Patents by Inventor Matthew Wilson

Matthew Wilson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compound (S) and (R)-N-(2-fluoropyridin-4-yl)-3-methyl-2-(5-methyl-2,4-dioxo-1,2-dihydropyrido[3,4-d]pyrimidin-3(4H)-yl)butanamide and use
    Publication number: 20160311821
    Abstract: The present invention relates to a compound of Formula (I) having pharmacological activity, processes for its preparation, pharmaceutical compositions and their use in the treatment of certain parasitic certain parasitic protozoal infections such as malaria, in particular infection by Plasmodium falciparum. (S)-N-(2-fluoropyridin-4-yl)-3-methyl-2-(5-methyl-2,4-dioxo-1,2-dihydropyrido[3,4-d]pyrimidin-3(4H)-yl)butanamide.
    Type: Application
    Filed: April 19, 2016
    Publication date: October 27, 2016
    Inventors: Jose-Miguel COTERON LOPEZ, Esther Pilar FERNANDEZ VELANDO, Jorge FERNANDEZ-MOLINA, Maria Luisa LEON-DIAZ, David Matthew WILSON
  • Compounds
    Patent number: 9447074
    Abstract: A compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (SYK) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory diseases and/or allergic conditions, in cancer therapy, specifically heme malignancies, and autoimmune conditions.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: September 20, 2016
    Assignee: Glaxo Group Limited
    Inventors: Francis Louis Atkinson, Michael David Barker, John Liddle, David Matthew Wilson
  • Corded Dental Handpiece
    Publication number: 20160081766
    Abstract: An improved dental handpiece is described. The handpiece has a reverse radius grip and an angled bulkhead for attachment of a power cord.
    Type: Application
    Filed: September 22, 2015
    Publication date: March 24, 2016
    Inventors: Matthew Wilson, Schuring Amanda, Daniel Veile, Vincent Vella
  • 2 - (AZAINDOL-2-YL) BENZ IMIDAZOLES AS PAD4 INHIBITORS
    Publication number: 20160009716
    Abstract: Compounds of formula (I) wherein; R1 is hydrogen or C1-6alkyl; R2 is hydrogen, C1-6alkyl, perhalomethylC0-5alkyl-O—, or C1-6alkoxy; R3 is hydrogen, C1-6alkyl, or C1-6alkoxyC1-6alkyl; R4 is hydrogen, C1-6alkyl, perhalomethylC1-6alkyl; or unsubstituted C3-6cycloalkylC1-6alkyl; A is C—R5 or N; B is C—R6 or N; D is C—R7 or N; with the proviso that at least one of A, B, and D, is N; R5 is hydrogen or C1-6alkyl; R6 is hydrogen or C1-6alkyl; R7 is hydrogen, C1-6alkyl, C1-6alkoxy, or hydroxy; R8 is hydrogen or C1-6alkyl, with the proviso that one of R4 and R8 is hydrogen; R9 is hydrogen or hydroxy; Rio is hydrogen or C1-6alkyl; and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.
    Type: Application
    Filed: August 3, 2015
    Publication date: January 14, 2016
    Inventors: Stephen John Atkinson, Michael David Barker, Matthew Campbell, Hawa Diallo, Clement Douault, Neil Stuart Garton, John Liddle, Robert John Sheppard, Ann Louise Walker, Christopher Wellaway, David Matthew Wilson
  • Display mechanism for volatility-alteration features
    Patent number: 9230400
    Abstract: A gaming system includes an input device, a display device, a processor, and a memory device. The memory device stores instructions that, when executed by the processor, cause the gaming system to receive a wager for playing a wagering game having an overall volatility. A plurality of volatility components are displayed on the display device, the volatility components having respective component ratings. Each component rating contributes to a total rating of the overall volatility. The wagering game is selected from a plurality of wagering games, each of the plurality of wagering games having (a) the same total rating and (b) at least one different component rating.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: January 5, 2016
    Assignee: Bally Gaming, Inc.
