Patents by Inventor Mathieu Pernot

Mathieu Pernot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230309944
    Abstract: The invention relates to a method for determining at least one property of an object, the method comprising a step of: a) obtaining first data relative to the object by an ultrasound imaging technique imaging the object at a frame rate superior to 300 Hz, characterized in that the method further comprises a step of: b) obtaining second data relative to the object by imaging the object with at least one of a X-ray and a ?-ray, and c) determining the at least one property of the object based on the first data and the second data.
    Type: Application
    Filed: June 7, 2023
    Publication date: October 5, 2023
    Inventors: Jean PROVOST, Anikitos GAROFALAKIS, Mathieu PERNOT, Mickaël TANTER, Bertrand TAVITIAN, Thomas VIEL
  • Patent number: 11766242
    Abstract: A method for mapping fibrous media by propagation of ultrasound from a set transducers, wherein: a number of unfocused incident ultrasonic waves having different wavefronts are emitted; the signals reverberated by the medium toward each transducer are captured; coherent signals respectively corresponding, for each transducer, to contributions coming from different fictitious focal points in the medium are determined; and then the orientation of the fibers is determined by comparing a spatial coherence between said coherent signals, in a plurality of directions.
    Type: Grant
    Filed: July 16, 2014
    Date of Patent: September 26, 2023
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Mickaël Tanter, Mathias Fink, Mathieu Pernot, Clément Papadacci
  • Publication number: 20230225698
    Abstract: The present invention relates to the field of ultrasounds and imagining of the coronary blood flow of the heart. Patients with coronary microvascular dysfunction (CMD) have poor prognostic with significantly higher rates of cardiovascular events, including hospitalization for heart failure, sudden cardiac death, and myocardial infarction (MI). Despite the urgent clinical need, there are no non-ionizing and non-invasive techniques available in clinic to directly visualize the coronary microvasculature and assess the local coronary microvascular system. Flow imaging remains a difficult task to perform in the heart because of the fast movements of this organ. In order to overcome the limitations of actual imaging methods for the coronary blood flow, the inventors proposed an ultrasound ultrafast imaging method that automatically detect the time periods in which the myocardium velocity is low and estimate the coronary flow velocity and the tissue velocity from the same data acquisition.
    Type: Application
    Filed: April 13, 2021
    Publication date: July 20, 2023
    Inventors: Mathieu PERNOT, Mickael TANTER, Clément PAPADACCI, Oscar DEMEULENAERE
  • Patent number: 11633199
    Abstract: An apparatus for treating vascular thrombosis with ultrasound, includes a therapeutic ultrasonic transducer, suitable for generating focused ultrasonic waves that propagate along an emission axis; an imaging ultrasonic transducer associated with the therapeutic transducer; a means for moving the focal spot of the therapeutic ultrasonic transducer along the emission axis with respect to the imaging transducer; a motorized mechanical system for translating the transducers along at least a first axis parallel to the emission axis and a second axis perpendicular to the first; and an electronic control system for driving the motorized mechanical system and the means for moving the focal spot of the therapeutic transducer.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: April 25, 2023
    Assignee: CARDIAWAVE
    Inventors: Guillaume Goudot, Mathieu Pernot, Mickael Tanter, Michael Vion
  • Patent number: 11617560
    Abstract: The present invention aims at improving the Doppler imaging of a biological sample comprising blood. For this, it is proposed a method for imaging a biological sample (10), the sample (10) comprising blood (14) comprising diffusors and solid tissue (16), the method comprising obtaining observation, each observation being characterized by a different point spread function associating a signal to each location of the region of interest, the signal comprising a first contribution representative of the diffusors of blood vessels within the location, a second contribution representative of the tissue diffusors and a third contribution representative of blood signal associated to blood diffusors outside of the location, and estimating, for each location, the blood flow by using a statistical analysis.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: April 4, 2023
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIME INDUSTRIELLES DE LA VILLE DE PARIS, UNIVERSITÉ PARIS CITÉ, SORBONNE UNIVERSITÉ
    Inventors: Zsolt Lenkei, Mathieu Pernot, Mickael Tanter, Thomas Deffieux
  • Patent number: 11571230
