Patents by Inventor Matthew Alberts

Matthew Alberts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11000521
    Abstract: The success of anti-tumor immune responses requires effector T cells to infiltrate solid tumors, a process guided by chemokines. Herein, we demonstrate that in vivo post-translational processing of chemokines by dipeptidylpeptidase 4 (DPP4, also known as CD26) limits lymphocyte migration to sites of inflammation and tumors. Inhibition of DPP4 enzymatic activity enhanced tumor rejection by preserving biologically active CXCL10, and increasing trafficking into the tumor by lymphocytes expressing the counter-receptor CXCR3. Furthermore, DPP4 inhibition improved adjuvant-based immunotherapy, adoptive T cell transfer and checkpoint blockade. These findings provide the first direct in vivo evidence for controlling lymphocyte trafficking through CXCL10 cleavage and support the use of DPP4 inhibitors for stabilizing the biologically active form of chemokines as a strategy to enhance tumor immunotherapy.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: May 11, 2021
    Assignees: INSTITUT PASTEUR, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Rosa Barreira Da Silva, Matthew Albert
  • Patent number: 10989855
    Abstract: Described herein is an illumination device for projecting light in a predetermined illumination pattern on a surface. The illumination device includes a light module having a light source and a light pipe configured to transmit light in any suitable manner. The illumination device also includes a housing having a cavity, an entrance opening for receiving the light emitted from the light source, and an aperture at a second housing end. Within the housing between the entrance opening and the aperture is a screen at least partially disposed in the cavity, the screen having at least one opening defining a base pattern configuration corresponding to the predetermined illumination pattern. The light pipe is configured to selectively transmit light from the light source to the cavity and may be linear or non-linear such that the light source and the surface to be illuminated do not need to face one another.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: April 27, 2021
    Assignee: AGM Automotive, LLC
    Inventors: Bradley Matthew Albert Cox, Cye David Bittner
  • Publication number: 20210017777
    Abstract: In various aspects and embodiments a roofing guard device 200 comprises a mount portion 210, brace portion 220, optional lateral supports 240, and restraint flanges 214, 216, as well as optional fall-arrest mount(s) 230. By securely supporting a foot guard 12 such as a board or plank and providing secure attachment points for roofing harnesses 400 or other fall-arrest devices, the roofing guard device 200 provides increased protection against falls and other mishaps. When configured such that a gap between the foot guard 12 and an edge 101 of the roof 100 is entirely or substantially eliminated, roofing guard devices in accordance with the invention can further help to eliminate dangers from falling tools, hardware, etc.
    Type: Application
    Filed: July 19, 2019
    Publication date: January 21, 2021
    Inventors: Rino P. Albert, Matthew Albert
  • Patent number: 10786819
    Abstract: A process to beneficiate oxidized iron ore can include the steps of: (1) adding a polysaccharide to the oxidized iron ore; (2) adding at least one amine; and (3) adding at least one salt; wherein the pH of the process is below 10 and greater than 5.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: September 29, 2020
    Assignee: Regents of the University of Minnesota
    Inventors: Matthew Albert Mlinar, Tom Steven Petersen
  • Publication number: 20200268859
    Abstract: The success of anti-tumor immune responses requires effector T cells to infiltrate solid tumors, a process guided by chemokines. Herein, we demonstrate that in vivo post-translational processing of chemokines by dipeptidylpeptidase 4 (DPP4, also known as CD26) limits lymphocyte migration to sites of inflammation and tumors. Inhibition of DPP4 enzymatic activity enhanced tumor rejection by preserving biologically active CXCL10, and increasing trafficking into the tumor by lymphocytes expressing the counter-receptor CXCR3. Furthermore, DPP4 inhibition improved adjuvant-based immunotherapy, adoptive T cell transfer and checkpoint blockade. These findings provide the first direct in vivo evidence for controlling lymphocyte trafficking through CXCL10 cleavage and support the use of DPP4 inhibitors for stabilizing the biologically active form of chemokines as a strategy to enhance tumor immunotherapy.
    Type: Application
    Filed: May 12, 2020
    Publication date: August 27, 2020
    Inventors: Rosa BARREIRA DA SILVA, Matthew ALBERT
  • Publication number: 20200182005
    Abstract: A sealing apparatus includes a moveable seal holder with a cavity and includes a seal assembly disposed at least partially in the cavity. The seal assembly includes a resilient seal member including a fluid-facing end with a fluid-facing end surface, and the seal assembly includes an actuator plate configured to reciprocate between a first and a second position relative to the protective plate. The first actuator plate includes a fluid-facing end surface and a first camming surface. The seal assembly further includes a first protective plate disposed between the seal member and the first actuator plate. The actuator plate is configured to compress the seal member and to move the fluid-facing end surface of the seal member outward from a resting position when the actuator plate is in the second position.
    Type: Application
    Filed: April 27, 2018
    Publication date: June 11, 2020
    Applicant: National Oilwell Varco, L.P.