    Inventors: Dion K. Aoki, Mary M. Burke, Michael R. Bytnar, Mark A. Hettinger, Michael W. Mastropietro, Matthew Wilson
  • 2-(azaindol-2-yl)benzimidazoles as PAD4 inhibitors
    Patent number: 9127003
    Abstract: Compounds of formula (I): wherein; R1 is hydrogen or C1-6alkyl; R2 is hydrogen, C1-6alkyl, perhalomethylC0-5alkyl-O—, or C1-6alkoxy; R3 is hydrogen, C1-6alkyl, or C1-6alkoxyC1-6alkyl; R4 is hydrogen, C1-6alkyl, perhalomethylC1-6alkyl; or unsubstituted C3-6cycloalkylC1-6 alkyl; A is C—R5 or N; B is C—R6 or N; D is C—R7 or N; with the proviso that at least one of A, B, and D, is N; R5 is hydrogen or C1-6alkyl; R6 is hydrogen or C1-6alkyl; R7 is hydrogen, C1-6alkyl, C1-6alkoxy, or hydroxy; R8 is hydrogen or C1-6alkyl, with the proviso that one of R4 and R8 is hydrogen; R9 is hydrogen or hydroxy; R10 is hydrogen or C1-6alkyl; and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: September 8, 2015
    Assignee: Glaxo Group Limited
    Inventors: Stephen John Atkinson, Michael David Barker, Matthew Campbell, Hawa Diallo, Clement Douault, Neil Stuart Garton, John Liddle, Robert John Sheppard, Ann Louise Walker, Christopher Wellaway, David Matthew Wilson
  • INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN PCAF FOR THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES OR FOR THE TREATMENT OF CANCER
    Publication number: 20150203851
    Abstract: A method of treating autoimmune and inflammatory diseases or conditions or cancer in a mammal, such as a human, which comprises the administration of an inhibitor of the bromodomain-containing protein PCAF.
    Type: Application
    Filed: September 4, 2013
    Publication date: July 23, 2015
    Inventors: Laurens Kruidenier, Kevin Lee, David Francis Tough, David Matthew Wilson
  • 2-(AZAINDOL-2-YL)BENZIMIDAZOLES AS PAD4 INHIBITORS
    Publication number: 20150175600
    Abstract: Compounds of formula (I): wherein; R1 is hydrogen or C1-6alkyl; R2 is hydrogen, C1-6alkyl, perhalomethylC0-5alkyl-O—, or C1-6alkoxy; R3 is hydrogen, C1-6alkyl, or C1-6alkoxyC1-6alkyl; R4 is hydrogen, C1-6alkyl, perhalomethylC1-6alkyl; or unsubstituted C3-6cycloalkylC1-6 alkyl; A is C—R5 or N; B is C—R6 or N; D is C—R7 or N; with the proviso that at least one of A, B, and D, is N; R5 is hydrogen or C1-6alkyl; R6 is hydrogen or C1-6alkyl; R7 is hydrogen, C1-6alkyl, C1-6alkoxy, or hydroxy; R8 is hydrogen or C1-6alkyl, with the proviso that one of R4 and R8 is hydrogen; R9 is hydrogen or hydroxy; R10 is hydrogen or C1-6alkyl; and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.
    Type: Application
    Filed: July 26, 2012
    Publication date: June 25, 2015
    Inventors: Stephen John Atkinson, Michael David Barker, Matthew Campbell, Hawa Diallo, Clement Douault, Neil Stuart Garton, John Liddle, Robert John Sheppard, Ann Louise Walker, Christopher Wellaway, David Matthew Wilson
  • NOVEL COMPOUNDS
    Publication number: 20150166508
    Abstract: A compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (SYK) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory diseases and/or allergic conditions, in cancer therapy, specifically heme malignancies, and autoimmune conditions.
    Type: Application
    Filed: February 19, 2015
    Publication date: June 18, 2015
    Inventors: Francis Louis ATKINSON, Michael David BARKER, John LIDDLE, David Matthew WILSON
  • Compounds
    Patent number: 8993560
    Abstract: A compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (SYK) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory diseases and/or allergic conditions, in cancer therapy, specifically heme malignancies, and autoimmune conditions.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: March 31, 2015
    Assignee: Glaxo Group Limited
    Inventors: Francis Louis Atkinson, Michael David Barker, John Liddle, David Matthew Wilson
  • Power control for a low power display
    Patent number: 8952665
    Abstract: A low power display device including a power control circuit for controlling power from an environmental energy source to a power storage device that is charged by the environmental energy source, is described.
    Type: Grant
    Filed: July 27, 2012
    Date of Patent: February 10, 2015
    Assignee: Google Inc.
    Inventors: Aaron Spangler, Matthew Wilson
  • Walker for improved stairway mobility
    Patent number: 8820338
    Abstract: A walker adapted to navigate stairways and inclined surfaces is provided.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: September 2, 2014
    Inventors: Thomas Catricala, Benjamin Grant, Griffin Latulippe, Alexander Mutchler, Purven Parikh, Charles Persaud, Matthew Wilson, Matthew Thomas, Jeffrey Epp
  • Tetrahydroquinoline derivatives and their pharmaceutical use
    Patent number: 8697725
    Abstract: Tetrahydroquinoline compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.
