Abstract: A software development system and method which reduces development cycle times, improves software quality, and indicates speed to market for software is provided. The system integrates development resources to streamline the process of utilizing those resources by a developer or other personnel. A software development workbench and associated toolchain may be used to further improve the software development process.

Abstract: In some embodiments, a delivery device includes a device actuator and a cannula portion through which a therapeutic substance is ejected. The cannula portion includes an outer shaft, a needle that is configured to move through the outer shaft, and a plunger that is configured to move through the needle, forming a positive displacement arrangement.

Abstract: Provided herein are delivery particle systems (XDP) useful for the delivery of payloads of any type. In some embodiments, a XDP particle system with tropism for target cells of interest is used to deliver CRISPR/Cas polypeptides (e.g., CasX proteins) and guide nucleic acids (gNA), for the modification of nucleic acids in target cells. Also provided are methods of making and using such XDP to modify the nucleic acids in such cells.

Abstract: In some embodiments, a delivery device includes a device actuator and a cannula portion through which a therapeutic substance is ejected. The cannula portion includes an outer shaft, a needle that is configured to move through the outer shaft, and a plunger that is configured to move through the needle, forming a positive displacement arrangement.

Abstract: The invention relates to proteins that contain the CD4 domain 1 and the CD4 domain 2 (CD4 D1D2), wherein the CD4 D1D2 contains one or more mutations compared to wild-type human CD4 D1D2, and to methods of using the proteins for treating a human immunodeficiency virus (HIV) infection in a subject.

Abstract: A reciprocating piston pump may include a fluid handling portion comprising a fluid inlet, a fluid outlet, and a pump chamber; a drive assembly portion comprising a piston drive assembly, a reciprocating piston, a drive assembly housing, and a drive assembly chamber; and an electro-fluidic leak detection element comprising a fluid sensing portion. The reciprocating piston of the drive assembly portion extends into the pump chamber of the fluid handling portion. The piston drive assembly operates to reciprocate the reciprocating piston within the pump chamber. The electro-fluidic leak detection element is mounted within the drive assembly portion. The electro-fluidic leak detection element is configured to generate a fluid leakage signal when fluid from the pump chamber enters the drive assembly chamber and contacts the fluid sensing portion of the electro-fluidic leak detection element. A plurality of reciprocating piston pumps may be incorporated into fluid handling systems.

Abstract: A threaded fluidic fitting may include a fluid passage, at least one fluid port, a threaded fitting portion, an engageable body portion, and an electro-fluidic leak detection element. The fluid passage extends from the fluid port of the threaded fluidic fitting. The threaded fitting portion comprises a helical thread, extends from a leak detection face of the engageable body portion, and is configured to rotate with the engageable body portion to enhance a fluidically sealed engagement of one of the fluid ports with a complementary fluidic component. The electro-fluidic leak detection element is positioned on the leak detection face of the engageable body portion or on a drip edge portion of a face extending from the leak detection face. A fluid handling system may include a plurality of threaded fluidic fittings and a leak detecting computing hub in communication with the plurality of threaded fluidic fittings.

Abstract: In some embodiments, a delivery device includes a device actuator and a cannula portion through which a therapeutic substance is ejected. The cannula portion includes an outer shaft, a needle that is configured to move through the outer shaft, and a plunger that is configured to move through the needle, forming a positive displacement arrangement.

Abstract: A pinch valve configuration may include a pinch valve comprising a valve body, a valve plunger, and a fluidic tubing pinch passage defined between a tubing seat of the valve body and an operative end of the valve plunger. The pinch valve configuration may further include a Hall effect sensor assembly comprising a stationary element anchored to the valve body and a motive element anchored to the valve plunger. The pinch valve configuration additionally includes a failure prediction module in communication with the Hall effect sensor assembly. The failure prediction module is programmed to process an output signal of the Hall effect sensor assembly as a displacement reading, to compare the displacement reading with a failure prediction threshold, and to generate a failure prediction signal from the comparison of the displacement reading with the failure prediction threshold.

Abstract: A software development system and method which reduces development cycle times, improves software quality, and indicates speed to market for software is provided. The system integrates development resources to streamline the process of utilizing those resources by a developer or other personnel. A software development workbench and associated toolchain may be used to further improve the software development process.

Abstract: A system and method for managing a software development project is provided. The system integrates software development workbench and associated toolchain to link a plurality of software development tools according to a dependency that illustrates a relationship between the plurality of software development tools to indicate to a developer that the one or more software development tools necessary to build, test, deploy, and/or run the software development project, and to indicate the operational status of the a plurality of software development tools to streamline the process of utilizing those tools by a developer or other personnel.