    Inventors: Geoffrey A. Pickett, Matthew Albert Franchek, Seyed Mohammad Parvasi
  • Patent number: 10651492
    Abstract: The present disclosure relates to electrochemical energy storage systems. In particular, the present disclosure relates to particular systems and methods for providing a compact framework in which to house an electrochemical energy storage system. Various embodiments of electrochemical energy storage systems are disclosed that include a flow manifold and a flow manifold cover. The flow manifold may provide a plurality of channels for distributing liquid reactant to an electrical cell stack. The flow manifold may be utilized in conjunction with a flow manifold cover. The flow manifold cover may be configured to support a variety of components of a liquid reactant distribution system. Such components may include liquid reactant pump motors, inlet and outlet ports, a reference cell, and a variety of sensors. The distribution of liquid reactants to the cell stack from the inlet and outlet ports may be accomplished by way of the flow manifold cover.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: May 12, 2020
    Assignee: VRB ENERGY INC.
    Inventors: Matthew Albert MacLennan Harper, Gary Lepp
  • Patent number: 10549922
    Abstract: A device for maintaining a pneumatic conveyance line can include a body having one or more wings. In some examples, the body is configured to be positioned between opposing rails of a pneumatic conveyance track with the one or more wings positioned on a respective opposing rail of the track. The wings can carry one or more agents for at least one of cleaning and lubricating the track. As the device is pushed along the track, the device can clean and/or lubricate the track.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: February 4, 2020
    Assignee: Ecolab USA Inc.
    Inventors: Matthew Albert Bilski, Chad Aaron Thompson, Jill Kristen Hodowanic, Pablo Segovia, Brian Joseph Doffing
  • Publication number: 20190293344
    Abstract: A cryogenic storage system includes a transfer module configured to service one or more cryogenic storage freezers. The transfer module includes a working chamber that maintains a cryogenic environment for the transfer of sample tubes between different sample boxes. One or more freezer ports enable the transfer module to receive a sample box extracted from a respective freezer. An input/output (I/O) port enables external access to samples. A box transport robot operates to transport sample boxes between the freezer ports, the working chamber, and the I/O port. A picker robot operates to transfer sample tubes between sample boxes within the working chamber.
    Type: Application
    Filed: March 15, 2019
    Publication date: September 26, 2019
    Inventors: Lingchen Sun, Bruce Zandi, Frank Hunt, Aaron Plaisted, Tiffany Holmes, Matthew Albert, Fang Cui, Yuri Rubenchik, Daniel Lamothe
  • Publication number: 20190248596
    Abstract: A device for maintaining a pneumatic conveyance line can include a body having one or more wings. In some examples, the body is configured to be positioned between opposing rails of a pneumatic conveyance track with the one or more wings positioned on a respective opposing rail of the track. The wings can carry one or more agents for at least one of cleaning and lubricating the track. As the device is pushed along the track, the device can clean and/or lubricate the track.
    Type: Application
    Filed: April 29, 2019
    Publication date: August 15, 2019
    Inventors: Matthew Albert Bilski, Chad Aaron Thompson, Jill Kristen Hodowanic, Pablo Segovia, Brian Joseph Doffing
  • Patent number: 10315857
    Abstract: A device for maintaining a pneumatic conveyance line can include a body having one or more wings. In some examples, the body is configured to be positioned between opposing rails of a pneumatic conveyance track with the one or more wings positioned on a respective opposing rail of the track. The wings can carry one or more agents for at least one of cleaning and lubricating the track. As the device is pushed along the track, the device can clean and/or lubricate the track.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: June 11, 2019
    Assignee: Ecolab USA Inc.
    Inventors: Matthew Albert Bilski, Chad Aaron Thompson, Jill Kristen Hodowanic, Pablo Segovia, Brian Joseph Doffing
  • Publication number: 20190137677
    Abstract: Described herein is an illumination device for projecting light in a predetermined illumination pattern on a surface. The illumination device includes a light module having a light source and a light pipe configured to transmit light in any suitable manner. The illumination device also includes a housing having a cavity, an entrance opening for receiving the light emitted from the light source, and an aperture at a second housing end. Within the housing between the entrance opening and the aperture is a screen at least partially disposed in the cavity, the screen having at least one opening defining a base pattern configuration corresponding to the predetermined illumination pattern. The light pipe is configured to selectively transmit light from the light source to the cavity and may be linear or non-linear such that the light source and the surface to be illuminated do not need to face one another.
