Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.

Abstract: Single crystal CVD diamond material comprising a total nitrogen concentration of at least 5 ppm and a neutral single substitutional nitrogen, Ns0, to total single substitutional nitrogen, Ns, ratio of at least 0.7. Such a diamond is observed to have a relatively low amount of brown colouration despite the relatively high concentration of nitrogen. A method of making the single crystal diamond is also disclosed, the method including growing the CVD diamond in process gases comprising 60 to 200 ppm nitrogen, in addition to a carbon-containing gas, and hydrogen, wherein the ratio of carbon atoms in the carbon-containing gas to hydrogen atoms in the hydrogen gas is 0.5 to 1.5%.

Abstract: This document discusses systems, devices, and methods for monitoring and managing patients with chronic pain. A patient monitoring system comprises a sensor circuit to sense a physiological or functional signal indicative of or correlated to patient mobility, an electrostimulator to generate and deliver neuromodulation therapy to the patient, and a controller circuit to generate a mobility metric using the sensed physiological or functional signal. The mobility metric represents respective times spent in different activity intensity levels associated with one or more types of activities during a specific time period. The controller circuit can trend the mobility metric over time and determine a progress toward a personalized mobility goal of the patient, and control the electrostimulator to initiate or adjust the neuromodulation therapy in accordance with the trended mobility metric or the determined progress toward the mobility goal.

Abstract: Systems and methods are described herein for processing electronic medical images to predict a biomarker's presence, including receiving one or more digital medical images, the one or more digital medical images being of at least one pathology specimen associated with a patient. A machine learning system may determine a biomarker expression level prediction for the one or more digital medical images. The biomarker expression level prediction may be based on a determined transcriptomic score and protein expression score for the one or more digital medical images. A slide overlay indicating a region of tissue on the one or more digital medical images that is most likely to contribute to the slide level biomarker expression prediction may be generated.

Abstract: Systems and techniques are disclosed to generate programming parameters and modifications during closed-loop adjustment of an implantable neurostimulation device treatment programming, through the identification and application of weights determined from user input indications and rankings of therapy objectives.

Abstract: A wet wipe is provided. The wet wipe includes a sheet formed from non-plastic materials. The sheet has a weight of between 40-90 gsm. The sheet comprises a blend of wood pulp fluff fiber and cellulosic staple fibers and/or cross-linked curly pulp. The wood pulp fluff fiber has a weight percent of between 60-95%. The cellulosic staple fibers and/or cross-linked curly pulp has a weight percent of between 40-5%. A plastic free binder is included. The sheet has an effective wet strength of at least 150 grams per linear inch in the cross-direction.

Abstract: A medical device with audio output for use in a sterile field may include a housing and an audio output device. The housing may include an interior surface and an exterior surface, the interior surface may define an interior space of the housing including the audio output device, and the interior space of the housing may be fluidically sealed from an external environment by the housing. The audio output device may include a speaker and/or an audio exciter.

Abstract: Systems and methods for determining whether a user employs System 1 type thinking or System 2 type thinking when engaged in a task are disclosed. The systems and methods include determining one or more properties of the task based on information regarding the task received from a database storing information regarding the task, determining one or more properties of the user with respect to the task, determining a state of the user based on one or more physiological sensors configured to sense one or more characteristics of the user, and determining that the user employs System 1 type thinking or System 2 type thinking when engaged in the task based on the determined one or more properties of the task, the determined one or more properties of the user, and the determined state of the user.

Abstract: A driving circuit to control/drive a contactor using a high-side driver integrated into the battery pack controller. The driver circuit may electrically isolate the controller pins of the battery pack controller (which interface the contactors) from the low-voltage digital processing core of the battery pack controller. The driver circuit may provide techniques to diagnose a fault by monitoring the voltage at the output of the driver as compared to the reference voltage. The driver circuit may include an electronic switch, such as a field-effect transistor, that is configured on the high side of the contactor to control voltage from an energy source to the contactor.

Abstract: Evaluation data sets may be programmatically generated for code generation models. An evaluation data set is obtained that includes items that correspond to different evaluation tests for a code generation system. The individual items of the evaluation data set maybe converted, including the conversion of a function signature for the items, the test statements for the items and using a code generation system to generate the body of the function.

