Patents by Inventor Mats Inganas
Mats Inganas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10620194Abstract: A microscale method for the characterization of one or more reaction variables that influence the formation or dissociation of an affinity complex comprising a ligand and a binder, which have mutual affinity for each other.Type: GrantFiled: March 17, 2014Date of Patent: April 14, 2020Assignee: GYROS Patent ABInventors: Per Andersson, Mats Inganas, Gunnar Thorsén, Gunnar Kylberg
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Patent number: 10052630Abstract: A microfluidic device comprising one, two or more microchannel structures (101a-h), each of which comprises a reaction microcavity (104a-h) intended for retaining a solid phase material in the form of a wet porous bed. Each of said one, two or more microchannel structures comprises the solid phase material in a dry state together with a bed-preserving agent comprising one or more compounds having bed-preserving activity.Type: GrantFiled: February 2, 2011Date of Patent: August 21, 2018Assignee: GYROS PATENT ABInventors: Mats Inganas, Susanna Lindman, Helene Derand
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Patent number: 10036745Abstract: A method of quantitatively determining an analyte in a fluid sample by an immunoassay comprises binding of the analyte to a ligand capable of specifically binding to the analyte, wherein at least part of the analyte is present as an analyte complex is disclosed. The method comprises the steps of: a) subjecting the sample to a first acidic pH to at least substantially dissociate any analyte complex present and provide substantially all analyte in free form, b) raising the first acidic pH to a second acidic pH where re-formation of complexes is prevented but where binding of analyte to the ligand is permitted, and c) determining the binding of analyte to the ligand to quantitatively determine the analyte in the sample.Type: GrantFiled: October 3, 2013Date of Patent: July 31, 2018Assignee: GYROS Patent ABInventors: Mats Inganäs, Pirjo Lehtonen
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Publication number: 20160097777Abstract: The present invention relates to an in vitro method for the detection of an anti-drug antibody (ADA) against a therapeutic drug antibody (TDA) in a biological sample. The in vitro method comprises detecting and capturing said ADA using affinity moieties obtained from an intact therapeutic drug antibody, or a Fab fragment thereof, in a certain manner. Avoiding using only intact therapeutic drug antibodies or only Fab fragments thereof as reagents in such a method has been proven as an efficient way of increasing sensitivity, decreasing unspecific binding and the formation of large protein complexes. Such a method has great utility in therapeutic drug development or in the evaluation of a particular treatment of a patient.Type: ApplicationFiled: September 9, 2015Publication date: April 7, 2016Inventors: Cecilia Bill, Ann-Charlott Steffen, Mats Inganäs
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Publication number: 20150377873Abstract: A microscale method for the characterization of one or more reaction variables that influence the formation or dissociation of an affinity complex comprising a ligand and a binder, which have mutual affinity for each other.Type: ApplicationFiled: March 17, 2014Publication date: December 31, 2015Applicant: Gyros Patent ABInventors: Per Andersson, Mats Inganas, Gunnar Thorsén, Gunnar Kylberg
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Publication number: 20150268238Abstract: A method of quantitatively determining an analyte in a fluid sample by an immunoassay comprises binding of the analyte to a ligand capable of specifically binding to the analyte, wherein at least part of the analyte is present as an analyte complex is disclosed. The method comprises the steps of: a) subjecting the sample to a first acidic pH to at least substantially dissociate any analyte complex present and provide substantially all analyte in free form, b) raising the first acidic pH to a second acidic pH where re-formation of complexes is prevented but where binding of analyte to the ligand is permitted, and c) determining the binding of analyte to the ligand to quantitatively determine the analyte in the sample.Type: ApplicationFiled: October 3, 2013Publication date: September 24, 2015Applicant: GYROS PATENT ABInventors: Mats Inganäs, Pirjo Lehtonen
