Abstract: Among other things, a chiller for chilling water to be dispensed as part of beverages includes a tank configured to contain a cooling mass for chilling the water. A first tube in the tank is configured to be immersed in the cooling mass and to carry the water along a path from a source towards a location where the chilled water is to be dispensed as part of the beverages. A second tube is configured to be immersed in the cooling mass and to carry a coolant along a recirculation path from a coolant source and back to the coolant source. The coolant has a sufficiently low temperature to cause a frozen mass to be formed as part of the cooling mass within the tank and in the vicinity of the second tube. The first tube and the second tube are configured and positioned relative to one another within the tank so that the frozen mass occupies at least 30 percent of the volume of the cooling mass in the tank but does not touch the first tube.

Abstract: The invention relates to compounds of Formula (I): wherein R1, R2 and R3 are as defined in the description and claims, or pharmaceutically acceptable salts thereof, having ?v?6 integrin antagonist activity. The invention also relates to pharmaceutical compositions including a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and to the use of a compound of Formula (I), or a pharmaceutically acceptable salt thereof, in therapy, including in the treatment of a disease or condition for which an ?v?6 integrin antagonist is indicated, in particular the treatment of idiopathic pulmonary fibrosis.

Abstract: Improved battery separators are disclosed herein for use in flooded lead-acid batteries, and in particular enhanced flooded lead-acid batteries. The improved separators disclosed herein provide for enhanced electrolyte mixing and substantially reduced acid stratification. The improved flooded lead-acid batteries may be advantageously employed in applications in which the battery remains in a partial state of charge, for instance in start/stop vehicle systems. Also, improved lead-acid batteries, such as flooded lead-acid batteries, improved systems that include a lead-acid battery and a battery separator, improved battery separators, improved vehicles including such systems, and/or methods of manufacture and/or use may be provided.

Abstract: Improved battery separators are disclosed herein for use in flooded lead-acid batteries, and in particular enhanced flooded lead-acid batteries. The improved separators disclosed herein provide for enhanced electrolyte mixing and substantially reduced acid stratification. The improved flooded lead-acid batteries may be advantageously employed in applications in which the battery remains in a partial state of charge, for instance in start/stop vehicle systems. Also, improved lead-acid batteries, such as flooded lead-acid batteries, improved systems that include a lead-acid battery and a battery separator, improved battery separators, improved vehicles including such systems, and/or methods of manufacture and/or use may be provided.

Abstract: The spinal cord stimulation device of this invention is configured for implantation into a patient so as to traverse the dura mater that surrounds the spinal cord. Placing the device in this location provides direct contact between the electrode and the cerebrospinal fluid (CSF), in close proximity to the spinal cord. The device has an intradural portion and an extradural portion that compresses and seals the dural membrane between them, securing the device in position and preventing leakage of CSF. The position of the device may be stabilized in relation to the spinal cord by way of a laminoplasty plate, bridging between the device and a vertebra. The device is electronically powered by an implanted pulse generator that produces a spectrum of signals to interrupt or otherwise attenuate transmission of pain mediating neural signals through the spinal cord.

Abstract: An adjustable cranioplasty plate assembly is provided for use following a craniectomy. The assembly includes a ring which is attached to the skull around the skull opening and a plate adjustably mounted to the ring. The plate is moveable between a raised position spaced above the ring and a lower position substantially flush with the ring. The plurality of extendable and retractable struts extends between the ring and the plate to provide the plate adjustability. The plurality of stay cables extending between the ring and the plate provide lateral stability in the raised position. The assembly replaces the native bone and eliminates the need for subsequent cranioplasty surgery. In one embodiment, the plate includes a rigid central portion, three rigid mounting tabs, and a plurality of malleable tapered perimeter petals which provide a smooth interface between the plate and the skull of the patient.