Abstract: Pre-fix matching may constrain the generation of next token predictions. Input text to perform a next token prediction may be received. Multiple tokens may be determined from the input text, including a partial token. From possible tokens, one or more matching possible tokens with the partial token may be identified. Next token predictions may then be filtered using the identified possible tokens in order to ensure that the partial token is matched.

Abstract: Code completion suggestions may be proactively obtained and validated. An event that triggers obtaining a code completion suggestion for inclusion in a code file being edited using an integrated development environment may be detected. The code completion suggestion may be obtained. The characters of the code completion suggestion may be compared with characters added to the code file after the detection of the event that triggered obtaining the code completion suggestion to determine whether the code completion suggestion is valid. A valid code completion suggestion may then be displayed.

Abstract: In various example embodiments, a system and method for managing media bandwidth usage are disclosed. One disclosed method includes determining a network connection state of a computing device, receiving a request that requests media content, altering the request to request a synthetic representation of the media content instead of the media content in response to the network connection state being one of a set of predefined network connection states and the media content violating one or more restrictions of the network connection state, and requesting the media content in response to a user selecting the synthetic representation.

Abstract: Embodiments of this disclosure pertain to glass articles that comprise a maximum CS magnitude (CSmax) of about 900 MPa or greater, a CS magnitude of 750 MPa or greater at a depth of about 5 micrometers, and a maximum CT magnitude (CTmax) disposed at a depth from the first major surface in a range from about 0.25t to about 0.75t. Embodiments of a curved glass article are also disclosed. In one or more embodiments, such curved glass articles include the first major concave surface comprising a maximum radius of curvature of about 100 mm or greater and a first maximum CS value (CSmax1) of greater than about 800 MPa, a second major convex surface comprising a second maximum CS value (CSmax2), wherein the CSmax2 is less than CSmax1. Embodiments of an automotive interior system including such curved glass articles and methods of making glass articles are also disclosed.

Abstract: Systems and techniques are disclosed to generate programming parameters and modifications during closed-loop adjustment of an implantable neurostimulation device treatment programming, through the identification and application of weights determined from user input indications and rankings of therapy objectives.

Abstract: This invention discloses a method of using calcium channel blockers as a prophylaxis in a predetermined population susceptible to tuberculosis. Also disclosed herein are pharmaceutical compositions useful for preventing or reducing the risk of activating latent TB in a patient infected with HIV, and a computer-aided drug development method for developing and optimizing a pharmaceutical composition useful for preventing or reducing the risk of activating latent TB.

Abstract: Rotary assist apparatus for recirculating ball steering gears are disclosed. An example motor vehicle steering system includes an input shaft to couple to a steering shaft of a motor vehicle, a worm gear, a first end of the worm gear coupled to the input shaft, a second end of the worm gear fixed to a helical spur gear, a ball nut surrounding a portion of the worm gear, the ball nut including ball bearings and ball guides, an intermediate gear fixed to a first pinion, the first pinion engaged with the helical spur gear, a motor fixed to a second pinion, the second pinion engaged with the intermediate gear, the motor to rotate the worm gear to translate the ball nut, and a sector gear engaged with the ball nut, the sector gear to rotate as the ball nut translates.

Abstract: Single crystal CVD diamond material comprising a total nitrogen concentration of at least 5 ppm and a neutral single substitutional nitrogen. Ns0, to total single substitutional nitrogen, Ns, ratio of at least 0.7. Such a diamond is observed to have a relatively low amount of brown colouration despite the relatively high concentration of nitrogen A method of making the single crystal diamond is also disclosed, the method including growing the CVD diamond in process gases comprising 60 to 200 ppm nitrogen, in addition to a carbon-containing gas, and hydrogen, wherein the ratio of carbon atoms in the carbon-containing gas to hydrogen atoms in the hydrogen gas is 0.5 to 1.5%.

Abstract: A synthetic diamond material comprises a surface, wherein the surface comprises a first surface region comprising a first concentration of quantum spin defects. A second surface region has a predetermined area and is located adjacent to the first surface region, the second region comprising a second concentration of quantum spin defects. The first concentration of quantum spin defects is at least ten times greater than the second concentration of quantum spin defects, and at least one of the first or second surface regions comprises chemical vapour deposition, CVD, synthetic diamond. A method of producing the synthetic diamond material is also disclosed.

Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.