Abstract: The present invention includes compounds of formula (I) and methods for its preparation and treatment of disorders with activated peroxisome preoliferator-activated receptor gamma (PPARG), particularly cancer.

Abstract: A method for partially publishing edits to a document is described. A first document including a first cell and a second cell is displayed on first user account on a first computing device and on a second user account. A second document including a linked version of the first cell and a linked version of the second cell is displayed. An edit of the first cell is received from the first user account and an edit of the second cell is received. In response to receiving an indication from the first user account that the edit of the first cell is to be published, the edit of the first cell is made to the linked version of the first cell, while the linked version of the second cell is unchanged so that the content of the linked version of the second cell no longer matches that of the second cell.

Abstract: A processing machine (10) for building an object (11) from powder (12) includes a build platform (26A); a powder supply assembly (18) that deposits the powder (12) onto the build platform (26A) to form a powder layer (13); and an energy system (22) that directs an energy beam (22D) at a portion of the powder (12) on the build platform (26A) to form a portion of the object (11). The powder supply assembly (18) can include (i) a powder container (640A) that retains the powder (12); (ii) a supply outlet (639) positioned over the build platform (26A); and (ii) a flow control assembly (642) that selectively controls the flow of the powder (12) from the supply outlet (639).

Abstract: In general, a method for treating biosolids may include measuring one or more of pH, alkalinity, magnesium concentration, ortho-phosphorus concentration, total phosphorus content, ammonia content, total nitrogen content, total solids content, total volatile solids, polymer consumption, and metal salt consumption associated with a treatment process for wastewater solids. A metal salt dosage for amending the wastewater solids may be determined based upon, at least in part, an initial ortho-phosphorus concentration and a reduction capacity of the metal salt. A magnesium compound dosage may be determined for one or more of increasing, decreasing, and maintaining a pH of the wastewater solids. The magnesium compound dosage may be based upon, at least in part, a calculated anticipated change in pH of the wastewater solids resulting from an addition of the metal salts. The method may also include amending the treatment process with the determined metal salt dosage and the determined magnesium compound dosage.

Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: Systems and methods for providing cross-partition preemption analysis and prevention. Computing devices typically include a main central processing unit (CPU) with multiple cores to execute instructions independently, cooperatively, or in other suitable manners. In some examples, one or more cores are partitioned and dedicated to a particular application, where exclusive access of the cores in the partition is intended for running processes of the application. In some examples, some “noise” can be introduced in a partition, where preemptions associated with other processes can interrupt execution of the particular application. A preemption diagnostics system and method identify and prevent sources of cross-partition preemption events from running in a dedicated CPU partition. Thus, the particular application has dedicated use of the cores in the partition. As a result, latency of the application is reduced and bounded latency corresponding to a service level agreement can be achieved.

Abstract: A breathing assistance apparatus and method of controlling a breathing assistance apparatus is disclosed. Particularly, the breathing assistance apparatus is controlled such that it has a drying cycle to enable drying of the tubing that supplies gases to a user and prevent the harbouring of pathogens within the tube. The drying cycle is preferably operated automatically by internal controllers in the apparatus. However, it may be manually activated by pressing a button on the apparatus. The drying cycle is preferably activated at the end of a user's treatment session.

Abstract: Provided in the present disclosure are complexes and solutions demonstrating improved aqueous solubility of derivatized cytotoxic taxane drug moieties. In some other aspects, the disclosure provides methods of using such complexes and solutions for the treatment of cancer. In some further aspects, the disclosure provides combination therapies that may be suitable when used in combination with the use of the complexes disclosed herein.

Abstract: Systems are provided for isolation of a protein, such as immunoglobulin G (IgG), from plasma, where the protein is initially fractioned by salt precipitation, followed by successive ion exchange steps in which the protein appears in unbound, flow-through fractions of the ion exchange steps. Some embodiments employ successive anion exchange steps. Other embodiments employ an anion exchange step followed by application of flow-through of the anion exchange step to a cation exchange step, with the protein collected in flow-through fractions from the cation exchange step. IgG is collected at high yield (typically about 75% or greater) and high purity. Avoidance of binding and elution from chromatography media simplifies processing and scale up without sacrificing IgG quality or yield.

Abstract: A crossbow having an energy storage system configured for storing energy when a bowstring is cocked at full-draw and releasing at least a portion of the stored energy when a trigger is pulled releasing the bowstring. The stored energy is defined by an area under a power-curve or draw-curve of the crossbow. The power-curve is defined by the force required to draw the bowstring from an un-cocked position to the cocked position. Between the un-cocked position and an intermediate position, the force required to draw the bowstring is substantially proportional to the draw distance. Between the intermediate position and the cocked position, the force required to draw the bowstring is substantially constant. When the cocked bowstring is released, at least a portion of the stored energy is transferred in the form of kinetic energy of an arrow or bolt nocked on the cocked bowstring.

