Abstract: Provided herein are novel anti-CD20 x anti-CD28 antibodies and methods of using such antibodies for the treatment of B-cell malignancies. Subject anti-CD20 x anti-CD28 antibodies are capable of agonistically binding to CD28 costimulatory molecules on T cells and CD20 on tumor cells. Thus, such antibodies enhance anti-tumor activity at tumor sites. The subject antibodies provided herein are particularly useful in combination with other anti-cancer therapies (e.g., anti-CD3 x anti-CD20 x anti-CD79b antibodies) for the treatment of B-cell malignancies.

Abstract: The use of a compound as a corrosion inhibitor for metallic equipment, where the compound includes (i) a salt of an optionally substituted polycarboxylic acid or an anhydride thereof; and/or (ii) the reaction product of reactants comprising an optionally substituted polycarboxylic acid or an anhydride thereof and an alcohol and/or an amine, or a salt of the reaction product.

Abstract: A system and method for multimedia scene break detection, including: a computer processor, a scene break detection service executing on the computer processor and comprising functionality to: (i) receive a request for scene break detection on a media item, (ii) identify a set of candidate scene break timestamps selected based on analysis of an audio component of the media item and a video component of the media item, (iii) execute a computer vision scoring model for each candidate scene break timestamp to generate a score representing a visual distance between a first set of proximal frames and a second set of proximal frames of the candidate scene break timestamp, and (iv) select, based at least on the score of each of the set of candidate scene break timestamps, a final set of scene break timestamps for the media item.

Abstract: A microscope may receive a fiber optic connector via a connector adapter that includes an opening and may align a ferrule of the fiber optic connector with the opening of the connector adapter, where the ferrule includes a ferrule endface. The microscope may transmit light onto the ferrule endface and may receive reflected light, as an image of the ferrule endface, with a camera of the microscope. The microscope may determine intensities of brightness of the image and may create a topographical map of the intensities of the brightness of the image. The microscope may determine a radius and an apex of the ferrule endface based on the topographical map and may calculate an apex offset of the ferrule endface based on the radius and the apex of the ferrule endface. The microscope may perform one or more actions based on the apex offset of the ferrule endface.

Abstract: A variable optical attenuator (VOA) may include an input collimator with an input fiber connected on one side and an output collimator with an output fiber connected on one side, where the collimators are on a same surface of a VOA enclosure. A retroreflector may receive a light beam from the input collimator and reflect the light beam to the output collimator. The VOA may include an attenuation element positioned between the input collimator and the retroreflector and/or another attenuation element positioned between the retroreflector and the output collimator to provide variable attenuation to the light beam. The attenuation elements may be moved to set an attenuation level by one or more adjustment elements such as a miniature motor. The attenuation element may include a gradient index (GRIN) element, a polarizer, a neutral density filter, or a wavelength tunable filter.

Abstract: Aspects of the present disclosure are directed to creating interactive avatars that can be pinned as world-locked artificial reality content. Once pinned, an avatar can interact with the environment according to contextual queues and rules, without active control by the avatar owner. An interactive avatar system can configure the avatar with action rules, visual elements, and settings based on user selections. Once an avatar is configured and pinned to a location by an avatar owner, when other XR devices are at that location, a central system can provide the avatar (with its configurations) to the other XR device. This allows a user of that other XR device to discover and interact with the avatar according to the configurations established by the avatar owner.

Abstract: A hybrid battery charger is disclosed that includes a linear charger circuit for providing vehicle starting current and battery charging and a high frequency battery charging circuit that provides battery charging current. The linear charger circuit and the high frequency battery charging circuits are selectively enabled to provide vehicle starting current, maximum charging current and optimum efficiency.

Abstract: A system and method for multimedia scene break detection, including: a computer processor, a scene break detection service executing on the computer processor and comprising functionality to: (i) receive a request for scene break detection on the media item, (ii) perform audio break detection on an audio component of the media item to obtain a set of audio break timestamps, (iii) identify a set of video break timestamps, each corresponding to at least one frame of a video component of the media item, (iv) identify a set of candidate scene break timestamps based on the audio break timestamps and the video break timestamps, (v) execute a computer vision scoring model for each candidate scene break timestamp, and (vi) select, based at least on a score of each of the set of candidate scene break timestamps, a final set of scene break timestamps for performing a media action.

Abstract: Provided herein are novel antigen binding domains and antibodies (e.g., heterodimeric antibodies) that bind Prostate Specific Membrane Antigen (PSMA). In exemplary embodiments, the anti-PSMA antibodies also bind CD3. Such antibodies that bind PSMA and CD3 are useful, for example in the treatment of PSMA-related cancer.

Abstract: The present invention is directed to a system for storage, evaluation, and transmission of information related to suspicious underlying activity that in turn is related to financial transactions comprising: (1) a secure data processing center, wherein the secure data processing center receives, stores, and transmits reports related to suspicious underlying activity that in turn is related to financial transactions, the secure data processing center including therein a storage mechanism for the reports including a memory; (2) at least one terminal in communication with the secure data processing center, wherein the terminal transmits and receives the reports related to suspicious underlying activity that in turn is related to financial transactions; and (3) means for authenticating and controlling communication between the at least one terminal and the secure data processing center; wherein the storage of the reports in the secure data processing center modifies the state of the secure data processing center i

Abstract: A method for processing an image. The method comprises receiving intensity values of pixels for each of a plurality of images captured by an image sensor during a detection window. The method comprises identifying, using the intensity values, a plurality of transitions occurring at different times during the detection window, each transition of the plurality of transitions being identified on the basis of detecting intensity values of pixels that have been clipped in images between which such transitions may occur. The method comprises, based on identifying the plurality of transitions occurring during the detection window, at least one of: adjusting an exposure level of the image sensor; and determining a tonemapping function having a tonemapping strength, and applying the tonemapping function to the intensity values of a current image to generate tonemapped intensity values, wherein the image sensor has a current exposure level when the current image is captured.

