Abstract: An intelligent item receptacle, system, and method for providing supplemental media content in response to depositing an item having media indicia disposed thereon. An intelligent item receptacle includes an item receptacle securely enclosing an interior volume, an item sensor configured to detect an inserted item, a camera within the interior volume configured to capture an image of the item, and an output configured to play audio or visual content to bystanders outside the item receptacle. Processing circuitry within the item receptacle analyzes the image to determine if the media indicia are present on the item and, if present, causes the output to play the audio or visual content associated with the media indicia.

Abstract: The success of anti-tumor immune responses requires effector T cells to infiltrate solid tumors, a process guided by chemokines. Herein, we demonstrate that in vivo post-translational processing of chemokines by dipeptidylpeptidase 4 (DPP4, also known as CD26) limits lymphocyte migration to sites of inflammation and tumors. Inhibition of DPP4 enzymatic activity enhanced tumor rejection by preserving biologically active CXCL10, and increasing trafficking into the tumor by lymphocytes expressing the counter-receptor CXCR3. Furthermore, DPP4 inhibition improved adjuvant-based immunotherapy, adoptive T cell transfer and checkpoint blockade. These findings provide the first direct in vivo evidence for controlling lymphocyte trafficking through CXCL10 cleavage and support the use of DPP4 inhibitors for stabilizing the biologically active form of chemokines as a strategy to enhance tumor immunotherapy.

Abstract: A laser display may include a light engine, which includes a laser diode and a temperature sensor configured to measure a temperature of the laser diode. The light engine may be coupled to a controller configured to determine a drive current for the laser diode to generate an optical power based on a threshold of the laser diode and an efficiency of the laser diode. The controller is configured to calculate the threshold and the efficiency of the laser diode at the measured temperature using a threshold model and an efficiency model of the laser diode, which are generated using a calibration process.

Abstract: A cryogenic storage system includes a transfer module configured to service one or more cryogenic storage freezers. The transfer module includes a working chamber that maintains a cryogenic environment for the transfer of sample tubes between different sample boxes. One or more freezer ports enable the transfer module to receive a sample box extracted from a respective freezer. An input/output (I/O) port enables external access to samples. A box transport robot operates to transport sample boxes between the freezer ports, the working chamber, and the I/O port. A picker robot operates to transfer sample tubes between sample boxes within the working chamber.

Abstract: The success of anti-tumor immune responses requires effector T cells to infiltrate solid tumors, a process guided by chemokines. Herein, we demonstrate that in vivo post-translational processing of chemokines by dipeptidylpeptidase 4 (DPP4, also known as CD26) limits lymphocyte migration to sites of inflammation and tumors. Inhibition of DPP4 enzymatic activity enhanced tumor rejection by preserving biologically active CXCL10, and increasing trafficking into the tumor by lymphocytes expressing the counter-receptor CXCR3. Furthermore, DPP4 inhibition improved adjuvant-based immunotherapy, adoptive T cell transfer and checkpoint blockade. These findings provide the first direct in vivo evidence for controlling lymphocyte trafficking through CXCL10 cleavage and support the use of DPP4 inhibitors for stabilizing the biologically active form of chemokines as a strategy to enhance tumor immunotherapy.

Abstract: A cryogenic storage system includes a transfer module configured to service one or more cryogenic storage freezers. The transfer module includes a working chamber that maintains a cryogenic environment for the transfer of sample tubes between different sample boxes. One or more freezer ports enable the transfer module to receive a sample box extracted from a respective freezer. An input/output (I/O) port enables external access to samples. A box transport robot operates to transport sample boxes between the freezer ports, the working chamber, and the I/O port. A picker robot operates to transfer sample tubes between sample boxes within the working chamber.

Abstract: The present disclosure relates to a discovery platform including machine-learning techniques for using medical imaging data to study a phenotype of interest, such as complex diseases with weak or unknown genetic drivers. An exemplary method of identifying a covariant of interest with respect to a phenotype comprises: receiving covariant information of a covariate class and corresponding phenotypic image data related to the phenotype obtained from a group of clinical subjects; inputting the phenotypic image data into a trained unsupervised machine-learning model to obtain a plurality of embeddings in a latent space, each embedding corresponding to a phenotypic state reflected in the phenotypic image data; and determining, based on the covariant information for the group of clinical subjects, the plurality of embeddings, and one or more linear regression models, an association between each candidate covariant of a plurality of candidate covariants and the phenotype state to identify the covariant of interest.

