Abstract: A method for completing a project using a content-generating device. The method includes receiving a task defining a content item to be generated, restricting operation of at least a first component of the content-generating device, operating at least a second component of the content-generating device to generate the content item, and making available the generated content item.

Abstract: A method of using RNA interference (RNAi) for the transient, reversible and controlled opening of the tight junctions of the blood brain barrier and/or the blood retinal barrier. This method may be used in the treatment of many diseases and disorders which require the opening of the blood brain barrier and/or blood retinal barrier. Such methods generally involve the use of an RNAi-inducing agent, such as siRNA, miRNA, shRNA or an RNAi-inducing vector whose presence within a cell results in production of an siRNA or shRNA, targeting tight junction proteins to open the blood brain barrier and/or blood retinal barrier.

Abstract: A watercraft and a waterproof electronics container are provided. The watercraft includes a flotation portion. A strut is removably affixed to a portion of the watercraft. A first connector portion is mounted to the upper end of the strut. A waterproof electronics container includes a second connector portion is disposed such that the second connector forms at least one electrically conductive pathway with the first connector portion when both are affixed to the watercraft. The waterproof electronics container is removably affixed to the said watercraft. In one aspect, the waterproof electronics container houses a power source capable of powering an electric motor that propels the watercraft.

Abstract: A bearing assembly may include an integral sensor module retained within a bore in the bearing housing. The sensor module includes at least one strain gauge oriented to sense a compressive load acting on the bearing housing. The sensor module may be retained within the bore under an axial compressive load. The sensor module may include a power source and a wired or wireless communications module for transmitting information indicative of the compressive load to an external instrument or other system.

Abstract: Provided are embodiments that include a circuit configured to operate in a disabled mode error reduction for high-voltage bilateral operational amplifier current source. The circuit includes an operational amplifier, and a switching circuit coupled to the operation amplifier, wherein the switching circuit is operable in a normal mode and a disabled mode, wherein the disabled mode reduces error current at the output of the operational amplifier. Also provided are embodiments for a method for operating a circuit in a disabled mode for error reduction.

Abstract: Compounds of formula (I): wherein X, Y, R1 and R3-R11 are as herein defined, and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.

Abstract: A method for completing a project using a content-generating device. The method includes receiving a task defining a content item to be generated, restricting operation of at least a first component of the content-generating device, operating at least a second component of the content-generating device to generate the content item, and making available the generated content item.

Abstract: A detonation transfer assembly is disclosed. A detonation transfer assembly may comprise an external casing comprising an input end and an output end axially opposite the input end, an explosive column spanning axially inside the external casing, a primary explosive disposed within the explosive column, and a secondary explosive disposed within the explosive column axially between the primary explosive and the output end. The primary explosive and/or the secondary explosive may comprise a thermally insensitive initiation material that resists at least one of detonation or thermal degradation in response to temperature increase rate of 3.3° C. per hour over at least twenty hours.

Abstract: Some embodiments of the invention are directed to techniques for suppressing or attenuating noise in audio circuitry, such as which may result from a source of electromagnetic energy being coupled to the audio circuitry. Some embodiments may employ two separate channels, a first of which captures audio information and noise, and a second of which captures the noise. Noise compensation may be performed by transforming the signal of the first channel in accordance with noise in the second channel which is identified as comprising a particular type of noise.

Abstract: A method for completing a project using a content-generating device. The method includes receiving a task defining a content item to be generated, restricting operation of at least a first component of the content-generating device, operating at least a second component of the content-generating device to generate the content item, and making available the generated content item.

Abstract: Compounds of formula (I): wherein X, Y, R1 and R3-R11 are as herein defined, and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.

Abstract: The present invention relates to a method and compositions for the treatment of age-related macular degeneration (AMD), in particular dry-AMD, specifically geographic atrophy (GA) or advanced dry-AMD. Specifically, the invention relates to an inner-blood-retinal-barrier (iBRB) or blood-brain-barrier (BBB) tight junction protein and/or a circadian clock protein for use in the prevention and/or treatment of age-related macular degeneration.

