Abstract: Purified Ref polypeptides with increased nuclease site-specific targeting activity, recombinant nucleic acids and cells for expression of such Ref polypeptides, and methods for using the Ref polypeptides in combination with RecA protein and variants thereof to effect targeted nuclease cleavage of a DNA duplex are disclosed.

Abstract: This present invention describes the derivation and selection of antibodies capable of neutralising the major exotoxins; TcdA and TcdB of Clostridium difficile. The invention also describes novel neutralisation and antigen binding properties of individual Mabs and mixtures thereof.

Abstract: A computer can be configured to provide seamless access to a proxy server by, upon connection to a computer network, determining whether a proxy server using authentication is connected to the computer network, and then prompting a user of the computer to enter authentication information for that proxy server. This authentication information for the proxy server then can be stored in a manner accessible by applications on the computer to use the authentication information to connection with requests by the applications to access the second computer network. For example, the operating system can store the authentication information. It also can include a module that processes all requests from applications that access the proxy server, and then includes in such requests the stored authentication information.

Abstract: Pressed and segmented gas generant grain assemblies formed from a plurality of symmetric gas generant pieces or segments are disclosed. The symmetric pieces or segments are arranged circumferentially to define a substantially round, segmented body. In certain variations, the symmetric segments are substantially free of polymeric binder and have a high density. The segmented pressed grain assemblies are more robust and less expensive to manufacture, while still exhibiting desired combustion performance. Methods of making such segmented gas generant grain assemblies are also provided.

Abstract: An airbag assembly may include an airbag and an inflator in fluid communication with the airbag. The inflator may have a first chamber containing a first gas source and a second chamber containing a second gas source. A filter module may be positioned to filter and redirect gas flows from the first and second gas sources. The filter module may be constructed by securing a baffle within an interior cavity of a filter medium having a generally tubular shape, prior to installation of the filter module the inflator. The baffle may be supported directly by the material of the filter module, by a bracket, or by a support structure formed of wire thicker than that of the filter medium. The baffle may maintain isolation between the first and second chambers, or may help gas from the first gas source initiate gas provision from the second gas source.

Abstract: An airbag assembly may include an airbag and an inflator in fluid communication with the airbag. The inflator may have a first chamber containing a first gas source and a second chamber containing a second gas source. A filter module may be positioned to filter and redirect gas flows from the first and second gas sources. The filter module may be constructed by securing a baffle within an interior cavity of a filter medium having a generally tubular shape, prior to installation of the filter module the inflator. The baffle may be supported directly by the material of the filter module, by a bracket, or by a support structure formed of wire thicker than that of the filter medium. The baffle may maintain isolation between the first and second chambers, or may help gas from the first gas source initiate gas provision from the second gas source.

Abstract: A system for a system administrator to distribute and manage multiple content feeds and supplemental content using an on-screen interactive interface includes: (a) a multimedia server configured for integrating streaming contents from various streaming content providers through a network, (b) a multimedia controller adapted for receiving broadcast contents from various broadcast systems, and the streaming contents from the multimedia server, and (c) a multimedia control platform for a user to manage, access, and select the broadcast and streaming contents from the multimedia server through an on-screen interactive interface, and to display selected contents on an end user device.

Abstract: A system for system administrator to distribute and manage multiple content feeds and supplemental content using an on-screen interactive interface includes: (a) various multimedia sources configured to provide multiple content feeds and supplemental contents, (b) a multimedia server configured to integrate multiple content feeds and supplemental contents over a network, (c) a computer communicatively coupled to the network configured for the system administrator to manage the schedule and the source of the multimedia sources, and (d) a multimedia control platform for various viewers to manage, access, and select the multiple content feeds and supplemental contents from the multimedia server through an on-screen interactive interface, and to display selected contents in various end user devices.

Abstract: A pyrotechnic inflator assembly including a shell member and an end cap joinable with the shell member to form a subassembly. The subassembly contains a quantity of pyrotechnic material and at least in part defines a combustion chamber wherein at least a portion of the quantity of pyrotechnic material is reactable to form product gas for inflation of an associated airbag cushion and to generate pressure therewithin. A diffuser assembly can be disposed adjacent an end of the shell member and includes flow control features for controlling flow of product gas from the inflator assembly. The inflator assembly further includes a composite overwrap about at least a portion of the subassembly and the diffuser assembly such that the pyrotechnic inflator assembly can withstand the pressure generated within the combustion chamber upon reaction of the pyrotechnic material. Corresponding methods of making a pyrotechnic inflator assembly are also provided.