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Publication number: 20140199783Abstract: A microscale method for the characterization of one or more reaction variables that influence the formation or dissociation of an affinity complex comprising a ligand and a binder, which have mutual affinity for each other.Type: ApplicationFiled: March 17, 2014Publication date: July 17, 2014Applicant: Gyros Patent ABInventors: Per Andersson, Mats Inganas, Gunnar Thorsén, Gunnar Kylberg
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Patent number: 8592219Abstract: A method for transporting in a microfluidic conduit an aliquot of a liquid, possibly containing a substance I, which is dissolved in the liquid and typically exhibits charged groups and/or hydrophobic groups. The method is characterized in that the liquid contains an amphiphilic macromolecular substance.Type: GrantFiled: January 20, 2005Date of Patent: November 26, 2013Assignee: Gyros Patent ABInventors: Rickard Kange, Mats Inganas, Magnus Gustafsson, Johan Engstrom, Bo Ek, Helene Dérand, Ann-Kristine Honerud
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Patent number: 8133438Abstract: A microfluidic device that comprises a microchannel structure in which there are one, two or more flow paths (101;201a,b;301a,a?,b) all of which comprises a porous bed I (104,204,304) that is common for all of the flow paths and exposes an immobilized reactant R that is capable of interacting with a solute S that passes through the bed. The characteristics are that at least one of the flow paths comprises/comprise a second porous bed II (105,205,305) that is placed upstream of porous bed I (104,204,304) and is dummy with respect to interaction with solute S but capable of interacting with a substance DS that is present in a liquid aliquot together with solute S and is capable of disturbing the result of the interaction between solute S and said immobilized reactant R. There is also disclosed a method utilizing the device and variant of the device in which the immobilized R is replaced with a generic affinity ligand LI and/or porous bed II exposes a generic ligand LII that may be different from LI.Type: GrantFiled: January 31, 2005Date of Patent: March 13, 2012Assignee: Gyros Patent ABInventors: Johan Engström, Mats Inganäs, Gunnar Thorsén
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Publication number: 20110195524Abstract: The invention is related to a method for detection of an analyte in a sample, wherein the method is a semi-sequential assay procedure.Type: ApplicationFiled: October 6, 2009Publication date: August 11, 2011Inventors: Mats Inganas, Karolina Osterlund, Anna Moller
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Publication number: 20110131830Abstract: A microfluidic device comprising one, two or more microchannel structures (101a-h), each of which comprises a reaction microcavity (104a-h) intended for retaining a solid phase material in the form of a wet porous bed. Each of said one, two or more microchannel structures comprises the solid phase material in a dry state together with a bed-preserving agent comprising one or more compounds having bed-preserving activity.Type: ApplicationFiled: February 2, 2011Publication date: June 9, 2011Inventors: Mats Inganas, Susanna Lindman, Helene Dérand
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Publication number: 20110091904Abstract: The invention is related to a method for quantification of a first dissociation equilibrium constant Kd1 for a complex AB between interactants A and B relative to a second dissociation equilibrium constant Kd2 for a complex CD between interactants C and D.Type: ApplicationFiled: March 5, 2009Publication date: April 21, 2011Applicant: GYROS PATENT ABInventors: Mats Inganas, Josefin Bolik, Johan Engstroem, Karolina Osterlund
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Publication number: 20110071050Abstract: A collection of one or more microfluidic devices which together carry a plurality of microchannel structures each of which comprises a reaction microcavity in which there is a solid phase with an immobilized affinity ligand L, characterized in that (i) the plurality is divided into sets of microchannel structures, and (ii) the affinity ligand L is directed to the same counterpart (binder, B) independent of set, and (iii) the sets differ in a) the capacity per reaction microcavity and/or the capacity/unit volume of the solid phase in a reaction microcavity for binder B, and/or b) the base matrix of the solid phase between the sets but are equal within each set.Type: ApplicationFiled: November 18, 2010Publication date: March 24, 2011Inventor: Mats Inganäs
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Publication number: 20110033953Abstract: A microscale method for the characterization of one or more reaction variables that influence the formation or dissociation of an affinity complex comprising a ligand and a binder, which have mutual affinity for each other.Type: ApplicationFiled: June 7, 2010Publication date: February 10, 2011Inventors: Per Andersson, Mats Inganas, Gunnar Thorsen, Gunnar Kylberg
