28, 2013Inventors: Thyvalikakath Mathew Paul, Thankam Paul Thyvalikakath
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Patent number: 8351541Abstract: A data processing apparatus communicates data bits on a predetermined number of sub-carrier signals of an Orthogonal Frequency Division Multiplexed (OFDM) symbol. The data processing apparatus comprises a parity interleaver operable to perform parity interleaving on Low Density Parity Check (LDPC) encoded data bits obtained by performing LDPC encoding according to a parity check matrix of an LDPC code including a parity matrix corresponding to parity bits of the LDPC code, the parity matrix having a stepwise structure, so that a parity bit of the LDPC encoded data bits is interleaved to a different parity bit position. A mapping unit maps the parity interleaved bits onto data symbols corresponding to modulation symbols of a modulation scheme of the OFDM sub-carrier signals.Type: GrantFiled: January 27, 2012Date of Patent: January 8, 2013Assignee: Sony CorporationInventors: Mathew Paul Athol Taylor, Samuel Asanbeng Atungsiri, Takashi Yokokawa, Makiko Yamamoto
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Publication number: 20120187034Abstract: A multi-stage filtering and treatment apparatus comprising a minimum of three stages, wherein the first stage comprises a container for separation of large scale aggregate or particulate matter from the washout slurry, the second stage comprises a container for separation of small scale aggregate or particular matter from the washout slurry, and the third stage comprises a container for separation of suspended particles and fines from the washout slurry and adjustment of the pH as needed. Each such stage comprises a pass-though container that temporarily retains the washout liquid before allowing passage of liquid from one stage container to the next and then out of the apparatus altogether.Type: ApplicationFiled: January 20, 2011Publication date: July 26, 2012Inventors: Mark D. Shaw, Jacqueline Hahn, Mathew Paul Clancy, Earl Thomas Saxon, JR., Dorian Thurston True, III
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Publication number: 20110109459Abstract: A system is disclosed for detecting and calculating the level of ambient and/or environmental noise, such as electromagnetic interference generated by electric power lines, ambient lights, light dimmers, television or computer displays, power supplies or transformers, and medical equipment. In some embodiments, the system performs frequency analysis on the interference signal detected by light photodetectors and determines the power of the interference signal concentrated in the analyzed frequency bands. The worst-case interference level can be determined by selecting the maximum from the computed power values. In some embodiments, the determined interference signal power can be compared with the noise tolerance of a patient monitoring system configured to reliably and non-invasively detect physiological parameters of a user. The results of the comparison can be presented to the user audio-visually. In some embodiments, the system can be used to perform spot check measurements of electromagnetic interference.Type: ApplicationFiled: July 22, 2010Publication date: May 12, 2011Applicant: MASIMO Laboratories, Inc.Inventors: Jeroen Poeze, Jesse Chen, Mathew Paul, Marcelo Lamego, Massi Joe E. Kiani
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Patent number: 6653923Abstract: A method for fabricating an inductor which includes a core, a shield and a length of epoxy tape is provided which includes the steps of winding the wire into a coil onto the core, wrapping the epoxy tape around a perimeter of the core, installing the core including the coil and epoxy tape into the shield, and heating the inductor causing the epoxy tape to bond to the shield. An inductor incorporating the method is also described.Type: GrantFiled: June 19, 2001Date of Patent: November 25, 2003Assignee: Cooper Technologies CompanyInventors: Yanjing Li, Mathew Paul Sespaniak
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Publication number: 20020190834Abstract: A method for fabricating an inductor which includes a core, a shield and a length of epoxy tape is provided which includes the steps of winding the wire into a coil onto the core, wrapping the epoxy tape around a perimeter of the core, installing the core including the coil and epoxy tape into the shield, and heating the inductor causing the epoxy tape to bond to the shield. An inductor incorporating the method is also disclosed.Type: ApplicationFiled: June 19, 2001Publication date: December 19, 2002Inventors: Yanjing Li, Mathew Paul Sespaniak
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Patent number: 6108001Abstract: A system provides dynamic control of a visual and/or audio presentation. The system comprises a storage such as DASD for data defining "stories" i.e. a multiplicity of still images or video segments and/or respective audio clips. A program file defines a list of the stories for the presentation, a sequence for presenting the stories in the list, and a time interval for presenting each story or between successive stories in the sequence. A control program directs display of the stories in the list in the sequence according to the time interval. The time interval can be dynamically changed during the presentation by a user via a system console. Pursuant to such a change, the subsequent stories are presented according to the changed time interval. This permits the user to tailor the speed of the presentation to the audience.Type: GrantFiled: May 21, 1993Date of Patent: August 22, 2000Assignee: International Business Machines CorporationInventor: Mathew Paul Tuttle