    Abstract: An ultrasonic processing apparatus is provided. The ultrasonic processing apparatus comprises an ultrasonic therapy transducer (ATA) adapted to generate focused ultrasonic waves; an ultrasonic imaging transducer (UID) connected to the ultrasonic therapy transducer; and an electronic system configured to control the ultrasonic therapy transducer so as to emit a pulse train of ultrasonic waves generating a cloud of cavitation bubbles (BC); control the ultrasonic imaging transducer so as to acquire at least one image of the region to be processed; acquire a plurality of echo signals of ultrasonic wave pulses emitted by the ultrasonic therapy transducer captured by the ultrasonic imaging transducer; process the plurality of echo signals so as to reconstruct an image of the cloud of cavitation bubbles; and display said image of the cloud of cavitation bubbles superposed on said image of the region to be processed. The processing includes spatio-temporal filtering.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: February 7, 2023
    Assignees: CARDIAWAVE SA, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
    Inventors: Mathieu Pernot, Daniel Suarez
  • Patent number: 11554386
    Abstract: An ultrasound imaging and therapy device includes an array of concentric annular ultrasound transducers, and an ultrasound imaging device situated inside an innermost transducer of the plurality of concentric annular ultrasound transducers, wherein it further comprises a mechanical linkage allowing a tilting movement of the array of concentric annular ultrasound transducers with respect to the ultrasound imaging device and in that the ultrasound imaging device protrudes in an axial direction from the array of concentric annular ultrasound transducers; whereby the ultrasound imaging device can be kept stationary and in direct or indirect contact with a patient's skin while the array of concentric annular ultrasound transducers is tilted so as to move a focal point of ultrasound waves generated by the concentric annular ultrasound transducers within an imaging region of the ultrasound imaging device.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: January 17, 2023
    Assignees: CARDIAWAVE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
    Inventors: Mathieu Pernot, Michael Vion, Mickael Tanter
  • Patent number: 11508261
    Abstract: The invention relates to a method for obtaining a numerical model, the numerical model associating at least one objective measurement to a subjective sensation, the method comprising the steps of: a) imaging the at least one area of the brain by using unfocused waves produced by a transcranial ultrasound probe (20), to obtain at least one acquired image of the activity of the area, b) evaluating a physical quantity representative of the activity of the at least one area based on the acquired images, to obtain at least one objective measurement, c) obtaining from the subject at least one numerical value representative of a subjective sensation, and d) determining the numerical model by using the obtained objective measurement and the obtained numerical value.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: November 22, 2022
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), Centre National de la recherche scientifique, Université Pierre et Marie Curie, Université Paris Diderot, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
    Inventors: Thomas Deffieux, Mickaël Tanter, Jean-Luc Gennisson, Zsolt Lenkei, Mathieu Pernot
  • Publication number: 20220346748
    Abstract: Because of the increase of the obesity related diseases, it is desirable to be able to detect a fatty liver and quantify the content in fat for the fatty liver. Known methods are biopsy and magnetic resonance imaging. However, biopsy is an invasive method and magnetic resonance imaging is a complicated method to carry out. The inventors propose a new ultrasonic method which is more compliant with a regular control of the content in fat for the fatty liver for a subject. This method notably relies on a smart exploitation of the coherence properties of ultrasound pulses applied to the liver. This method has already been validated on sane subjects as providing accurate measurements, notably for fat content.
    Type: Application
    Filed: September 25, 2020
    Publication date: November 3, 2022
    Inventors: Mathieu PERNOT, Thomas DEFFIEUX, Mickael TANTER, Clément PAPADACCI
  • Publication number: 20220346749
    Abstract: Because of the increase of the obesity related diseases, it is desirable to be able to detect a fatty liver and quantify the content in fat for the fatty liver. Known methods are biopsy and magnetic resonance imaging. However, biopsy is an invasive method and magnetic resonance imaging is a complicated method to carry out. The inventors propose a new ultrasonic method, which is more compliant with a regular control of the content in fat for the fatty liver for a subject. This method notably relies on a smart exploitation of the coherence properties of ultrasound pulses applied to the liver. This method has already been validated on sane subjects as providing accurate measurements, notably for fat content.
