Abstract: An improved customizable dosage form comprising a substrate, such as a tablet core, that has one or more distinct, discreet cavities on its exterior surface, wherein simethicone is deposited into at least one of the cavities.

Abstract: Management of the health status of an animal colony using a plurality of blood collection cards and the analysis of dried blood from members of the colony that has been collected on the cards. Members of the colony may be removed from the colony as a result of the analysis.

Abstract: This invention provides an device for electrical stimulation of the spinal cord. The device has an electrode assembly with a sufficiently thin profile to be implanted between the pial surface of the spinal cord and the dura mater, and secured to the dura. Electrodes on the electrode assembly are directed towards the surface of the spinal cord, and connected through the dura to a signal generator located outside the dura. Following implantation, the subject is treated by transmitting electrical signals from the signal generator through the leads to the electrodes, stimulating the subject's spinal cord.

Abstract: Methods and systems for managing register content is described. A register content management module receives an identity of the retail location register, identifies a geographic location associated with the retail location register, identifies a time for which the updated register content is requested, generates a new register content, and sends the new register content to the retail location register independently from sending an application update to the retail location register.

Abstract: This invention provides an device for electrical stimulation of the spinal cord. The device has an electrode assembly with a sufficiently thin profile to be implanted between the pial surface of the spinal cord and the dura mater, and secured to the dura. Electrodes on the electrode assembly are directed towards the surface of the spinal cord, and connected through the dura to a signal generator located outside the dura. Following implantation, the subject is treated by transmitting electrical signals from the signal generator through the leads to the electrodes, stimulating the subject's spinal cord.

Abstract: A composition for use in generating an inhalable medium, the composition comprising an extruded material, wherein the extruded material comprises a flavorant and no tobacco-derived components.

Abstract: A method for altering the appearance of molded articles is described herein. The method includes the steps of providing a plurality of articles; feeding a first article to a conveyor; transporting the first article to a treatment station; activating an activatable colorant of the first article by exposing the first article to at least one energy source, thereby causing a color change in the first article; manipulating the exposure of the first article to create a first discernable pattern in the first article; feeding a second article to the conveyor; transporting the second article to the treatment station; activating an activatable colorant of the second article by exposing the second article to the at least one energy source, thereby causing a color change in the second article; and manipulating the exposure of the second article to create a second discernable pattern in the second article.

Abstract: An improved customizable dosage form comprising a substrate, such as a tablet core, that has two or more distinct, discrete cavities on opposing sides of its exterior surface; and/or two or more distinct, discrete cavities on a first side of its exterior surface and an identification feature on a second opposing side of its exterior surface. A process for making such a customizable dosage form wherein one or more active ingredients and inactive ingredients such as colors, flavors and/or sensates are deposited into at least one of the cavities.

Abstract: The present disclosure relates to a cartomiser for a vapour provision system configured to selectively generate vapours with different flavour characteristics. Also disclosed is a vapour provision system comprising said cartomiser and a method of operating the vapour provision system. The flavour characteristics may be used to provide an end-of-life indication to a user.

Abstract: A caliper type device is provided for identifying the cranial midline on a patient. The device includes a pair of arms have first ends for receipt in a patients ears, and opposite, pivotally connected second ends which allow the arms to open and close to fit to different sized heads of various patients. A housing at the second end of the arms holds a laser pointer or other tool for identifying the cranial midline after the device is positioned on the patients head.

Abstract: Among other things, a chiller for chilling water to be dispensed as part of beverages includes a tank configured to contain a cooling mass for chilling the water. A first tube in the tank is configured to be immersed in the cooling mass and to carry the water along a path from a source towards a location where the chilled water is to be dispensed as part of the beverages. A second tube is configured to be immersed in the cooling mass and to carry a coolant along a recirculation path from a coolant source and back to the coolant source. The coolant has a sufficiently low temperature to cause a frozen mass to be formed as part of the cooling mass within the tank and in the vicinity of the second tube. The first tube and the second tube are configured and positioned relative to one another within the tank so that the frozen mass occupies at least 30 percent of the volume of the cooling mass in the tank but does not touch the first tube.

Abstract: The invention relates to compounds of Formula (I): wherein R1, R2 and R3 are as defined in the description and claims, or pharmaceutically acceptable salts thereof, having ?v?6 integrin antagonist activity. The invention also relates to pharmaceutical compositions including a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and to the use of a compound of Formula (I), or a pharmaceutically acceptable salt thereof, in therapy, including in the treatment of a disease or condition for which an ?v?6 integrin antagonist is indicated, in particular the treatment of idiopathic pulmonary fibrosis.