Abstract: A computer-implemented method of training a classification model includes the steps of obtaining, by at least one computer, a plurality of historical resistance trends from a plurality of installed rectifier sites and rectifier site metadata for each installed rectifier site of the plurality of installed rectifier sites; labelling each historical resistance trend of the plurality of historical resistance trends as one of a plurality of historic resistance trend classifications; and, inputting into a machine learning algorithm the historical resistance trends and the rectifier site metadata of the plurality of installed rectifier sites to train the classification model to output a predicted resistance trend classification in response to rectifier site metadata input into the model.

Abstract: Embodiments described herein relate to a system for positioning indicator lights of a network device. The system may include a circuit board, which may include a circuit board edge positioned behind a front panel of the network device, two surfaces; and a side of the circuit board edge positioned between the two surfaces. The system may also include a hole through the circuit board near the circuit board edge, a cutout extending from a portion of the hole to the side of the circuit board edge, a LED coupled to the surface of the circuit board and adapted to emit light into the hole, and a lightpipe disposed in the hole to receive light emitted from the LED into a first end of the lightpipe. The lightpipe may direct the light from a second end of the lightpipe toward an opening in the front panel of the network device.

Abstract: Embodiments described herein relate to a system for positioning indicator lights of a network device. The system may include a circuit board, which may include a circuit board edge positioned behind a front panel of the network device, two surfaces; and a side of the circuit board edge positioned between the two surfaces. The system may also include a hole through the circuit board near the circuit board edge, a cutout extending from a portion of the hole to the side of the circuit board edge, a LED coupled to the surface of the circuit board and adapted to emit light into the hole, and a lightpipe disposed in the hole to receive light emitted from the LED into a first end of the lightpipe. The lightpipe may direct the light from a second end of the lightpipe toward an opening in the front panel of the network device.

Abstract: A sealing apparatus includes a moveable seal holder with a cavity and includes a seal assembly disposed at least partially in the cavity. The seal assembly includes a resilient seal member including a fluid-facing end with a fluid-facing end surface, and the seal assembly includes an actuator plate configured to reciprocate between a first and a second position relative to the protective plate. The first actuator plate includes a fluid-facing end surface and a first camming surface. The seal assembly further includes a first protective plate disposed between the seal member and the first actuator plate. The actuator plate is configured to compress the seal member and to move the fluid-facing end surface of the seal member outward from a resting position when the actuator plate is in the second position.

Abstract: The success of anti-tumor immune responses requires effector T cells to infiltrate solid tumors, a process guided by chemokines. Herein, we demonstrate that in vivo post-translational processing of chemokines by dipeptidylpeptidase 4 (DPP4, also known as CD26) limits lymphocyte migration to sites of inflammation and tumors. Inhibition of DPP4 enzymatic activity enhanced tumor rejection by preserving biologically active CXCL10, and increasing trafficking into the tumor by lymphocytes expressing the counter-receptor CXCR3. Furthermore, DPP4 inhibition improved adjuvant-based immunotherapy, adoptive T cell transfer and checkpoint blockade. These findings provide the first direct in vivo evidence for controlling lymphocyte trafficking through CXCL10 cleavage and support the use of DPP4 inhibitors for stabilizing the biologically active form of chemokines as a strategy to enhance tumor immunotherapy.

Abstract: The success of anti-tumor immune responses requires effector T cells to infiltrate solid tumors, a process guided by chemokines. Herein, we demonstrate that in vivo post-translational processing of chemokines by dipeptidylpeptidase 4 (DPP4, also known as CD26) limits lymphocyte migration to sites of inflammation and tumors. Inhibition of DPP4 enzymatic activity enhanced tumor rejection by preserving biologically active CXCL10, and increasing trafficking into the tumor by lymphocytes expressing the counter-receptor CXCR3. Furthermore, DPP4 inhibition improved adjuvant-based immunotherapy, adoptive T cell transfer and checkpoint blockade. These findings provide the first direct in vivo evidence for controlling lymphocyte trafficking through CXCL10 cleavage and support the use of DPP4 inhibitors for stabilizing the biologically active form of chemokines as a strategy to enhance tumor immunotherapy.