Abstract: A relief valve is provided and may include a housing having a first inlet port and a second inlet port. An initiator may be disposed within the housing and an engagement member may be slideably disposed within the housing and may be moveable between a retracted position and an extended position under force of the initiator. The engagement member may include a first bore aligned with the first inlet port in the extended position and a second bore aligned with the second inlet port in the extended position.

Abstract: An inflator including an initiator and a bulkhead molded around the initiator. The inflator includes a housing formed of two overlapping housing portions mechanically coupled together around a portion of the bulkhead. One of the housing portions includes cut tabs that are crimped into cut receivers of the other housing portion.

Abstract: An inflator including an initiator and a bulkhead molded around the initiator. The inflator includes a housing formed of two overlapping housing portions mechanically coupled together around a portion of the bulkhead. One of the housing portions includes cut tabs that are crimped into cut receivers of the other housing portion.

Abstract: A power miter saw of the type which has an upper fixed blade guard and a lower swinging blade guard for covering the lower reach of an installed blade when the saw is in its rest position and for exposing the lower reach of the saw blade when moved to its operational position, the saw comprising an adjustable length elongated linkage mechanism interconnecting a frame support and the lower blade guard for moving the lower blade guard in response to movement of the saw between the rest and operational positions, such that the lower blade guard covers the lower reach of the blade when the saw is in its rest position and uncovers the blade when the saw is moved to its operational position, the linkage mechanism permitting the exposure of a blade arbor to facilitate changing of the blade.

Abstract: Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Abstract: A client system and a server system use a Hypertext Transfer Protocol (HTTP) authentication mode preference header to negotiate an HTTP authentication mode. The client system sends an HTTP request to the server system. In response to the HTTP request, the server system sends an HTTP response to the client system. The HTTP response includes an HTTP authentication mode preference header. The HTTP authentication mode preference header indicates whether a preferred HTTP authentication mode is connection-based HTTP authentication or request-based HTTP authentication. In subsequent HTTP requests to the server system, the client system uses the HTTP authentication mode indicated by the HTTP authentication mode preference header.

Abstract: A miter saw with work surface extensions comprises a base with a rotatable table positioned on the base. The miter saw further comprises a bevel support is that is pivotable with respect to a table surface. A cutting blade is supported by the bevel support. A work surface extension is moveably connected to the base between a retracted position and an extended position. The work surface extension provides a work surface that is substantially planar with the table surface. At least one elongated member is fixed to the work surface extension and moveably engages the base. A substantial portion of the at least one elongated member is positioned within or under the base when the work surface extension is in the retracted position. The substantial portion of the at least one elongated member is positioned between the base and the work surface extension when the at least one elongated member is in the extended position.

Abstract: Inflators for safe transport and use with an inflatable airbag cushion and airbag systems include a diffuser comprising a first aperture and at least one vent aperture each disposed in a lateral sidewall of the diffuser. The first aperture and the at least one vent aperture are positioned to face in at least substantially opposite directions in the diffuser. A filter is positioned within the diffuser and includes an outer surface having a lateral extent less than a lateral extent of an inner surface of the lateral sidewall of the diffuser, resulting in a gap between the outer surface of the filter and the inner surface of the lateral sidewall of the diffuser. At least one reaction device is coupled to a longitudinal end of the diffuser. Methods of making such inflators are also included.

Abstract: An inflator including a housing with a first chamber that contains a quantity of gas generant. An initiator is operatively associated with the first chamber and in reaction initiating communication with at least a portion of the quantity of gas generant. The initiator, upon actuation, acts to ignite at least a portion of the quantity of gas generant to form gas. The housing further has a second chamber adjacently disposed to the first chamber. The second chamber contains a sealed storage reservoir and a piston assembly. The sealed storage reservoir includes a liner and a lid and contains a quantity of liquid. The piston assembly includes a piston. During deployment, the piston moves to unseal the storage reservoir to release at least a portion of the quantity of liquid such that the released liquid contacts and cools gas formed by the ignition of the gas generant. A discharge opening permits gas to exit the housing.