Abstract: A racked modular system includes a rack frame defining a bay and a module that is received in the bay and removably mounted to the rack frame at a seated position. A locating interface constrains at least pitch and yaw at the seated position, and a quick-release latch with an over-center cam draws the module into the seated position. A backplane at the rear of the bay provides a blind-mate connector aligned with a corresponding connector of the module. Embodiments include floating mounts, vibration isolation, airflow shrouds, safety interlocks, and latch sensors. A vehicle cargo platform embodiment includes a pivot mast, a swing-arm, perforated trays with side rails, a ground-contacting stabilizer post configured to reduce hinge loading under payload, stops that define deployed positions, a travel latch, and an accessory hole matrix. Methods of installation, servicing, loading, and stabilizing the platform are also disclosed.

Abstract: A remotely deployed and operated drone-based sealed tank inspector comprises a direct replacement of normal hatch cover which is a sealed hatch cover comprising electrical penetrations, a sealing cable transit, and a predetermined set of eyelets for retention of lifting slings, and is handled using small hoist and parking stand. Drone-based inspections, including ultrasonic (UT) and visual inspections, may be remotely accomplished by deploying the remotely deployed and operated drone-based sealable tank inspector and using it for inspection and testing, including visual inspection, such as those required to be performed inside a sealed, inert-environment tank.

Abstract: The present disclosure provides thiazolidine (Tz) linkers for protein-drug conjugates. In addition, the disclosure also encompasses compounds useful for producing such protein-drug conjugates, as well as methods for production of such protein-drug conjugates. The disclosure also encompasses methods of using the protein-drug conjugates for the treatment of a disease or disorder in a subject.

Abstract: A delivery portal, which may be at a loading dock, includes a sensor configured to detect a pallet, platform or stack of goods as it passes through the portal. A computer is programmed to receive information from the sensor and to identify the pallet based upon the information. The computer is further programmed to compare the identified pallet to a database to determine if the identified pallet should be passing through the portal. For example, the computer determines whether the pallet is being loaded onto the wrong truck or onto the right truck but in the wrong sequence. The sensor for detecting the pallet may be an RFID sensor reading an RFID tag on the pallets. The portal may be a loading dock. The database may indicate a sequence for loading a plurality of pallets including the identified pallet onto a truck at the loading dock.

Abstract: Described herein are systems, methods, and computer-readable medium for detecting a perfusion abnormality of a subject. In one embodiment, a method includes the following: obtaining, by dynamic radiography, imaging data for a dynamic series of a plurality of x-ray images that include areas of a subject corresponding to pulmonary vasculature; identifying, based on the imaging data, a dynamic signal corresponding to changing blood volume during the cardiac cycle of the subject; decomposing the dynamic signal into periodic components in frequency space; identifying, from the periodic components in frequency space, signals oscillating at the heart rate of the subject; generating, based on the identified signals oscillating at the heart rate of the subject, a perfusion map representation corresponding to pulmonary tissue perfusion in the subject; and detecting, based at least in part on the generated perfusion map representation, a perfusion abnormality of the subject.

Abstract: Systems, devices, and methods for tissue retraction include one or more instruments operatively couplable for retracting and/or retaining tissues or other materials during a procedure. In one aspect, a first instrument includes an elongate rigid body having a longitudinal axis extending from a proximal end to a distal end. The elongate rigid body has an outer polygonal profile and an interior surface defining a round channel extending along the longitudinal axis. The round channel may receive a tubular instrument therethrough. The elongate rigid body includes one or more sets of flanges protruding from lateral sides of the outer polygonal profile. The flanges positively engage one or more respective tracks of a tissue retraction blade. Additional instruments may be provided that operatively couple to the first instrument and/or to one or more tissue retractor blades, for example while the first instrument is coupled to the tissue retractor blades.

Abstract: Compounds of general formula (I) and their tautomeric forms all enantiomers and isotopic variants and salts and solvates thereof: wherein represents a single or a double bond and R1, R2, X1, X2, X3, X4, X5, Y and Z are as defined herein; are useful for treating respiratory disease and other diseases and conditions modulated by TMEM16A.

Abstract: Compounds of general formula (I), wherein R1, R2, R3, R4, R5, X1, X2 and X3 are as defined herein are useful for treating respiratory disease and other diseases and conditions modulated by TMEM16A.

Abstract: A delivery portal, which may be at a loading dock, includes a sensor configured to detect a pallet, platform or stack of goods as it passes through the portal. A computer is programmed to receive information from the sensor and to identify the pallet based upon the information. The computer is further programmed to compare the identified pallet to a database to determine if the identified pallet should be passing through the portal. For example, the computer determines whether the pallet is being loaded onto the wrong truck or onto the right truck but in the wrong sequence. The sensor for detecting the pallet may be an RFID sensor reading an RFID tag on the pallets. The portal may be a loading dock. The database may indicate a sequence for loading a plurality of pallets including the identified pallet onto a truck at the loading dock.