    Type: Grant
    Filed: November 3, 2010
    Date of Patent: April 15, 2014
    Assignee: GlaxoSmithKline LLC
    Inventors: Emmanuel Hubert Demont, Neil Stuart Garton, Romain Luc Marie Gosmini, Thomas George Christopher Hayhow, Jonathan Seal, David Matthew Wilson, Michael David Woodrow
  • Method of treatment based on ATAD2 inhibitors
    Patent number: 8691747
    Abstract: A method of treating autoimmune and inflammatory diseases or conditions in a mammal, such as a human, which comprises the administration of a inhibitor of the bromodomain-containing protein: ATAD2.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: April 8, 2014
    Assignee: Glaxo Group Limited
    Inventors: Laurens Kruidenier, Kevin Lee, David Francis Tough, David Matthew Wilson
  • Method of Treatment
    Publication number: 20140024558
    Abstract: The present invention relates to methods for treatment or prevention of autoimmune and inflammatory diseases and conditions by inhibiting or modifying histone demethylation. In a further aspect the invention relates to a method for identifying agents useful in said methods of treatment. The invention particularly describes the role of certain histone demethylase enzymes in these diseases and conditions and their use as therapeutic and screening targets.
    Type: Application
    Filed: September 20, 2013
    Publication date: January 23, 2014
    Applicant: Glaxo Group Limited
    Inventors: Kevin Lee, David Francis Tough, David Matthew Wilson
  • 7-(1H-pyrazol-4-yl)-1,6-naphthyridine compounds as Syk inhibitors
    Patent number: 8633319
    Abstract: The present invention relates to a compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (Syk) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast and/or basophil cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory disease and/or allergic disorders, and in cancer therapy, specifically heme malignancies, chronic spontaneous urticaria and autoimmune conditions.
    Type: Grant
    Filed: April 27, 2011
    Date of Patent: January 21, 2014
    Assignee: Glaxo Group Limited
    Inventors: Francis Louis Atkinson, Michael David Barker, Clement Douault, Neil Stuart Garton, John Liddle, Vipulkumar Kantibhai Patel, Alexander George Steven Preston, David Matthew Wilson
  • AUTHORIZATION OF CARDLESS PAYMENT TRANSACTIONS
    Publication number: 20140012689
    Abstract: A method of processing a transaction between a customer and a merchant includes receiving from a mobile device of the customer or from another device of the customer an indication of consent to perform a cardless payment transaction with the merchant, receiving from the mobile device an indication that the customer is within a predetermined distance of the merchant, after receiving both the indication of consent and the indication that the customer is within the predetermined distance, sending to a computer system of the merchant an indication of the presence of the customer and personal identifying information for the customer, receiving data indicating a transaction between the customer and the merchant, and submitting the transaction to a financial service for authorization.
    Type: Application
    Filed: September 4, 2013
    Publication date: January 9, 2014
    Applicant: Square, Inc.
    Inventors: William Henderson, Jack Dorsey, Brian Grassadonia, Matthew Wilson
  • AUTHORIZATION OF CARDLESS PAYMENT TRANSACTIONS
    Publication number: 20140012757
    Abstract: A method of processing a transaction between a customer and a merchant includes receiving from a mobile device of the customer or from another device of the customer an indication of consent to perform a cardless payment transaction with the merchant, receiving from the mobile device an indication that the customer is within a predetermined distance of the merchant, after receiving both the indication of consent and the indication that the customer is within the predetermined distance, sending to a computer system of the merchant an indication of the presence of the customer and personal identifying information for the customer, receiving data indicating a transaction between the customer and the merchant, and submitting the transaction to a financial service for authorization.
    Type: Application
    Filed: September 3, 2013
    Publication date: January 9, 2014
    Applicant: Square, Inc.
    Inventors: William Henderson, Jack Dorsey, Brian Grassadonia, Matthew Wilson
  • PYRIDO[3,4-B]PYRAZINE DERIVATIVES AS SYK INHIBITORS
    Publication number: 20140005188
    Abstract: A compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (Syk) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory disease and/or allergic disorders, and in cancer therapy, specifically heme malignancies, and autoimmune conditions.
    Type: Application
    Filed: March 8, 2012
    Publication date: January 2, 2014
    Applicant: GLAXO GROUP LIMITED
    Inventors: Francis Louis Atkinson, Stephen John Atkinson, Michael David Barker, Clement Douault, Neil Stuart Garton, John Liddle, Vipulkumar Kantibhai Patel, Alexander G. Preston, Tracy Jane Shipley, David Matthew Wilson, Robert J. Watson
  • PYRIDINYL- AND PYRAZINYL-METHYLOXY-ARYL DERIVATIVES USEFUL AS INHIBITORS OF SPLEEN TYROSINE KINASE (SYK)
    Publication number: 20140005177
    Abstract: A compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (SYK) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory diseases and/or allergic conditions, in cancer therapy, specifically heme malignancies, and autoimmune conditions.
    Type: Application
    Filed: March 8, 2012
    Publication date: January 2, 2014
    Applicant: GLAXO GROUP LIMITED
    Inventors: Francis Louis Atkinson, Michael David Barker, John Liddle, David Matthew Wilson