Abstract: Methods and systems for managing access to a data location associated with a vehicle. The method includes detecting, by one or more sensors of the vehicle, vehicle data. The method also includes recording, by an electronic control unit (ECU) of the vehicle, the vehicle data to the data location. The method also includes storing, by a smart contract located on a blockchain, an access state associated with the data location, the access state indicating one or more devices having access to the data location. The method also includes communicating, by the ECU, an instruction to the smart contract to change the access state associated with the data location to grant access to a third-party device or revoke access from the third-party device.

Abstract: The present invention provides methods and compositions for optimally co-expressing in a primate subject a tyrosylprotein sulfotransferase (TPST) and a lentiviral gp120-binding molecule to provide potent and long term protection against lentiviral infections.

Abstract: The present invention provides methods and compositions for optimally co-expressing in a primate subject a tyrosylprotein sulfotransferase (TPST) and a lentiviral gp120-binding molecule to provide potent and long term protection against lentiviral infections.

Abstract: A threaded fluidic fitting may include a fluid passage, at least one fluid port, a threaded fitting portion, an engageable body portion, and an electro-fluidic leak detection element. The fluid passage extends from the fluid port of the threaded fluidic fitting. The threaded fitting portion comprises a helical thread, extends from a leak detection face of the engageable body portion, and is configured to rotate with the engageable body portion to enhance a fluidically sealed engagement of one of the fluid ports with a complementary fluidic component. The electro-fluidic leak detection element is positioned on the leak detection face of the engageable body portion or on a drip edge portion of a face extending from the leak detection face. A fluid handling system may include a plurality of threaded fluidic fittings and a leak detecting computing hub in communication with the plurality of threaded fluidic fittings.

Abstract: A pinch valve configuration may include a pinch valve comprising a valve body, a valve plunger, and a fluidic tubing pinch passage defined between a tubing seat of the valve body and an operative end of the valve plunger. The pinch valve configuration may further include a Hall effect sensor assembly comprising a stationary element anchored to the valve body and a motive element anchored to the valve plunger. The pinch valve configuration additionally includes a failure prediction module in communication with the Hall effect sensor assembly. The failure prediction module is programmed to process an output signal of the Hall effect sensor assembly as a displacement reading, to compare the displacement reading with a failure prediction threshold, and to generate a failure prediction signal from the comparison of the displacement reading with the failure prediction threshold.

Abstract: A reciprocating piston pump may include a fluid handling portion comprising a fluid inlet, a fluid outlet, and a pump chamber; a drive assembly portion comprising a piston drive assembly, a reciprocating piston, a drive assembly housing, and a drive assembly chamber; and an electro-fluidic leak detection element comprising a fluid sensing portion. The reciprocating piston of the drive assembly portion extends into the pump chamber of the fluid handling portion. The piston drive assembly operates to reciprocate the reciprocating piston within the pump chamber. The electro-fluidic leak detection element is mounted within the drive assembly portion. The electro-fluidic leak detection element is configured to generate a fluid leakage signal when fluid from the pump chamber enters the drive assembly chamber and contacts the fluid sensing portion of the electro-fluidic leak detection element. A plurality of reciprocating piston pumps may be incorporated into fluid handling systems.

Abstract: A software development system and method which reduces development cycle times, improves software quality, and indicates speed to market for software is provided. The system integrates development resources to streamline the process of utilizing those resources by a developer or other personnel. A software development workbench and associated toolchain may be used to further improve the software development process.

Abstract: A cycloidal differential includes a driven body and a coupling ring supported for rotation within the driven body. The coupling ring defines a first eccentric race and a second eccentric race on opposing sides of the coupling ring. The cycloidal differential further includes first and second cycloidal drives. The first cycloidal drive includes a first roller disk received in the first eccentric race and a first output member operably coupled to the first roller disk and configured to couple with a half shaft. The second cycloidal drive includes a second roller disk received in the second eccentric race and a second output member operably coupled to the second roller disk and configured to couple with another half shaft.

Abstract: A cycloidal differential includes a driven body and a coupling ring supported for rotation within the driven body. The coupling ring defines a first eccentric race and a second eccentric race on opposing sides of the coupling ring. The cycloidal differential further includes first and second cycloidal drives. The first cycloidal drive includes a first roller disk received in the first eccentric race and a first output member operably coupled to the first roller disk and configured to couple with a half shaft. The second cycloidal drive includes a second roller disk received in the second eccentric race and a second output member operably coupled to the second roller disk and configured to couple with another half shaft.