Abstract: Described herein are systems, methods, and computer-readable medium for detecting a perfusion abnormality of a subject. In one embodiment, a method includes the following: obtaining, by dynamic radiography, imaging data for a dynamic series of a plurality of x-ray images that include areas of a subject corresponding to pulmonary vasculature; identifying, based on the imaging data, a dynamic signal corresponding to changing blood volume during the cardiac cycle of the subject; decomposing the dynamic signal into periodic components in frequency space; identifying, from the periodic components in frequency space, signals oscillating at the heart rate of the subject; generating, based on the identified signals oscillating at the heart rate of the subject, a perfusion map representation corresponding to pulmonary tissue perfusion in the subject; and detecting, based at least in part on the generated perfusion map representation, a perfusion abnormality of the subject.

Abstract: Provided herein is a method for sequence analysis that comprises analyzing PCR reactions that each contain different portions of the same sample, wherein at least some of the primer pairs are in more than one PCR reaction and at least one of the PCR reactions contains some but not all of the primer pairs of the other reaction(s).

Abstract: Provided herein is a method for the analysis of minimal residual disease, the method comprising obtaining multiple pairs of primers, performing a targeted multiplex amplification using the multiple pairs of primers to produce amplicons, sequencing the amplicons or an amplification product thereof, thereby generating sequence reads, calculating a score based on the minority of sequences containing identified sequence variations, and using the calculated score to determine the presence or absence of minimal residual disease in the patient.

Abstract: A gas lift device includes a housing, a valve, and a nozzle. The housing defines a chamber and defines an inlet and an outlet in communication with the chamber. The valve in the chamber permits fluid communication from the inlet toward the outlet and prevents fluid communication in the reverse. The nozzle disposed in the chamber has a converging section, a throat, and a diverging section, which extend along a longitudinal axis of the chamber. A surface of the converging section converges inwardly from the chamber to the throat to funnel fluid communication from the inlet to the throat. A flow restriction of the throat restricts the fluid communication from the converging section to the diverging section. A surface of the diverging section diverges outwardly from the throat toward the outlet. Vanes extend inwardly in the diverging section and spiral about the longitudinal axis.

Abstract: A fastener including: a sidewall oriented about a central axis, the sidewall including at least one of 1) at least one first type of deformable projection comprising a teardrop shaped radial face, or 2) an arcuate portion, a radial corrugation portion, and a circumferential corrugation portion, where the sidewall is a layered structure including a substrate and an insulating layer overlying the substrate.

Abstract: An internal combustion rotary engine comprising a housing, at least one sun wheel centered about the central axis and positioned within one of at least one cylindrical compartment of the housing, and including a sun wheel circumference and at least one semicylindrical receptable defined along the sun wheel circumference, at least one lobe extending from an inner cylindrical surface of the compartment, and at least one planet wheel received in the at least one semicylindrical receptable of the sun wheel. The at least one planet wheel may be configured to engage the inner cylindrical surface of the cylindrical compartment and include at least one indentation configured to be received by the at least one lobe when the at least one planet wheel rotates along the inner cylindrical surface. Air intake and compression as well as combustion and exhaust may be performed within the same or different compartments of the at least one cylindrical compartment.

Abstract: A belt body has an outer surface and an inner facing toothed surface and includes or is comprised of an elastomeric composition; and tensile members. The elastomeric composition including: from about 50 to 90 parts per hundred rubber of a zinc diacrylate modified hydrogenated acrylonitrile-butadiene rubber, and/or an unmodified hydrogenated acrylonitrile-butadiene rubber; from about 10 to 50 parts per hundred rubber of a peroxide curable polyepichlorohydrin copolymer or terpolymer; wherein the elastomeric composition is cured using a free radical promoting material, wherein the free radical promoting material is a peroxide selected from the group consisting of diacyl peroxides, peroxyesters, dialkyl peroxides and peroxyketals and is used in an amount from about 0.

Abstract: An inventory management device, system, and method that can be configured to increase radio frequency identification (RFID) read accuracy and diversity in warehouse-based applications and in other inventory management scenarios. In one implementation, the inventory management device comprises a transportable frame that at least partially surrounds a housing, the transportable frame having a motor attachment surface. The housing includes a radio frequency identification (RFID) interrogator and an RFID antenna. In some implementations, there is a second RFID antenna located in the housing, and the first RFID antenna is orthogonally offset from the second RFID antenna.

Abstract: A remotely deployed and operated drone-based sealed tank inspector comprises a direct replacement of normal hatch cover which is a sealed hatch cover comprising electrical penetrations, a sealing cable transit, and a predetermined set of eyelets for retention of lifting slings, and is handled using small hoist and parking stand. Drone-based inspections, including ultrasonic (UT) and visual inspections, may be remotely accomplished by deploying the remotely deployed and operated drone-based sealable tank inspector and using it for inspection and testing, including visual inspection, such as those required to be performed inside a sealed, inert-environment tank.

Abstract: Embodiments of negative pressure wound therapy systems and methods for operating the systems are disclosed. In some embodiments, a system includes a pump assembly, canister, and a wound dressing configured to be positioned over a wound. The pump assembly, canister, and the wound dressing can be fluidically connected to facilitate delivery of negative pressure to a wound. The pump assembly can present graphical user interface screens for controlling and monitoring delivery of negative pressure. The system can be configured to efficiently deliver negative pressure and to detect and indicate presence of certain conditions, such as low pressure, high pressure, leak, canister full, and the like. Monitoring and detection of operating condition can be performed by measuring one or more operational parameters, such as pressure, flow rate, and the like.