Abstract: An engine for an-auto injector for administering a dose of a liquid medicament includes a case arranged to be attached to a package syringe containing a syringe. The case contains a drive capable of, upon activation, pushing the needle from a covered position into an exposed position, and operating the syringe to supply the dose of medicament. The case contains a trigger arranged to lock the drive in a loaded state prior to manual operation and capable of, upon manual operation, releasing the drive for injections. The drive is arranged as a gas spring including a cylinder and a piston with a plunger for transmitting the spring force. A latch is arranged for preventing translating between the cylinder and the case. The latch is disengageable by the released gas spring being at least nearly fully extended thus allowing the extended gas spring to be translated in a distal direction.

Abstract: The invention relates to an auto-injector for administering a dose of a liquid medicament, comprising: an elongate tubular case, a carrier subassembly comprising a tubular carrier slidably arranged inside the case, the carrier adapted to contain a syringe with a hollow injection needle, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier, wherein the drive spring acts between the carrier and the plunger, wherein the plunger in an initial state is locked to the carrier by a ramped engagement to the carrier and by being prevented from rotating out of this ramped engagement depending on a relative longitudinal position of the carrier in the case, wherein the plunger is arranged to be released for rotating out of the ramped engagement upon the needle reaching at least nearly a predefined injection depth on translation of the carrier in the proximal direction for advancing the needle beyon

Abstract: An auto-injector with an interlock mechanism for defining an operation sequence of the auto-injector in a manner to allow a lateral trigger button to be operated only when a proximal end of the auto-injector is pressed against an injection site.

Abstract: The invention relates to an auto-injector for administering a dose of a liquid medicament, comprising: an elongate case arranged to be held by a user, a tubular chassis telescopable in the case and biased against the case so as to protrude from the case, a syringe with a hollow injection needle, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, a trigger button which is initially abutted against the case thus preventing actuation, wherein the chassis is arranged to translate into the case against the bias when pressed against an injection site, wherein the trigger button is at least initially coupled to the chassis in such a manner that the trigger button emerges from the case when the chassis is being pressed against the injection site so as to allow actuation by being translated towards the case for starting an injection cycle.

Abstract: According to the invention, a safety device for a pre-filled syringe comprises a hollow support body for retaining the pre-filled syringe, a hollow needle shield that is movable relative to the support body from a first position to a second position, releasable mounting means to mount the pre-filled syringe within the support body and a spring means arranged within the support body in a non-energized or only slightly energized state. The movement of the needle shield from the first position to the second position fully energizes the spring means.

Abstract: A safety device for a pre-filled syringe is proposed that comprises a hollow support body with a helical groove formed into an inner surface thereof, a mounting collar for mounting the pre-filled syringe to the support body, a spinning collar with a helical tongue formed to an outer surface thereof and a torsion spring. The helical groove accommodates the helical tongue. Upon release, the torsion spring is capable of exerting a torque upon the spinning collar which causes the spinning collar to rotate within the support body. The engagement of the helical groove and the helical tongue redirects the rotational movement of the spinning collar to a translatory movement that moves the mounting collar in a proximal direction.

Abstract: An auto-injector for administering a dose of a liquid medicament (M) is presented comprising an elongate housing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament (M), the housing having a distal end (D) and a proximal end (P) with an orifice intended to be applied against an injection site, wherein the syringe is slidably arranged with respect to the housing. The auto-injector contains a spring means capable of, upon activation, pushing the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end (P), operating the syringe to supply the dose of medicament (M), and retracting the syringe with the needle into the covered position after delivering the medicament (M). There is also an activating means arranged to lock the spring means in a pressurized state prior to manual operation.

Abstract: A safety device for a pre-filled syringe comprises a hollow support body to retain the pre-filled syringe therein, a hollow needle shield that is slidable relative to the support body and guiding means for guiding the movement of the needle shield relative to the support body. The guiding means comprise a deflectable flexible arm, a guide pin and a guide track. The deflectable flexible arm extends essentially parallel to a central axis of the safety device. The guide pin extends radial from the flexible arm. The guide track guides the guide pin within and along the guide track when the needle shield is slid relative to the support body.

