Abstract: A detonation transfer assembly is disclosed. A detonation transfer assembly may comprise an external casing comprising an input end and an output end axially opposite the input end, an explosive column spanning axially inside the external casing, a primary explosive disposed within the explosive column, and a secondary explosive disposed within the explosive column axially between the primary explosive and the output end. The primary explosive and/or the secondary explosive may comprise a thermally insensitive initiation material that resists at least one of detonation or thermal degradation in response to temperature increase rate of 3.3° C. per hour over at least twenty hours.

Abstract: Some embodiments of the invention are directed to techniques for suppressing or attenuating noise in audio circuitry, such as which may result from a source of electromagnetic energy being coupled to the audio circuitry. Some embodiments may employ two separate channels, a first of which captures audio information and noise, and a second of which captures the noise. Noise compensation may be performed by transforming the signal of the first channel in accordance with noise in the second channel which is identified as comprising a particular type of noise.

Abstract: A method for completing a project using a content-generating device. The method includes receiving a task defining a content item to be generated, restricting operation of at least a first component of the content-generating device, operating at least a second component of the content-generating device to generate the content item, and making available the generated content item.

Abstract: Compounds of formula (I): wherein X, Y, R1 and R3-R11 are as herein defined, and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.

Abstract: The present invention relates to a method and compositions for the treatment of age-related macular degeneration (AMD), in particular dry-AMD, specifically geographic atrophy (GA) or advanced dry-AMD. Specifically, the invention relates to an inner-blood-retinal-barrier (iBRB) or blood-brain-barrier (BBB) tight junction protein and/or a circadian clock protein for use in the prevention and/or treatment of age-related macular degeneration.

Abstract: The present invention is directed to an RNAi-inducing agent capable of reducing and/or inhibiting the expression of proteins associated with the tight junction complex joining Schlemm's canal endothelial cells (SCEC) in the eye of a subject for use in the prevention and/or treatment of glaucoma. Specifically, the RNAi-inducing agent is capable of reducing and/or inhibiting the expression of proteins expressed in the tight junction complex or supporting the tight junction complex joining Schlemm's canal endothelial cells (SCEC) in the eye of a subject for use in the prevention and/or treatment of glaucoma. Methods using this RNAi-inducing agent are also contemplated.

Abstract: The disclosure provides compositions and methods useful for treating glaucoma. In particular, the invention provides an adeno-associated viral (AAV)-mediated gene therapy for glaucoma in which transduced cells of the eye secrete a therapeutic protein (for example, a matrix metalloproteinase) resulting in remodeling of the extracellular matrix of the trabecular meshwork of said eye.

Abstract: The present invention relates to a system and method for interacting with a social network. The method includes displaying a web page provided by a content provider on a user device. The web page includes at least one social network access item. The social network access item may be selected by a user of the user device, with a first type of selection causing a link to an online resource associated with a social network provider to be followed by the web browser, the online resource enabling the user to login to a social network. Receiving a second type of selection causes at least one control option to be displayed within the web page. The control option may be for saving details of the web page to a storage location remote from the user device and provided by the social network provider, or accessing the details of at least one web page previously saved by the user from the storage location.

Abstract: The present invention is directed to compositions and methods for the treatment of degenerative retinal conditions. According to a general aspect, the present invention is directed to inflammatory mediators, preferably components or substrates of the NLRP3-inflammasome, for use in the treatment of degenerative retinal conditions involving drusen and anaphylatoxin-induced choroidal-neovascularisation. The invention is also directed to a method for the treatment of degenerative retinal conditions involving drusen and anaphylatoxin-induced choroidal-neovascularisation and to recombinant vectors and recombinant proteins for use in such methods. The present invention also provides a method for determining the risk of developing or monitoring the progression of diseases involving drusen and anaphylatoxin-induced choroidal neo-vascularisation.

Abstract: In various examples, physical sensor data may be generated by a vehicle in a real-world environment. The physical sensor data may be used to train deep neural networks (DNNs). The DNNs may then be tested in a simulated environment—in some examples using hardware configured for installation in a vehicle to execute an autonomous driving software stack—to control a virtual vehicle in the simulated environment or to otherwise test, verify, or validate the outputs of the DNNs. Prior to use by the DNNs, virtual sensor data generated by virtual sensors within the simulated environment may be encoded to a format consistent with the format of the physical sensor data generated by the vehicle.

