Abstract: A beverage capsule (101), a method of lidding a beverage capsule (101) and a sealing head (115) are disclosed. A capsule body and a lid (110) of the beverage capsule (101) together define an internal volume for containing beverage ingredients. A peripheral flange (105) of the capsule body comprises or consists of a thermoplastic polymer, the peripheral flange prior to sealing with the lid having a flat receiving surface (106). The lid (110) also comprises a thermoplastic polymer. The lid (110) is sealed to the peripheral flange (105) to form a first peripheral seal able to withstand pressurisation of the internal volume during use. The first peripheral seal comprises a weld between the thermoplastic polymer of the capsule body and the thermoplastic polymer of the lid (110). A face of the peripheral flange (105) in contact with the lid (110) comprises a recess formed into the flat receiving surface (106) and the lid (110) is sealed to the peripheral flange (105) within the recess.

Abstract: Presented herein are technologies and methods for improved production of AAV vectors.

Abstract: Presented herein are technologies and methods for improved production of AAV vectors.

Abstract: Disclosed herein are methods of treatment comprising administering a therapeutically effective amount of a myosin modulator or a pharmaceutically acceptable salt thereof to a subject in need thereof and diagnostic methods useful in connection with those treatments. Due to observations unfolding in clinical trials with mavacamten and with mavacamten and other myosin inhibitors in the pre-clinical setting, new insights into how myosin inhibitors can be used beneficially to impact the disease state of HCM and other diseases are provided herein.

Abstract: Presented herein are technologies and methods for improved production of AAV vectors.

Abstract: The present disclosure is directed to an energy management system that allows leveraging DC energy at user premises. The system allows for use of local or remote DC energy generated by photovoltaic modules or a battery pack. The system comprises a premises electricity network interface arranged to deliver and draw energy to and from a premises electricity network; a premises energy measurement module arranged to measure the amount of energy required by the premises electricity network; a DC energy input arranged to receive energy from one or more DC energy sources; and an energy analytics module arranged to receive data from the energy measurement module and, based on the received data, calculate an amount of energy to be delivered to the premises electricity network via the premises electricity network interface.

Abstract: The present disclosure is directed to an energy management system that allows leveraging DC energy at user premises. The system allows for use of local or remote DC energy generated by photovoltaic modules or a battery pack. The system comprises a premises electricity network interface arranged to deliver and draw energy to and from a premises electricity network; a premises energy measurement module arranged to measure the amount of energy required by the premises electricity network; a DC energy input arranged to receive energy from one or more DC energy sources; and an energy analytics module arranged to receive data from the energy measurement module and, based on the received data, calculate an amount of energy to be delivered to the premises electricity network via the premises electricity network interface.

Abstract: A method of hydrogenation of a silicon photovoltaic junction device is provided, the silicon photovoltaic junction device comprising p-type silicon semiconductor material and n-type silicon semiconductor material forming at least one p-n junction. The method comprises: i) ensuring that any silicon surface phosphorus diffused layers through which hydrogen must diffuse have peak doping concentrations of 1×1020 atoms/cm3 or less and silicon surface boron diffused layers through which hydrogen must diffuse have peak doping concentrations of 1×1019 atoms/cm3 or less; ii) Providing one or more hydrogen sources accessible by each surface of the device; and iii) Heating the device, or a local region of the device to at least 40° C.

Abstract: An article, garment and method protect a user's coccyx. Articles include: a core member constructed of an elastic composite, the core member including a upper lobe and a lower lobe, the core member further having an outer face, an inner face and a thickness between the outer face and the inner face; an arched outer shell attached to the outer face of the core member, the outer shell having a thickness less than the thickness of the core member, the outer shell biasing the core member toward an arched configuration; and a layer of resilient material attached to the inner face of the core member.

Abstract: An article, garment and method protect a user's coccyx. Articles include: a core member constructed of an elastic composite, the core member including a upper lobe and a lower lobe, the core member further having an outer face, an inner face and a thickness between the outer face and the inner face; an arched outer shell attached to the outer face of the core member, the outer shell having a thickness less than the thickness of the core member, the outer shell biasing the core member toward an arched configuration; and a layer of resilient material attached to the inner face of the core member.

