Abstract: A therapy planning system and method generate an optimal treatment plan accounting for changes in anatomy. Therapy is delivered to the subject according to a first auto-planned optimal treatment plan based on a first image of a subject. A second image of the subject is received after a period of time. The second image is registered with the first image to generate a deformation map accounting for physiological changes. The second image is segmented into regions of interest using the deformation map. A mapped delivered dose is computed for each region of interest using the dose delivery goals and the deformation map. The first treatment plan is merged with the segmented regions of the second image and the mapped delivered dose during optimization.

Abstract: A multiple-firing clip device comprises a shaft comprising an exterior surface, an interior receiving therein suture fixation clips, and a distal end opening shaped to eject a suture fixation clip therefrom. The shaft defines a lateral opening and a distal shaft portion between the lateral opening and the distal end opening. A shuttle moves on the shaft and comprises a shuttle body, a snare having a distal snare portion, and a snare extension slide movable from the shuttle body along a given extent defining a slide distance and a distal end. The shuttle extends at least the distal snare portion distally through the lateral opening from the environment into the interior, through the distal shaft portion, and through the distal end opening along a length that is at least equal to the slide distance when the snare extension slide moves to the distal end of the given extent.

Abstract: Provided is an air or gas cleaning blower with a spiral separation chamber. An impeller draws in particulate-pervaded air or gas and imposes a centrifugal force that accelerates the particulate-pervaded air or gas outwards in the chamber. The particulates, because of their heavier mass relative to the air or gas, accumulate against the outer chamber wall. Most of the lighter air or gas is unable to penetrate through the layer of particulates and is trapped in between the particulates about the outer wall and the inner wall of the chamber. The impeller pushes the separated particulates and cleaned air or gas further down the chamber with the particulates ejecting out a first outlet about the outer chamber wall and the cleaned air or gas circulating around the first outlet, moving further down the chamber, and ejecting out a second outlet.

Abstract: A delivery apparatus can include a handle portion and at least one rotatable drive shaft. The handle portion can have an actuation mechanism with a motor. The rotatable drive shaft can have a proximal end portion and a distal end portion. The proximal end portion of the rotatable drive shaft can be coupled to the motor, and the distal end portion of the rotatable drive shaft can be configured to be releasably coupled to a prosthetic heart valve. The actuation mechanism can be configured to control and monitor expansion of the prosthetic heart valve and to control and monitor torque of the motor.

Abstract: A controllable stiffness catheter comprising a shaft comprising an inner sheath defining an access lumen, an outer sheath surrounding the inner sheath and defining an annulus therebetween, the annulus having a vacuum connection at which a vacuum is applied to the annulus, and a mechanical stiffener disposed at least at a portion of the annulus.

Abstract: An ultrasonic surgical device includes a handle body, an ultrasonic waveguide engaged with the handle body and extending distally therefrom and including a proximal end portion disposed at the handle body, an ultrasonic generator releasably engagable with the handle body and including a first set of contacts, and an ultrasonic transducer releasably engagable with the handle body independently of the ultrasonic generator. The ultrasonic transducer includes a distal end portion configured to engage the proximal end portion of the ultrasonic waveguide and a second set of contacts configured to electrically couple to the first set of contacts.

Abstract: A method for operating a surgical instrument, which comprises providing a surgical instrument handle, electrically connecting a controller disposed within the surgical instrument handle to a communication connection of a receiving portion of the surgical instrument, removably securing an interchangeable part at the receiving portion, the interchangeable part having an encryption device electrically connected to the communication connection when the interchangeable part is at the receiving portion, authenticating the interchangeable part upon an exchange between the controller and the encryption device, and after at least a partial use of the interchangeable part, storing within the encryption device a used status of the interchangeable part.

Abstract: This disclosure describes exemplary screw and intramedullary devices that are better able to bring bone fragments into close proximity with each other, generate a compressive load, and maintain that compressive load for a prolonged period of time while healing occurs. The devices are made of a shape memory material.

Abstract: A disposable ultrasonic surgical handle includes a disposable handle body defining a battery-holding compartment shaped to receive a battery therein and operable to couple a proximal end of an ultrasonic waveguide to an ultrasonic transducer therethrough. The body has a transducer dock exposed to the environment and interchangeably housing the transducer and a waveguide attachment dock shaped to align and attach the proximal end of the waveguide to the transducer and hold them at the body when the respectively docked at the transducer and attachment docks. A disposable driving-wave generation circuit in the handle body electrically contacts the battery and the transducer when the battery and the transducer are disposed respectively in the battery-holding compartment and the transducer dock. The circuit generates an output waveform sufficient to cause ultrasonic movement along the waveguide by exciting the transducer when the transducer is coupled to the waveguide.

Abstract: Arthrodesis devices and arthrodesis procedures are disclosed herein. In an embodiment, an arthrodesis device includes a shape memory material connecting member attached to two points of fixation.

