Abstract: The present invention relates to methods for treatment or prevention of autoimmune and inflammatory diseases and conditions by inhibiting or modifying histone demethylation. In a further aspect the invention relates to a method for identifying agents useful in said methods of treatment. The invention particularly describes the role of certain histone demethylase enzymes in these diseases and conditions and their use as therapeutic and screening targets.

Abstract: The present invention relates to a compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (Syk) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast and/or basophil cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory disease and/or allergic disorders, and in cancer therapy, specifically heme malignancies, chronic spontaneous urticaria and autoimmune conditions.

Abstract: A method of processing a transaction between a customer and a merchant includes receiving from a mobile device of the customer or from another device of the customer an indication of consent to perform a cardless payment transaction with the merchant, receiving from the mobile device an indication that the customer is within a predetermined distance of the merchant, after receiving both the indication of consent and the indication that the customer is within the predetermined distance, sending to a computer system of the merchant an indication of the presence of the customer and personal identifying information for the customer, receiving data indicating a transaction between the customer and the merchant, and submitting the transaction to a financial service for authorization.

Abstract: A method of processing a transaction between a customer and a merchant includes receiving from a mobile device of the customer or from another device of the customer an indication of consent to perform a cardless payment transaction with the merchant, receiving from the mobile device an indication that the customer is within a predetermined distance of the merchant, after receiving both the indication of consent and the indication that the customer is within the predetermined distance, sending to a computer system of the merchant an indication of the presence of the customer and personal identifying information for the customer, receiving data indicating a transaction between the customer and the merchant, and submitting the transaction to a financial service for authorization.

Abstract: A compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (SYK) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory diseases and/or allergic conditions, in cancer therapy, specifically heme malignancies, and autoimmune conditions.

Abstract: A compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (Syk) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory disease and/or allergic disorders, and in cancer therapy, specifically heme malignancies, and autoimmune conditions.

Abstract: A gaming system includes an input device, a display device, a processor, and a memory device. The memory device stores instructions that, when executed by the processor, cause the gaming system to receive a wager for playing a wagering game having an overall volatility. A plurality of volatility components are displayed on the display device, the volatility components having respective component ratings. Each component rating contributes to a total rating of the overall volatility. The wagering game is selected from a plurality of wagering games, each of the plurality of wagering games having (a) the same total rating and (b) at least one different component rating.

Abstract: A method of treating autoimmune and inflammatory diseases or conditions in a mammal, such as a human, which comprises the administration of a inhibitor of the bromodomain-containing protein: ATAD2.

Abstract: Methods for reducing the impact of malware during a booting sequence for an interrupt driven computing device are disclosed. One or more parameters associated with an interrupt vector table (IVT) are manipulated to force the computing device into a clean state following a system level portion of the booting sequence. In another embodiment, occurring prior to the loading of an operating system or a call to a non-returnable main( ) function, one or more unused interrupt vectors in an IVT are replaced. A function filter is implemented for one or more interrupt vectors in the IVT to disallow unnecessary interrupt functions from being executed. One or more required interrupt vector functions are replaced with one or more corresponding custom vector functions. One or more memory locations are wiped if the one or more memory locations do not hold at least a portion of the IVT and/or the interrupt vector functions.

Abstract: The present invention relates to a compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (Syk) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast and/or basophil cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory disease and/or allergic disorders, and in cancer therapy, specifically heme malignancies, chronic spontaneous urticaria and autoimmune conditions.

Abstract: Disclosed are compounds having the formula: wherein R1A, R1B, R2 and R3 are defined herein, and methods of making and using the same.

Abstract: A gaming system comprises a wager input device and at least one display for displaying a primary wagering game and a secondary wagering game. The secondary wagering game comprises a playing field, the playing field having a set of field attributes associated therewith. The system further comprises a controller operative to (i) determine and display a first outcome of the primary wagering game, (ii) determine if a first set of game attributes associated with first outcome is eligible for play in the secondary wagering game, (iii) if the first outcome is eligible, determine a second outcome of the secondary wagering game by resolving the first set of game attributes with the set of field attributes in accordance with a first rule set, and (iv) if the second outcome is a winning outcome, award a first award.

Abstract: A compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (SYK) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory diseases and/or allergic conditions, in cancer therapy, specifically heme malignancies, and autoimmune conditions.

Abstract: A low power display device including a power control circuit for controlling power from an environmental energy source to a power storage device that is charged by the environmental energy source, is described.

Abstract: Tetrahydroquinoline compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.

Abstract: The present invention relates to methods for treatment or prevention of autoimmune and inflammatory diseases and conditions by inhibiting or modifying histone demethylation. In a further aspect the invention relates to a method for identifying agents useful in said methods of treatment. The invention particularly describes the role of certain histone demethylase enzymes in these diseases and conditions and their use as therapeutic and screening targets.

Abstract: The present invention relates to novel benzazepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

Abstract: A low power display device capable of receiving display information on a wireless network and powered by environmental power, without requiring a battery or a wired power connection, is described.

Abstract: Methods for reducing the impact of malware during a booting sequence for an interrupt driven computing device are disclosed. One or more parameters associated with an interrupt vector table (IVT) are manipulated to force the computing device into a clean state following a system level portion of the booting sequence. In another embodiment, occurring prior to the loading of an operating system or a call to a non-returnable main( ) function, one or more unused interrupt vectors in an IVT are replaced. A function filter is implemented for one or more interrupt vectors in the IVT to disallow unnecessary interrupt functions from being executed. One or more required interrupt vector functions are replaced with one or more corresponding custom vector functions. One or more memory locations are wiped if the one or more memory locations do not hold at least a portion of the IVT and/or the interrupt vector functions.