    Type: Application
    Filed: September 25, 2020
    Publication date: November 3, 2022
    Inventors: Mathieu PERNOT, Thomas DEFFIEUX, Mickael TANTER, Clément PAPADACCI
  • Publication number: 20220273268
    Abstract: A cardiac device comprises a transmitter (10) arranged to transmit at least one wave, a probe (12) arranged to measure a shear wave caused by a wave coming from the transmitter (10), a detector (14) arranged to detect a systole phase in an electrocardiographic signal, and an estimator (16) arranged to determine, during at least one cardiac cycle, the propagation speed of a plurality of shear waves caused by the transmission of waves in several directions towards the heart of a patient, to determine using the detector (14) that which has a maximum propagation speed during the systole phase, and to derive an active cardiac stress response therefrom (160).
    Type: Application
    Filed: July 29, 2020
    Publication date: September 1, 2022
    Inventors: Dominique Chapelle, Philippe Moireau, Mathieu Pernot, Mickaël Tanter
  • Patent number: 11399804
    Abstract: A method for characterizing an anisotropic soft medium (C) including fibers and having an outer surface (1), by observing in different propagation directions, the propagation of a divergent shear wave from a central area (10) in the anisotropic soft medium. A propagation parameter of the shear wave is inferred therefrom in each of the propagation directions, and then a direction of the fibers of the anisotropic soft medium, a rheological elasticity parameter are determined in a direction perpendicular to the fibers and a rheological elasticity parameter in the direction of the fibers.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: August 2, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), ECOLE SUPRERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, UNIVERSITÉ PARIS DIDEROT—PARIS 7
    Inventors: Mickaël Tanter, Mathieu Pernot, Mathias Fink, Jean-Luc Gennisson
  • Publication number: 20220039776
    Abstract: The invention concerns a multi-sensor brain detecting apparatus, the detecting apparatus being adapted to obtain two different physical values of a brain of a subject, the detecting apparatus comprising: a set of sensors comprising an ultrasound transducer adapted to produce ultrasound waves, a frame with a position with relation to the brain known with a stereotaxic precision, the frame being adapted to hold a sensor that can be positioned at a specific location by a user of the detecting apparatus without using a tool.
    Type: Application
    Filed: October 21, 2021
    Publication date: February 10, 2022
    Inventors: Jean-Luc GENNISSON, Mickaël TANTER, Thomas DEFFIEUX, Mathieu PERNOT
  • Patent number: 11234677
    Abstract: The invention concerns a detecting apparatus (12) comprising:—at least two sensors (24, 26, 28), with at least one sensor (24) being an ultrasound transducer adapted to produce ultrasound waves, and—a positioning device (16) defining several compartments (22), each compartment (22) being adapted to hold a sensor (24, 26, 28) and each compartment (22) being located at predetermined location, the positioning device (16) comprising a holder adapted to be fixed on the skull of a subject, the positioning device (16) being adapted to be maintained on the head of the subject using the holder.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: February 1, 2022
    Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale), Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie (Paris 6), Université Paris Diderot—Pris 7, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris
    Inventors: Jean-Luc Gennisson, Mickaël Tanter, Thomas Deffieux, Mathieu Pernot
  • Patent number: 11141130
    Abstract: In order to obtain a predetermined ultrasonic wave field in a homogeneous internal part of a medium masked by an aberrating barrier, an ultrasonic lens is interposed between the emitting ultrasonic probe and the aberrating barrier. The ultrasonic lens is calculated by using a model of the medium comprising a mapping of ultrasonic wave propagation properties obtained from actual imaging of the medium such that when the ultrasound probe sends a predetermined ultrasonic wave, said predetermined wave generates the predetermined objective ultrasonic wave field in the medium.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: October 12, 2021
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MEDICALE)
    Inventors: Mickaël Tanter, Jean-François Aubry, Thomas Deffieux, Mathieu Pernot
  • Publication number: 20210212709
    Abstract: An ultrasonic processing apparatus is provided. The ultrasonic processing apparatus comprises an ultrasonic therapy transducer (ATA) adapted to generate focused ultrasonic waves; an ultrasonic imaging transducer (UID) connected to the ultrasonic therapy transducer; and an electronic system configured to control the ultrasonic therapy transducer so as to emit a pulse train of ultrasonic waves generating a cloud of cavitation bubbles (BC); control the ultrasonic imaging transducer so as to acquire at least one image of the region to be processed; acquire a plurality of echo signals of ultrasonic wave pulses emitted by the ultrasonic therapy transducer captured by the ultrasonic imaging transducer; process the plurality of echo signals so as to reconstruct an image of the cloud of cavitation bubbles; and display said image of the cloud of cavitation bubbles superposed on said image of the region to be processed. The processing includes spatio-temporal filtering.