Abstract: An adjustable bed system includes a frame structure, a back lifting assembly and a leg lifting assembly pivotally connected to the frame structure, platforms having a plurality of openings, disposed on the frame structure and operably coupled with the back and leg lifting assemblies, a mattress having a plurality of through holes and disposed on the platforms so that the plurality of through holes is aligned with the plurality of openings, respectively, and a plurality of fans installed in the plurality of openings of the platforms such that each fan is in communication with a respective through hole of the mattress for operably moving air via said through hole into the mattress body and outputting the air from the top surface of the mattress. Positions of upper and lower portions of the mattress are adjustable based on operations of the back and assemblies.

Abstract: This invention provides an device for electrical stimulation of the spinal cord. The device has an electrode assembly with a sufficiently thin profile to be implanted between the pial surface of the spinal cord and the dura mater, and secured to the dura. Electrodes on the electrode assembly are directed towards the surface of the spinal cord, and connected through the dura to a signal generator located outside the dura. Following implantation, the subject is treated by transmitting electrical signals from the signal generator through the leads to the electrodes, stimulating the subject's spinal cord.

Abstract: This invention provides a device for implantation directly into the spinal cord for the purpose of treating back pain. Electrodes on a backing that conforms directly to the spinal cord are installed as a source of electrical stimulation and pain relief. The floating electrodes can be flexibly mounted to the substrate such that when the electrode array is implanted into the subject, individual electrodes float or move resiliently relative to the substrate to an extent sufficient to accommodate pulsations of the surface of the spinal cord within the dura.

Abstract: Among other things, a chiller for chilling water to be dispensed as part of beverages includes a tank configured to contain a cooling mass for chilling the water. A first tube in the tank is configured to be immersed in the cooling mass and to carry the water along a path from a source towards a location where the chilled water is to be dispensed as part of the beverages. A second tube is configured to be immersed in the cooling mass and to carry a coolant along a recirculation path from a coolant source and back to the coolant source. The coolant has a sufficiently low temperature to cause a frozen mass to be formed as part of the cooling mass within the tank and in the vicinity of the second tube. The first tube and the second tube are configured and positioned relative to one another within the tank so that the frozen mass occupies at least 30 percent of the volume of the cooling mass in the tank but does not touch the first tube.

Abstract: A compound of formula (I) or a salt thereof: wherein R1 represents a five-membered aromatic heterocycle selected from a N- or a C-linked mono- or di-substituted pyrazole, an N- or a C-linked optionally mono- or di-substituted triazole or an N- or a C-linked optionally mono- or di-substituted imidazole, which five-membered aromatic heterocycle may be substituted by one or two of the groups selected from a hydrogen atom, a methyl group, an ethyl group, a fluorine atom, a hydroxymethyl group, a 2-hydroxypropan-2-yl group, a trifluoromethyl group, a difluoromethyl group or a fluoromethyl group, except that when R1 represents an N-linked mono- or di-substituted pyrazole, R1 does not represent 3,5-Dimethyl-1H-pyrazol-1-yl, 5-Methyl-1H-pyrazol-1-yl, 5-Ethyl-3-methyl-1H-pyrazol-1-yl, 3,5-Diethyl-1H-pyrazol-1-yl, 4-Fluoro-3,5-dimethyl-1H-pyrazol-1-yl, 3-Methyl-1H-pyrazol-1-yl or 1H-pyrazol-1-yl.

Abstract: The invention relates to compounds of Formula (I): wherein R1, R2 and R3 are as defined in the description and claims, or pharmaceutically acceptable salts thereof, having ?v?6 integrin antagonist activity. The invention also relates to pharmaceutical compositions including a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and to the use of a compound of Formula (I), or a pharmaceutically acceptable salt thereof in therapy, including in the treatment of a disease or condition for which an ?v?6 integrin antagonist is indicated, in particular the treatment of idiopathic pulmonary fibrosis.

Abstract: The present disclosure generally relates to thermoplastic truss structures and methods of forming the same. The truss structures are formed using thermoplastic materials, such as fiber reinforced thermoplastic resins, and facilitate directional load support based on the shape of the truss structure. In one example, multiple two-dimensional patterns of fiber reinforced thermoplastic resin are disposed on one another in a saw tooth pattern, sinusoidal pattern, or other repeating pattern, and adhered to one another in selective locations. The two dimensional patterns may then be expanded in a third dimension to form a three-dimensional, cross-linked truss structure. The three-dimensional, cross-linked truss structure may then be heated or otherwise treated to maintain the three-dimensional shape.

