Abstract: The present invention relates to pyridazinthione derivatives that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

Abstract: An out-of-order execution microprocessor for reducing load instruction replay likelihood due to store collisions. A register alias table (RAT) is coupled to first and second queues of entries and generates dependencies used to determine when instructions may execute out of order. The RAT allocates an entry of the first queue and populates the allocated entry with an instruction pointer of a load instruction, when it determines that the load instruction must be replayed. The RAT allocates an entry of the second queue when it encounters a store instruction and populates the allocated entry with a dependency that identifies an instruction upon which the store instruction depends for its data. The RAT causes a subsequent instance of the load instruction to share the dependency when it encounters the subsequent instance of the load instruction and determines that its instruction pointer matches the instruction pointer of an entry of the first queue.

Abstract: The present invention relates to 1,4-dihydropyridazinone derivatives, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

Abstract: A pipette component for use in performing an experimental procedure with a fluid sample and a pipette, the pipette component including: a pipette interface configured to engage sealingly and separably with a body of the pipette; a tip interface configured to engage sealingly and separably with a replaceable tip; and an experiment region configured to receive at least part of the fluid sample by operation of the pipette, and configured to perform at least part of the experimental procedure in the experiment region using the at least part of the fluid sample.

Abstract: The present invention relates to a shoe, in particular a sports shoe, with a cushioning system comprising a lower sole element and an upper sole element. The cushioning system further comprises at least one lever having at least two arms where an angle ? between the arms lies within the range 0°<?<180°. The first arm is connected to a deformation element and the second arm is connected to one of the two sole elements, wherein the lever is pivotably arranged at the other sole element.

Abstract: A data center includes a modular building structure forming an enclosure having a bottom side. An external support system extends from the modular building structure. A series of heat sinks are each configured to extend from an interior to an exterior of the enclosure and protrude below the bottom side of the modular building structure into a fluid. Electronic components and devices are housed within the enclosure.

Abstract: A market making node in a network routes machine readable documents to connect businesses with customers, suppliers and trading partners. The self defining electronic documents, such as XML based documents, can be easily understood amongst the partners. Definitions of these electronic business documents, called business interface definitions, are posted on the Internet, or otherwise communicated to members of the network. The business interface definitions tell potential trading partners the services the company offers and the documents to use when communicating with such services. Thus, a typical business interface definition allows a customer to place an order by submitting a purchase order or a supplier checks availability by downloading an inventory status report.

Abstract: An out-of-order execution microprocessor includes a register alias table configured to generate a first indicator that indicates whether an instruction is dependent upon a condition code result of a shift instruction. The microprocessor also includes a first execution unit configured to execute the shift instruction and to generate a second indicator that indicates whether a shift amount of the shift instruction is zero. The microprocessor also includes a second execution unit configured to receive the first and second indicators and to generate a replay signal to cause the instruction to be replayed if the first indicator indicates the instruction is dependent upon the condition code result of the shift instruction and a second indicator indicates the shift amount of the shift instruction is zero.

Abstract: Functional encryption (FE) ciphertext is transformed into partially-decrypted (PD) ciphertext. The PD ciphertext has a shorter bit length than the FE ciphertext, or the decryption time of the PD ciphertext is less than the decryption time of the FE ciphertext. The FE ciphertext can be an attribute-based encryption ciphertext. The transformation can be performed with a transformation key generated by an authority with a master key or by a user with a decryption key. The transformation can also be performed, without a transformation key, based on unencrypted components of the FE ciphertext and on auxiliary information associated with the unencrypted components of the FE ciphertext. The PD ciphertext can require less transmission time across a network than the FE ciphertext. The PD ciphertext can require less time to decrypt than the FE ciphertext, particularly when the computational resources performing the decryption are limited.

Abstract: Device for measuring hair damage comprising a handle (2) and a shaft (3) and a mandrel, a clip (4) and a feedback indicator, wherein the mandrel and clip are attachable to the shaft and the mandrel is drivable along the length of the shaft to measure the friction of a lock of hair which is wound around the mandrel and back onto itself and held in place by the clip such that fibres in the lock of hair are rubbed against themselves along the general direction of the hair fibres and use of such a device.