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Patent number: 7759067Abstract: A microscale method for the characterization of one or more reaction variables that influence the formation or dissociation of an affinity complex comprising a ligand and a binder, which have mutual affinity for each other.Type: GrantFiled: March 19, 2002Date of Patent: July 20, 2010Assignee: Gyros Patent ABInventors: Per Andersson, Mats Inganas, Gunnar Thorsen, Gunnar Kylberg
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Publication number: 20100151594Abstract: A collection of one or more microfluidic devices which together carry a plurality of microchannel structures each of which comprises a reaction microcavity (104a-h) in which there is a solid phase with an immobilized affinity ligand L, characterized in that (i) the plurality is divided into sets of microchannel structures, and (ii) the affinity ligand L is directed to the same counterpart (binder, B) independent of set, and (iii) the sets differ in a) the capacity per reaction microcavity and/or the capacity/unit volume of the solid phase in a reaction microcavity for binder B, and/or b) the base matrix of the solid phase between the sets but are equal within each set.Type: ApplicationFiled: March 1, 2010Publication date: June 17, 2010Inventor: Mats Inganäs
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Patent number: 7616791Abstract: The present invention relates to a method, a system, a neural network and a computer program product for determining the quality of an analytical process, preferably the confidence value. The analytical process is performed in a microchannel structure of a microfluidic device, from which data information of the analytic process is acquired by scanning at least one search area of the microchannel structure for signal data. The search area comprises the result of the analytical process and the acquired data information is stored as an image, one image for each scanned search area.Type: GrantFiled: June 30, 2004Date of Patent: November 10, 2009Assignee: Gyros Patent ABInventors: Tobias Söderman, Mats Inganäs
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Publication number: 20090215196Abstract: A method for determination of an analyte in an original liquid sample by performing an inhibition affinity assay in a microchannel structure of a microfluidic device.Type: ApplicationFiled: July 15, 2005Publication date: August 27, 2009Applicant: GYROS Patent ABInventors: Bo Ek, Mats Holmquist, Karolina Osterlund, Mats Inganas
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Publication number: 20090010819Abstract: A flow path comprising a reaction cavity in which there is a solid phase to which an affinity reactant I1 has been immobilized by the use of an immobilizing pair of reactive structures that comprises a) a plurality of functional equal structures RSsp on the solid phase, and b) a structure RSari on affinity reactant I1, where RSsp and RSari are mutually reactive with each other to the formation of a link structure that immobilizes affinity reactant I1 to the solid phase. The characteristic feature is that the solid phase comprises a plurality of structures that derive from RSsp but do not immobilize affinity reactant I1 to the solid phase.Type: ApplicationFiled: January 17, 2006Publication date: January 8, 2009Applicant: GYROS Patent ABInventors: Mats Holmquist, Mats Inganas, Gerald Jesson, Magnus Ljungstrom
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Publication number: 20080280378Abstract: The invention is a method for grading a polyclonal antibody response with respect to a desired 5 binding specificity. The response is provoked by an antigenic agent in a host, preferably a vertebrate host. The characteristic feature of the method comprises the steps of: (i) providing a reaction microcavity having an inlet end and an outlet end and containing a solid phase that exposes an immobilized binding structure (BS) that are capable of affinity binding antibodies (Ab) of the response, (ii) flowing a liquid sample containing antibodies of the response in the direction from the inlet end to the outlet end through the solid phase, (iii) determining the distribution of antibodies, which are captured during step (ii), along the flow direction of the solid phase, and (iv) grading the response based on the distribution determined in step (iii).Type: ApplicationFiled: July 15, 2005Publication date: November 13, 2008Applicant: GYROS Patent AB Gyros ABInventor: Mats Inganas