Abstract: In one embodiment, the disclosure is directed to an integrated apparatus for delivering energy to a tissue. The integrated apparatus included a housing having a distal end and a tubular structure located within the housing forming a first annulus between the tubular structure and the housing. The tubular structure is configured to accept an energy delivery component and is configured to form a second annulus between the tubular structure and the energy delivery component. The first annulus and the second annulus are configured to communicate with each other proximate to the distal end of the housing.

Abstract: A web rendering module in the operating system is used to render and display a web page. The web rendering module also generates layout data that describes the position and size of each visual element on the rendered web page. A web editing application uses the layout data to generate a native overlay. The native overlay is an arrangement of cells, and each cell has the same position and size as a respective visual element. The application displays the native overlay on top of the rendered web page so that each visual element on the web page is aligned with a cell in the native overlay. The cells in the native overlay are transparent so that the rendered web page remains visible to the user, but the native overlay captures any interactions that the user performs. The interactions are then processed to make a corresponding change to the web page.

Abstract: A method for producing an isotope of interest includes providing a target including a first isotope of a target element, and bombarding the target with accelerated ions to produce in the target by nuclear reactions between the accelerated ions and the first isotope of the target element: a second isotope of the target element, wherein the second isotope of the target element is the isotope of interest or a radioisotope within a decay chain of the isotope of interest; and transmutation products of a different elemental form than the target element.

Abstract: In one embodiment, the disclosure is directed to an integrated apparatus for delivering energy to a tissue. The integrated apparatus included a housing having a distal end and a tubular structure located within the housing forming a first annulus between the tubular structure and the housing. The tubular structure is configured to accept an energy delivery component and is configured to form a second annulus between the tubular structure and the energy delivery component. The first annulus and the second annulus are configured to communicate with each other proximate to the distal end of the housing.

Abstract: A process of producing heat energy for use in heat exchange with other fluids and substances so as to impart said heat energy to said fluid or substances which includes several steps. In a first step, a mixture of fuel and oxidant is ignited in a combustion zone or zones (16, 18, 98, 122) to create a combusted fuel mix which in the form of shockwaves are carried away from the combustion zone or zones (16, 18, 98, 122) to provide a low pressure area within the combustion zone or zones (16, 18, 98, 122).

Abstract: In one embodiment, the disclosure is directed to an integrated apparatus for delivering energy to a tissue. The integrated apparatus included a housing having a distal end and a tubular structure located within the housing forming a first annulus between the tubular structure and the housing. The tubular structure is configured to accept an energy delivery component and is configured to form a second annulus between the tubular structure and the energy delivery component. The first annulus and the second annulus are configured to communicate with each other proximate to the distal end of the housing.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: Devices and methods for evacuating fluids from a flexible conduit, particularly to evacuating water from a fire hose. In one aspect, a fluid evacuating apparatus is utilized to evacuate a fluid, such as water, from a flexible conduit, such as, for example, a fire hose. The apparatus may further be utilized to collapse the flexible conduit for storage and/or transport. In exemplary embodiments, a fluid evacuating apparatus may be utilized to evacuate the water from hoses of a wide range of diameters that collapse into a compact form for storage. The apparatus may include a frame with a handle, a mobility mechanism, such as, for example, wheels or rollers, a roller which may evacuate water, and a restraining mechanism which may hold down the hose, such as a roller or rollers.

Abstract: In one embodiment, the disclosure is directed to an integrated apparatus for delivering energy to a tissue. The integrated apparatus included a housing having a distal end and a tubular structure located within the housing forming a first annulus between the tubular structure and the housing. The tubular structure is configured to accept an energy delivery component and is configured to form a second annulus between the tubular structure and the energy delivery component. The first annulus and the second annulus are configured to communicate with each other proximate to the distal end of the housing.

