Abstract: A sealing apparatus includes a moveable seal holder with a cavity and includes a seal assembly disposed at least partially in the cavity. The seal assembly includes a resilient seal member including a fluid-facing end with a fluid-facing end surface, and the seal assembly includes an actuator plate configured to reciprocate between a first and a second position relative to the protective plate. The first actuator plate includes a fluid-facing end surface and a first camming surface. The seal assembly further includes a first protective plate disposed between the seal member and the first actuator plate. The actuator plate is configured to compress the seal member and to move the fluid-facing end surface of the seal member outward from a resting position when the actuator plate is in the second position.

Abstract: The present disclosure relates to electrochemical energy storage systems. In particular, the present disclosure relates to particular systems and methods for providing a compact framework in which to house an electrochemical energy storage system. Various embodiments of electrochemical energy storage systems are disclosed that include a flow manifold and a flow manifold cover. The flow manifold may provide a plurality of channels for distributing liquid reactant to an electrical cell stack. The flow manifold may be utilized in conjunction with a flow manifold cover. The flow manifold cover may be configured to support a variety of components of a liquid reactant distribution system. Such components may include liquid reactant pump motors, inlet and outlet ports, a reference cell, and a variety of sensors. The distribution of liquid reactants to the cell stack from the inlet and outlet ports may be accomplished by way of the flow manifold cover.

Abstract: A device for maintaining a pneumatic conveyance line can include a body having one or more wings. In some examples, the body is configured to be positioned between opposing rails of a pneumatic conveyance track with the one or more wings positioned on a respective opposing rail of the track. The wings can carry one or more agents for at least one of cleaning and lubricating the track. As the device is pushed along the track, the device can clean and/or lubricate the track.

Abstract: A cryogenic storage system includes a transfer module configured to service one or more cryogenic storage freezers. The transfer module includes a working chamber that maintains a cryogenic environment for the transfer of sample tubes between different sample boxes. One or more freezer ports enable the transfer module to receive a sample box extracted from a respective freezer. An input/output (I/O) port enables external access to samples. A box transport robot operates to transport sample boxes between the freezer ports, the working chamber, and the I/O port. A picker robot operates to transfer sample tubes between sample boxes within the working chamber.

Abstract: A device for maintaining a pneumatic conveyance line can include a body having one or more wings. In some examples, the body is configured to be positioned between opposing rails of a pneumatic conveyance track with the one or more wings positioned on a respective opposing rail of the track. The wings can carry one or more agents for at least one of cleaning and lubricating the track. As the device is pushed along the track, the device can clean and/or lubricate the track.

Abstract: A device for maintaining a pneumatic conveyance line can include a body having one or more wings. In some examples, the body is configured to be positioned between opposing rails of a pneumatic conveyance track with the one or more wings positioned on a respective opposing rail of the track. The wings can carry one or more agents for at least one of cleaning and lubricating the track. As the device is pushed along the track, the device can clean and/or lubricate the track.

Abstract: Described herein is an illumination device for projecting light in a predetermined illumination pattern on a surface. The illumination device includes a light module having a light source and a light pipe configured to transmit light in any suitable manner. The illumination device also includes a housing having a cavity, an entrance opening for receiving the light emitted from the light source, and an aperture at a second housing end. Within the housing between the entrance opening and the aperture is a screen at least partially disposed in the cavity, the screen having at least one opening defining a base pattern configuration corresponding to the predetermined illumination pattern. The light pipe is configured to selectively transmit light from the light source to the cavity and may be linear or non-linear such that the light source and the surface to be illuminated do not need to face one another.

Abstract: The invention provides methods for the identification of patients capable of controlling HIV progression, as well as to the identification of an antagonist form of IP-10 associated to HIV progression control and the uses thereof for improving the immunological response of HIV patients.

Abstract: A process to beneficiate oxidized iron ore can include the steps of: (1) adding a polysaccharide to the oxidized iron ore; (2) adding at least one amine; and (3) adding at least one salt; wherein the pH of the process is below 10 and greater than 5.

