Abstract: The present invention relates to cell penetrating molecules comprising two oligonucleotide cargo molecules.

Abstract: A computer system operates to determine a traction value for each of a plurality of regions of a road network. The computer system identifies a region of the road network for which the traction value is known. The computer system may direct a vehicle to operate over a region of the road network where the traction value is known, in order to obtain sensor data that is indicative of a traction capability of the vehicle.

Abstract: Systems, computer program products, and methods are described herein for generating and maintaining source capability objects for application components. The present invention may be configured to receive a request to initiate a development process for an application, where the request identifies one or more components of the application, and cause a user device to prompt a user to select, for each component of the application, one or more source capabilities from a plurality of source capabilities. The present invention may be further configured to receive, from the user device and for each component of the application, the one or more source capabilities selected by the user. The present invention may be further configured to generate, for each component of the application, a source capability object including information identifying the one or more source capabilities selected by the user for the component.

Abstract: A radio receiver system configured to remove click noise from a demodulated signal is disclosed. The radio receiver system may employ digital demodulation or analog demodulation. The radio receiver system may be configured to determine measures of a statistical distribution of amplitudes of the demodulated signal, and thresholds for limiting the demodulated signal based on the measures of the statistical distribution of amplitudes. Portions of the demodulated signal exceeding the thresholds are either soft limited or hard limited.

Abstract: The present invention relates to peptides, in particular cell penetrating peptides, of 40 amino acid residues or less comprising at least one directly glycosylated amino residue and one or more arginine rich arm domains, and to conjugates of such cell penetrating peptides with a therapeutic molecule. The present invention further relates to the use of the peptides or conjugates in methods of treatment or as a medicament, especially in the treatment of genetic disorders of the central nervous system.

Abstract: The present invention relates to exosomes, loaded with genetic material and methods of producing them and to the use of such exosomes for delivering genetic material in vivo, in particular the use of such exosomes in methods of gene therapy or gene silencing.

Abstract: A pallet includes a top deck that includes a product support surface and an opposing underside, and with the product support surface including a pair of pallet support leg receiving areas. A pair of pallet support legs is on the underside of the top deck and aligned with the pallet support leg receiving areas. Each pallet support leg including a center leg section having a first end adjacent the underside of the top deck and a second end opposite the first end, and a pair of leg extensions extending outwards from the second end of the center leg section. An underside of the center leg section and the pair of leg extensions are configured to engage one of the pallet support leg receiving areas of an identical pallet when stacked thereon.

Abstract: Embodiments of the invention are directed to a system, method, or computer program product structured for determining platform stability and resiliency.

Abstract: A reconfigurable pallet/dolly platform includes a top deck that includes a product support surface and an opposing underside. The underside includes pallet support leg attachment areas for receiving pallet support legs when configured as a pallet, and dolly wheel attachment areas for receiving dolly wheels when configured as a dolly. The product support surface includes pallet support leg receiving areas aligned with the pallet support leg attachment areas and configured to engage the pallet support legs from an identical platform stacked thereon when configured as a pallet. The product support surface also includes dolly wheel receiving areas aligned with the dolly wheel wells and configured to engage the dolly wheels from an identical platform stacked thereon when configured as a dolly. Each dolly wheel receiving area partially overlaps with one of the pallet support leg receiving areas.

Abstract: The present invention relates to exosomes, loaded with biotherapeutic protein and/or peptide and methods of producing them and to the use of such exosomes for delivering protein and/or peptide in vivo, in particular the use of such exosomes in methods of therapy.

Abstract: The present invention relates to peptides, in particular cell-penetrating peptides, and to conjugates of such cell-penetrating peptides with a therapeutic molecule. The present invention further relates to use of such peptides or conjugates in methods of treatment or as a medicament, especially in the treatment of genetic disorders and in particular muscular dystrophies such as Duchenne muscular dystrophy.

Abstract: the present invention relates to peptides, in particular cell-penetrating peptides, having a first hydrophobic domain positioned at the C-terminus of the peptide and a second hydrophobic domain positioned at the N-terminus of the peptide, and to conjugates of such cell-penetrating peptides with a therapeutic molecule. The present invention further relates to use of such peptides or conjugates in methods of treatment or as a medicament, especially in the treatment of genetic disorders and in particular muscular dystrophies such as Duchenne muscular dystrophy.

Abstract: A method of routing a first signal in a telecommunication network is disclosed. The telecommunication network comprises plural nodes and uses time-division multiple access (TDMA) frames, with each TDMA frame divided into time slots and each time slot is divided into subslots. The method includes the step of transmitting a first signal from an initiating node in a first subslot. The method further includes the step of receiving the first signal at other nodes in the network in the first subslot, wherein the first signal is retransmitted in a second subslot subsequent to the first subslot. An improvement in the method includes the step of preparing for the retransmission at least one of a time-dispersed first signal or time-dispersed algorithmically related first signal by two or more nodes via a controller.

Abstract: The present invention relates to exosomes, loaded with biotherapeutic protein and/or peptide and methods of producing them and to the use of such exosomes for delivering protein and/or peptide in vivo, in particular the use of such exosomes in methods of therapy.

Abstract: A method for operating a pallet positioning station for positioning a pallet to be impacted by a pallet impact station is provided. The pallet positioning station includes a pallet push arm assembly adjacent the pallet impact station. The pallet push arm assembly includes a pallet push arm movable between a retracted position and a pallet positioning position. The method includes moving the pallet push arm to the retracted position to receive the pallet for positioning, and moving the pallet push arm to the pallet positioning position to position the pallet towards the pallet impact station for impact.

Abstract: A pallet positioning station for positioning a pallet to be impacted by a pallet impact station includes a pallet push arm assembly adjacent the pallet impact station. The pallet push arm assembly includes a pallet push arm movable between a retracted position and a pallet positioning position. A controller is configured to move the pallet push arm to the retracted positions to receive the pallet for positioning, and move the pallet push arm to the pallet positioning position to position the pallet towards the pallet impact station for impact.

Abstract: The present invention relates to exosomes, loaded with genetic material and methods of producing them and to the use of such exosomes for delivering genetic material in vivo, in particular the use of such exosomes in methods of gene therapy or gene silencing.

Abstract: A pallet includes a plastic top deck and a bamboo bottom deck. The bamboo bottom deck includes bamboo boards made from bamboo strips layered together. Support blocks are coupled between the bamboo bottom deck and the plastic top deck, with a gap being formed therebetween for receiving a lifting member.

Abstract: A method for making a pallet includes forming a base layer, forming a cargo layer, and forming wooden support blocks. The method further includes coating the wooden support blocks with a plastic layer to form plastic coated wooden support blocks. The base and cargo layers are coupled to the plastic coated wooden support blocks, with a gap being formed therebetween for receiving a lifting member.

Abstract: A pallet impact station includes a frame, at least one pendulum swing arm rotatably coupled to the frame, a carriage assembly carried by the at least one pendulum swing arm for impacting a pallet, and a latching mechanism extending between the frame and the at least one pendulum swing arm. The latching mechanism disengages the at least one pendulum swing arm at a raised position so that the carriage assembly impacts the pallet. A controller operates the latching mechanism to disengage the at least one pendulum swing arm.