Abstract: A method for the delayed processing of image data captured by a wrist-wearable device is provided. The method includes receiving, at a wrist-wearable device, image data having a first resolution. The method includes, responsive to receiving the image data having the first resolution, storing the image data on the wrist-wearable device. The method further includes downscaling at least a portion of the image data to produce downscaled image data having a second resolution and presenting, on the wrist-wearable device, the downscaled image data having the second resolution. The method further includes receiving a request to send a representation of the image data to a device distinct from the wrist-wearable device. Responsive to the request, the method includes causing image-processing algorithms to be applied to the stored image data such that processed image data is generated and made available at the distinct device.

Abstract: A system and method for multimedia scene break detection, including: a computer processor, a scene break detection service executing on the computer processor and comprising functionality to: (i) receive a request for scene break detection on the media item, (ii) perform audio break detection on an audio component of the media item to obtain a set of audio break timestamps, (iii) identify a set of video break timestamps, each corresponding to at least one frame of a video component of the media item, (iv) identify a set of candidate scene break timestamps based on the audio break timestamps and the video break timestamps, (v) execute a computer vision scoring model for each candidate scene break timestamp, and (vi) select, based at least on a score of each of the set of candidate scene break timestamps, a final set of scene break timestamps for performing a media action.

Abstract: A method of providing virtual items based on location-based action is disclosed. An indication is received of a performance of a location-based action by a player of a computer-implemented game. A virtual item is provided based on the receiving of the indication of the performance of the location-based action by the player of the computer-implemented game. The virtual item may be usable within the computer-implemented game.

Abstract: In some implementations, a device may selectively illuminate, via a lighting module of the device, one or more fibers in a fiber optic cable using an illumination pattern. The device may detect, via a detection module of the device, illuminated fibers associated with the fiber optic cable based on the illumination pattern. The device may output, via the detection module of the device, information regarding the illuminated fibers. The device may generate, via one or more processors of the device, a report, based on the information, indicating a fiber mapping between the one or more fibers that were selectively illuminated via the lighting module and the illuminated fibers detected via the detection module.

Abstract: A method for processing an image. The method comprises receiving intensity values for each of a plurality of images captured by an image sensor during a detection window. The method comprises identifying, using the intensity values, one or more transitions occurring during the detection window, the one or more transitions each comprising a transition between an image in which a maximum clipping criterion is not satisfied and an image in which the maximum clipping criterion is satisfied. The method comprises, based on the identified transitions, at least one of: adjusting an exposure level of the image sensor; and determining a tonemapping function having a tonemapping strength, and applying the tonemapping function to the intensity values of a current image to generate tonemapped intensity values, wherein the image sensor has a current exposure level when the current image is captured.

Abstract: A clinical trial matching platform can have an inventory of clinical trials that are recruiting participants. The clinical trial matching platform can present lists of such clinical trials to medical providers, who can agree to perform pre-screening activities associated with any of the clinical trials to identify any patients of the medical providers who may be eligible to participate in the clinical trials. The medical providers can also use the clinical trial matching platform to refer any identified qualifying patients to participate in the clinical trials. The clinical trial matching platform can provide information about qualifying patients to trial sponsors of the clinical trials. The clinical trial matching platform can additionally provide navigation services to the patients, for instance to help resolve any issues that might otherwise prevent the patients from participating in the clinical trials.

Abstract: According to examples, a system for measuring polarization dependent loss (PDL) for a device-under-test (DUT) may include a tunable laser, a polarization element and a power meter. The tunable laser may emit an optical signal to sweep across an optical band at a constant rate. The polarization element may scramble polarizations states of the optical signal emitted from the tunable laser. The power meter may take power measurements associated with the optical signal emitted from the tunable laser, wherein the power measurements from the power meter are used to determine a maximum insertion loss (IL) and a minimum insertion loss (IL) associated with the device-under-test (DUT). An average insertion loss (IL) and a polarization dependent loss (PDL) for the device-under-test (DUT) may be calculated based on the maximum insertion loss (IL) and the minimum insertion loss (IL) associated with the device-under-test (DUT).

Abstract: A method of changing a virtual world of a computer-implemented game based on real-world locations of players of the computer-implemented game is disclosed. A presence of a player of the computer-implemented game is detected at a physical location. A presence of an additional player of the computer-implemented game is detected at the physical location based on a communication received from the player of the computer-implemented game. An aspect of the virtual world of the computer-implemented game is changed based on the detecting of the presence of the player at the physical location and the detecting of the presence of the additional player of the computer-implemented game at the physical location.

Abstract: Provided herein are novel anti-CD28 x anti-PSMA antibodies and methods of using such antibodies for the treatment of PSMA-associated cancers. Subject anti-CD28 x anti-PSMA antibodies are capable of agonistically binding to CD28 costimulatory molecules on T cells and PSMA on tumor cells. Thus, such antibodies selectively enhance anti-tumor activity at tumor sites while minimizing peripheral toxicity. The subject antibodies provided herein are particularly useful in combination with other anti-cancer therapies (e.g., anti-CD3 x anti-PSMA antibodies) for the treatment of prostate cancers.