Abstract: An article, garment and method protect a participant in an athletic activity against injury to the coccyx as well as to the buttocks of the participant. A core member of the article is constructed of an elastic composite that establishes a resistive load under deformation, in a lobed protective contour configuration, and an outer shell is integrated with the core member to provide a degree of stiffness for biasing the elastic composite of the core member toward the protective contour configuration during conduct of the athletic activity, while enabling flexing of the article to accommodate the athletic activity, such that upon fitting the article over the coccyx of the participant, as well as in juxtaposition with the participant's buttocks, the core member will protect against an impact, while the outer shell resists damage to the core member.

Abstract: A method of hydrogenation of a silicon photovoltaic junction device is provided, the silicon photovoltaic junction device comprising p-type silicon semiconductor material and n-type silicon semiconductor material forming at least one p-n junction. The method comprises: i) ensuring that any silicon surface phosphorus diffused layers through which hydrogen must diffuse have peak doping concentrations of 1×1020 atoms/cm3 or less and silicon surface boron diffused layers through which hydrogen must diffuse have peak doping concentrations of 1×1019 atoms/cm3 or less; ii) Providing one or more hydrogen sources accessible by each surface of the device; and iii) Heating the device, or a local region of the device to at least 40° C.

Abstract: A method of hydrogenation of a silicon photovoltaic junction device is provided, the silicon photovoltaic junction device comprising p-type silicon semiconductor material and n-type silicon semiconductor material forming at least one p-n junction. The method comprises: i) ensuring that any silicon surface phosphorus diffused layers through which hydrogen must diffuse have peak doping concentrations of 1×1020 atoms/cm3 or less and silicon surface boron diffused layers through which hydrogen must diffuse have peak doping concentrations of 1×1019 atoms/cm3 or less; ii) providing one or more hydrogen sources accessible by each surface of the device; and iii) heating the device, or a local region of the device to at least 40° C.

Abstract: A method of hydrogenation of a silicon photovoltaic junction device is provided, the silicon photovoltaic junction device comprising p-type silicon semiconductor material and n-type silicon semiconductor material forming at least one p-n junction. The method comprises: i) ensuring that any silicon surface phosphorus diffused layers through which hydrogen must diffuse have peak doping concentrations of 1×1020 atoms/cm3 or less and silicon surface boron diffused layers through which hydrogen must diffuse have peak doping concentrations of 1×1019 atoms/cm3 or less; ii) Providing one or more hydrogen sources accessible by each surface of the device; and iii) Heating the device, or a local region of the device to at least 40° C.

Abstract: A method of hydrogenation of a silicon photovoltaic junction device is provided, the silicon photovoltaic junction device comprising p-type silicon semiconductor material and n-type silicon semiconductor material forming at least one p-n junction. The method comprises: i) ensuring that any silicon surface phosphorus diffused layers through which hydrogen must diffuse have peak doping concentrations of 1×1020 atoms/cm3 or less and silicon surface boron diffused layers through which hydrogen must diffuse have peak doping concentrations of 1×1019 atoms/cm3 or less; ii) Providing one or more hydrogen sources accessible by each surface of the device; and iii) Heating the device, or a local region of the device to at least 40° C.

Abstract: A method of hydrogenation of a silicon photovoltaic junction device is provided, the silicon photovoltaic junction device comprising p-type silicon semiconductor material and n-type silicon semiconductor material forming at least one p-n junction. The method comprises: i) ensuring that any silicon surface phosphorus diffused layers through which hydrogen must diffuse have peak doping concentrations of 1×1020 atoms/cm3 or less and silicon surface boron diffused layers through which hydrogen must diffuse have peak doping concentrations of 1×1019 atoms/cm3 or less; ii) Providing one or more hydrogen sources accessible by each surface of the device; and iii) Heating the device, or a local region of the device to at least 40° C.

Abstract: Rounded vault forming structures and the systems and methods for making the same are disclosed. Such structures include a monolithic building having one or more arches, one or more integrated hip structures, and a non-circular outer circumferential shaped base. At least some of the structures result in zero to extremely low amounts of waste material from building such structures.

Abstract: The present invention relates to human thymic stromal lymphopoietin (hTSLP) antibodies and especially those which neutralize hTSLP activity. It further relates to methods for using anti-hTSLP antibody molecules in diagnosis or treatment of hTSLP related disorders, such as asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and Hodgkin's lymphoma.