Abstract: An illustrative computing device may include a processor and a non-transitory memory device for storing a data structure capable of being compressed, where the data structure includes a plurality of data elements and each of the plurality of data elements includes a date field and a quantity field. The computing device may process instructions to arrange the plurality of data elements in a consecutive series in date order based on a value stored in the date field of each data element, determine whether a gap appears in the consecutive series of data elements based on a value stored in the quantity field of each element, remove the determined gaps in each of the data elements, and repeat the determining and removing steps until a predetermined criterion has been reached.

Abstract: A guidewire for use in penetrating through complex and stenosed lesions. The distal tip of the guidewire has a roughened surface to increase frictional engagement with calcified and fibrous tissue to increase the penetration of the distal tip and the guidewire into and through the lesion and reduce the likelihood of deflection of the guidewire tip. The average surface roughness of the distal tip is in the range from 1 micron to 200 microns.

Abstract: Broadly speaking, embodiments of the present techniques provide haptic button assemblies in which the haptic button has a low profile while still providing a satisfying tactile response or sensation to a user. Advantageously, the haptic button assemblies may have a profile that, for example, enables the assembly to be incorporated into the free space along an edge of a portable computing device. The haptic assemblies may, for example, be arranged to move the button perpendicularly with respect to the edge of the device.

Abstract: Systems and methods relating to a keyboard interceptor are disclosed. The keyboard interceptor receives a first input by a user into a keyboard application on a mobile device. A search query is generated based on the first input and data is located based on the search query. The data is associated with a record comprising a record identifier. The keyboard interceptor associates a GUI element of the keyboard application with the record identifier. A second input is received corresponding to selection of the GUI element. A unique tracking link is generated comprising a URL associated with the locate data and an identifier associated with the selection of the GUI element. The unique tracking link is passed to a web browser application executing on the mobile device to access the website. The web browser application stores a cookie comprising the identifier associated with the selection of the GUI element.

Abstract: Broadly speaking, the present techniques provide specific arrangements of shape memory alloy (SMA) actuator wires in SMA actuation apparatuses. In one arrangement, a single straight shape memory alloy actuator wire may be used, which may be inclined at an acute angle greater than 0 degrees with respect to a plane normal to the movement direction. In another arrangement, two straight lengths of shape memory alloy actuator wire may be used, where the SMA wires may be inclined at an acute angle greater than 0 degrees with respect to a plane normal to the movement direction.

Abstract: An SMA actuator assembly (1a) for driving or rotating a movable part (20) in a predetermined direction or sense by a plurality of repeated incremental steps is provided. The SMA actuator assembly comprises the movable part; a first engagement portion (31) for engaging the movable part; two SMA wires (41, 42) arranged to move the first engagement portion such that the first engagement portion repeatedly, for each of said incremental steps, is configured to do the following: engage with the movable part from a starting position, exert a force or torque on the movable part in the predetermined direction and disengage from the movable part and return to the starting position. The exertion of the force or torque on the movable part and the engaging or disengaging with the movable part are caused by contraction or relaxation of the two SMA wires.

Abstract: Compositions and methods are described for the delivery of recombinant human iduronate-2-sulfatase (IDS) produced by human neuronal or glial cells to the cerebrospinal fluid of the central nervous system (CNS) of a human subject diagnosed with mucopolysaccharidosis II (MPS II).

Abstract: An actuator assembly comprising: a support structure comprising a first friction surface; a movable part comprising a second friction surface engaging the first friction surface; one or more SMA wires arranged, on contraction, to move the movable part relative to the support structure to any position within a range of movement; a biasing arrangement arranged to bias the first and second friction surfaces against each other with a normal force, thereby generating a static frictional force that constrains the movement of the movable part relative to the support structure at any position within the range of movement when the one or more SMA wires are not contracted; wherein the one or more SMA wires are arranged, on contraction, to reduce the normal force between first and second friction surfaces.

Abstract: An actuator assembly (1) comprising: a support structure (10) comprising a first friction surface (10f); a movable part (20) comprising a second friction surface (20f) engaging the first friction surface; one or more SMA wires (40) arranged, on contraction, to move the movable part relative to the support structure to any position within a range of movement; a biasing arrangement (30) arranged to bias the first and second friction surfaces against each other with a normal force, thereby generating a static frictional force that constrains the movement of the movable part relative to the support structure at any position within the range of movement when the one or more SMA wires are not contracted, wherein the one or more SMA wires are arranged such that the normal force between the first and second friction surfaces remains substantially constant on contraction of the one or more SMA wires.

