Abstract: The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts or solvates thereof. Such compounds can be used in the treatment of RORgammaT-mediated diseases or conditions.

Abstract: A conventional containment vessel is retrofitted into a complete integral tank double-hull cargo containment vessel that includes a primary hull and a secondary hull disposed within the primary hull. The primary hull includes a topside deck structural member. The secondary hull includes an interior cargo containment tank. The secondary hull includes a topside structural member configured to seal the cargo containment tank. The primary hull is configured to serve as a first boundary between an operating environment of the vessel and the cargo. The secondary hull is configured to serve as a second boundary between the operating environment of the vessel and the cargo. The topside deck member of the primary hull and the topside structural member of the secondary hull are configured to provide a double-hull on the topside of the cargo containment tank.

Abstract: Functional encryption (FE) ciphertext is transformed into partially-decrypted (PD) ciphertext. The PD ciphertext has a shorter bit length than the FE ciphertext, or the decryption time of the PD ciphertext is less than the decryption time of the FE ciphertext. The FE ciphertext can be an attribute-based encryption ciphertext. The transformation can be performed with a transformation key generated by an authority with a master key or by a user with a decryption key. The transformation can also be performed, without a transformation key, based on unencrypted components of the FE ciphertext and on auxiliary information associated with the unencrypted components of the FE ciphertext. The PD ciphertext can require less transmission time across a network than the FE ciphertext. The PD ciphertext can require less time to decrypt than the FE ciphertext, particularly when the computational resources performing the decryption are limited.

Abstract: A market making node in a network routes machine readable documents to connect businesses with customers, suppliers and trading partners. The self defining electronic documents, such as XML based documents, can be easily understood amongst the partners. Definitions of these electronic business documents, called business interface definitions, are posted on the Internet, or otherwise communicated to members of the network. The business interface definitions tell potential trading partners the services the company offers and the documents to use when communicating with such services. Thus, a typical business interface definition allows a customer to place an order by submitting a purchase order or a supplier checks availability by downloading an inventory status report.

Abstract: An out-of-order execution microprocessor for reducing the likelihood of having to replay a load instruction due to a store collision. The microprocessor includes a queue of entries, each entry configured to hold information that identifies sources of a store instruction used to compute its store address and to hold a dependency that identifies an instruction upon which the store instruction depends for its data. A register alias table (RAT), coupled to the queue of entries, is configured to encounter instructions in program order and to generate dependencies used to determine when the instructions may execute out of program order. In response to encountering a load instruction the RAT determines whether sources of the load instruction used to compute its load address match the sources of the store instruction in an entry of the queue, and if so, causes the load instruction to share the dependency of the matching store instruction.

Abstract: An agriculture production system includes a plurality of plant housings interconnected by conduit portions of a conduit assembly. Each plant housing has an upper housing portion that supports a plant in a growing media therein and a lower housing portion defining a chamber cavity below the upper housing portion so that roots of the plant extend into the chamber, said conduit portions fluidly interconnecting the chambers of the plant housings. A conditioned air unit is coupled to the conduit assembly and conditions air that flows through the conduit assembly into the chambers of the plant housings. A water supply assembly has a plurality of irrigation units, each associated with one of the plant housings and delivering water to the plant housing from a water supply source. The plant housings are arranged in a circuit allowing conditioned air to flow through the chambers of the plant housings to control a temperature and/or humidity in said chambers to promote root development and plant growth.

Abstract: A spam detector accesses a message body of an email, extracts one or more features of a return path from the message body, and uses the extracted features to detect the return path for a user to respond to the email. The return path may include a postal address, and the extracted feature may comprise one or more of a complete or partial street name, city name, state name, country name, street number address, postal code, designations for post office box, and post office box number.

Abstract: A data center includes a modular building structure forming an enclosure having a bottom side. An external support system extends from the modular building structure. A series of heat sinks are each configured to extend from an interior to an exterior of the enclosure and protrude below the bottom side of the modular building structure into a fluid. Electronic components and devices are housed within the enclosure.

Abstract: Systems and methods are disclosed to improve performance of a communications device receiving encrypted communications from multiple sources. The communications device is configured to increase the amount of decryption performed using a hardware-based process as compared to a software-based process by reprogramming the hardware to store a shared security key corresponding to a frame received from a source, allowing the hardware-based process to decrypt subsequent frames from that source.

Abstract: An agriculture production system includes a plurality of plant housings interconnected by conduit portions of a conduit assembly. Each plant housing has an upper housing portion that supports a plant in a growing media therein and a lower housing portion defining a chamber cavity below the upper housing portion so that roots of the plant extend into the chamber, said conduit portions fluidly interconnecting the chambers of the plant housings. A conditioned air unit is coupled to the conduit assembly and conditions air that flows through the conduit assembly into the chambers of the plant housings. A water supply assembly has a plurality of irrigation units, each associated with one of the plant housings and delivering water to the plant housing from a water supply source. The plant housings are arranged in a circuit allowing conditioned air to flow through the chambers of the plant housings to control a temperature and/or humidity in said chambers to promote root development and plant growth.