    Type: Application
    Filed: November 8, 2018
    Publication date: May 9, 2019
    Applicant: AGM Automotive, LLC
    Inventors: Bradley Matthew Albert COX, Cye David BITTNER
  • Patent number: 10254282
    Abstract: The invention provides methods for the identification of patients capable of controlling HIV progression, as well as to the identification of an antagonist form of IP-10 associated to HIV progression control and the uses thereof for improving the immunological response of HIV patients.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: April 9, 2019
    Assignees: INSTITUT PASTEUR, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS
    Inventors: Michaela Müller-Trutwin, Mickaël J. Y. Ploquin, Matthew Albert, Yoann Madec, Cécile Goujard, Laurence Meyer
  • Publication number: 20190070616
    Abstract: A process to beneficiate oxidized iron ore can include the steps of: (1) adding a polysaccharide to the oxidized iron ore; (2) adding at least one amine; and (3) adding at least one salt; wherein the pH of the process is below 10 and greater than 5.
    Type: Application
    Filed: January 20, 2017
    Publication date: March 7, 2019
    Inventors: Matthew Albert Mlinar, Tom Steven Petersen
  • Patent number: 10132133
    Abstract: A method of sealing a wellbore with a blowout preventer (BOP) is disclosed. The method involves providing the BOP with a BOP seal. The BOP has BOP parameters and a fluid flowing through the BOP has fluid parameters. The method also involves simulating erosion of a BOP seal using a BOP model based on the BOP parameters and the fluid parameters, measuring erosion of the blowout preventer seal by performing a lab test of the blowout preventer seal in a tester according to the blowout preventer model, validating the simulating by comparing the simulated erosion with the measured erosion, determining an erosion rate of the blowout preventer seal based on the validated simulating, defining closing parameters based on the determined erosion rate, and operating the blowout preventer rams according to the defined closing parameters.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: November 20, 2018
    Assignee: NATIONAL OILWELL VARCO, L.P.
    Inventors: Frank Benjamin Springett, Geoffrey Pickett, Matthew Albert Franchek
  • Publication number: 20180228881
    Abstract: The success of anti-tumor immune responses requires effector T cells to infiltrate solid tumors, a process guided by chemokines. Herein, we demonstrate that in vivo post-translational processing of chemokines by dipeptidylpeptidase 4 (DPP4, also known as CD26) limits lymphocyte migration to sites of inflammation and tumors. Inhibition of DPP4 enzymatic activity enhanced tumor rejection by preserving biologically active CXCL10, and increasing trafficking into the tumor by lymphocytes expressing the counter-receptor CXCR3. Furthermore, DPP4 inhibition improved adjuvant-based immunotherapy, adoptive T cell transfer and checkpoint blockade. These findings provide the first direct in vivo evidence for controlling lymphocyte trafficking through CXCL10 cleavage and support the use of DPP4 inhibitors for stabilizing the biologically active form of chemokines as a strategy to enhance tumor immunotherapy.
    Type: Application
    Filed: December 14, 2015
    Publication date: August 16, 2018
    Inventors: Rosa BARREIRA DA SILVA, Matthew ALBERT
  • Publication number: 20170297827
    Abstract: A device for maintaining a pneumatic conveyance line can include a body having one or more wings. In some examples, the body is configured to be positioned between opposing rails of a pneumatic conveyance track with the one or more wings positioned on a respective opposing rail of the track. The wings can carry one or more agents for at least one of cleaning and lubricating the track. As the device is pushed along the track, the device can clean and/or lubricate the track.
    Type: Application
    Filed: April 19, 2017
    Publication date: October 19, 2017
    Inventors: Matthew Albert Bilski, Chad Aaron Thompson, Jill Kristen Segl, Pablo Segovia, Brian Joseph Doffing
  • Publication number: 20170269084
    Abstract: The invention provides methods for the identification of patients capable of controlling HIV progression, as well as to the identification of an antagonist form of IP-10 associated to HIV progression control and the uses thereof for improving the immunological response of HIV patients.
    Type: Application
    Filed: October 31, 2016
    Publication date: September 21, 2017
    Applicants: INSTITUT PASTEUR, ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
    Inventors: Michaela MÜLLER-TRUTWIN, Mickaël J.Y. PLOQUIN, Matthew ALBERT, Yoann MADEC, Cécile GOUJARD, Laurence MEYER
  • Patent number: 9571576
    Abstract: A storage appliance system is disclosed which may include at least one application server for locally executing an application, and one or more storage servers in communication with the application server for I/O transmission therebetween. Also disclosed are an application server, a method, and a computer program product.
    Type: Grant
    Filed: November 30, 2010
    Date of Patent: February 14, 2017
    Assignee: International Business Machines Corporation
    Inventors: Michael E. Factor, Matthew Albert Huras, Aamer Sachedina, Paula Kim Ta-Shma, Avishay Traeger
  • Patent number: 9523687
    Abstract: The invention provides methods for the identification of patients capable of controlling HIV progression, as well as to the identification of an antagonist form of IP-10 associated to HIV progression control and the uses thereof for improving the immunological response of HIV patients.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: December 20, 2016
    Assignee: INSTITUT PASTEUR
    Inventors: Michaela Müller-Trutwin, Mickaël J. Y. Ploquin, Matthew Albert, Yoann Madec, Cécile Goujard, Laurence Meyer