Abstract: Methods, compositions, processes, and uses related to recombinant RSV soluble F protein polypeptides are provided.

Abstract: The success of anti-tumor immune responses requires effector T cells to infiltrate solid tumors, a process guided by chemokines. Herein, we demonstrate that in vivo post-translational processing of chemokines by dipeptidylpeptidase 4 (DPP4, also known as CD26) limits lymphocyte migration to sites of inflammation and tumors. Inhibition of DPP4 enzymatic activity enhanced tumor rejection by preserving biologically active CXCL10, and increasing trafficking into the tumor by lymphocytes expressing the counter-receptor CXCR3. Furthermore, DPP4 inhibition improved adjuvant-based immunotherapy, adoptive T cell transfer and checkpoint blockade. These findings provide the first direct in vivo evidence for controlling lymphocyte trafficking through CXCL10 cleavage and support the use of DPP4 inhibitors for stabilizing the biologically active form of chemokines as a strategy to enhance tumor immunotherapy.

Abstract: Described herein is an illumination device for projecting light in a predetermined illumination pattern on a surface. The illumination device includes a light module having a light source and a light pipe configured to transmit light in any suitable manner. The illumination device also includes a housing having a cavity, an entrance opening for receiving the light emitted from the light source, and an aperture at a second housing end. Within the housing between the entrance opening and the aperture is a screen at least partially disposed in the cavity, the screen having at least one opening defining a base pattern configuration corresponding to the predetermined illumination pattern. The light pipe is configured to selectively transmit light from the light source to the cavity and may be linear or non-linear such that the light source and the surface to be illuminated do not need to face one another.

Abstract: In various aspects and embodiments a roofing guard device 200 comprises a mount portion 210, brace portion 220, optional lateral supports 240, and restraint flanges 214, 216, as well as optional fall-arrest mount(s) 230. By securely supporting a foot guard 12 such as a board or plank and providing secure attachment points for roofing harnesses 400 or other fall-arrest devices, the roofing guard device 200 provides increased protection against falls and other mishaps. When configured such that a gap between the foot guard 12 and an edge 101 of the roof 100 is entirely or substantially eliminated, roofing guard devices in accordance with the invention can further help to eliminate dangers from falling tools, hardware, etc.

Abstract: A process to beneficiate oxidized iron ore can include the steps of: (1) adding a polysaccharide to the oxidized iron ore; (2) adding at least one amine; and (3) adding at least one salt; wherein the pH of the process is below 10 and greater than 5.

Abstract: The success of anti-tumor immune responses requires effector T cells to infiltrate solid tumors, a process guided by chemokines. Herein, we demonstrate that in vivo post-translational processing of chemokines by dipeptidylpeptidase 4 (DPP4, also known as CD26) limits lymphocyte migration to sites of inflammation and tumors. Inhibition of DPP4 enzymatic activity enhanced tumor rejection by preserving biologically active CXCL10, and increasing trafficking into the tumor by lymphocytes expressing the counter-receptor CXCR3. Furthermore, DPP4 inhibition improved adjuvant-based immunotherapy, adoptive T cell transfer and checkpoint blockade. These findings provide the first direct in vivo evidence for controlling lymphocyte trafficking through CXCL10 cleavage and support the use of DPP4 inhibitors for stabilizing the biologically active form of chemokines as a strategy to enhance tumor immunotherapy.

Abstract: A sealing apparatus includes a moveable seal holder with a cavity and includes a seal assembly disposed at least partially in the cavity. The seal assembly includes a resilient seal member including a fluid-facing end with a fluid-facing end surface, and the seal assembly includes an actuator plate configured to reciprocate between a first and a second position relative to the protective plate. The first actuator plate includes a fluid-facing end surface and a first camming surface. The seal assembly further includes a first protective plate disposed between the seal member and the first actuator plate. The actuator plate is configured to compress the seal member and to move the fluid-facing end surface of the seal member outward from a resting position when the actuator plate is in the second position.