Abstract: A method of processing documents is described. The method includes the operation of receiving a document in a search engine crawler. The document includes an embedded first link tag. The first link tag includes one or more information pairs. A respective information pair includes a respective parameter and a corresponding value. The parameters in the one or more information pairs may correspond to content at one or more content locations or one or more document locations. The method also includes selecting a method of processing content associated with the first link tag in accordance with one or more of the information pairs.

Abstract: An airflow restrictor door is pivotably supported by and extends from a support towards a card receiving bay.

Abstract: A fluid collection device comprising a body comprising a capsule interface, and a capsule configured to interface with the body via the capsule interface and configured to hold a sample receiving chip. The sample receiving chip comprises a substrate that receives an aliquot volume of a sample fluid, wherein the substrate is operatively shaped to receive the aliquot volume of sample fluid through capillary action, and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region, whereupon energy properties of the sample fluid can be transduced to produce a sample fluid reading.

Abstract: The present invention is directed to a novel trifluoromethylsulfonamide derivative which inhibits the processing of APP by the putative ?-secretase and thus is useful in the treatment or prevention of Alzheimer's disease. This compound possesses favorable pharmacokinetic properties in higher species (rhesus) and thus can be dosed on an intermittent dosing regiment (e.g., once weekly). When dosed on such a regiment the compound exhibits significant and continuous A? lowering without the manifestation of Notch associated gastrointestinal toxicity for extended periods, e.g., 7 days. Pharmaceutical compositions and methods of use are also included.

Abstract: A method of processing documents is described. The method includes the operation of receiving a document in a search engine crawler. The document includes an embedded first link tag. The first link tag includes one or more information pairs. A respective information pair includes a respective parameter and a corresponding value. The parameters in the one or more information pairs may correspond to content at one or more content locations or one or more document locations. The method also includes selecting a method of processing content associated with the first link tag in accordance with one or more of the information pairs.

Abstract: A fluid collection device comprising a body comprising a capsule interface, and a capsule configured to interface with the body via the capsule interface and configured to hold a sample receiving chip. The sample receiving chip comprises a substrate that receives an aliquot volume of a sample fluid, wherein the substrate is operatively shaped to receive the aliquot volume of sample fluid through capillary action, and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region, whereupon energy properties of the sample fluid can be transduced to produce a sample fluid reading.

Abstract: Machine readable documents connect businesses with customers, suppliers and trading partners. The self defining electronic documents, such as XML based documents, can be easily understood amongst the partners. Definitions of these electronics business documents, called business interface definitions, are posted on the Internet, or otherwise communicated to members of the network. The business interface definitions tell potential trading partners the services the company offers and the documents to use when communicating with such services. Thus, a typical business interface definition allows a customer to place an order by submitting a purchase order or a supplier checks availability by downloading an inventory status report. Also, composition of the input and output documents, coupled with interpretation information in a common business library, programs the transaction in a way which closely parallels the way in which paper based businesses operate.

Abstract: A method of processing documents is described. The method includes the operation of receiving a document in a search engine crawler. The document includes an embedded first link tag. The first link tag includes one or more information pairs. A respective information pair includes a respective parameter and a corresponding value. The parameters in the one or more information pairs may correspond to content at one or more content locations or one or more document locations. The method also includes selecting a method of processing content associated with the first link tag in accordance with one or more of the information pairs.

Abstract: An airflow restrictor door is pivotably supported by and extends from a support towards a card receiving bay.

Abstract: An out-of-order execution microprocessor includes a register alias table configured to generate a first indicator that indicates whether an instruction is dependent upon a condition code result of a shift instruction. The microprocessor also includes a first execution unit configured to execute the shift instruction and to generate a second indicator that indicates whether a shift amount of the shift instruction is zero. The microprocessor also includes a second execution unit configured to receive the first and second indicators and to generate a replay signal to cause the instruction to be replayed if the first indicator indicates the instruction is dependent upon the condition code result of the shift instruction and a second indicator indicates the shift amount of the shift instruction is zero.