Abstract: The invention relates to methods of treating COVID-19 in a patient by administering therapeutically effective amounts of certain SARS-CoV-2 inhibitor compounds or pharmaceutical compositions containing them to a patient in need thereof. The invention also relates to inhibiting SARS-CoV-2 coronavirus viral replication activity comprising contacting SARS-CoV-2-related coronavirus protease with a therapeutically effective amount of a SARS-Cov-2 protease inhibitor, such as a SARS-Cov-2 3CL protease inhibitor and compositions comprising the same.

Abstract: An information processing device includes an obtaining section configured to obtain position information of a plurality of parts of a photographing target, a deriving section configured to derive a length between two parts, and a production control section configured to perform production on the basis of the derived length.

Abstract: Described herein are compounds of Formula I: and their pharmaceutically acceptable salts, wherein R1, R2, R3, X1, Y1, Y2, Y3, Y4 and Y5 are defined herein; their use as MC4R antagonists; pharmaceutical compositions containing such compounds and salts; the use of such compounds and salts to treat, for example, cachexia, anorexia, or anorexia nervosa; and intermediates and processes for preparing such compounds and salts.

Abstract: The invention relates to compounds of Formula I? wherein R, R1, R2, R3, p, q and q? are as defined herein, pharmaceutical compositions comprising the compounds, methods of treating coronavirus infection such as COVID-19 in a patient by administering therapeutically effective amounts of the compounds, and methods of inhibiting or preventing replication of coronaviruses such as SARS-CoV-2 with the compounds.

Abstract: The invention relates to compounds of Formula I? wherein R, R1, R2, R3, p, q and q? are as defined herein, pharmaceutical compositions comprising the compounds, methods of treating coronavirus infection such as COVID-19 in a patient by administering therapeutically effective amounts of the compounds, and methods of inhibiting or preventing replication of coronaviruses such as SARS-CoV-2 with the compounds.

Abstract: The invention relates to compounds of Formula I? wherein R, R1, R2, R3, p, q and q? are as defined herein, pharmaceutical compositions comprising the compounds, methods of treating coronavirus infection such as COVID-19 in a patient by administering therapeutically effective amounts of the compounds, and methods of inhibiting or preventing replication of coronaviruses such as SARS-CoV-2 with the compounds.

Abstract: The invention relates to compounds of Formula I? wherein R, R1, R2, R3, p, q and q? are as defined herein, pharmaceutical compositions comprising the compounds, methods of treating coronavirus infection such as COVID-19 in a patient by administering therapeutically effective amounts of the compounds, and methods of inhibiting or preventing replication of coronaviruses such as SARS-CoV-2 with the compounds.

Abstract: The invention relates to compounds of Formula I? wherein R, R1, R2, R3, p, q and q? are as defined herein, pharmaceutical compositions comprising the compounds, methods of treating coronavirus infection such as COVID-19 in a patient by administering therapeutically effective amounts of the compounds, and methods of inhibiting or preventing replication of coronaviruses such as SARS-CoV-2 with the compounds.

Abstract: The invention relates to processes for performing biochemical reactions, such as in an aqueous in vitro reaction system. The processes involve macromolecules, particularly polypeptides, comprising one or more functional intrinsically disordered regions (IDRs). The invention also relates to IDR-macromolecules, including IDR-polypeptides, including macromolecules or polypeptides comprising a tagged amino acid sequence which comprises or consists of one or more functional IDRs. Such functional IDRs are capable of increasing the efficiency of the biochemical reaction. The invention relates to kits comprising any such macromolecules and polypeptides. The invention further relates to processes for stimulating or enhancing liquid-liquid demixing in a solution using any such macromolecules and polypeptides, including in combination with multivalent metal ions, thereby providing reagents capable of increasing the efficiency of a biochemical reaction.

Abstract: The invention relates to processes for performing biochemical reactions, such as in an aqueous in vitro reaction system. The processes involve macromolecules, particularly polypeptides, comprising one or more functional intrinsically disordered regions (IDRs). The invention also relates to IDR-macromolecules, including IDR-polypeptides, including macromolecules or polypeptides comprising a tagged amino acid sequence which comprises or consists of one or more functional IDRs. Such functional IDRs are capable of increasing the efficiency of the biochemical reaction. The invention relates to kits comprising any such macromolecules and polypeptides. The invention further relates to processes for stimulating or enhancing liquid-liquid demixing in a solution using any such macromolecules and polypeptides, including in combination with multivalent metal ions, thereby providing reagents capable of increasing the efficiency of a biochemical reaction.

Abstract: The invention relates to compounds of Formula I? wherein R, R1, R2, R3, p, q and q? are as defined herein, pharmaceutical compositions comprising the compounds, methods of treating coronavirus infection such as COVID-19 in a patient by administering therapeutically effective amounts of the compounds, and methods of inhibiting or preventing replication of coronaviruses such as SARS-CoV-2 with the compounds.