Abstract: A method for manufacturing a surgical instrument to have a manual release, which comprises mechanically coupling a manual release to a transmission of a surgical instrument having a self-contained power source disposed within a handle thereof, the transmission mechanically connecting an electrically-powered motor inside the handle to a movable part of a surgical end effector connected to the handle such that the transmission is operable to displace the movable part to a starting position, an actuated position, and at least one point between the starting position and the actuated position when the motor is operated; and wherein the manual release is operable to interrupt the transmission from operation of the motor and, during interruption, displace the movable part towards the starting position irrespective of the position of the movable part and independent of operation of the motor.

Abstract: An external LAA exclusion clip comprises a clipping assembly comprising first and second opposing clip struts each of the clip struts having a tissue-contacting surface and first and second bias surfaces, a bias assembly connecting the first clip strut to the second clip strut to align the first and second clip struts in a strut plane passing through the tissue-contacting surface. The bias assembly comprises at least one first bias spring connected to the first bias surface of the first clip strut and to the first bias surface of the second clip strut and at least one second bias spring connected to the second bias surface of the first clip strut and the second bias surface of the second clip strut. The first bias spring and the second bias spring are configured to permit movement of the first and second clip struts in the strut plane.

Abstract: A delivery apparatus can include a handle portion and at least one rotatable drive shaft. The handle portion has an actuation mechanism. The actuation mechanism includes a motor and one or more actuators. The rotatable drive shaft has a proximal end portion and a distal end portion. The proximal end portion is coupled to the motor, and the distal end portion is configured to be releasably coupled to a prosthetic heart valve. The actuation mechanism is configured to control and monitor expansion of the prosthetic heart valve. The handle is configured for actuating the actuation mechanism, tracking a response of native tissue when the prosthetic heart valve is in contact with the native tissue, and stopping expansion of the prosthetic heart valve once a rate of change of expansion of the prosthetic heart valve declines below a threshold.

Abstract: A multiple-firing crimp device comprises crimps, a shaft, a crimp movement assembly, and a snare. Each crimp has an internal hollow. The shaft has a distal crimping location, an exterior surface, and an interior with the clips stacked therein, the crimps moving therein along a longitudinal axis. The shaft defines a lateral opening proximal to the crimping location and communicates the interior to the environment outside the exterior surface. The crimp movement assembly within the shaft delivers the first crimp to the distal crimping location by moving the first crimp longitudinally from a first proximal position into the distal crimping location and returning to a second proximal position without the first crimp. The snare pulls at least one cord from distal of the first crimp through the first crimp and through a portion of the shaft and out the side of the shaft through the lateral opening.

Abstract: A multiple-firing crimp device comprises crimps, a shaft, a crimp movement assembly, and a snare. Each crimp has an internal hollow. The shaft has a distal crimping location, an exterior surface, and an interior with the clips stacked therein, the crimps moving therein along a longitudinal axis. The shaft defines a lateral opening proximal to the crimping location and communicates the interior to the environment outside the exterior surface. The crimp movement assembly within the shaft delivers the first crimp to the distal crimping location by moving the first crimp longitudinally from a first proximal position into the distal crimping location and returning to a second proximal position without the first crimp. The snare pulls at least one cord from distal of the first crimp through the first crimp and through a portion of the shaft and out the side of the shaft through the lateral opening.

Abstract: A downhole sensor includes a sensor housing with one or more of a pressure sensor or a temperature sensor. A cable segment having a conductor is coupled to the sensor housing. A spacer or retention element is coupled to or secured to at least a portion of the conductor at a location proximate an interface between the cable segment and the sensor housing. Downhole sensor arrays include such sensor housings. Methods relate to forming such sensor arrays.

Abstract: A surgical instrument comprising a surgical end effector, operable to effect a surgical procedure when actuated, and an actuation assembly operable to actuate said surgical end effector. The actuation assembly comprises a part operable to move between a starting position and an actuated position in which the part actuates the surgical end effector, an electrically-powered motor, a transmission mechanically connecting the motor to the part and being operable to selectively displace the part to the starting position, the actuated position, and at least one point between the starting position and the actuated position when the motor is operated, and a manual release mechanically coupled to the transmission to selectively interrupt the transmission and, during interruption, displace the part towards the starting position independent of operation of the motor.

Abstract: A surgical instrument that comprises a receiving portion for removably receiving therein an interchangeable part, wherein the receiving portion has a communication connection, a handle having a controller electrically connected to the communication connection, and an interchangeable part removably connected to the receiving portion and having an encryption device electrically removably connected to the communication connection when at the receiving portion, wherein the encryption device is programmed to authenticate the interchangeable part upon an exchange with the controller when the interchangeable part is at the receiving portion and, after at least a partial use of the interchangeable part, store a used status of the interchangeable part.

Abstract: Arthrodesis devices and arthrodesis procedures are disclosed herein. In an embodiment, an arthrodesis device includes a shape memory material connecting member attached to two points of fixation.

Abstract: This disclosure describes exemplary screw and intramedullary devices that are better able to bring bone fragments into close proximity with each other, generate a compressive load, and maintain that compressive load for a prolonged period of time while healing occurs. The devices are made of a shape memory material.