Abstract: A non-combustible aerosol provision device for generating an aerosol from an aerosol-generating material is provided. The device includes a chamber for receiving a consumable including aerosol-generating material to enable the non-combustible aerosol provision device to generate an aerosol from the aerosol-generating material. The device further includes an adjustment mechanism to allow a user to adjust a dimension of the chamber to allow the chamber to accommodate, one at a time, each of a plurality of consumables having different sizes.

Abstract: In one aspect, a movable barrier operator includes a housing and a motor. The movable barrier operator further includes a camera mount that is connected to the housing and that supports a camera. The camera mount is configured to facilitate movement of the camera between a storage position wherein at least a portion of the camera is inside the housing and an operative position wherein the at least a portion of the camera is outside of the housing.

Abstract: A non-combustible aerosol provision device for generating an aerosol from aerosol-generating material in a consumable is disclosed. The non-combustible aerosol provision device includes a retention apparatus configured to hold in position, one at a time, each of the plurality of consumables comprising aerosol-generating material of different sizes.

Abstract: A razor cartridge having a housing including a frame with a non-cutting element, a guard and a cap. The non-cutting element has a plurality of open slots defined between a pair of projections disposed next to each other. A first razor blade is positioned between the guard and the non-cutting element and has a blade edge extending toward the guard. The non-cutting element is spaced apart from the first razor blade. A second razor blade is positioned between the non-cutting element and the cap and has a blade edge extending toward the guard. The non-cutting element is spaced apart from the second razor blade. A first rinse-through gap between the first razor blade and the non-cutting element of about 0.05 mm to about 0.5 mm. A second rinse-through gap between the second razor blade and the non-cutting of about 0.05 mm to about 0.6 mm.

Abstract: The gases temperature supplied to a patient when the patient is undergoing treatment such as oxygen therapy or positive pressure treatment for conditions such as Obstructive Sleep Apnea (OSA) or Chronic Obstructive Pulmonary Disease (COPD) is often measured for safety and to enable controlling of the humidity delivered to the patient. The invention disclosed is related to measurement of properties, particularly temperature (thermistor), of gases flowing through a heated tube, supplying gases to a patient, which utilises the heating wire within the tube.

Abstract: A method for maintaining revisions for a plurality of documents is described. Pending requests are stored in a workspace revision queue that is shared by the plurality of documents. The pending requests indicate revisions to be carried out on the plurality of documents. A pending request graph is generated for at least some pending requests from the workspace revision queue using a dependency graph for the plurality of documents. The dependency graph represents interdependencies of content references among the plurality of documents. The revisions indicated by the pending requests of the pending request graph are caused to be performed on the plurality of documents according to a dependency ordering based on the pending request graph. The dependency ordering is different from an ordering for the workspace revision queue.

Abstract: The present invention relates to a method for communicating in a network from a first station to a second station, wherein the first station comprises at least one buffer memory for storing data packets to be transmitted, the method comprising the steps of (a) the first station estimating the status of the at least one buffer memory, (b) the first station transmitting at least one buffer status packet representative of the buffer memory status, wherein the method further comprises (c) adapting the value of a first parameter of the buffer status packets on the basis of a data traffic characteristic.

Abstract: Embodiments provide a method for preventing shutdowns in LNG facilities by removing heavy hydrocarbons from the inlet gas supply. According to an embodiment, there is provided an LNG facility treating pipeline quality natural gas that is contaminated with lubrication oil and low concentrations of heavy hydrocarbons. Due to contamination, the behavior of the pipeline quality natural gas is not properly predicted by thermodynamic modeling. In an embodiment, heavy hydrocarbons are removed by a drain system in a heat exchanger. In an embodiment, heavy hydrocarbons are removed by a treatment bed.

Abstract: A method for partially publishing edits to a document is described. A first document including a first cell and a second cell is displayed on first user account on a first computing device and on a second user account. A second document including a linked version of the first cell and a linked version of the second cell is displayed. An edit of the first cell is received from the first user account and an edit of the second cell is received. In response to receiving an indication from the first user account that the edit of the first cell is to be published, the edit of the first cell is made to the linked version of the first cell, while the linked version of the second cell is unchanged so that the content of the linked version of the second cell no longer matches that of the second cell.

Abstract: A crossbow includes a riser. The crossbow includes a first limb and a second limb. The first limb includes a first end and a second end. The second limb includes a first end and a second end. The first end of the first limb and the first end of the second limb are coupled to the riser. A first wheel is rotatably coupled to the first limb proximate the second end thereof. A second wheel is rotatably coupled to the second limb proximate the second end thereof. The crossbow includes a first power cord that includes a first end coupled to the riser and a second end coupled to the first wheel. The crossbow includes a second power cord a first end coupled to the riser and a second end coupled to the first wheel. The crossbow includes a bowstring. The crossbow includes an efficiency of at least 80%.