Abstract: The invention is directed to compounds of formula (I), and salts thereof. The compounds are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: In various examples, physical sensor data may be generated by a vehicle in a real-world environment. The physical sensor data may be used to train deep neural networks (DNNs). The DNNs may then be tested in a simulated environment—in some examples using hardware configured for installation in a vehicle to execute an autonomous driving software stack—to control a virtual vehicle in the simulated environment or to otherwise test, verify, or validate the outputs of the DNNs. Prior to use by the DNNs, virtual sensor data generated by virtual sensors within the simulated environment may be encoded to a format consistent with the format of the physical sensor data generated by the vehicle.

Abstract: The present disclosure relates methods and compositions useful for prevention of porcine reproductive and respiratory syndrome virus (PRRSv) in animals, including animals of the species Sus scrofa. The present teachings relate to swine wherein at least one allele of a CD163 gene has been inactivated, and to specific methods and nucleic acid sequences used in gene editing to inactivate the CD163 gene. Swine wherein both alleles of the CD163 gene are inactivated are resistant to porcine reproductive and respiratory syndrome virus (PRRSv). Elite lines comprising homozygous CD163 edited genes retain their superior properties.

Abstract: Provided is a unit dose of recombinant adeno-associated virus (AAV) particles for expression of matrix metalloproteinase 3 (MMP-3). Further provided is a unit dose of recombinant MMP-3. Also provided are methods of use thereof, e.g., in transducing the corneal endothelium of a subject; reducing intraocular pressure in an eye of a subject; treating and/or preventing elevated intraocular pressure in a subject; and treating and/or preventing glaucoma in a subject. Subjects include primates.

Abstract: A personal watercraft is disclosed including a flotation portion, a strut extending from the flotation portion, and a motor pod is disposed along the strut with an electric motor operably coupled to a driveshaft. A hydrojet unit is removably attached to the motor pod and includes an inlet portion removably attached to the motor pod and a substantially cylindrical housing. The inlet portion includes a substantially conical motor interface with a shaft through-hole for receiving the driveshaft therein, one or more fins extending outwardly from the conical motor interface, and at least one ring encircling the conical motor interface and connecting to each of the one or more fins for inhibiting objects from passing through the inlet region. The housing defines a fluid flow path to an outlet portion. The hydrojet unit includes an impeller coupled to the driveshaft and a stator disposed within the housing.

Abstract: The invention is directed to compounds of formula (I), and salts thereof. The compounds are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: A method for completing a project using a content-generating device. The method includes receiving a task defining a content item to be generated, restricting operation of at least a first component of the content-generating device, operating at least a second component of the content-generating device to generate the content item, and making available the generated content item.

Abstract: In various examples, physical sensor data may be generated by a vehicle in a real-world environment. The physical sensor data may be used to train deep neural networks (DNNs). The DNNs may then be tested in a simulated environment—in some examples using hardware configured for installation in a vehicle to execute an autonomous driving software stack—to control a virtual vehicle in the simulated environment or to otherwise test, verify, or validate the outputs of the DNNs. Prior to use by the DNNs, virtual sensor data generated by virtual sensors within the simulated environment may be encoded to a format consistent with the format of the physical sensor data generated by the vehicle.

Abstract: The present invention relates to a method of treating age-related macular degeneration. In particular embodiments, the invention relates to methods of treating age-related macular degeneration in a subject in need thereof, the method comprising the step of decreasing the expression or activation of a toll-like receptor in the subject.

Abstract: A flexible coupling mechanism may be used to suspend a structural component, such as a propulsion pod, from a support member, such as a strut of a hydrofoil watercraft. The flexible coupling mechanism may include multiple vibration isolating mounts configured to extend through the support member to suspend the structural component. The vibration isolating mounts may include a plurality of elastomeric bushings configured to prevent direct contact between a component rigidly coupled to the support member and a component rigidly coupled to the structural component. The elastomeric bushings may include a tapered outer profile configured to provide a nonlinear force feedback profile in response to rotation of the support member relative to the structural component.

