Abstract: Monoclonal antibodies that specifically bind to and block the function of Fas ligand (FasL) are described. The FasL-specific antibodies can be used for the development of therapeutics for the treatment of diseases, disorders and conditions associated with the Fas/FasL signaling pathway, such as cancer, sepsis, ischemia-reperfusion injury, and coronavirus disease 2019 (COVID-19).

Abstract: The present disclosure provides methods and lubricant blends for increasing lubricity of a brine-based drilling fluid having an alkaline pH and a threshold divalent cation concentration. An embodiment of the methods herein comprise providing a produced water or a brine having a threshold divalent cation concentration and an alkaline pH; adding to the produced water or brine at least one source of free fatty acids; and optionally further adding a dispersant. Also provided are brine-based drilling fluids produced by the methods and lubricant blends disclosed herein. Also, provided are methods for improving lubricity in a wellbore during drilling operations, which comprise, combining in a modulated manner, a quantity of a produced water or brine and a quantity of a lubricant blend comprising at least one source of free fatty acids and a dispersant, to target formation of a semi-solid lubricant that adheres to downhole surfaces.

Abstract: The present disclosure provides methods and lubricant blends for increasing lubricity of a brine-based drilling fluid having an alkaline pH and a threshold divalent cation concentration. An embodiment of the methods herein comprise providing a produced water or a brine having a threshold divalent cation concentration and an alkaline pH; adding to the produced water or brine at least one source of free fatty acids; and optionally further adding a dispersant. Also provided are brine-based drilling fluids produced by the methods and lubricant blends disclosed herein. Also, provided are methods for improving lubricity in a wellbore during drilling operations, which comprise, combining in a modulated manner, a quantity of a produced water or brine and a quantity of a lubricant blend comprising at least one source of free fatty acids and a dispersant, to target formation of a semi-solid lubricant that adheres to downhole surfaces.

Abstract: Embodiments disclosed herein include an interposer. In an embodiment, the interposer comprises a substrate with a first surface and a second surface opposite from the first surface. In an embodiment, a via is provided through the substrate, where a portion of the via extends past the second surface. In an embodiment, a first layer is over the substrate, where the first layer is an electrically insulating material. In an embodiment, a second layer is over the first layer and over the portion of the via that extends past the second surface.

Abstract: A magnetic debris level measuring device for a magnetic filter is disclosed. The magnetic debris level measuring device includes a magnetometer and a temperature sensor. The temperature measured by the temperature sensor is used to calculate a corrected magnetometer reading, which in turn can be used to determine the amount of captured magnetic debris held within the filter. The device has a stored threshold for the corrected magnetometer reading, and when the corrected magnetometer reading crosses the stored threshold a notification is issued that the filter is full. If it is detected that debris continues to be captured after the ‘full’ notification has been issued, the stored threshold will be updated accordingly.

Abstract: A magnetic debris level measuring device for a magnetic filter is disclosed. The magnetic debris level measuring device includes a magnetometer and a temperature sensor. The temperature measured by the temperature sensor is used to calculate a corrected magnetometer reading, which in turn can be used to determine the amount of captured magnetic debris held within the filter. The device has a stored threshold for the corrected magnetometer reading, and when the corrected magnetometer reading crosses the stored threshold a notification is issued that the filter is full. If it is detected that debris continues to be captured after the ‘full’ notification has been issued, the stored threshold will be updated accordingly.

Abstract: The present disclosure provides methods and lubricant blends for increasing lubricity of a brine-based drilling fluid having an alkaline pH and a threshold divalent cation concentration. An embodiment of the methods herein comprise providing a produced water or a brine having a threshold divalent cation concentration and an alkaline pH; adding to the produced water or brine at least one source of free fatty acids; and optionally further adding a dispersant. Also provided are brine-based drilling fluids produced by the methods and lubricant blends disclosed herein. Also, provided are methods for improving lubricity in a wellbore during drilling operations, which comprise, combining in a modulated manner, a quantity of a produced water or brine and a quantity of a lubricant blend comprising at least one source of free fatty acids and a dispersant, to target formation of a semi-solid lubricant that adheres to downhole surfaces.

Abstract: An in-line fitment for connection of a filter to a pipe includes first and second fluid-carrying portions and a non-fluid-carrying spacer. Each fluid-carrying portion includes a socket for receiving an open end of a pipe and a connector for connection of the filter. A screw compression fitting is provided on each of the sockets of the first and second fluid-carrying portions for forming a sealed connection with the open ends of the pipe. The socket of the first fluid-carrying portion has a pipe receiving depth greater than that of the socket of the second fluid-carrying portion for enabling movement of the fitment parallel to the pipe when engaged with one of the open ends of the pipe. The sockets of the first and second fluid-carrying portions are positioned on a common axis and facing away from each other when the fluid-carrying portions are linked by the spacer.