Abstract: A system and computer implemented method for acting on search results in a webpage. The invention displays selectable items in the form of search results determined by a web search engine in response to a search query received from a user. A first type of selection of one of the search results by the user causes a link to an online resource associated with the selected search result to be followed. A second type of selection by the user causes at least one control option to be displayed to the user, the control options including at least one of: saving details of the search result to a remote storage location, or accessing the details of at least one previously saved search results.

Abstract: Systems and methods for visually displaying instances of increased susceptibility for commission of medical errors are provided. Execution of programming instructions on a computer-readable medium causes a processor to retrieve historical workload data corresponding to environmental conditions experienced by and near misses associated with an individual or team of individuals during a first period of time from one or more data repositories. Retrieved workload data is processed to establish threshold limits for distinct working conditions represented within the workload data for the individual or team of individuals. Workload data corresponding to a second period of time is retrieved for the individual or team of individuals and compared to established threshold limits by the processor. Based on the comparison, the processor generates one or more displayable indicia indicative of the individual's or team of individuals' risk of committing a medical error due to an experienced workload.

Abstract: Compounds of formula (I): wherein X, Y, R1 and R3-R11 are as herein defined, and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.

Abstract: The present invention relates to a system and method for interacting with a social network. The method includes displaying a web page provided by a content provider on a user device. The web page includes at least one social network access item. The social network access item may be selected by a user of the user device, with a first type of selection causing a link to an online resource associated with a social network provider to be followed by the web browser, the online resource enabling the user to login to a social network. Receiving a second type of selection causes at least one control option to be displayed within the web page. The control option may be for saving details of the web page to a storage location remote from the user device and provided by the social network provider, or accessing the details of at least one web page previously saved by the user from the storage location.

Abstract: A system for selecting an ejection mode on an aircraft may include an egress actuator, a ballistic signal system operatively connected to the egress actuator, and a processor operatively connected to the ballistic signal system and the egress actuator. The processor may be configured to receive, from an aircraft controller, a flight characteristic, and select, based on the flight characteristic, an ejection mode from two ejection modes. The processor may be further configured to receive a pilot egress command from the ballistic signal system, and transmit, to the egress actuator, a signal to actuate the ejection mode from the two ejection modes.

Abstract: An energetic one way sequence termination arrangement may comprise a housing, a first inlet in operable communication with the housing, a second inlet in operable communication with the housing, and an outlet in operable communication with the housing. The energetic one way sequence termination arrangement is configured such that the second inlet is blocked from fluidic communication with the outlet in response to a first signal being received at the first inlet before a second signal is received at the second inlet, and the first inlet establishes fluidic communication with the outlet in response to the second signal being received at the second inlet before the first signal is received at the first inlet.

Abstract: A system for discharging hydrogen from two or more hydrogen storage vessels (1A, 1B, 1C) containing solid hydrogen storage material. The system includes at least one hydrogen supply line for connecting the hydrogen storage vessels to a hydrogen demand (3), and energy delivery system (6A, 6B, 6C) to provide heat to the hydrogen storage material in each hydrogen storage vessel to desorb hydrogen from the solid hydrogen storage material, and one or more supply connection conduits (4A, 4B, 4C) for connecting the supply line of lines to the hydrogen storage vessels (1A, 1B, 1C). Each supply connection conduit has a backflow prevention device (5A, 5B, 5C) to prevent hydrogen in the supply line from flowing back into the hydrogen storage vessels (1A, 1B, 1C). Also disclosed is a system for delivering a supply of hydrogen to a hydrogen supply line including a control system (7) to determine the timing of activation of an energy delivery system based (6A, 6B, 6C) on the hydrogen demand in the hydrogen supply line.

Abstract: A method of using RNA interference (RNAi) for the transient, reversible and controlled opening of the tight junctions of the blood brain barrier and/or the blood retinal barrier. This method may be used in the treatment of many diseases and disorders which require the opening of the blood brain barrier and/or blood retinal barrier. Such methods generally involve the use of an RNAi-inducing agent, such as siRNA, miRNA, shRNA or an RNAi-inducing vector whose presence within a cell results in production of an siRNA or shRNA, targeting tight junction proteins to open the blood brain barrier and/or blood retinal barrier.

Abstract: Compounds of formula (I): wherein X, Y, R1 and R3-R11 are as herein defined, and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.