Abstract: The invention relates to an auto-injector (A) for administering a dose of a liquid medicament, comprising of a substantially tubular front-end device adapted to contain a syringe with an injection needle and a barrel containing the dose of the medicament and comprising a needle shroud adapted to rest on the skin of a patient receiving an injection and a reusable back-end device comprising of a housing, a plunger connected to or adapted to engage a stopper providing a fluid tight seal for a distal end of the barrel, a motor for displacing the plunger connected to the stopper, wherein the front-end device is attachable to the back-end device, wherein the needle shroud is slidably arranged with respect to the injection needle and wherein an interlock switch is capable of detecting an axial position (PA, PR) of the needle shroud.

Abstract: The invention relates to a clutch mechanism for the transmission of a rotary movement from a gear arrangement comprising a first gear member and a second gear member. The first gear member is rotatable about a longitudinal axis but axially fixed wherein the first gear member, upon rotation, is arranged for translatively moving a second gear member which is prevented from rotating. The clutch mechanism comprises a circumferential shoulder arranged at the second gear member and at least one or a number of resilient clutch fingers with respective inclined inner surfaces arranged at the first gear member, the shoulder arranged for increasingly pressing against the inclined surfaces thereby flexing the clutch fingers outward when the shoulder reaches the clutch fingers in the course of its translation. The clutch mechanism further comprises tube arranged around the clutch fingers, the tube having a number of internal longitudinal splines for engaging the flexed-out clutch fingers.

Abstract: The invention relates to a front-end device of an auto-injector (A) for administering a dose of a liquid medicament, comprising of a support sleeve with a first screw thread adapted to engage a housing of a back-end device of the auto-injector (A) to attach the front-end device to the back-end device and an outer sleeve mounted onto a support sleeve of the front-end device by a second screw thread, wherein the front-end device is adapted to receive a syringe with an injection needle and a barrel containing the dose of the medicament and wherein the direction of rotation of the first screw thread is opposite to the direction of rotation of the second screw thread.

Abstract: A needle shield comprising at least two different plastic materials of different flexibility and a central aperture of variable diameter. The central aperture comprises a first diameter for retaining a needle cap therein. The diameter of the central aperture changes upon removal of the needle cap from the first diameter to a second diameter by virtue of a memory effect of the material of the needle shield. The needle shield is made by an injection molding process.

Abstract: Described is an autoinjector comprising a case, a needle shroud slidably arranged in the case, a chassis slidably arranged in the case and rotatably coupled to the needle shroud, an outer plunger selectively engaged to the chassis, an inner plunger selectively engaged to the outer plunger, and a drive spring applying a biasing force to the outer plunger. The biasing force is applied to the inner plunger when the inner plunger is engaged to the outer plunger. Axial movement of the needle shroud relative to the case causes rotation of the chassis relative to the needle shroud. The rotation of the chassis causes the inner plunger to rotate relative to the outer plunger and disengage the outer plunger to remove the biasing force from the drive spring on the inner plunger.

Abstract: Auto-injector for administering a dose of a liquid medicament includes a housing to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament (M), the housing having a distal end (D) and a proximal end (P) with an orifice to apply against an injection site. A spring means, upon activation, can push the needle from inside the housing through the orifice and past the proximal end (P), operate the syringe to supply the dose of medicament (M), and retract the syringe with the needle after delivering the medicament (M). An activating means can lock the spring means in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means for injection.