Abstract: The present invention is directed to an RNAi-inducing agent capable of reducing and/or inhibiting the expression of proteins associated with the tight junction complex joining Schlemm's canal endothelial cells (SCEC) in the eye of a subject for use in the prevention and/or treatment of glaucoma. Specifically, the RNAi-inducing agent is capable of reducing and/or inhibiting the expression of proteins expressed in the tight junction complex or supporting the tight junction complex joining Schlemm's canal endothelial cells (SCEC) in the eye of a subject for use in the prevention and/or treatment of glaucoma. Methods using this RNAi-inducing agent are also contemplated.

Abstract: The disclosure provides compositions and methods useful for treating glaucoma. In particular, the invention provides an adeno-associated viral (AAV)-mediated gene therapy for glaucoma in which transduced cells of the eye secrete a therapeutic protein (for example, a matrix metalloproteinase) resulting in remodeling of the extracellular matrix of the trabecular meshwork of said eye.

Abstract: The present invention relates to a system and method for interacting with a social network. The method includes displaying a web page provided by a content provider on a user device. The web page includes at least one social network access item. The social network access item may be selected by a user of the user device, with a first type of selection causing a link to an online resource associated with a social network provider to be followed by the web browser, the online resource enabling the user to login to a social network. Receiving a second type of selection causes at least one control option to be displayed within the web page. The control option may be for saving details of the web page to a storage location remote from the user device and provided by the social network provider, or accessing the details of at least one web page previously saved by the user from the storage location.

Abstract: The present invention is directed to compositions and methods for the treatment of degenerative retinal conditions. According to a general aspect, the present invention is directed to inflammatory mediators, preferably components or substrates of the NLRP3-inflammasome, for use in the treatment of degenerative retinal conditions involving drusen and anaphylatoxin-induced choroidal-neovascularisation. The invention is also directed to a method for the treatment of degenerative retinal conditions involving drusen and anaphylatoxin-induced choroidal-neovascularisation and to recombinant vectors and recombinant proteins for use in such methods. The present invention also provides a method for determining the risk of developing or monitoring the progression of diseases involving drusen and anaphylatoxin-induced choroidal neo-vascularisation.

Abstract: In various examples, physical sensor data may be generated by a vehicle in a real-world environment. The physical sensor data may be used to train deep neural networks (DNNs). The DNNs may then be tested in a simulated environment—in some examples using hardware configured for installation in a vehicle to execute an autonomous driving software stack—to control a virtual vehicle in the simulated environment or to otherwise test, verify, or validate the outputs of the DNNs. Prior to use by the DNNs, virtual sensor data generated by virtual sensors within the simulated environment may be encoded to a format consistent with the format of the physical sensor data generated by the vehicle.

Abstract: A system and computer implemented method for acting on search results in a webpage. The invention displays selectable items in the form of search results determined by a web search engine in response to a search query received from a user. A first type of selection of one of the search results by the user causes a link to an online resource associated with the selected search result to be followed. A second type of selection by the user causes at least one control option to be displayed to the user, the control options including at least one of: saving details of the search result to a remote storage location, or accessing the details of at least one previously saved search results.

Abstract: Systems and methods for visually displaying instances of increased susceptibility for commission of medical errors are provided. Execution of programming instructions on a computer-readable medium causes a processor to retrieve historical workload data corresponding to environmental conditions experienced by and near misses associated with an individual or team of individuals during a first period of time from one or more data repositories. Retrieved workload data is processed to establish threshold limits for distinct working conditions represented within the workload data for the individual or team of individuals. Workload data corresponding to a second period of time is retrieved for the individual or team of individuals and compared to established threshold limits by the processor. Based on the comparison, the processor generates one or more displayable indicia indicative of the individual's or team of individuals' risk of committing a medical error due to an experienced workload.