Abstract: A processor-implemented method for a memory storage format to accelerate machine learning (ML) on a computing device is described. The method includes receiving an image in a first layer storage format of a neural network. The method also includes assigning addresses to image pixels of each of three channels of the first layer storage format for accessing the image pixels in a blocked ML storage acceleration format. The method further includes storing the image pixels in the blocked ML storage acceleration format according to the assigned addresses of the image pixels. The method also includes accelerating inference video processing of the image according to the assigned addresses for the image pixels corresponding to the blocked ML storage acceleration format.

Abstract: Compositions and methods are described for the delivery of a fully human post-translationally modified (HuPTM) monoclonal antibody (“mAb”) or the antigen-binding fragment of a mAb against human vascular endothelial growth factor (“hVEGF”) —such as, e.g., a fully human-glycosylated (HuGly) anti-h VEGF antigen-binding fragment—to the retina/vitreal humour in the eye(s) of human subjects diagnosed with ocular diseases caused by increased neovascularization, for example, neovascular age-related macular degeneration (“nAMD”), also known as “wet” age-related macular degeneration (“WAMD”), age-related macular degeneration (“AMD”), and diabetic retinopathy.

Abstract: An illustrative computing device may include a processor and a non-transitory memory device for storing a data structure capable of being compressed, where the data structure includes a plurality of data elements and each of the plurality of data elements includes a date field and a quantity field. The computing device may process instructions to arrange the plurality of data elements in a consecutive series in date order based on a value stored in the date field of each data element, determine whether a gap appears in the consecutive series of data elements based on a value stored in the quantity field of each element, remove the determined gaps in each of the data elements, and repeat the determining and removing steps until a predetermined criterion has been reached.

Abstract: In a method for cathodically protecting and/or passivating a metal section in an ionically conductive material such as steel reinforcement in concrete or mortar, an impressed current or sacrificial anode communicates electrical current to the metal section and a storage component of electrical energy which can be a cell, battery or capacitor is provided as a component of the anode. The storage component can have replacement energy introduced by re-charging or replacing the component from an outside supply. Typically the cell or storage capacitor has an outer case which carries an anode material as an integral outer component.

Abstract: An illustrative computing device may include a processor and a non-transitory memory device for storing a data structure capable of being compressed, where the data structure includes a plurality of data elements and each of the plurality of data elements includes a date field and a quantity field. The computing device may process instructions to arrange the plurality of data elements in a consecutive series in date order based on a value stored in the date field of each data element, determine whether a gap appears in the consecutive series of data elements based on a value stored in the quantity field of each element, remove the determined gaps in each of the data elements, and repeat the determining and removing steps until a predetermined criterion has been reached.

Abstract: A processor-implemented method for a memory storage format to accelerate machine learning (ML) on a computing device is described. The method includes receiving an image in a first layer storage format of a neural network. The method also includes assigning addresses to image pixels of each of three channels of the first layer storage format for accessing the image pixels in a blocked ML storage acceleration format. The method further includes storing the image pixels in the blocked ML storage acceleration format according to the assigned addresses of the image pixels. The method also includes accelerating inference video processing of the image according to the assigned addresses for the image pixels corresponding to the blocked ML storage acceleration format.

Abstract: Compositions and methods are described for the delivery of a fully human-glycosylated (HuGly) ?-L-iduronidase (IDUA) to the cerebrospinal fluid of the central nervous system (CNS) of a human subject diagnosed with mucopolysaccharidosis I (MPS I).

Abstract: A vehicle configurable to tow a charging trailer having at least one electric outlet configured to charge a battery powered device includes a human-machine interface (HMI), a wireless transceiver, and a controller in communication with the wireless transceiver and the HMI, the controller programmed to, in response to the wireless transceiver receiving signals associated with at least one battery powered device in a connected charging trailer having a battery state of charge (SOC) below a corresponding threshold, signal the HMI to generate an associated output. Input from the HMI may enable or disable regenerative braking of the charging trailer to charge connected battery powered devices to control the associated effect of the charging of devices in the charging trailer on efficiency of the towing vehicle.

Abstract: An illustrative computing device may include a processor and a non-transitory memory device for storing a data structure capable of being compressed, where the data structure includes a plurality of data elements and each of the plurality of data elements includes a date field and a quantity field. The computing device may process instructions to arrange the plurality of data elements in a consecutive series in date order based on a value stored in the date field of each data element, determine whether a gap appears in the consecutive series of data elements based on a value stored in the quantity field of each element, remove the determined gaps in each of the data elements, and repeat the determining and removing steps until a predetermined criterion has been reached.