    Type: Application
    Filed: May 24, 2019
    Publication date: July 15, 2021
    Inventors: Mathieu PERNOT, Daniel SUAREZ
  • Publication number: 20210196295
    Abstract: An apparatus for treating vascular thrombosis with ultrasound, includes a therapeutic ultrasonic transducer, suitable for generating focused ultrasonic waves that propagate along an emission axis; an imaging ultrasonic transducer associated with the therapeutic transducer; a means for moving the focal spot of the therapeutic ultrasonic transducer along the emission axis with respect to the imaging transducer; a motorized mechanical system for translating the transducers along at least a first axis parallel to the emission axis and a second axis perpendicular to the first; and an electronic control system for driving the motorized mechanical system and the means for moving the focal spot of the therapeutic transducer.
    Type: Application
    Filed: October 18, 2018
    Publication date: July 1, 2021
    Inventors: Guillaume GOUDOT, Mathieu PERNOT, Mickael TANTER, Michael VION
  • Patent number: 10974080
    Abstract: A method and system for secure ultrasound treatment of living tissues using an ultrasound probe comprising a reflective cavity in acoustic communication with living tissues, a transducer to emit an ultrasound wave in the reflective cavity and a transducer to acquire a backscattered signal in the reflective cavity. The method comprises the steps of a) emitting a first ultrasound wave in the reflective cavity that generates a backscattered ultrasound wave in the reflective cavity, b) acquiring a backscattered signal in the reflective cavity, c) determining whether an insonification can be safely performed by computing a similarity value between the backscattered signal and a predefined reference signal, and d) if an insonification can be safely performed, treating the living tissues with a second ultrasound wave emitted in the reflective cavity. The second ultrasound wave is focused a target point of the living tissues and generates a pressure point resulting in cavitation at this target point.
    Type: Grant
    Filed: February 19, 2018
    Date of Patent: April 13, 2021
    Assignees: CARDIAWAVE, ECOLE SUPÉRIEURE DE PHYSIQUE, INSERM, CNRS, UNIVERSITÉ PARIS DIDEROT—PARIS 7
    Inventors: Mickaël Tanter, Mathieu Pernot, Justine Robin
  • Patent number: 10955535
    Abstract: According to the invention, n incident acoustic waves Ei(t), obtained by linearly combining n elemental incident waves E0i(t) with an encoding matrix Hc are consecutively transmitted in a medium to be imaged. n reverberated waves Ri(t) from the medium to be imaged are then consecutively detected, following the transmission of the n incident waves; then n elemental reverberated waves R0i(t) are determined by linearly combining the detected n reverberated waves Ri(t) with a decoding matrix Hd. The Hc and Hd matrices are such that Hc·Hd=D, where D is a diagonal matrix of order n, all the diagonal elements of which are greater than 1.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: March 23, 2021
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM
    Inventors: Mickaël Tanter, Bruno-Félix Osmanski, Mathieu Pernot, Jean-Luc Gennisson
  • Patent number: 10952701
    Abstract: The invention concerns a detecting apparatus (12) for imaging at least two areas of a brain of a subject (10), the detecting apparatus (12) comprising: —a holder comprising: —a frame (14) devoted to be cemented on the skull of the subject (10), the frame (14) delimitating an inner portion (18) which is transparent to ultrasound waves, —a removable imaging device comprising: —a platform (16) delimitating an inner space (28), the inner space (28) facing the inner portion (18), —a fixing element (30) adapted to temporary fix and lock the platform (16) to the holder, —an ultrasound probe (32), and —a moving stage (34) holding the ultrasound probe (32) and being adapted to move the ultrasound probe (32) within the inner space (28).
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: March 23, 2021
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE RECHERCHE MEDICAL (INSERM), UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), UNIVERSITE PARIS DIDEROT—PARIS 7, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
    Inventors: Thomas Deffieux, Jean-Luc Gennisson, Mickaël Tanter, Ivan Cohen, Mathieu Pernot