Abstract: A method of sealing a wellbore with a blowout preventer (BOP) is disclosed. The method involves providing the BOP with a BOP seal. The BOP has BOP parameters and a fluid flowing through the BOP has fluid parameters. The method also involves simulating erosion of a BOP seal using a BOP model based on the BOP parameters and the fluid parameters, measuring erosion of the blowout preventer seal by performing a lab test of the blowout preventer seal in a tester according to the blowout preventer model, validating the simulating by comparing the simulated erosion with the measured erosion, determining an erosion rate of the blowout preventer seal based on the validated simulating, defining closing parameters based on the determined erosion rate, and operating the blowout preventer rams according to the defined closing parameters.

Abstract: The success of anti-tumor immune responses requires effector T cells to infiltrate solid tumors, a process guided by chemokines. Herein, we demonstrate that in vivo post-translational processing of chemokines by dipeptidylpeptidase 4 (DPP4, also known as CD26) limits lymphocyte migration to sites of inflammation and tumors. Inhibition of DPP4 enzymatic activity enhanced tumor rejection by preserving biologically active CXCL10, and increasing trafficking into the tumor by lymphocytes expressing the counter-receptor CXCR3. Furthermore, DPP4 inhibition improved adjuvant-based immunotherapy, adoptive T cell transfer and checkpoint blockade. These findings provide the first direct in vivo evidence for controlling lymphocyte trafficking through CXCL10 cleavage and support the use of DPP4 inhibitors for stabilizing the biologically active form of chemokines as a strategy to enhance tumor immunotherapy.

Abstract: A device for maintaining a pneumatic conveyance line can include a body having one or more wings. In some examples, the body is configured to be positioned between opposing rails of a pneumatic conveyance track with the one or more wings positioned on a respective opposing rail of the track. The wings can carry one or more agents for at least one of cleaning and lubricating the track. As the device is pushed along the track, the device can clean and/or lubricate the track.

Abstract: The invention provides methods for the identification of patients capable of controlling HIV progression, as well as to the identification of an antagonist form of IP-10 associated to HIV progression control and the uses thereof for improving the immunological response of HIV patients.

Abstract: A storage appliance system is disclosed which may include at least one application server for locally executing an application, and one or more storage servers in communication with the application server for I/O transmission therebetween. Also disclosed are an application server, a method, and a computer program product.

Abstract: The invention provides methods for the identification of patients capable of controlling HIV progression, as well as to the identification of an antagonist form of IP-10 associated to HIV progression control and the uses thereof for improving the immunological response of HIV patients.

Abstract: A method of sealing a wellbore with a blowout preventer (BOP) is disclosed. The method involves providing the BOP with a BOP seal. The BOP has BOP parameters and a fluid flowing through the BOP has fluid parameters.

Abstract: The invention provides methods for the identification of patients capable of controlling HIV progression, as well as to the identification of an antagonist form of IP-10 associated to HIV progression control and the uses thereof for improving the immunological response of HIV patients.

Abstract: A first and a second identical or different mycobacterial immunogenic compositions, each comprising at least a Mycobacterium bovis bacillus Calmette-Guerin (BCG), an antigenically related non-pathogenic mycobacteria, or one or more immunogenic component(s) thereof, as therapeutic active ingredient(s) for use in the treatment of cancer by parenteral or oral administration of the first composition to a cancer patient before local administration of the second composition at tumor site. A method in vitro for monitoring cancer treatment by immunotherapy with BCG, antigenically related non-pathogenic mycobacteria, or immunogenic component(s) thereof, comprising assaying BCG-specific immune response in a patient.

Abstract: An exhaust gas treatment system for treating an exhaust gas. The exhaust gas treatment system includes a first section, a bypass section, and a common second section. The first section may include a first valve and at least one exhaust gas treatment component, such as, for example, a DOC and/or DPF. The bypass section may include a bypass valve and a heater that is configured to elevate the temperature of at least a portion of the exhaust gas. The second section is in fluid communication with the first section and the bypass section and includes a selective catalytic reduction system. Further, exhaust gas may be diverted into the bypass section when the exhaust gas fails to satisfy the threshold condition, so that the heater may elevate the temperature of the passing exhaust gas.

Abstract: A method, computer program product, and system for detecting and fencing off a failed entity instance so that failover time in the computing system is reduced. Upon detection of a failed entity, for example a failed process, a signal handler invokes an operating system interface to fence off the failed instance from modifying its persistent state, so that the entity may be re-instantiated prior to termination of the failed instance. This approach reduces failover time and eliminates split-brain problems without compromising access to the failed instance to obtain diagnostic information, core dumps, and the like.