Abstract: The invention refers to a needle safety arrangement for protecting a hollow injection needle of a syringe after an injection, the needle safety arrangement comprising: a needle sheath having essentially the shape of a hollow cylinder arranged to surround the needle, the needle sheath slidable in longitudinal direction with respect to the syringe and biased in proximal direction (P), a sheath linkage, slidable in longitudinal direction, a syringe carrier for holding the syringe, the syringe and syringe carrier arranged for joint axial translation and rotation relative to the needle sheath, wherein the sheath linkage comprises means for restricting translation in proximal direction (P) with respect to the syringe by abutting against the syringe carrier, wherein in an initial state the sheath linkage is abutted against the syringe carrier and latched to the needle sheath for joint axial translation, wherein the syringe carrier exhibits at least one cam on its circumference, wherein the cam is arranged to de-l

Abstract: The invention refers to a shuttering mechanism for controlling translation of a longitudinally moveable component within an elongate housing, the shuttering mechanism comprising at least one set of castellations on the housing and at least one resilient arm associated with the longitudinally moveable component, the resilient arm having a dog resiliently biased towards the castellations so as to engage between or behind the castellations and block the translation, wherein a respective shutter arm is arranged alongside the set of castellations, the shutter arm having a number of consecutive ramped protrusions spaced from each other, wherein the castellations and the ramped protrusions have the same pitch, wherein a profiled surface is formed by the castellations and the ramped protrusions, wherein the shutter arm is moveable in longitudinal direction with respect to the set of castellations, wherein the shutter arm has at least one locking position with its ramped protrusions essentially in phase with the caste

Abstract: The invention refers to an auto-injector for delivering a liquid medicament, comprising: an elongate housing arranged to contain a syringe with a hollow injection needle and a stopper, wherein the syringe is slidably arranged with respect to the housing, spring means capable of, upon activation: pushing the needle from a covered position inside the housing into an advanced position for insertion into the injection site, operating the syringe to inject the dose of medicament, and advancing a needle shroud over the needle for providing needle safety, activating means arranged to lock and release the spring means, wherein the spring means is a single drive spring in the shape of a compression spring grounded distally in the housing and proximally bearing against a thrust collar arranged to transmit load from the spring means via a plunger to the syringe and/or the stopper for needle insertion and injection, wherein the plunger is engageable to the thrust collar for joint axial translation, wherein the plunge

Abstract: An arrangement for coupling a plunger to either a syringe or a stopper arranged in the syringe. The arrangement includes a syringe holder which is slidably arranged in a housing. The syringe holder is provided with at least one resilient syringe holder arm arranged distally, the syringe holder arm having an inclined surface for bearing against a shoulder, which is arranged at the plunger. The syringe holder arm is supportable by an inner surface of the housing in order to prevent it from being flexed outward in a first position. A widened portion is provided in the housing for allowing the syringe holder arm to flex outwards and disconnect from the plunger when in a more proximal position so as to switch load of the plunger from the syringe to the stopper.

Abstract: According to the invention, a back-end device of an auto-injector adapted to be attached to a packaged syringe comprises a plunger arranged to abut against a stopper of the packaged syringe to translate an injection needle of the packaged syringe in a proximal direction and to expel a dose of a medicament contained in the packaged syringe through the injection needle, a drive means capable of, upon release, driving the plunger in the proximal direction towards a proximal position, a rotary sleeve with a cam surface adapted to be engaged by a plunger follower formed to the plunger, a torsion spring arranged to exert a torque upon the rotary sleeve and a release element capable of, upon manual actuation, releasing the engagement of the plunger follower with the cam surface. The plunger follower is arranged to engage the cam surface to prevent the rotary sleeve from rotating with respect to the chassis in an initial state.

Abstract: According to the invention, a safety device for a pre-filled syringe with an injection needle comprises of a support body adapted to mount the pre-filled syringe, a needle shield slidably arranged with respect to the support body, a retention and locking means (M) for retaining and locking the needle shield with respect to the support body in a first and a second advanced position (PA1, PA2) and in a retracted position (PR). The needle shield comprises an annular flange adapted to rest on the skin of the patient receiving an injection. The retention and locking means (M) are arranged at a distal end of the safety device.