Abstract: In one embodiment, the disclosure is directed to an integrated apparatus for delivering energy to a tissue. The integrated apparatus included a housing having a distal end and a tubular structure located within the housing forming a first annulus between the tubular structure and the housing. The tubular structure is configured to accept an energy delivery component and is configured to form a second annulus between the tubular structure and the energy delivery component. The first annulus and the second annulus are configured to communicate with each other proximate to the distal end of the housing.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: A light diffusing tip is provided. The light diffusing tip comprises a housing and a monolithic light scattering medium disposed within the housing. The monolithic light scattering medium comprises a first scattering region at a first position, the scattering region having a first scattering property and a second scattering region at a second position, the second scattering region having a second scattering property different from the first scattering property, wherein the first scattering region and the second scattering region are coextensive along a substantial portion of a length of the housing. A light diffusing applicator also is provided. The light diffusing applicator comprises at least one optical waveguide, a first termination coupled to a first end of the at least one optical waveguide, the first termination to couple to a light source and a light diffusing tip coupled to a second end of the at least one optical waveguide.

Abstract: The present invention is directed to devices and methods for evacuating fluids from a flexible conduit, particularly to evacuating water from a fire hose. In one aspect, a fluid evacuating apparatus is utilized to evacuate a fluid, such as water, from a flexible conduit, such as, for example, a fire hose. The apparatus may further be utilized to collapse the flexible conduit for storage and/or transport. In exemplary embodiments, a fluid evacuating apparatus may be utilized to evacuate the water from hoses of a wide range of diameters that collapse into a compact form for storage. The apparatus may include a frame with a handle, a mobility mechanism, such as, for example, wheels or rollers, a roller which may evacuate water, and a restraining mechanism which may hold down the hose, such as a roller or rollers.

Abstract: The invention relates to the soybean variety designated D4682156. Provided by the invention are the seeds, plants and derivatives of the soybean variety D4682156. Also provided by the invention are tissue cultures of the soybean variety D4682156 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety D4682156 with itself or another soybean variety and plants produced by such methods.

Abstract: A light diffusing tip is provided. The light diffusing tip comprises a housing and a monolithic light scattering medium disposed within the housing. The monolithic light scattering medium comprises a first scattering region at a first position, the scattering region having a first scattering property and a second scattering region at a second position, the second scattering region having a second scattering property different from the first scattering property, wherein the first scattering region and the second scattering region are coextensive along a substantial portion of a length of the housing. A light diffusing applicator also is provided. The light diffusing applicator comprises at least one optical waveguide, a first termination coupled to a first end of the at least one optical waveguide, the first termination to couple to a light source and a light diffusing tip coupled to a second end of the at least one optical waveguide.

Abstract: A light diffusing tip is provided. The light diffusing tip comprises a housing and a monolithic light scattering medium disposed within the housing. The monolithic light scattering medium comprises a first scattering region at a first position, the scattering region having a first scattering property and a second scattering region at a second position, the second scattering region having a second scattering property different from the first scattering property, wherein the first scattering region and the second scattering region are coextensive along a substantial portion of a length of the housing. A light diffusing applicator also is provided. The light diffusing applicator comprises at least one optical waveguide, a first termination coupled to a first end of the at least one optical waveguide, the first termination to couple to a light source and a light diffusing tip coupled to a second end of the at least one optical waveguide.

Abstract: The invention relates to the soybean variety designated D4361423. Provided by the invention are the seeds, plants and derivatives of the soybean variety D4361423. Also provided by the invention are tissue cultures of the soybean variety D4361423 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety D4361423 with itself or another soybean variety and plants produced by such methods.

Abstract: The invention relates to the soybean variety designated D4301279. Provided by the invention are the seeds, plants and derivatives of the soybean variety D4301279. Also provided by the invention are tissue cultures of the soybean variety D4301279 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety D4301279 with itself or another soybean variety and plants produced by such methods.

Abstract: The invention relates to the soybean variety designated D4367012. Provided by the invention are the seeds, plants and derivatives of the soybean variety D4367012. Also provided by the invention are tissue cultures of the soybean variety D4367012 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety D4367012 with itself or another soybean variety and plants produced by such methods.

Abstract: The invention relates to the soybean variety designated D4682156. Provided by the invention are the seeds, plants and derivatives of the soybean variety D4682156. Also provided by the invention are tissue cultures of the soybean variety D4682156 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety D4682156 with itself or another soybean variety and plants produced by such methods.