Abstract: The invention relates to compounds of formula I wherein R1, R2 and - - - - - are as defined herein, pharmaceutical compositions comprising the compounds and methods of treating COVID-19 in a patient by administering therapeutically effective amounts of the compounds and methods of inhibiting or preventing replication of SARS-CoV-2 with the compounds.

Abstract: A control method and related apparatus are disclosed for controlling actuation voltages applied to array elements of an element array on an electrowetting on dielectric (EWOD) device, wherein test metrics are determined and employed for optimizing subsequent droplet manipulation operations. The control method includes the steps of: receiving a liquid droplet onto the element array; applying an electrowetting actuation pattern of actuation voltages to actuate the droplet to modify a footprint of the droplet from a first state having an initial footprint to a second state having a modified footprint; sensing the modified footprint with a sensor; determining a test metric from sensing the modified footprint indicative of one or more droplet properties based on a droplet response of the liquid droplet to the electrowetting actuation pattern; and controlling actuation voltages applied to the array elements based on the test metric.

Abstract: A field controller adapter includes a bracket that includes a plate having a first side and a second side with a plurality of feet extending therefrom, and a connector assembly coupled to the second side. The connector assembly includes a circuit board, a terminal block coupled to the circuit board, and a connector coupled to the circuit board with a plurality of wires. The first side is configured to facilitate coupling a field controller thereto. The connector is configured to electrically couple the field controller to the circuit board. The plurality of feet are configured to engage with mounts on a housing of a base unit to facilitate mechanically coupling the bracket thereto. The terminal block is configured to engage with a corresponding terminal block on a base circuit board disposed within the housing of the base unit to electrically couple the circuit board to the base circuit board.

Abstract: A control method and related apparatus are disclosed for controlling actuation voltages applied to array elements of an element array on an electrowetting on dielectric (EWOD) device, wherein test metrics are determined and employed for optimizing subsequent droplet manipulation operations. The control method includes the steps of: receiving a liquid droplet onto the element array; applying an electrowetting actuation pattern of actuation voltages to actuate the droplet to modify a footprint of the droplet from a first state having an initial footprint to a second state having a modified footprint; sensing the modified footprint with a sensor; determining a test metric from sensing the modified footprint indicative of one or more droplet properties based on a droplet response of the liquid droplet to the electrowetting actuation pattern; and controlling actuation voltages applied to the array elements based on the test metric.

Abstract: A field controller adapter includes a bracket that includes a plate having a first side and a second side with a plurality of feet extending therefrom, and a connector assembly coupled to the second side. The connector assembly includes a circuit board, a terminal block coupled to the circuit board, and a connector coupled to the circuit board with a plurality of wires. The first side is configured to facilitate coupling a field controller thereto. The connector is configured to electrically couple the field controller to the circuit board. The plurality of feet are configured to engage with mounts on a housing of a base unit to facilitate mechanically coupling the bracket thereto. The terminal block is configured to engage with a corresponding terminal block on a base circuit board disposed within the housing of the base unit to electrically couple the circuit board to the base circuit board.

Abstract: This cosmetic product dispensing head (30) comprises: a dispensing member (32) for the cosmetic product, having a tubular duct (34) defining a passage (36) for the cosmetic product, and a stopper (60) for closing off the passage (36), movable between a position freeing the passage (36) and a position closing off the passage (36), the stopper (60) comprising a finger (62) and a skirt (64), the outer face (48) of the duct (34) and the inner face (78) of the skirt (64) having complementary cooperating means (80, 82) for securing the stopper (60) to the dispensing member (32). The finger (62) bears a peripheral scraping member (70) protruding radially from a peripheral face (72) of the finger (62), the scraping member (70) having at least one perimeter line (74) suitable for being in contact with the duct (34) when the stopper (60) is in the closing off position.

Abstract: A method includes obtaining an original image; dividing the original image into a plurality of pixel blocks; forming a scrambled image by rearranging the plurality of pixel blocks; and forming a markup language description to display the original image from the scrambled image. Each pixel block may represent a rectangular region of the original image. The markup language description may be an HTML description.

Abstract: An automatic nailing assembly includes lower and upper skeletal frames for attachment to a pneumatic nailer; front and rear wheels mounted on the bottom frame; a linkage defined by pulleys or sprockets mounted on the frames interconnected by an endless belt or chain and driven by the rear wheel; a cam wheel for rotation by the pulley or sprocket on the upper frame; and a lever operated by the cam wheel to actuate a trigger for causing nails to be ejected at intervals from the nailer as the assembly rolls along a workpiece.