Abstract: Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy.

Abstract: Accesses to locally-relevant and contextually-relevant services information within a mobile communications environment are enabled. The solutions include an improved location determination in which a first mobile communications device processes location information broadcast by other devices via short-range wireless signals to determine its approximate location. The described solutions include a context-based selection of the most relevant of a set of locally-available services, including filtering services according to whether the first mobile device is currently moving and filtering according to a personal profile of the device user.

Abstract: The present invention relates to compounds of formula (I), and salts thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders, such as allergic rhinitis.

Abstract: The present invention relates to novel pyrazole derivatives of formula I having pharmacological activity as H3 antagonists processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

Abstract: The present invention relates to novel fused thiazole derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

Abstract: Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy. Wherein X is O, CH2 CO, S or NH, or the moiety X—R1 is hydrogen; Y1 and Y2 independently represent CH or N; Ar is a mono- or fused bicyclic aromatic or heteroaromatic group which may be optionally substituted; one of X1 and X2 is selected from O, S or NR11 and the other is CH, wherein R11 is hydrogen, C1-6alkyl, aryl or arylC1-6alkyl.

Abstract: A compound of the formula and physiologically acceptable salts and or N-oxides thereof wherein, X1 is N or CR3; X2 is N or CR4; X3 is N or CR5; X4 is N or CR6. with the proviso that at least one but not more than two of X1, X2, X3 and X4 represents N. R1 is a 5-, or 6-membered heterocyclic group selected from group a, b, c or d wherein X5 is a group selected from N or CR7 and X6 is a group selected from O, S or NR8; X7 and X8 which may be the same or different is a group selected from N or CR9; X9 is a group selected from O, S or NR8 and X10 is N or CR10; X11, X12 and X13 may be the same or different and selected from a group N or CR11; processes for their preparation, pharmaceutical compositions containing them and their use in medicine.

Abstract: A cargo enclosure for a vehicle includes a side panel having at least one pocket is formed therein. The pocket has a back wall, a pair of opposing side walls and a front wall having an aperture therein. A bottom surface of the pocket is canted downwardly from the back wall toward the aperture in the front wall such that any debris or other material that may infiltrate the pocket will readily slide down the canted bottom surface, through the aperture and onto a bottom surface of the cargo enclosure.

Abstract: An automatic balancing device for counterbalancing an out-of-balance mass includes a plurality of counterbalancing masses, each of which is movable in a circular path about the axis so as to generate a balancing force. The balancing forces combine to produce a resultant balancing force which varies between minimum and maximum values. At a first speed of rotation of the body about the axis, the movement of at least one of the counterbalancing masses is restrained so that a substantially constant, non-zero resultant balancing force is produced, the resultant balancing force being freely movable about the axis. At a second speed of rotation of the body about the axis, the counterbalancing masses are free to adopt a position in which the out-of-balance mass is counterbalanced. The device allows at least partial counterbalancing of the out-of-balance mass at speeds below the critical speed of the system in which it is used.

Abstract: The present invention is directed to compounds of Formula I: that are potassium channel modulators and pharmaceutical compositions thereof. The present invention is further directed to methods of treatment using the compounds and pharmaceutical compositions of the invention. The present invention is still further directed to synthetic processes for producing the compounds of the invention.

Abstract: The present invention is directed to compounds of Formula I: that are potassium channel modulators and pharmaceutical compositions thereof. The present invention is further directed to methods of treatment using the compounds and pharmaceutical compositions of the invention. The present invention is still further directed to synthetic processes for producing the compounds of the invention.

Abstract: The preferred embodiments are directed to a probe cassette for a scanning probe microscope that includes a base having at least one probe storage receptacle, a lid mountable on the base with the probe storage receptacle at least substantially covering the at least one receptacle, and a probe retainer that retains a probe device of the scanning probe microscope in the receptacle under a compressive force. The probe cassette can be pre-loaded and shipped to a user site where the cassette can be loaded in an AFM without manual manipulation of the individual probe devices.

Abstract: The air blower (18) of a fuel cell power plant (9) is used to force water out of the coolant flow fields (27) of a fuel cell stack (10), a coolant pump (35) and a heat exchanger (40) through a valve (46) which is closed during normal operation. The water removal occurs as part of a shutdown procedure in which the fuel cell stack continues to operate so that it provides the power for the air pump and to assist in water removal (such as retaining low vapor pressure). The water flow to an accumulator (33) is blocked by a valve (29) during the shutdown procedure.

Abstract: Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy.

Abstract: Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy.

Abstract: The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, use as Raf Kinase Inhibitors and treatment methods for neurotraumatic diseases and cancer.

Abstract: Novel compounds (I) and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy wherein Ar is a group of formula a) or b).

Abstract: A technique facilitates joining of coiled tubing sections. A framework has one or more movable stands with features designed to grip and manipulate an end of a coiled tubing section. The ability to hold and selectively move an end of a coiled tubing section or the ends of both coiled tubing sections enables an operator to easily prepare the coiled tubing ends and to couple the coiled tubing ends with a coiled tubing connector.

Abstract: An appliance having a driving mechanism is provided including two rotatable portions which are rotatable by the driving mechanism about an axis. The driving mechanism includes a gearbox having an input gear, two output gears and a locking mechanism movable between a first position and a second position. The arrangement is such that, when the locking mechanism is in the first position and the input gear is driven, both output gears rotate in the same direction and, when the locking mechanism is in the second position and the input gear is driven, the output gears rotate in opposite directions. The arrangement of the axis is horizontal or substantially horizontal. The invention is particularly suitable for use in a front-loading washing machine having a drum including two rotatable portions. The driving mechanism can be used to selectively cause rotation of the rotatable portions either in the same direction or in opposite directions.

Abstract: Generally, the present disclosure is directed to, in one embodiment, a process for controlling a converting line web. More specifically, a sheet material is provided on the converting line. A loss of control is detected in the sheet material web and the sheet material web is broken at a location upstream from the converting line web rewinder. The broken sheet material web is redirected.