Abstract: An adjustable cranioplasty plate assembly is provided for use following a craniectomy. The assembly includes a ring which is attached to the skull around the skull opening and a plate adjustably mounted to the ring. The plate is moveable between a raised position spaced above the ring and a lower position substantially flush with the ring. The plurality of extendable and retractable struts extends between the ring and the plate to provide the plate adjustability. The plurality of stay cables extending between the ring and the plate provide lateral stability in the raised position. The assembly replaces the native bone and eliminates the need for subsequent cranioplasty surgery. In one embodiment, the plate includes a rigid central portion, three rigid mounting tabs, and a plurality of malleable tapered perimeter petals which provide a smooth interface between the plate and the skull of the patient.

Abstract: A compound of formula (I): being 4-(3-Fluoro-3-(2-(5, 6, 7, 8-tetrahydro-1, 8-naphthyridin-2-yl) ethyl) pyrrolidin-1-yl)-3-(3-(2-methoxyethoxy) phenyl) butanoic acid, or a salt thereof.

Abstract: The present disclosure generally relates to thermoplastic truss structures and methods of forming the same. The truss structures are formed using thermoplastic materials, such as fiber reinforced thermoplastic resins, and facilitate directional load support based on the shape of the truss structure. In one example, multiple two-dimensional patterns of fiber reinforced thermoplastic resin are disposed on one another in a saw tooth pattern, sinusoidal pattern, or other repeating pattern, and adhered to one another in selective locations. The two dimensional patterns may then be expanded in a third dimension to form a three-dimensional, cross-linked truss structure. The three-dimensional, cross-linked truss structure may then be heated or otherwise treated to maintain the three-dimensional shape.

Abstract: A compound of formula (I): being 4-(3-Fluoro-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl) ethyl) pyrrolidin-1-yl)-3-(3-(2-methoxyethoxy) phenyl) butanoic acid, or a salt thereof.

Abstract: The invention relates to compounds of Formula (I): wherein R1, R2 and R3 are as defined in the description and claims, or pharmaceutically acceptable salts thereof, having ?v?6 integrin antagonist activity. The invention also relates to pharmaceutical compositions including a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and to the use of a compound of Formula (I), or a pharmaceutically acceptable salt thereof in therapy, including in the treatment of a disease or condition for which an ?v?6 integrin antagonist is indicated, in particular the treatment of idiopathic pulmonary fibrosis.

Abstract: A compound of formula (I) or a salt thereof: wherein R1 represents a five-membered aromatic heterocycle selected from a N- or a C-linked mono- or di-substituted pyrazole, an N- or a C-linked optionally mono- or di-substituted triazole or an N- or a C-linked optionally mono- or di-substituted imidazole, which five-membered aromatic heterocycle may be substituted by one or two of the groups selected from a hydrogen atom, a methyl group, an ethyl group, a fluorine atom, a hydroxymethyl group, a 2-hydroxypropan-2-yl group, a trifluoromethyl group, a difluoromethyl group or a fluoromethyl group, except that when R1 represents an N-linked mono- or di-substituted pyrazole, R1 does not represent 3,5-Dimethyl-1H-pyrazol-1-yl, 5-Methyl-1H-pyrazol-1-yl, 5-Ethyl-3-methyl-1H-pyrazol-1-yl, 3,5-Diethyl-1H-pyrazol-1-yl, 4-Fluoro-3,5-dimethyl-1H-pyrazol-1-yl, 3-Methyl-1H-pyrazol-1-yl or 1H-pyrazol-1-yl.

Abstract: Apparatus and methods for bone cavity preparation. Formed broaching members may be supported inside a bone by a rotator. The broaching members may be bowed out inside the bone to create a cavity having a shape determined by the broaching members and bone anatomy.