Abstract: Fabrication of a microfluidic multi-temperature reaction device (MMR) and the design and fabrication of the equipment to drive various molecular biological methods on the device are provided. The device can be applicable, for example, to nucleic acid (DNA, RNA, cDNA, etc) amplification, cell lysis, reverse transcription and other enzymatic temperature sensitive and also temperature cycling reactions.

Abstract: Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the extraction and fractionation of DNA molecules, from whole or lysed samples, in a single flow-through device.

Abstract: A complete double-hull cargo containment vessel includes a primary hull and a secondary hull disposed within the primary hull. The primary hull includes a topside deck structural member. The secondary hull includes an interior cargo containment tank. The secondary hull includes a topside structural member configured to seal the cargo containment tank. The primary hull is configured to serve as a first boundary between an operating environment of the vessel and the cargo. The secondary hull is configured to serve as a second boundary between the operating environment of the vessel and the cargo. The topside deck member of the primary hull and the topside structural member of the secondary hull are configured to provide a double-hull on the topside of the cargo containment tank.

Abstract: A conventional containment vessel is retrofitted into a complete integral tank double-hull cargo containment vessel that includes a primary hull and a secondary hull disposed within the primary hull. The primary hull includes a topside deck structural member. The secondary hull includes an interior cargo containment tank. The secondary hull includes a topside structural member configured to seal the cargo containment tank. The primary hull is configured to serve as a first boundary between an operating environment of the vessel and the cargo. The secondary hull is configured to serve as a second boundary between the operating environment of the vessel and the cargo. The topside deck member of the primary hull and the topside structural member of the secondary hull are configured to provide a double-hull on the topside of the cargo containment tank.

Abstract: Systems and methods are disclosed to improve performance of a communications device receiving encrypted communications from multiple sources. The communications device is configured to increase the amount of decryption performed using a hardware-based process as compared to a software-based process by reprogramming the hardware to store a shared security key corresponding to a frame received from a source, allowing the hardware-based process to decrypt subsequent frames from that source.

Abstract: The present invention is directed to a novel trifluoromethylsulfonamide derivative which inhibits the processing of APP by the putative ?-secretase and thus is useful in the treatment or prevention of Alzheimer's disease. This compound possesses favorable pharmacokinetic properties in higher species (rhesus) and thus can be dosed on an intermittent dosing regiment (e.g., once weekly). When dosed on such a regiment the compound exhibits significant and continuous A? lowering without the manifestation of Notch associated gastrointestinal toxicity for extended periods, e.g., 7 days. Pharmaceutical compositions and methods of use are also included.

Abstract: An applicator instrument for dispensing surgical fasteners includes a housing, a firing system disposed in the housing and being moveable in distal and proximal directions along a first axis, and an elongated shaft extending from the housing, the elongated shaft having a proximal section and a distal section that is oriented at an angle relative to the proximal section. A plurality of surgical fasteners are disposed in the elongated shaft. The applicator instrument has a handle that extends upwardly from the housing along a second axis that defines an acute angle with the first axis. A trigger is mounted on the handle, and a linkage couples the trigger with the handle and the firing system. When the trigger is squeezed, the linkage guides the trigger along a linear path of movement relative to the handle.

Abstract: An applicator instrument for dispensing surgical fasteners includes a housing defining a bottom of the applicator instrument, a firing system disposed in the housing and being moveable in distal and proximal directions along a first axis, a handle extending upwardly from the housing along a second axis that defines an acute angle with the first axis, the handle having an upper end that defines a top of the applicator instrument, and a trigger mounted on the handle for actuating the firing system. The applicator instrument includes an elongated shaft extending from the housing, the elongated shaft having a proximal section that extends along the first axis and a distal section that is oriented at an angle relative to the proximal section for extending upwardly toward the top of the application instrument. A distal end cap has a proximally sloping distal face and a dispensing window for dispensing surgical fasteners.

Abstract: A mobile insurance architecture includes a wireless communication interface that connects mobile client devices to wireless networks. An insurance server cluster that includes a group of independent network servers operates and appears to mobile client devices as if the group of independent network servers were a single computer server. An adaptive transmission controller communicates with the insurance server cluster and processes content in multiple mobile formats that may be optimized to the screen sizes of the mobile client devices. The insurance server cluster responds to native application clients resident to the mobile client devices. The native application clients contain code stored on a non-transitory media that render insurance quoting services, insurance claims services, on-line insurance policy services, usage based insurance services, mobile monitoring services, or insurance agency management services.

Abstract: Systems, methods, and apparatus for providing a communication network free of bridge loops by providing a first message from one of two bridges and a second message in response to the first message from the other of the two bridges and establishing a communicative path if both the first and second messages were received.