Abstract: A method comprising: obtaining an image; identifying a rotation angle for the image by processing the image with a first neural network; rotating the image by the identified rotation angle to generate a rotated image; classifying the image with a second neural network; and outputting an indication of an outcome of the classification, wherein the first neural network is trained, at least in part, based on a categorical distance between training data and an output that is produced by the first neural network.

Abstract: The present disclosure relates methods and compositions useful for prevention of porcine reproductive and respiratory syndrome virus (PRRSv) in animals, including animals of the species Sus scrofa. The present teachings relate to swine wherein at least one allele of a CD163 gene has been inactivated, and to specific methods and nucleic acid sequences used in gene editing to inactivate the CD163 gene. Swine wherein both alleles of the CD163 gene are inactivated are resistant to porcine reproductive and respiratory syndrome virus (PRRSv).

Abstract: A small-gap device system, preferably including two or more electrodes and one or more spacers maintaining a gap between two or more of the electrodes. A spacer for a small-gap device system, preferably including a plurality of legs defining a mesh structure. A method of spacer and/or small-gap device fabrication, preferably including: defining lateral features, depositing spacer material, selectively removing spacer material, separating the spacer from a fabrication substrate, and/or assembling the small-gap device.

Abstract: Methods and systems for processing semen samples from straws for determining genetic identity, testing the purity of the sample, detecting errors or contamination, calculating an amount of contamination, and determining the identity of the contaminant. The methods herein can detect low levels of contamination, such as contamination of about 0.5%, 1%, 2%, etc.

Abstract: A bearing assembly may include an integral sensor module retained within a bore in the bearing housing. The sensor module includes at least one strain gauge oriented to sense a compressive load acting on the bearing housing. The sensor module may be retained within the bore under an axial compressive load. The sensor module may include a power source and a wired or wireless communications module for transmitting information indicative of the compressive load to an external instrument or other system.

Abstract: A system and method are provided for interacting with a web site having a plurality of web pages delivering user services and content sources including a web search service, electronic messaging service and web content page. Each web page includes portal script executable by a web browser to enable unique functions within the web site accessed using different types of selection of selectable items of the web pages.

Abstract: The present invention is directed to compositions and methods for the treatment of degenerative retinal conditions. According to a general aspect, the present invention is directed to inflammatory mediators, preferably components or substrates of the NLRP3-inflammasome, for use in the treatment of degenerative retinal conditions involving drusen and anaphylatoxin-induced choroidal-neovascularisation. The invention is also directed to a method for the treatment of degenerative retinal conditions involving drusen and anaphylatoxin-induced choroidal-neovascularisation and to recombinant vectors and recombinant proteins for use in such methods. The present invention also provides a method for determining the risk of developing or monitoring the progression of diseases involving drusen and anaphylatoxin-induced choroidal neo-vascularisation.

Abstract: The present invention relates to a method and compositions for the treatment of age-related macular degeneration (AMD), in particular dry-AMD, specifically geographic atrophy (GA) or advanced dry-AMD. Specifically, the invention relates to an inner-blood-retinal-barrier (iBRB) or blood-brain-barrier (BBB) tight junction protein and/or a circadian clock protein for use in the prevention and/or treatment of age-related macular degeneration.

Abstract: The present disclosure relates methods and compositions useful for prevention of porcine reproductive and respiratory syndrome virus (PRRSv) in animals, including animals of the species Sus scrofa. The present teachings relate to swine wherein at least one allele of a CD163 gene has been inactivated, and to specific methods and nucleic acid sequences used in gene editing to inactivate the CD163 gene. Swine wherein both alleles of the CD163 gene are inactivated are resistant to porcine reproductive and respiratory syndrome virus (PRRSv).

Abstract: The present invention relates to a method and compositions for the treatment of age-related macular degeneration (AMD), in particular dry-AMD, specifically geographic atrophy (GA) or advanced dry-AMD. Specifically, the invention relates to an inner-blood-retinal-barrier (iBRB) or blood-brain-barrier (BBB) tight junction protein and/or a circadian clock protein for use in the prevention and/or treatment of age-related macular degeneration.