Abstract: Improved battery separators are disclosed herein for use in flooded lead-acid batteries, and in particular enhanced flooded lead-acid batteries. The improved separators disclosed herein provide for enhanced electrolyte mixing and substantially reduced acid stratification. The improved flooded lead-acid batteries may be advantageously employed in applications in which the battery remains in a partial state of charge, for instance in start/stop vehicle systems. Also, improved lead-acid batteries, such as flooded lead-acid batteries, improved systems that include a lead-acid battery and a battery separator, improved battery separators, improved vehicles including such systems, and/or methods of manufacture and/or use may be provided.

Abstract: Improved battery separators are disclosed herein for use in flooded lead-acid batteries, and in particular enhanced flooded lead-acid batteries. The improved separators disclosed herein provide for enhanced electrolyte mixing and substantially reduced acid stratification. The improved flooded lead-acid batteries may be advantageously employed in applications in which the battery remains in a partial state of charge, for instance in start/stop vehicle systems. Also, improved lead-acid batteries, such as flooded lead-acid batteries, improved systems that include a lead-acid battery and a battery separator, improved battery separators, improved vehicles including such systems, and/or methods of manufacture and/or use may be provided.

Abstract: The spinal cord stimulation device of this invention is configured for implantation into a patient so as to traverse the dura mater that surrounds the spinal cord. Placing the device in this location provides direct contact between the electrode and the cerebrospinal fluid (CSF), in close proximity to the spinal cord. The device has an intradural portion and an extradural portion that compresses and seals the dural membrane between them, securing the device in position and preventing leakage of CSF. The position of the device may be stabilized in relation to the spinal cord by way of a laminoplasty plate, bridging between the device and a vertebra. The device is electronically powered by an implanted pulse generator that produces a spectrum of signals to interrupt or otherwise attenuate transmission of pain mediating neural signals through the spinal cord.

Abstract: An adjustable cranioplasty plate assembly is provided for use following a craniectomy. The assembly includes a ring which is attached to the skull around the skull opening and a plate adjustably mounted to the ring. The plate is moveable between a raised position spaced above the ring and a lower position substantially flush with the ring. The plurality of extendable and retractable struts extends between the ring and the plate to provide the plate adjustability. The plurality of stay cables extending between the ring and the plate provide lateral stability in the raised position. The assembly replaces the native bone and eliminates the need for subsequent cranioplasty surgery. In one embodiment, the plate includes a rigid central portion, three rigid mounting tabs, and a plurality of malleable tapered perimeter petals which provide a smooth interface between the plate and the skull of the patient.

Abstract: An adjustable bed system includes a frame structure, a back lifting assembly and a leg lifting assembly pivotally connected to the frame structure, platforms having a plurality of openings, disposed on the frame structure and operably coupled with the back and leg lifting assemblies, a mattress having a plurality of through holes and disposed on the platforms so that the plurality of through holes is aligned with the plurality of openings, respectively, and a plurality of fans installed in the plurality of openings of the platforms such that each fan is in communication with a respective through hole of the mattress for operably moving air via said through hole into the mattress body and outputting the air from the top surface of the mattress. Positions of upper and lower portions of the mattress are adjustable based on operations of the back and assemblies.

Abstract: This invention provides an device for electrical stimulation of the spinal cord. The device has an electrode assembly with a sufficiently thin profile to be implanted between the pial surface of the spinal cord and the dura mater, and secured to the dura. Electrodes on the electrode assembly are directed towards the surface of the spinal cord, and connected through the dura to a signal generator located outside the dura. Following implantation, the subject is treated by transmitting electrical signals from the signal generator through the leads to the electrodes, stimulating the subject's spinal cord.

Abstract: This invention provides a device for implantation directly into the spinal cord for the purpose of treating back pain. Electrodes on a backing that conforms directly to the spinal cord are installed as a source of electrical stimulation and pain relief. The floating electrodes can be flexibly mounted to the substrate such that when the electrode array is implanted into the subject, individual electrodes float or move resiliently relative to the substrate to an extent sufficient to accommodate pulsations of the surface of the spinal cord within the dura.

Abstract: Among other things, a chiller for chilling water to be dispensed as part of beverages includes a tank configured to contain a cooling mass for chilling the water. A first tube in the tank is configured to be immersed in the cooling mass and to carry the water along a path from a source towards a location where the chilled water is to be dispensed as part of the beverages. A second tube is configured to be immersed in the cooling mass and to carry a coolant along a recirculation path from a coolant source and back to the coolant source. The coolant has a sufficiently low temperature to cause a frozen mass to be formed as part of the cooling mass within the tank and in the vicinity of the second tube. The first tube and the second tube are configured and positioned relative to one another within the tank so that the frozen mass occupies at least 30 percent of the volume of the cooling mass in the tank but does not touch the first tube.